3c4e A 1.98 BS01 C4E A 1 F49 A65 K67 L174 D186 F17 A33 K35 L142 D154 D167 K169 N172 D186 L193 T204 D135 K137 N140 D154 L161 T172 2.7.11.1 0004672,0004674,0005524,0006468,0043066 ic50~100uM -logKd/Ki=4.00, IC50=100uM P11309 18287029 306 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH 3c4e B 1.98 BS01 C4E B 1 L44 F49 A65 K67 L174 I185 D186 L12 F17 A33 K35 L142 I153 D154 D167 K169 N172 D186 L193 T204 D135 K137 N140 D154 L161 T172 2.7.11.1 0004672,0004674,0005524,0006468,0043066 ic50~100uM P11309 18287029 306 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH 3c4e C 1.98 BS01 C4E C 1 F49 A65 K67 R122 L174 I185 D186 F16 A32 K34 R89 L141 I152 D153 D167 K169 N172 D186 L193 T204 D134 K136 N139 D153 L160 T171 2.7.11.1 0004672,0004674,0005524,0006468,0043066 ic50~100uM P11309 18287029 306 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH 3c4e D 1.98 BS01 C4E D 1 L44 F49 A65 K67 I104 R122 L174 I185 D186 L12 F17 A33 K35 I72 R90 L142 I153 D154 D167 K169 N172 D186 L193 T204 D135 K137 N140 D154 L161 T172 2.7.11.1 0004672,0004674,0005524,0006468,0043066 ic50~100uM P11309 18287029 306 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH