2fs9 A 2.3 BS01 C4A A 1 F41 H57 C58 K60D A63 D189 S190 C191 Q192 G193 S195 V213 S214 F28 H44 C45 K51 A55 D188 S189 C190 Q191 G192 S194 V212 S213 H57 D102 Q192 G193 D194 S195 G196 H44 D91 Q191 G192 D193 S194 G195 3.4.21.59 0004252,0005515,0005576,0005615,0006508,0008236,0062023 -logKd/Ki=8.52, Ki=3nM Ki=3nM P20231 16681368 999 IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPK 2fs9 B 2.3 BS01 C4A B 1 F41 H57 C58 K60D D189 S190 C191 Q192 G193 S195 S214 F28 H44 C45 K51 D188 S189 C190 Q191 G192 S194 S213 H57 D102 Q192 G193 D194 S195 G196 H44 D91 Q191 G192 D193 S194 G195 3.4.21.59 0004252,0005515,0005576,0005615,0006508,0008236,0062023 Ki=3nM P20231 16681368 998 IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPK 2fs9 C 2.3 BS01 C4A C 1 F41 H57 C58 K60D D189 S190 Q192 G193 S195 S214 F28 H44 C45 K51 D188 S189 Q191 G192 S194 S213 H57 D102 Q192 G193 D194 S195 G196 H44 D91 Q191 G192 D193 S194 G195 3.4.21.59 0004252,0005515,0005576,0005615,0006508,0008236,0062023 Ki=3nM P20231 16681368 997 IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPK 2fs9 D 2.3 BS01 C4A D 1 F41 H57 C58 K60D D189 S190 Q192 G193 D194 S195 S214 F28 H44 C45 K51 D188 S189 Q191 G192 D193 S194 S213 H57 D102 Q192 G193 D194 S195 G196 H44 D91 Q191 G192 D193 S194 G195 3.4.21.59 0004252,0005515,0005576,0005615,0006508,0008236,0062023 -logKd/Ki=8.52, Ki=3nM Ki=3nM P20231 16681368 996 IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPK