4cff A 3.924 BS02 C1V B 1 L18 G19 K29 K31 I46 D88 L11 G12 K22 K24 I39 D81 D139 K141 E143 N144 D157 S176 D132 K134 E136 N137 D150 S169 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 24352254 1271 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEAVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIAAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cff B 3.924 BS01 C1V B 1 V81 R83 R107 S108 N111 V113 V4 R6 R30 S31 N34 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 Kd=487nM, EC50=390nM Q9Y478 24352254 1271 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCYHQEPYVPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4cff C 3.924 BS02 C1V C 1 G19 K29 K31 I46 D88 G10 K20 K22 I37 D79 D139 K141 E143 N144 D157 S176 D130 K132 E134 N135 D148 S167 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 -logKd/Ki=6.40, Kd=0.40uM P54646 24352254 1553 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVAYHLIIDNRRIMNQASEFYLASSPLKPHPERMPPLIADAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4cff D 3.924 BS01 C1V C 1 S108 V113 S31 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 -logKd/Ki=6.40, Kd=0.40uM Kd=487nM, EC50=390nM Q9Y478 24352254 1553 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCQEPYVCKPPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4zhx A 2.99 BS02 C1V B 1 G19 K29 K31 I46 D88 G11 K21 K23 I38 D80 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 26952388 301 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVKEVCEAVAYHLIIDNRRIMNQASEFYLASKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDLGSHTMDFFEMCASLITTL 4zhx B 2.99 BS01 C1V B 1 R83 T106 R107 S108 V113 R6 T29 R30 S31 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 Kd=487nM, EC50=390nM Q9Y478 26952388 301 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKQEPYVCKFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKP 4zhx C 2.99 BS02 C1V C 1 V11 G19 K29 K31 I46 D88 V3 G11 K21 K23 I38 D80 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.31 0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006633,0006695,0006914,0007165,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016239,0016241,0016310,0016607,0030424,0030425,0031588,0031669,0032007,0034599,0042149,0042593,0042752,0043025,0043066,0044024,0045821,0046872,0047322,0048511,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 26952388 602 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVKEVCECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSSAMHIPPGLKPHPERMPPLIAAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4zhx D 2.99 BS01 C1V C 1 V81 R83 S108 V113 V4 R6 S31 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 Kd=487nM, EC50=390nM Q9Y478 26952388 602 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDEPYVCKPERAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKP 5ezv A 2.99 BS02 C1V A 1 V11 L18 G19 K29 K31 I46 D88 V4 L11 G12 K22 K24 I39 D81 D139 K141 E143 N144 D157 S176 D132 K134 E136 N137 D150 S169 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54646,Q13131 26952388 602 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASRPHPERVPFKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDLGSHTMDFFEMCASLITTLA 5ezv B 2.99 BS01 C1V A 1 R83 S108 V113 R6 S31 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 Kd=487nM, EC50=390nM Q9Y478 26952388 602 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 5ezv C 2.99 BS02 C1V C 1 V11 L18 G19 K29 K31 I46 D88 V3 L10 G11 K21 K23 I38 D80 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0004672,0004679,0005524,0006468 P54646,Q13131 26952388 602 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQLAVAYHLIIDNRRIMNQASEFYLASSRPHPERVKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEPRLGSHTMDFFEMCASLITTLA 5ezv D 2.99 BS01 C1V C 1 V81 R83 R107 S108 V113 V5 R7 R31 S32 V37 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 Kd=487nM, EC50=390nM Q9Y478 26952388 602 ARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELPYHQEPYVCKEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKP