1npz A 2.0 BS01 C1P A 1 Q19 C25 N67 G68 G69 F70 A140 N163 H164 W186 Q19 C25 N67 G68 G69 F70 A140 N163 H164 W186 Q19 C25 H164 N184 Q19 C25 H164 N184 3.4.22.27 0006508,0008234 -logKd/Ki=7.89, Ki=13nM P25774 12641451 468 LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVTLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI 1npz B 2.0 BS01 C1P B 1 Q269 C275 W276 N317 G318 G319 F320 M321 A390 V412 N413 H414 W436 F461 Q19 C25 W26 N67 G68 G69 F70 M71 A140 V162 N163 H164 W186 F211 Q269 C275 H414 N434 Q19 C25 H164 N184 3.4.22.27 0006508,0008234 P25774 12641451 469 LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVTLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI 3bwk A 2.42 BS01 C1P A 1 Q45 G49 C51 N87 Y90 G91 G92 Y93 N182 H183 W215 Q38 G42 C44 N80 Y83 G84 G85 Y86 N175 H176 W208 Q45 C51 H183 N213 Q38 C44 H176 N206 3.4.22.- 0006508,0008234 -logKd/Ki=3.94, Kd=0.114mM Q8IIL0 19620707 300 YEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLL 3bwk B 2.42 BS01 C1P B 1 Q45 G49 C51 N87 Y90 G91 G92 Y93 N182 H183 W215 Q38 G42 C44 N80 Y83 G84 G85 Y86 N175 H176 W208 Q45 C51 H183 N213 Q38 C44 H176 N206 3.4.22.- 0006508,0008234 Q8IIL0 19620707 300 YEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLL 3bwk B 2.42 BS02 C1P D 1 D163 F167 D156 F160 Q45 C51 H183 N213 Q38 C44 H176 N206 3.4.22.- 0006508,0008234 Q8IIL0 19620707 300 YEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLL 3bwk C 2.42 BS01 C1P C 1 Q45 G49 C51 N87 Y90 G91 G92 Y93 P181 N182 H183 W215 Q38 G42 C44 N80 Y83 G84 G85 Y86 P174 N175 H176 W200 Q45 C51 H183 N213 Q38 C44 H176 N198 3.4.22.- 0006508,0008234 -logKd/Ki=3.94, Kd=0.114mM Q8IIL0 19620707 300 YEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDIEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLL 3bwk D 2.42 BS01 C1P D 1 Q45 G49 C51 Y90 G91 G92 Y93 P181 N182 H183 W215 Q38 G42 C44 Y83 G84 G85 Y86 P174 N175 H176 W197 Q45 C51 H183 N213 Q38 C44 H176 N195 3.4.22.- 0006508,0008234 Q8IIL0 19620707 300 YEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLL 3s3q A 1.8 BS01 C1P A 1 Q94 G98 C100 W101 E142 G143 G144 L146 I193 V247 G269 H270 W292 Q25 G29 C31 W32 E73 G74 G75 L77 I124 V178 G200 H201 W223 Q94 C100 H270 N290 Q25 C31 H201 N221 3.4.22.1 0006508,0008234 -logKd/Ki=8.77, IC50=1.71nM Q8MNY2 21832058 1 VEIPSSFDSRKKWPRCKSIATIRDQSRCGSCWAFGAVEAMSDRSCIQSGGKQNVELSAVDLLSCCESCGLGCEGGILGPAWDYWVKEGIVTGSSKENHAGCEPYPFPKCEHHTKGKYPPCGSKIYKTPRCKQTCQKKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEAGFTVYEDFLNYKSGIYKHITGETLGGHAIRIIGWGVENKAPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVTAGRIN