1cbx A 2.0 BS02 BZS A 1 H69 R127 N144 R145 H196 I243 Y248 E270 H69 R127 N144 R145 H196 I243 Y248 E270 H69 E72 R127 H196 E270 H69 E72 R127 H196 E270 3.4.17.1 0004181,0006508,0008270 Ki=0.45uM -logKd/Ki=6.35, Ki=0.45uM Ki=500nM P00730 1738164 500 ARSTNTFNYATYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDLGIHSREWITQATGVWFAKKFTENYGQNPSFTAILDSMDIFLEIVTNPNGFAFTHSENRLWRKTRSVTSSSLCVGVDANRNWDAGFGKAGASSSPCSETYHGKYANSEVEVKSIVDFVKNHGNFKAFLSIHSYSQLLLYPYGYTTQSIPDKTELNQVAKSAVAALKSLYGTSYKYGSIITTIYQASGGSIDWSYNQGIKYSFTFELRDTGRYGFLLPASQIIPTAQETWLGVLTIMEHTVNN 1hyt A 1.7 BS06 BZS A 1 N112 L133 V139 H142 E143 H146 E166 L202 R203 H231 N112 L133 V139 H142 E143 H146 E166 L202 R203 H231 H142 E143 H146 Y157 E166 D226 H231 H142 E143 H146 Y157 E166 D226 H231 3.4.24.27 0004222,0006508 P00800 8034637 807 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGDGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSEMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 1wht A 2.0 BS01 BZS A 1 N51 G52 G53 C56 Y60 E145 S146 Y147 Y239 N56 G57 G58 C61 Y66 E153 S154 Y155 Y247 G53 S146 Y147 G58 S154 Y155 3.4.16.6 0004185,0006508 Ki=0.2mM -logKd/Ki=3.70, Ki=0.2mM P08819 7727364 430 GHAADRIARLPGQPAVDFDMYSGYITVDEGAGRSLFYLLQEAPEDAQPAPLVLWLNGGPGCSSVAYGASEELGAFRVKPRGAGLVLNEYRWNKVANVLFLDSPAGVGFSYTNTSSDIYTSGDNRTAHDSYAFLAKWFERFPHYKYRDFYIAGESYAGHYVPELSQLVHRSKNPVINLKGFMVGNGLIDDYHDYVGTFEFWWNHGIVSDDTYRRLKEACLHDSFIHPSPACDAATDVATAEQGNIDMYSLYTPVCNI 1wht B 2.0 BS01 BZS A 1 H397 E398 H127 E128 D338 H397 D75 H127 3.4.16.6 0004185,0006508 -logKd/Ki=3.70, Ki=0.2mM P08819 7727364 430 SYDPCTERYSTAYYNRRDVQMALHANVTGAMNYTWATCSDTINTHWHDAPRSMLPIYRELIAAGLRIWVFSGDTDAVVPLTATRYSIGALGLPTTTSWYPWYDDQEVGGWSQVYKGLTLVSVRGAGHEVPLHRPRQALVLFQYFLQGKPMPGQ 4a38 A 2.0 BS02 BZS A 1 H167 E170 R218 N227 R228 H260 E335 H167 E170 R218 N227 R228 H260 E335 ? 0004181,0006508,0008270,0046872 Q9I012 22645247 1376 MQIRADFDSGNIQVIDASDPRRIRLAIRPDLASQHFQWFHFKVEGMAPATEHCFTLVNAGQSAYSHAWSGYQAVASYDGERWFRVPSQYDADGLHFQLEPEESEVRFAYFEPYSRERHARLVERALGIEGVERLAVGTSVQGRDIELLRVRRHPDSHLKLWVIAQQHPGEHMAEWFMEGLIERLQRPDDTEMQRLLEKADLYLVPNMNPDGAFHGNLRTNAAGQDLNRAWLEPSAERSPEVWFVQQEMKRHGVDLFLDIHGDEEIPHVFAAGCEGNPGYTPRLERLEQRFREELMARGEFQIRHGYPRSAPGQANLALACNFVGQTYDCLAFTIEMPFKDHDDNPEPGTGWSGARSKRLGQDVLSTLAVLVDELR 4duk A 1.57 BS05 BZS A 1 H69 E72 R129 N146 R147 H204 A251 Y255 T257 D260 E277 H69 E72 R129 N146 R147 H204 A251 Y255 T257 D260 E277 H69 E72 R129 H204 E277 H69 E72 R129 H204 E277 3.4.17.18 0004181,0006508,0008270 P29068 25619204 405 DFPSYDSGYHNYNEMVNKINTVASNYPNIVKKFSIGKSYEGRELWAVKISDNVGTDENEPEVLYTALHHAREHLTVEMALYTLDLFTQNYNLDSRITNLVNNREIYIVFNINPDGGEYDISSGSYKSWRKNRQPNSGSSYVGTDLNRNYGYKWGCCGGSSGSPSSETYRGRSAFSAPETAAMRDFINSRVVGGKQQIKTLITFHTYSELILYPYGYTYTDVPSDMTQDDFNVFKTMANTMAQTNGYTPQQASDLYITDGDMTDWAYGQHKIFAFTFEMYPTSYNPGFYPPDEVIGRETSRNKEAVLYVAEKADCPYSVIGKSC