1c3b A 2.25 BS01 BZB A 1 S64 Y150 N152 Y221 G317 A318 S61 Y147 N149 Y218 G314 A315 S64 K67 Y112 A114 V121 Y150 G156 E272 K315 A318 S61 K64 Y109 A111 V118 Y147 G153 E269 K312 A315 3.5.2.6 0008800,0016787,0017001,0030288,0042597,0046677 -logKd/Ki=7.57, Ki=27nM IC50=200nM, Ki=27nM P00811 10595535 362 APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ 1c3b B 2.25 BS01 BZB B 1 S64 Q120 Y150 N152 Y221 G317 A318 S61 Q117 Y147 N149 Y218 G314 A315 S64 K67 Y112 A114 V121 Y150 G156 E272 K315 A318 S61 K64 Y109 A111 V118 Y147 G153 E269 K312 A315 3.5.2.6 0008800,0016787,0017001,0030288,0042597,0046677 IC50=200nM, Ki=27nM P00811 10595535 362 APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ 3fkv A 1.847 BS01 BZB A 1 S64 R67 Y150 N152 Y221 A318 S61 R64 Y147 N149 Y218 A313 S64 R67 Y112 A114 V121 Y150 G156 E272 K315 A318 S61 R64 Y109 A111 V118 Y147 G153 E269 K310 A313 3.5.2.6 0008800,0016787,0017001,0042597,0046677 -logKd/Ki=7.57, Ki=0.027uM IC50=200nM, Ki=27nM P00811 19241376 362 APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSRTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ 3fkv B 1.847 BS01 BZB B 1 S64 Q120 Y150 N152 Y221 G317 A318 S61 Q117 Y147 N149 Y218 G314 A315 S64 R67 Y112 A114 V121 Y150 G156 E272 K315 A318 S61 R64 Y109 A111 V118 Y147 G153 E269 K312 A315 3.5.2.6 0008800,0016787,0017001,0042597,0046677 IC50=200nM, Ki=27nM P00811 19241376 362 APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSRTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ 3ixb A 1.63 BS01 BZB A 1 S64 L119 Q120 Y150 N152 Y221 A318 S61 L116 Q117 Y147 N149 Y218 A309 S64 K67 Y112 A114 V121 Y150 G156 E272 K315 A318 S61 K64 Y109 A111 V118 Y147 G153 E269 K306 A309 3.5.2.6 0008800,0016787,0017001,0030288,0042597,0046677 IC50=200nM, Ki=27nM P00811 19913034 363 APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAKAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIIIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ 3ixb B 1.63 BS01 BZB B 1 S64 Q120 Y150 N152 Y221 A318 S61 Q117 Y147 N149 Y218 A315 S64 K67 Y112 A114 V121 Y150 G156 E272 K315 A318 S61 K64 Y109 A111 V118 Y147 G153 E269 K312 A315 3.5.2.6 0008800,0016787,0017001,0030288,0042597,0046677 IC50=200nM, Ki=27nM P00811 19913034 362 APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAKAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ 3ixg B 2.14 BS01 BZB B 1 S64 L119 Q120 Y150 N152 Y221 A318 S61 L116 Q117 Y147 N149 Y218 A315 S64 K67 Y112 A114 V121 Y150 G156 E272 K315 A318 S61 K64 Y109 A111 V118 Y147 G153 E269 K312 A315 3.5.2.6 0008800,0016787,0017001,0030288,0042597,0046677 -logKd/Ki=7.57, Ki=27nM IC50=200nM, Ki=27nM P00811 19913034 362 APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFIGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ 4bd0 A 1.207 BS01 BZB A 1 S70 K73 N104 Y105 S130 N132 N170 G236 S237 S43 K46 N77 Y78 S103 N105 N143 G209 S210 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Q47066 23255594 300 NSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAENRNDILAAAAKIVTHGF 4bd1 A 2.002 BS01 BZB A 1 S70 K73 N104 Y105 S130 N132 G236 S237 S43 K46 N77 Y78 S103 N105 G209 S210 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0046677 Q47066 23255594 300 NSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAENRNDILAAAAKIVTHGF 4c3q A 2.2 BS01 BZB A 1 C69 S70 K73 N104 Y105 S130 N132 P167 N170 G236 S237 C42 S43 K46 N77 Y78 S103 N105 P140 N143 G209 S210 S70 K73 S130 E166 K234 S237 S43 K46 S103 E139 K207 S210 3.5.2.6 0008800,0016787,0046677 Q47066 300 NSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAENRNDILAAAAKIVTHGF