2e41 A 1.75 BS01 BTX A 1 S21 T22 N23 Q42 G45 H46 G47 A48 R51 K52 W53 E54 L62 A111 G114 I128 G129 N131 P137 A140 S21 T22 N23 Q42 G45 H46 G47 A48 R51 K52 W53 E54 L62 A111 G114 I128 G129 N131 P137 A140 A48 A111 A48 A111 6.3.4.15 0004077,0005524,0005737,0016874,0036211,0046872 O57883 18372281 1301 MLGLKTSIIGRRVIYFQEITSTNEFAKTSYLEEGTVIVADKQTMGHGALNRKWESPEGGLWLSIVLSPKVPQKDLPKIVFLGAVGVVETLKEFSIDGRIKWPNDVLVNYKAIAGVLVEGKGDKIVLGIGLNVNNKVPNGATSMKLELGSEVPLLSVFRSLITNLDRLYLNFLKNPMDILNLVRDNMILGVRVKILGDGSFEGIAEDIDDFGRLIIRLDSGEVKKVIYGDVSLRFL 2e41 B 1.75 BS01 BTX B 1 S21 T22 N23 Q42 G45 H46 G47 A48 R51 K52 W53 E54 L62 N103 G114 I128 G129 N131 P137 S21 T22 N23 Q42 G45 H46 G47 A48 R51 K52 W53 E54 L62 N103 G114 I128 G129 N131 P137 A48 A111 A48 A111 6.3.4.15 0004077,0005524,0005737,0016874,0036211,0046872 O57883 18372281 1302 MLGLKTSIIGRRVIYFQEITSTNEFAKTSYLEEGTVIVADKQTMGHGALNRKWESPEGGLWLSIVLSPKVPQKDLPKIVFLGAVGVVETLKEFSIDGRIKWPNDVLVNYKAIAGVLVEGKGDKIVLGIGLNVNNKVPNGATSMKLELGSEVPLLSVFRSLITNLDRLYLNFLKNPMDILNLVRDNMILGVRVKILGDGSFEGIAEDIDDFGRLIIRLDSGEVKKVIYGDVSL 2ewn A 2.8 BS01 BTX A 1 S89 T90 Q112 R116 G117 R118 R121 K122 W123 F124 D176 G186 I187 A205 G206 N208 V218 V219 S87 T88 Q110 R114 G115 R116 R119 K120 W121 F122 D174 G184 I185 A203 G204 N206 V216 V217 R118 K183 R317 R116 K181 R315 6.3.4.15 0000976,0003676,0003677,0004077,0005515,0005524,0005737,0006355,0006768,0009102,0009374,0016874,0017053,0036211,0042803 Ki=87nM, Kd=1.5nM P06709 16438984 501 DNTVPLKLIALLANGEFHSGEQLGETLGMSRAAINKHIQTLRDWGVDVFTVPGKGYSLPEPIQLLNAKQILGQLDGGSVAVLPVIDSTNQYLLDRIGELKSGDACIAEYQQAGRGRRGRKWFSPFGANLYLSMFWRLEQGPAAAIGLSLVIGIVMAEVLRKLGADKVRVKWPNDLYLQDRKLAGILVELTGKTGDAAQIVIGAGINMAMRRVEESVVNQGWITLQEAGINLDRNTLAAMLIRELRAALELFEQEGLAPYLSRWEKLDNFINRPVKLIIGDKEIFGISRGIDKQGALLLEQDGIIKPWMGGEISLRSAE 2ewn B 2.8 BS01 BTX B 1 S89 T90 Q112 G115 R116 G117 R118 R121 K122 W123 F124 K183 G186 I187 A205 G206 N208 V219 Q221 S88 T89 Q111 G114 R115 G116 R117 R120 K121 W122 F123 K182 G185 I186 A204 G205 N207 V218 Q220 R118 K183 R317 R117 K182 R316 6.3.4.15 0000976,0003676,0003677,0004077,0005515,0005524,0005737,0006355,0006768,0009102,0009374,0016874,0017053,0036211,0042803 Ki=87nM, Kd=1.5nM P06709 16438984 500 KDNTVPLKLIALLANGEFHSGEQLGETLGMSRAAINKHIQTLRDWGVDVFTVPGKGYSLPEPIQLLNAKQILGQLDGGSVAVLPVIDSTNQYLLDRIGELKSGDACIAEYQQAGRGRRGRKWFSPFGANLYLSMFWRLEQGPAAAIGLSLVIGIVMAEVLRKLGADKVRVKWPNDLYLQDRKLAGILVELTGKTGDAAQIVIGAGINMAMRRVEESVVNQGWITLQEAGINLDRNTLAAMLIRELRAALELFEQEGLAPYLSRWEKLDNFINRPVKLIIGDKEIFGISRGIDKQGALLLEQDGIIKPWMGGEISLRS 4dq2 A 2.5 BS01 BTX A 1 S93 T94 Q116 R120 G121 R122 R125 H126 W127 S128 M137 K187 G190 G208 I209 N212 I224 S92 T93 Q115 R119 G120 R121 R124 H125 W126 S127 M136 K186 G189 G207 I208 N211 I223 0004077,0006355,0036211 Ki=0.03uM -logKd/Ki=7.52, Ki=0.03uM 22437830 500 SKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLLQQLPDIWYQGIIDQYTKSSALFDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGRGRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALGIRDAIQHFSQDEVKVKWPNDIYIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLDRYQFLERLLQEIEKRYNQFLTLPFSEIREEYIAASNIWNRTLLFTENDKQFKGQAIDLDYDGYLIVRDEAGESHRLISADIDF 4wf2 A 2.31 BS01 BTX A 1 S89 T90 Q112 R116 G117 R118 R121 K122 W123 F124 Y132 K183 G186 I187 A205 G206 N208 S87 T88 Q110 R114 G115 R116 R119 K120 W121 F122 Y130 K181 G184 I185 A199 G200 N202 R118 K183 R317 R116 K181 R301 6.3.4.15 0000976,0003676,0003677,0004077,0005515,0005524,0005737,0006355,0006768,0009102,0009374,0016874,0017053,0036211,0042803 -logKd/Ki=8.10, Kd=8.03nM Ki=87nM, Kd=1.5nM P06709 25746672 501 DNTVPLKLIALLANGEFHSGEQLGETLGMSRAAINKHIQTLRDWGVDVFTVPGKGYSLPEPIQLLNAKQILGQLDGGSVAVLPVIDSTNQYLLDRIGELKSGDACIAEYQQAGRGRRGRKWFSPFGANLYLSMFWRLEQAPAAAIGLSLVIGIVMAEVLRKLGADKVRVKWPNDLYLQDRKLAGILVELTDAAQIVIGAGINMAMGWITLQEAGINLDRNTLAAMLIRELRAALELFEQEGLAPYLSRWEKLDNFINRPVKLIIGDKEIFGISRGIDKQGALLLEQDGIIKPWMGGEISLRSAE