2zjf A 2.4 BS01 BSU A 1 D104 W105 I137 Y164 V193 Y272 H333 W334 D101 W102 I134 Y161 V190 Y262 H323 W324 F36 D104 W105 I127 Y164 Y272 D302 H333 F33 D101 W102 I124 Y161 Y262 D292 H323 3.3.2.10 0003824,0004301,0009636,0016787,0042803 ic50=19nM -logKd/Ki=7.72, IC50=19nM IC50=19nM P95276 18585390 360 VHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSKYRVQKAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAGVVGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAVQDGIITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVSMDPIDVIRAGPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLSFYHNIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMPNYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP 3e85 A 1.95 BS01 BSU A 1 L22 V23 L55 H68 Y80 F142 L22 V23 L55 H68 Y80 F142 3.1.27.- 0004518,0004540,0004864,0005509,0005634,0005737,0005829,0006952,0009738,0010427,0038023,0044373,0046872,1904408 Kd=4.2uM -logKd/Ki=5.38, Kd=4.2uM Q9LLQ2 19220853 158 GVFTFQDEYTSTIAPAKLYKALVTDADIIIPKAVETIQSVEIVEGNGGPGTIKKLTFIEGGESKYVLHKIEAIDEANLGYNYSIVGGVGLPDTIEKISFETKLVEGANGGSIGKVTIKIETKGDAQPNEEEGKAAKARGDAFFKAIESYLSAHP 3e85 A 1.95 BS02 BSU A 2 I37 F57 R138 I37 F57 R138 3.1.27.- 0004518,0004540,0004864,0005509,0005634,0005737,0005829,0006952,0009738,0010427,0038023,0044373,0046872,1904408 Kd=4.2uM -logKd/Ki=5.38, Kd=4.2uM Q9LLQ2 19220853 159 GVFTFQDEYTSTIAPAKLYKALVTDADIIIPKAVETIQSVEIVEGNGGPGTIKKLTFIEGGESKYVLHKIEAIDEANLGYNYSIVGGVGLPDTIEKISFETKLVEGANGGSIGKVTIKIETKGDAQPNEEEGKAAKARGDAFFKAIESYLSAHP 3e85 A 1.95 BS03 BSU A 3 Y9 F99 V115 F143 Y9 F99 V115 F143 3.1.27.- 0004518,0004540,0004864,0005509,0005634,0005737,0005829,0006952,0009738,0010427,0038023,0044373,0046872,1904408 Kd=4.2uM -logKd/Ki=5.38, Kd=4.2uM Q9LLQ2 19220853 160 GVFTFQDEYTSTIAPAKLYKALVTDADIIIPKAVETIQSVEIVEGNGGPGTIKKLTFIEGGESKYVLHKIEAIDEANLGYNYSIVGGVGLPDTIEKISFETKLVEGANGGSIGKVTIKIETKGDAQPNEEEGKAAKARGDAFFKAIESYLSAHP 3e85 A 1.95 BS04 BSU A 4 F5 G89 G132 A135 R138 F5 G89 G132 A135 R138 3.1.27.- 0004518,0004540,0004864,0005509,0005634,0005737,0005829,0006952,0009738,0010427,0038023,0044373,0046872,1904408 Kd=4.2uM -logKd/Ki=5.38, Kd=4.2uM Q9LLQ2 19220853 161 GVFTFQDEYTSTIAPAKLYKALVTDADIIIPKAVETIQSVEIVEGNGGPGTIKKLTFIEGGESKYVLHKIEAIDEANLGYNYSIVGGVGLPDTIEKISFETKLVEGANGGSIGKVTIKIETKGDAQPNEEEGKAAKARGDAFFKAIESYLSAHP 5ai5 A 2.28 BS01 BSU A 1 F267 D335 W336 Y383 Q384 Y466 F266 D334 W335 Y382 Q383 Y465 F267 H334 D335 W336 N359 N378 Y383 Y466 D496 H524 F266 H333 D334 W335 N358 N377 Y382 Y465 D495 H523 3.1.3.76,3.3.2.10 0000287,0003824,0004301,0005737,0005777,0005782,0005829,0006629,0009056,0009636,0010628,0015643,0016311,0016787,0016791,0033885,0042577,0042632,0042803,0046272,0046839,0046872,0052642,0070062,0090181,0097176 ic50=0.093uM -logKd/Ki=7.03, IC50=0.093uM IC50=390nM P34913 25931264 1551 TLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDAR 5cw2 A 2.0 BS01 BSU A 1 D103 W104 L107 Y153 M178 Y238 M241 H297 D101 W102 L105 Y151 M176 Y236 M239 H295 F35 H102 D103 W104 L126 S127 Y153 R173 Y238 D268 H297 W298 F33 H100 D101 W102 L124 S125 Y151 R171 Y236 D266 H295 W296 3.3.2.3 0003824,0016787 G7CF24 401 TPSERSVETNGVRLRLVEAGERGDPLVVLAHGFPELAYSWRHQIPALVDAGYHVMAPDQRGYGGSSAPEAIEAYDITRLTADLMGLLDDIGAEKAAFIGHDWGALVVWNAALLYPDRVAAVAGLSVPPVPRSLTRPTEAFRALVGEDNFFYILYFQEPGVADAELDGDPARTMRRMFGGLTSDPDAAHRMLQPGPAGFIDRLPEPEALPDWLTAEELDHYIAEFTRTGFTGGLNWYRNMDRNWELTEHLAGATITAPALFLAGAADPVLGFMRPERATEVAVGPYRQVLLDGAGHWVQQERPQEVNAALIDFLRGLELQ 5cw2 B 2.0 BS01 BSU B 1 F35 D103 W104 L107 Y153 F200 Y238 F33 D101 W102 L105 Y151 F198 Y236 F35 H102 D103 W104 L126 S127 Y153 R173 Y238 D268 H297 W298 F33 H100 D101 W102 L124 S125 Y151 R171 Y236 D266 H295 W296 3.3.2.3 0003824,0016787 G7CF24 401 TPSERSVETNGVRLRLVEAGERGDPLVVLAHGFPELAYSWRHQIPALVDAGYHVMAPDQRGYGGSSAPEAIEAYDITRLTADLMGLLDDIGAEKAAFIGHDWGALVVWNAALLYPDRVAAVAGLSVPPVPRSLTRPTEAFRALVGEDNFFYILYFQEPGVADAELDGDPARTMRRMFGGLTSDPDAAHRMLQPGPAGFIDRLPEPEALPDWLTAEELDHYIAEFTRTGFTGGLNWYRNMDRNWELTEHLAGATITAPALFLAGAADPVLGFMRPERATEVAVGPYRQVLLDGAGHWVQQERPQEVNAALIDFLRGLELQ 5cw2 C 2.0 BS01 BSU C 1 D103 W104 Y153 M178 Y238 H297 D101 W102 Y151 M176 Y236 H295 F35 H102 D103 W104 L126 S127 Y153 R173 Y238 D268 H297 W298 F33 H100 D101 W102 L124 S125 Y151 R171 Y236 D266 H295 W296 3.3.2.3 0003824,0016787 G7CF24 401 TPSERSVETNGVRLRLVEAGERGDPLVVLAHGFPELAYSWRHQIPALVDAGYHVMAPDQRGYGGSSAPEAIEAYDITRLTADLMGLLDDIGAEKAAFIGHDWGALVVWNAALLYPDRVAAVAGLSVPPVPRSLTRPTEAFRALVGEDNFFYILYFQEPGVADAELDGDPARTMRRMFGGLTSDPDAAHRMLQPGPAGFIDRLPEPEALPDWLTAEELDHYIAEFTRTGFTGGLNWYRNMDRNWELTEHLAGATITAPALFLAGAADPVLGFMRPERATEVAVGPYRQVLLDGAGHWVQQERPQEVNAALIDFLRGLELQ 5cw2 D 2.0 BS01 BSU D 1 D103 W104 L107 Y153 F200 Y238 H297 D101 W102 L105 Y151 F198 Y236 H295 F35 H102 D103 W104 L126 S127 Y153 R173 Y238 D268 H297 W298 F33 H100 D101 W102 L124 S125 Y151 R171 Y236 D266 H295 W296 3.3.2.3 0003824,0016787 G7CF24 401 TPSERSVETNGVRLRLVEAGERGDPLVVLAHGFPELAYSWRHQIPALVDAGYHVMAPDQRGYGGSSAPEAIEAYDITRLTADLMGLLDDIGAEKAAFIGHDWGALVVWNAALLYPDRVAAVAGLSVPPVPRSLTRPTEAFRALVGEDNFFYILYFQEPGVADAELDGDPARTMRRMFGGLTSDPDAAHRMLQPGPAGFIDRLPEPEALPDWLTAEELDHYIAEFTRTGFTGGLNWYRNMDRNWELTEHLAGATITAPALFLAGAADPVLGFMRPERATEVAVGPYRQVLLDGAGHWVQQERPQEVNAALIDFLRGLELQ