1fm6 D 2.1 BS02 BRL D 1 I281 G284 C285 S289 H323 I341 M348 M364 H449 Y473 I76 G79 C80 S84 H118 I136 M143 M159 H244 Y268 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 10882139 503 PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 1fm6 X 2.1 BS02 BRL X 1 F282 G284 C285 S289 H323 I341 M364 H449 Y473 F77 G79 C80 S84 H118 I136 M159 H244 Y268 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 10882139 504 PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 1zgy A 1.8 BS02 BRL A 1 F282 G284 C285 S289 H323 I341 H449 Y473 F77 G79 C80 S84 H118 I136 H244 Y268 ? 0003677,0004879,0005634,0006355 ic50=0.5uM EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 15976031 503 PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 2prg A 2.3 BS01 BRL A 1 G284 C285 Q286 S289 H323 I341 H449 Y473 G78 C79 Q80 S83 H117 I135 H243 Y267 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 9744270 1 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 2prg B 2.3 BS01 BRL B 1 C285 Q286 S289 H323 L330 I341 H449 Y473 C54 Q55 S58 H92 L99 I110 H218 Y242 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 9744270 2 ESADLRALAKHLYDSYIKSFPLTKAKARAILTVIYDMNSLMQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 3cs8 A 2.3 BS02 BRL A 1 G284 C285 S289 L330 I341 M364 K367 H449 L453 L469 Y473 G77 C78 S82 L123 I134 M157 K160 H242 L246 L262 Y266 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 18469005 503 RGGSPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDL 3dzy D 3.1 BS04 BRL D 1 I281 C285 Q286 R288 S289 H323 L330 M364 H449 Y473 I158 C162 Q163 R165 S166 H200 L207 M241 H326 Y350 ? 0003677,0003700,0004879,0005634,0006355,0008270,0043565 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 19043829 478 AIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 4ema A 2.545 BS01 BRL A 1 G284 C285 S289 H323 I341 H449 Y473 G63 C64 S68 H102 I120 H228 Y252 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 22649490 601 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 4o8f A 2.6 BS01 BRL A 1 G284 C285 R288 S289 H323 V339 I341 M348 M364 H449 Y473 G63 C64 R67 S68 H102 V118 I120 M127 M143 H228 Y248 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 25004973 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTSPFVIYDMNSLMMGEDTPLEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLAKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTELHPLLQEIYKDLY 4o8f B 2.6 BS01 BRL B 1 I281 G284 C285 S289 H323 V339 I341 M348 F363 M364 H449 L453 L469 Y473 I62 G65 C66 S70 H104 V120 I122 M129 F144 M145 H230 L234 L241 Y245 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 25004973 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLAKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIHPLLQEIYKDLY 4xld A 2.45 BS01 BRL A 1 F282 G284 C285 S289 H323 I341 M364 H449 Y473 F68 G70 C71 S75 H109 I127 M150 H235 Y259 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 26249358 502 MQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTSPFVIYDMNSLMMGEDKIKFKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 5ji0 D 1.98 BS02 BRL D 1 F282 G284 C285 Q286 S289 H323 Y327 I341 H449 Y473 F74 G76 C77 Q78 S81 H115 Y119 I133 H241 Y265 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 501 GPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 5ycp A 2.0 BS02 BRL A 1 F282 C285 S289 H323 I341 H449 Y473 F68 C71 S75 H109 I127 H235 Y259 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 29311579 501 LNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 6md4 A 2.24 BS01 BRL A 1 F282 C285 S289 H323 M364 H449 Y473 F66 C69 S73 H107 M148 H233 Y257 ? 0003677,0004879,0005634,0006355 -logKd/Ki=6.16, Kd=0.69uM EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 30575522 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYK 6onj A 2.3 BS02 BRL A 1 I281 F282 G284 C285 S289 H323 L330 I341 M348 M364 H449 Y473 I62 F63 G65 C66 S70 H104 L111 I122 M129 M145 H230 Y254 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 32075969 501 ESADLRALAKHLYDSYIKSFPLTKAKARAILTSPFVIYDMNSLMMGEDKIKHITPLEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 7awc A 1.74 BS01 BRL A 1 F282 C285 S289 H323 I341 H449 Y473 F76 C79 S83 H117 I135 H243 Y267 ? 0003677,0004879,0005634,0006355 EC50=40nM, IC50=1.000000nM, Ki=8nM, Kd=0.145000nM P37231 33989565 501 SMQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY