3mwu A 1.98 BS05 BK3 A 1 A103 K105 M136 I150 Y155 E159 L205 D219 A38 K40 M71 I85 Y90 E94 L140 D154 D198 K200 E202 N203 D219 T238 D133 K135 E137 N138 D154 T169 2.7.11.17 0004672,0005509,0005524,0006468 -logKd/Ki=8.05, IC50=9nM A3FQ16 21116453 561 LYFQGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNDRIGTAYYIAPEVLRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQAEKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDSNSLIQNEGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDKDGSGKISTKELEQVDNNKDGEVDFNEFVEMLQNFVR 3n51 A 2.1 BS01 BK3 A 1 V65 A78 V79 K80 M112 L126 V130 Y131 E135 L181 D195 V21 A34 V35 K36 M68 L82 V86 Y87 E91 L137 D151 D174 K176 E178 N179 D195 T214 D130 K132 E134 N135 D151 T170 2.7.11.17 0004672,0004674,0004683,0005509,0005516,0005524,0005634,0005737,0006468,0009931,0016020,0016310,0018105,0035556,0046777,0046872 -logKd/Ki=7.82, IC50=15nM IC50=15.0nM Q9BJF5 21116453 701 AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLKLCGN