1gw6 A 2.2 BS01 BES A 1 Q136 Y267 G268 G269 M270 E271 H295 E296 H299 F314 E318 Y378 Y383 Q136 Y267 G268 G269 M270 E271 H295 E296 H299 F314 E318 Y378 Y383 E271 H295 E296 H299 E318 N375 Y383 E271 H295 E296 H299 E318 N375 Y383 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 IC50=4000nM, Kd=2050nM, Ki=320nM P09960 11917124 1611 PEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPNVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 1hs6 A 1.95 BS02 BES A 1 Q136 Y267 G268 G269 M270 E271 H295 E296 H299 F314 E318 Y378 Y383 Q136 Y267 G268 G269 M270 E271 H295 E296 H299 F314 E318 Y378 Y383 E271 H295 E296 H299 E318 D375 Y383 E271 H295 E296 H299 E318 D375 Y383 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 -logKd/Ki=5.38, IC50=4.2uM IC50=4000nM, Kd=2050nM, Ki=320nM P09960 11175901 901 PEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 1txr A 2.0 BS03 BES A 1 D117 E151 E152 L155 D179 C223 Y225 C227 F244 F248 Y251 H256 D117 E151 E152 L155 D179 C223 Y225 C227 F244 F248 Y251 H256 H97 D117 E151 E152 D179 H256 H97 D117 E151 E152 D179 H256 3.4.11.10 0006508,0008235 Ki=18nM -logKd/Ki=7.74, Ki=18nM IC50=1.6nM, Ki=1.6nM Q01693 15274616 503 MPPITQQATVTAWLPQVDASQITGTISSLESFTNRFYTTTSGAQASDWIASEWQALSASLPNASVKQVSHSGYNQKSVVMTITGSEAPDEWIVIGGHLDSTIGSHTNEQSVAPGADDDASGIAAVTEVIRVLSENNFQPKRSIAFMAYAAEEVGLRGSQDLANQYKSEGKNVVSALQLDMTNYKGSAQDVVFITDYTDSNFTQYLTQLMDEYLPSLTYGFDTCGYACSDHASWHNAGYPAAMPFESKFNDYNPRIHTTQDTLANSDPTGSHAKKFTQLGLAYAIEMGSATG 1xry A 2.1 BS03 BES A 1 H97 D117 E151 E152 L155 D179 M180 C223 Y225 C227 F244 F248 Y251 H256 H97 D117 E151 E152 L155 D179 M180 C223 Y225 C227 F244 F248 Y251 H256 H97 D117 E151 E152 D179 H256 H97 D117 E151 E152 D179 H256 3.4.11.10 0006508,0008235 IC50=1.6nM, Ki=1.6nM Q01693 2001 MPPITQQATVTAWLPQVDASQITGTISSLESFTNRFYTTTSGAQASDWIASEWQALSASLPNASVKQVSHSGYNQKSVVMTITGSEAPDEWIVIGGHLDSTIGSHTNEQSVAPGADDDASGIAAVTEVIRVLSENNFQPKRSIAFMAYAAEEVGLRGSQDLANQYKSEGKNVVSALQLDMTNYKGSAQDVVFITDYTDSNFTQYLTQLMDEYLPSLTYGFDTCGYACSDHASWHNAGYPAAMPFESKFNDYNPRIHTTQDTLANSDPTGSHAKKFTQLGLAYAIEMGSATG 2dqm A 1.6 BS02 BES A 1 E121 M260 G261 A262 E264 V294 H297 E298 H301 E320 Y376 Y381 E118 M257 G258 A259 E261 V291 H294 E295 H298 E317 Y373 Y378 E264 H297 E298 H301 E320 N373 Y381 E261 H294 E295 H298 E317 N370 Y378 3.4.11.2 0004177,0005515,0005886,0006508,0008237,0008270,0042802,0046872 P04825 16885166 901 QPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 2ek9 A 1.97 BS05 BES A 1 D240 E272 E273 D301 R345 I362 V366 Y370 H371 D236 E268 E269 D297 R341 I358 V362 Y366 H367 H228 D240 E272 E273 D301 H371 H224 D236 E268 E269 D297 H367 ? 0004177,0006508,0008235,0046872 A2V759 2001 ADHQITKRTDAENMYNTIQFLSQAPRVAGSPEELKAVRYIEQQFKSYGYHVEVQPFQFEGYTAPSEVTLKIGTEKKEGEAFTYSPNSDVTAELVYVGLGTTADVAGKDLNGKIALIQRGNISFADKVRNAAKQGAKAVIIYNNTDGKLNGTLGGSDASFVAAVGITKQEGDALAANLRAGEKITATVKVAGAEVKTLTSHNVIATKKPDANKKNTNDIIIIGSHHDSVEKAPGANDDASGVAVTLELARVMSKLKTDTELRFITFGAEENGLIGSKKYAASLSEDEIKRTIGMFQLDMVGSKDAGDLIMYTIDGKKNRVTDLGAAASSRLSGVLPYGQEGRSDHESFHALGIPAALFIHAPVEPWYHTPNDTLDKISKEKLDNVADIVGSAVYQAARPGELVIEPIDYPRRN 2hpt A 2.3 BS02 BES A 1 E121 M260 G261 A262 E264 H297 E298 H301 E320 N373 Y376 Y381 E117 M256 G257 A258 E260 H293 E294 H297 E316 N369 Y372 Y377 E264 H297 E298 H301 E320 N373 Y381 E260 H293 E294 H297 E316 N369 Y377 3.4.11.2 0004177,0005515,0005886,0006508,0008237,0008270,0042802,0046872 P04825 16938892 960 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 2xq0 A 1.955 BS01 BES A 1 E186 Y312 G313 G314 E316 H340 H344 E363 Y429 E144 Y266 G267 G268 E270 H294 H298 E317 Y383 E316 H340 E341 H344 E363 D421 Y429 E270 H294 E295 H298 E317 D375 Y383 3.3.2.10,3.4.11.- 0004177,0004301,0005634,0005737,0005829,0006508,0008237,0008270,0030163,0043171,0044255,0046872 Q10740 21146536 901 MLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHNKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRTTDKCTALQWLNSKQTKGGKPYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESPLPVVFSGIRIEDTNIYRFEQKVPIPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPTLLAHDRSNIDVIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDSMKDPERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWETWLYKPGMPPRPHFITALADNVYQLADKWVEMAQHLKTTEDFRSEFNAIDIKDFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDRRLALATFDKFKDTYHPICKALVKQDLKL 2yd0 A 2.7 BS02 BES A 1 Q181 E183 S316 G317 A318 M319 E320 H353 E354 H357 E376 K380 Y438 Q132 E134 S267 G268 A269 M270 E271 H304 E305 H308 E327 K331 Y389 E320 H353 E354 H357 E376 R430 Y438 E271 H304 E305 H308 E327 R381 Y389 3.4.11.- 0001525,0002250,0002474,0004175,0004177,0005138,0005151,0005515,0005576,0005615,0005737,0005783,0005788,0005789,0005829,0006508,0006509,0008217,0008233,0008235,0008237,0008270,0009617,0016020,0019885,0042277,0043171,0045088,0045444,0045766,0046872,0070006,0070062 IC50=50000nM Q9NZ08 21508329 1950 PFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASIGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQEHYMKGDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKLER 2zof A 2.3 BS03 BES A 1 D132 E166 E167 D195 R343 E414 G416 S417 H445 D136 E170 E171 D199 R347 E418 G420 S421 H449 3.4.13.18 0004180,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070573,0103046 ic50=7nM -logKd/Ki=8.15, IC50=7nM Q9D1A2 18550540 1080 SPNSMSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLK 2zof A 2.3 BS04 BES B 1 H228 T330 H232 T334 3.4.13.18 0004180,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070573,0103046 ic50=7nM -logKd/Ki=8.15, IC50=7nM Q9D1A2 18550540 1081 SPNSMSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLK 2zof B 2.3 BS01 BES A 1 H228 T330 H232 T334 3.4.13.18 0004180,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070573,0103046 ic50=7nM -logKd/Ki=8.15, IC50=7nM Q9D1A2 18550540 1080 SPNSMSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLK 2zof B 2.3 BS04 BES B 1 D132 E166 E167 D195 R343 E414 G416 S417 H445 D136 E170 E171 D199 R347 E418 G420 S421 H449 3.4.13.18 0004180,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070573,0103046 ic50=7nM -logKd/Ki=8.15, IC50=7nM Q9D1A2 18550540 1081 SPNSMSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLK 2zog A 1.7 BS03 BES A 1 H99 D132 E166 E167 D195 Y197 R343 E414 S417 H445 H103 D136 E170 E171 D199 Y201 R347 E418 S421 H449 3.4.13.18 0004180,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070573,0103046 Q9D1A2 18550540 1080 SPNSMSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLK 2zog A 1.7 BS04 BES B 1 H228 T330 H232 T334 3.4.13.18 0004180,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070573,0103046 Q9D1A2 18550540 1081 SPNSMSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLK 2zog B 1.7 BS01 BES A 1 H228 T330 H232 T334 3.4.13.18 0004180,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070573,0103046 Q9D1A2 18550540 1080 SPNSMSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLK 2zog B 1.7 BS04 BES B 1 H99 D132 E166 E167 D195 Y197 R343 E414 G416 S417 H445 H103 D136 E170 E171 D199 Y201 R347 E418 G420 S421 H449 3.4.13.18 0004180,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070573,0103046 Q9D1A2 18550540 1081 SPNSMSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLK 3ebh A 1.65 BS02 BES A 1 E319 V459 G460 A461 E463 H496 E497 H500 E519 Y575 Y580 E124 V264 G265 A266 E268 H301 E302 H305 E324 Y380 Y385 E463 H496 E497 H500 E519 E572 Y580 E268 H301 E302 H305 E324 E377 Y385 3.4.11.- 0006508,0008237,0008270 Ki=478.2nM -logKd/Ki=6.32, Ki=478.2nM Ki=190nM, IC50=284nM O96935 19196988 1085 PKIHYRKDYKPSGFIINQVTLNINIHDQETIVRSVLDMDISKHNVGEDLVFDGVGLKINEISINNKKLVEGEEYTYDNEFLTIFSKFVPKSKFAFSSEVIIHPETNYALTGLYKSKNIIVSQCEATGFRRITFFIDRPDMMAKYDVTVTADKEKYPVLLSNGDKVNEFEIPGGRHGARFNDPPLKPCYLFAVVAGDLKHLSATYITKYTKKKVELYVFSEEKYVSKLQWALECLKKSMAFDEDYFGLEYDLSRLNLVAVSDFNVGAMENKGLNIFNANSLLASKKNSIDFSYARILTVVGHEYFHQYTGNRVTLRDWFQLTLKEGLTVHRENLFSEEMTKTVTTRLSHVDLLRSVQFLEDSSPLSHPIRPESYVSMENFYTTTVYDKGSEVMRMYLTILGEEYYKKGFDIYIKKNDGNTATCEDFNYAMEQAYKMKKADNSANLNQYLLWFSQSGTPHVSFKYNYDAEKKQYSIHVNQYTKPDENQKEKKPLFIPISVGLINPENGKEMISQTTLELTKESDTFVFNNIAVKPIPSLFRGFSAPVYIEDQLTDEERILLLKYDSDAFVRYNSCTNIYMKQILMNYNEFLKAKNEKLESFQLTPVNAQFIDAIKYLLEDPHADAGFKSYIVSLPQDRYIINFVSNLDTDVLADTKEYIYKQIGDKLNDVYYKMFKSLEAKADDLTYFNDESHVDFDQMNMRTLRNTLLSLLSKAQYPNILNEIIEHSKSPYPSNWLTSLSVSAYFDKYFELYDKTYKLSKDDELLLQEWLKTVSRSDRKDIYEILKKLENEVLKDSKNPNDIRAVYLPFTNNLRRFHDISGKGYKLIAEVITKTDKFNPMVATQLCEPFKLWNKLDTKRQELMLNEMNTMLQEPQISNNLKEYLLRLTNK 3ftx A 1.96 BS03 BES A 1 Q136 Y267 G268 G269 E271 H295 E296 H299 F314 E318 Y378 Y383 Q133 Y264 G265 G266 E268 H292 E293 H296 F311 E315 Y375 Y380 E271 H295 E296 H299 E318 D375 Y383 E268 H292 E293 H296 E315 D372 Y380 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 IC50=4000nM, Kd=2050nM, Ki=320nM P09960 19618939 720 VDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 3fue A 2.38 BS03 BES A 1 Q134 Q136 Y267 G268 G269 E271 H295 E296 H299 F314 Y378 Y383 Q131 Q133 Y264 G265 G266 E268 H292 E293 H296 F311 Y375 Y380 E271 H295 E296 H299 E318 D375 Y383 E268 H292 E293 H296 E315 D372 Y380 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 IC50=4000nM, Kd=2050nM, Ki=320nM P09960 19618939 720 VDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 3fuf A 2.6 BS03 BES A 1 Q134 Q136 Y267 G268 G269 E271 H295 E296 H299 F314 E318 Y378 Y383 Q131 Q133 Y264 G265 G266 E268 H292 E293 H296 F311 E315 Y375 Y380 E271 H295 E296 H299 E318 D375 Y383 E268 H292 E293 H296 E315 D372 Y380 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 IC50=4000nM, Kd=2050nM, Ki=320nM P09960 19618939 720 VDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 3fuh A 1.8 BS03 BES A 1 Q136 Y267 G268 G269 E271 H295 E296 H299 F314 E318 Y378 Y383 Q133 Y264 G265 G266 E268 H292 E293 H296 F311 E315 Y375 Y380 E271 H295 E296 H299 E318 D375 Y383 E268 H292 E293 H296 E315 D372 Y380 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 IC50=4000nM, Kd=2050nM, Ki=320nM P09960 19618939 720 VDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 3h8g A 1.5 BS04 BES A 1 K267 D272 M287 D290 D349 E351 T376 L377 W470 K267 D272 M287 D290 D349 E351 T376 L377 W470 K279 R353 K279 R353 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 O86436 20359484 505 MELVVKSVAAASVKTATLVIPVGENRKLGAVAKAVDLASEGAISAVLKRGDLAGKPGQTLLLQNLQGLKAERVLLVGSGKDEALGDRTWRKLVASVAGVLKGLNGADAVLALDDVAVNNRDAHYGKYRLLAETLLDGEYVFDRFKSQKVEPRALKKVTLLADKAGQAEVERAVKHASAIATGMAFTRDLGNLPPNLCHPSFLAEQAKELGKAHKALKVEVLDEKKIKDLGMGAFYAVGQGSDQPPRLIVLNYQGGKKADKPFVLVGKGITFDTGGISLKPGAGMDEMKYDMCGAASVFGTLRAVLELQLPVNLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFKPQAVIDIATLTGACIVALGSHTTGLMGNNDDLVGQLLDAGKRADDRAWQLPLFDEYQEQLDSPFADMGNIGGPKAGTITAGCFLSRFAKAYNWAHMDIAGTAWISGGKDKGATGRPVPLLTQYLLDRAGA 3h8g B 1.5 BS04 BES B 1 K267 D272 M287 D290 D349 E351 T376 L377 W470 K267 D272 M287 D290 D349 E351 T376 L377 W470 K279 R353 K279 R353 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 O86436 20359484 505 MELVVKSVAAASVKTATLVIPVGENRKLGAVAKAVDLASEGAISAVLKRGDLAGKPGQTLLLQNLQGLKAERVLLVGSGKDEALGDRTWRKLVASVAGVLKGLNGADAVLALDDVAVNNRDAHYGKYRLLAETLLDGEYVFDRFKSQKVEPRALKKVTLLADKAGQAEVERAVKHASAIATGMAFTRDLGNLPPNLCHPSFLAEQAKELGKAHKALKVEVLDEKKIKDLGMGAFYAVGQGSDQPPRLIVLNYQGGKKADKPFVLVGKGITFDTGGISLKPGAGMDEMKYDMCGAASVFGTLRAVLELQLPVNLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFKPQAVIDIATLTGACIVALGSHTTGLMGNNDDLVGQLLDAGKRADDRAWQLPLFDEYQEQLDSPFADMGNIGGPKAGTITAGCFLSRFAKAYNWAHMDIAGTAWISGGKDKGATGRPVPLLTQYLLDRAGA 3h8g C 1.5 BS04 BES C 1 K267 D272 M287 D290 D349 E351 T376 L377 W470 K267 D272 M287 D290 D349 E351 T376 L377 W470 K279 R353 K279 R353 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 O86436 20359484 505 MELVVKSVAAASVKTATLVIPVGENRKLGAVAKAVDLASEGAISAVLKRGDLAGKPGQTLLLQNLQGLKAERVLLVGSGKDEALGDRTWRKLVASVAGVLKGLNGADAVLALDDVAVNNRDAHYGKYRLLAETLLDGEYVFDRFKSQKVEPRALKKVTLLADKAGQAEVERAVKHASAIATGMAFTRDLGNLPPNLCHPSFLAEQAKELGKAHKALKVEVLDEKKIKDLGMGAFYAVGQGSDQPPRLIVLNYQGGKKADKPFVLVGKGITFDTGGISLKPGAGMDEMKYDMCGAASVFGTLRAVLELQLPVNLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFKPQAVIDIATLTGACIVALGSHTTGLMGNNDDLVGQLLDAGKRADDRAWQLPLFDEYQEQLDSPFADMGNIGGPKAGTITAGCFLSRFAKAYNWAHMDIAGTAWISGGKDKGATGRPVPLLTQYLLDRAGA 3h8g D 1.5 BS04 BES D 1 K267 D272 M287 D290 D349 E351 T376 L377 I382 W470 K267 D272 M287 D290 D349 E351 T376 L377 I382 W470 K279 R353 K279 R353 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 O86436 20359484 505 MELVVKSVAAASVKTATLVIPVGENRKLGAVAKAVDLASEGAISAVLKRGDLAGKPGQTLLLQNLQGLKAERVLLVGSGKDEALGDRTWRKLVASVAGVLKGLNGADAVLALDDVAVNNRDAHYGKYRLLAETLLDGEYVFDRFKSQKVEPRALKKVTLLADKAGQAEVERAVKHASAIATGMAFTRDLGNLPPNLCHPSFLAEQAKELGKAHKALKVEVLDEKKIKDLGMGAFYAVGQGSDQPPRLIVLNYQGGKKADKPFVLVGKGITFDTGGISLKPGAGMDEMKYDMCGAASVFGTLRAVLELQLPVNLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFKPQAVIDIATLTGACIVALGSHTTGLMGNNDDLVGQLLDAGKRADDRAWQLPLFDEYQEQLDSPFADMGNIGGPKAGTITAGCFLSRFAKAYNWAHMDIAGTAWISGGKDKGATGRPVPLLTQYLLDRAGA 3h8g E 1.5 BS04 BES E 1 K267 D272 M287 D290 D349 E351 T376 L377 W470 K267 D272 M287 D290 D349 E351 T376 L377 W470 K279 R353 K279 R353 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 O86436 20359484 505 MELVVKSVAAASVKTATLVIPVGENRKLGAVAKAVDLASEGAISAVLKRGDLAGKPGQTLLLQNLQGLKAERVLLVGSGKDEALGDRTWRKLVASVAGVLKGLNGADAVLALDDVAVNNRDAHYGKYRLLAETLLDGEYVFDRFKSQKVEPRALKKVTLLADKAGQAEVERAVKHASAIATGMAFTRDLGNLPPNLCHPSFLAEQAKELGKAHKALKVEVLDEKKIKDLGMGAFYAVGQGSDQPPRLIVLNYQGGKKADKPFVLVGKGITFDTGGISLKPGAGMDEMKYDMCGAASVFGTLRAVLELQLPVNLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFKPQAVIDIATLTGACIVALGSHTTGLMGNNDDLVGQLLDAGKRADDRAWQLPLFDEYQEQLDSPFADMGNIGGPKAGTITAGCFLSRFAKAYNWAHMDIAGTAWISGGKDKGATGRPVPLLTQYLLDRAGA 3h8g F 1.5 BS04 BES F 1 K267 D272 M287 D290 D349 E351 T376 L377 W470 K267 D272 M287 D290 D349 E351 T376 L377 W470 K279 R353 K279 R353 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 O86436 20359484 505 MELVVKSVAAASVKTATLVIPVGENRKLGAVAKAVDLASEGAISAVLKRGDLAGKPGQTLLLQNLQGLKAERVLLVGSGKDEALGDRTWRKLVASVAGVLKGLNGADAVLALDDVAVNNRDAHYGKYRLLAETLLDGEYVFDRFKSQKVEPRALKKVTLLADKAGQAEVERAVKHASAIATGMAFTRDLGNLPPNLCHPSFLAEQAKELGKAHKALKVEVLDEKKIKDLGMGAFYAVGQGSDQPPRLIVLNYQGGKKADKPFVLVGKGITFDTGGISLKPGAGMDEMKYDMCGAASVFGTLRAVLELQLPVNLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFKPQAVIDIATLTGACIVALGSHTTGLMGNNDDLVGQLLDAGKRADDRAWQLPLFDEYQEQLDSPFADMGNIGGPKAGTITAGCFLSRFAKAYNWAHMDIAGTAWISGGKDKGATGRPVPLLTQYLLDRAGA 3kr4 A 2.0 BS03 BES A 1 K374 M392 M396 F398 D399 N457 D459 E461 L487 T488 G489 K289 M307 M311 F313 D314 N372 D374 E376 L402 T403 G404 K386 R463 K301 R378 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM -logKd/Ki=7.60, Ki=25nM Q8IL11 20133789 1003 ASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSTDKNVMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND 3kr4 B 2.0 BS03 BES B 1 K374 D379 M392 M396 F398 D399 D459 E461 T486 L487 G489 K289 D294 M307 M311 F313 D314 D374 E376 T401 L402 G404 K386 R463 K301 R378 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM Q8IL11 20133789 1003 SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND 3kr4 C 2.0 BS03 BES C 1 K374 D379 M396 F398 D399 N457 D459 E461 T486 L487 T488 G489 K289 D294 M311 F313 D314 N372 D374 E376 T401 L402 T403 G404 K386 R463 K301 R378 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM Q8IL11 20133789 1003 SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND 3kr4 D 2.0 BS03 BES D 1 K374 D379 M392 M396 F398 D399 D459 E461 R463 T486 L487 T488 G489 K287 D292 M305 M309 F311 D312 D372 E374 R376 T399 L400 T401 G402 K386 R463 K299 R376 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM Q8IL11 20133789 1003 ASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND 3kr4 E 2.0 BS03 BES E 1 K374 D379 M392 M396 F398 D399 D459 E461 R463 T486 L487 T488 K282 D287 M300 M304 F306 D307 D367 E369 R371 T394 L395 T396 K386 R463 K294 R371 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM Q8IL11 20133789 1003 SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLN 3kr4 F 2.0 BS03 BES F 1 K374 D379 M396 F398 D399 N457 D459 E461 R463 T486 L487 G489 K281 D286 M303 F305 D306 N364 D366 E368 R370 T393 L394 G396 K386 R463 K293 R370 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM -logKd/Ki=7.60, Ki=25nM Q8IL11 20133789 1003 SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND 3kr4 G 2.0 BS03 BES G 1 K374 D379 M396 F398 D399 N457 D459 E461 T486 L487 T488 K287 D292 M309 F311 D312 N370 D372 E374 T399 L400 T401 K386 R463 K299 R376 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM Q8IL11 20133789 1003 SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSTDKNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND 3kr4 H 2.0 BS03 BES H 1 K374 D379 M396 F398 D399 N457 D459 E461 T486 L487 G489 K280 D285 M302 F304 D305 N363 D365 E367 T392 L393 G395 K386 R463 K292 R369 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM Q8IL11 20133789 1003 SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND 3kr4 I 2.0 BS03 BES I 1 K374 D379 M392 M396 F398 D399 N457 D459 E461 R463 T486 L487 G489 K289 D294 M307 M311 F313 D314 N372 D374 E376 R378 T401 L402 G404 K386 R463 K301 R378 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM Q8IL11 20133789 1003 SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND 3kr4 J 2.0 BS03 BES J 1 K374 D379 M392 M396 F398 D399 D459 E461 R463 T486 L487 T488 G489 A577 K284 D289 M302 M306 F308 D309 D369 E371 R373 T396 L397 T398 G399 A487 K386 R463 K296 R373 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM Q8IL11 20133789 1003 SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND 3kr4 K 2.0 BS03 BES K 1 K374 D379 M392 M396 F398 D399 N457 D459 E461 T486 L487 T488 G489 K280 D285 M298 M302 F304 D305 N363 D365 E367 T392 L393 T394 G395 K386 R463 K292 R369 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM Q8IL11 20133789 1003 SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND 3kr4 L 2.0 BS03 BES L 1 K374 D379 D399 N457 D459 E461 T486 L487 T488 G489 A577 K282 D287 D307 N365 D367 E369 T394 L395 T396 G397 A485 K386 R463 K294 R371 3.4.11.1,3.4.13.- 0005737,0006508,0019538,0030145,0046872,0070006 Ki=25nM Q8IL11 20133789 1003 SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLNDAL 3mdj A 2.95 BS02 BES A 1 E183 A318 E320 T350 H353 E354 E383 E135 A270 E272 T302 H305 E306 E335 E320 H353 E354 H357 E376 Y438 E272 H305 E306 H309 E328 Y373 3.4.11.- 0001525,0002250,0002474,0004175,0004177,0005138,0005151,0005515,0005576,0005615,0005737,0005783,0005788,0005789,0005829,0006508,0006509,0008217,0008233,0008235,0008237,0008270,0009617,0016020,0019885,0042277,0043171,0045088,0045444,0045766,0046872,0070006,0070062 IC50=50000nM Q9NZ08 21478864 1001 PFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGRLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLDITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASIVDVKTMMNTWTLQRGFPLITITVRGRNVHMKQEHYMKAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERMLRSELLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKSSSIAHMVMGTTNQFSTRTRLEEVKCVQQTIETIEENIGWMDKNFDKIRVWLQ 3mdj B 2.95 BS02 BES B 1 Q181 E183 S316 A318 M319 E320 H353 E354 E376 K380 Q136 E138 S271 A273 M274 E275 H308 E309 E331 K335 E320 H353 E354 H357 E376 Y438 E275 H308 E309 H312 E331 Y376 3.4.11.- 0001525,0002250,0002474,0004175,0004177,0005138,0005151,0005515,0005576,0005615,0005737,0005783,0005788,0005789,0005829,0006508,0006509,0008217,0008233,0008235,0008237,0008270,0009617,0016020,0019885,0042277,0043171,0045088,0045444,0045766,0046872,0070006,0070062 IC50=50000nM Q9NZ08 21478864 1001 PFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLDITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASIVDVKTMMNTWTLQRGFPLITITVRGRNVHMKQEHYMKAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERMLRSELLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKSSSIAHMVMGTTNQFSTRTRLEEVKCVQQTIETIEENIGWMDKNFDKIRVWLQ 3mdj C 2.95 BS02 BES C 1 E183 G317 A318 M319 E320 T350 E354 E136 G270 A271 M272 E273 T303 E307 E320 H353 E354 H357 E376 Y438 E273 H306 E307 H310 E329 Y374 3.4.11.- 0001525,0002250,0002474,0004175,0004177,0005138,0005151,0005515,0005576,0005615,0005737,0005783,0005788,0005789,0005829,0006508,0006509,0008217,0008233,0008235,0008237,0008270,0009617,0016020,0019885,0042277,0043171,0045088,0045444,0045766,0046872,0070006,0070062 IC50=50000nM Q9NZ08 21478864 1001 PFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLDITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASIVDVKTMMNTWTLQRGFPLITITVRGRNVHMKQEHYMKAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERMLRSELLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKSSSIAHMVMGTTNQFSTRTRLEEVKCVQQTIETIEENIGWMDKNFDKIRVWLQ 4fkk A 2.6 BS01 BES A 1 A346 A348 M349 E350 H383 E384 H387 E406 Y472 A284 A286 M287 E288 H321 E322 H325 E344 Y410 E350 H383 E384 H387 E406 S464 Y472 E288 H321 E322 H325 E344 S402 Y410 3.4.11.2 0001525,0001618,0004177,0005615,0005737,0005886,0006508,0008237,0008270,0030154,0042277,0043171,0046718,0046872,0070006 -logKd/Ki=9.30, Ki=0.5nM Ki=4100nM, IC50=9400nM P15145 23071329 1024 QSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRFLCQEPTDVIIIHSKKLNYTTQGHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGELADDLAGFYRSEYMEGNVKKVLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTALSNMPPKGSSTPLAEDPNWSVTEFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWARPNAIAEGHGMYALNVTGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRENALLFDPQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADHAEPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQISEMFDSISYSKGASVIRMLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEHLQKAVDAQTSIRLPDTVRAIMDRWTLQMGFPVITVDTKTGNISQKHFLLDSESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRDVSQAQNDLFKTASDDWVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLRKQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQGVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHSS 4fyr A 1.91 BS02 BES A 1 A353 H388 E389 H392 E411 S469 F472 Y477 G894 S895 A289 H324 E325 H328 E347 S405 F408 Y413 G830 S831 E355 H388 E389 H392 E411 S469 Y477 E291 H324 E325 H328 E347 S405 Y413 3.4.11.2 0001525,0001618,0004177,0005615,0005737,0005765,0005793,0005886,0006508,0008237,0008270,0009897,0030154,0030667,0038023,0042277,0043171,0046718,0046872,0070006,0070062 IC50=20120nM, Ki=2370nM P15144 22932899 1014 PDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK 4gaa A 2.26 BS02 BES A 1 Q133 Y264 G265 G266 E268 V289 H292 E293 H296 E315 F375 Y380 Q132 Y263 G264 G265 E267 V288 H291 E292 H295 E314 F374 Y379 E268 H292 E293 H296 E315 D372 Y380 E267 H291 E292 H295 E314 D371 Y379 3.3.2.6,3.4.11.4 0004177,0004301,0004463,0005634,0005737,0005829,0006508,0008237,0008270,0019370,0043171,0046872 Q6IP81 24333438 702 ADPSSFASPEKFNIKHMHLKLHVDFTSRAIAASTSLTVRSLQDSLASLILDTKDLTIKKVAVNGKDATFALGTTHSFKGTPLEITLPFSLTRGQEVIVEIDSVTSPKSSALQWLNKEQTAGKIHPYLFSQCQATHCRSIIPCQDTPSVKFTYYSQVSVPKELMALMSALRDGELSEQSDSNRKIYRFKQNVPIPSYLIALVVGALEGRKVGPRTTIWTEKELLEPSVYEFAETEKMLKYAEDLAGPYVWGQYDLLILPPSFPYGGMENPCLTFVTPTVLAGDRSLASVIAHEISHSWTGNLVTNETWENFWLNEGHTVYLERRIDGRLYGEEFRQFKALGGWKELQNSVNTFGATNPLTNLVPNLHEVDVDAAFSSVPYEKGFALLFYLEQLLGGPEIFLGFLKSYIQMFAFKSVTTEEWKKFLYSYFKDKVDILDKVDWKGWMHTPGMPPVQPKYDMTLANACITLGQKWVKATESDLGSFSADDVKDLSSHQLIEVLAILLLEKPLPVSHVKRMQEVYNLNDVKNSEIRFRWLRLCIRAGWEDVIPLALAMATEQGRMKFTRPLYRDLYNFEKAREQTVNTFLKNRSFMHPVTEMLVAKDLHIS 4gaa B 2.26 BS02 BES B 1 Q131 Q133 Y264 G265 G266 E268 H292 E293 H296 E315 F375 Y380 Q130 Q132 Y263 G264 G265 E267 H291 E292 H295 E314 F374 Y379 E268 H292 E293 H296 E315 D372 Y380 E267 H291 E292 H295 E314 D371 Y379 3.3.2.6,3.4.11.4 0004177,0004301,0004463,0005634,0005737,0005829,0006508,0008237,0008270,0019370,0043171,0046872 Q6IP81 24333438 702 ADPSSFASPEKFNIKHMHLKLHVDFTSRAIAASTSLTVRSLQDSLASLILDTKDLTIKKVAVNGKDATFALGTTHSFKGTPLEITLPFSLTRGQEVIVEIDSVTSPKSSALQWLNKEQTAGKIHPYLFSQCQATHCRSIIPCQDTPSVKFTYYSQVSVPKELMALMSALRDGELSEQSDSNRKIYRFKQNVPIPSYLIALVVGALEGRKVGPRTTIWTEKELLEPSVYEFAETEKMLKYAEDLAGPYVWGQYDLLILPPSFPYGGMENPCLTFVTPTVLAGDRSLASVIAHEISHSWTGNLVTNETWENFWLNEGHTVYLERRIDGRLYGEEFRQFKALGGWKELQNSVNTFGATNPLTNLVPNLHEVDVDAAFSSVPYEKGFALLFYLEQLLGGPEIFLGFLKSYIQMFAFKSVTTEEWKKFLYSYFKDKVDILDKVDWKGWMHTPGMPPVQPKYDMTLANACITLGQKWVKATESDLGSFSADDVKDLSSHQLIEVLAILLLEKPLPVSHVKRMQEVYNLNDVKNSEIRFRWLRLCIRAGWEDVIPLALAMATEQGRMKFTRPLYRDLYNFEKAREQTVNTFLKNRSFMHPVTEMLVAKDLHI 4kxb A 2.4 BS02 BES A 1 E223 T356 G357 A358 M359 E360 H393 E394 H397 E416 F474 Y479 R887 E148 T281 G282 A283 M284 E285 H318 E319 H322 E341 F399 Y404 R808 E360 H393 E394 H397 E416 T471 Y479 E285 H318 E319 H322 E341 T396 Y404 3.4.11.7 0001525,0002003,0003081,0004177,0005615,0005737,0005765,0005886,0005903,0006508,0007267,0008217,0008233,0008237,0008270,0008283,0009897,0016324,0016477,0031410,0032835,0042277,0043171,0045177,0046872,0070006,0070062 -logKd/Ki=4.12, Ki=75uM Q07075 23888046 1017 DICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGRVKSIAATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLL 4ruh A 2.25 BS01 BES A 1 H99 E166 E167 D195 L210 R343 H380 E414 G416 S417 H445 H96 E163 E164 D192 L207 R326 H363 E397 G399 S400 H428 3.4.13.18 0004180,0005515,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070062,0070573,0103046 Q96KP4 501 LTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRFCLEGMEESGSEGLDELIFARKDTFFKDVDYVCISDNYWLGKKKPCITYGLRGICYFFIEVECSNKDLHSGVYGGSVHEAMTDLILLMGSLVDKRGNILIPGINEDIDFDIEEFAKDVGAQILLHSHKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPNMTPEVVGEQVTSYLTKKFAELRSPNEFKVYMGHGGKPWVSDFSHPHYLAGRRAMKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRYNYIEGTKMLAAYLYEVSQLKD 4ruh A 2.25 BS04 BES B 1 H228 T330 H225 T313 3.4.13.18 0004180,0005515,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070062,0070573,0103046 Q96KP4 501 LTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRFCLEGMEESGSEGLDELIFARKDTFFKDVDYVCISDNYWLGKKKPCITYGLRGICYFFIEVECSNKDLHSGVYGGSVHEAMTDLILLMGSLVDKRGNILIPGINEDIDFDIEEFAKDVGAQILLHSHKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPNMTPEVVGEQVTSYLTKKFAELRSPNEFKVYMGHGGKPWVSDFSHPHYLAGRRAMKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRYNYIEGTKMLAAYLYEVSQLKD 4ruh B 2.25 BS01 BES A 1 H228 T330 H224 T309 3.4.13.18 0004180,0005515,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070062,0070573,0103046 Q96KP4 501 LTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRFCLEGMEESGSEGLDELIFARKDTFFKDVDYVCISDNYWLGKKPCITYGLRGICYFFIEVECSNKDLHSGVYGGSVHEAMTDLILLMGSLVDKRGNILIPGIIDFDIEEFAKDVGAQILLHSHKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPMTPEVVGEQVTSYLTKKFAELRSPNEFKVYMGHGGKPWVSDFSHPHYLAGRRAMKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRYNYIEGTKMLAAYLYEVSQLKD 4ruh B 2.25 BS02 BES B 1 D132 E166 E167 D195 Y197 I213 R343 E414 G416 S417 H445 D129 E163 E164 D192 Y194 I209 R322 E392 G394 S395 H423 3.4.13.18 0004180,0005515,0005654,0005737,0005829,0006508,0008233,0008237,0016787,0016805,0046872,0070062,0070573,0103046 Q96KP4 501 LTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRFCLEGMEESGSEGLDELIFARKDTFFKDVDYVCISDNYWLGKKPCITYGLRGICYFFIEVECSNKDLHSGVYGGSVHEAMTDLILLMGSLVDKRGNILIPGIIDFDIEEFAKDVGAQILLHSHKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPMTPEVVGEQVTSYLTKKFAELRSPNEFKVYMGHGGKPWVSDFSHPHYLAGRRAMKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRYNYIEGTKMLAAYLYEVSQLKD 4xmx A 2.3 BS02 BES A 1 E121 A260 G261 A262 M263 E264 R293 H297 E298 H301 E320 Y376 Y381 E117 A256 G257 A258 M259 E260 R289 H293 E294 H297 E316 Y372 Y377 E264 H297 E298 H301 E320 N373 Y381 E260 H293 E294 H297 E316 N369 Y377 3.4.11.2 0004177,0005515,0005886,0006508,0008237,0008270,0042802,0046872 P04825 902 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNAGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4zla A 1.9 BS05 BES A 1 K258 D263 D281 D340 E342 T367 L368 T369 G370 A461 K247 D252 D270 D329 E331 T356 L357 T358 G359 A450 K270 R344 K259 R333 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 ic50=49.9nM -logKd/Ki=7.30, IC50=49.9nM O25294 26616008 505 MLKIKLEKTTFENAKAECSLVFIINKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCGAHNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKSLEKSAKEALKYAEIMTESLNIVKDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLSVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGAGVRACTAFVEELLKKA 4zla B 1.9 BS05 BES B 1 K258 D263 D281 D340 E342 T367 L368 T369 G370 A461 K244 D249 D267 D326 E328 T353 L354 T355 G356 A447 K270 R344 K256 R330 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 ic50=49.9nM -logKd/Ki=7.30, IC50=49.9nM O25294 26616008 505 MLKIKLEKTTFENAKAECSLVFIINKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCGAALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKLEKSAKEALKYAEIMTESLNIVKDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLSVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGAGVRACTAFVEELLKKA 4zla C 1.9 BS05 BES C 1 K258 D263 M278 D281 D340 E342 T367 L368 T369 A461 K246 D251 M266 D269 D328 E330 T355 L356 T357 A449 K270 R344 K258 R332 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 ic50=49.9nM O25294 26616008 505 MLKIKLEKTTFENAKAECSLVFIINKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCGANALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKSLEKSAKEALKYAEIMTESLNIVKDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLSVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGAGVRACTAFVEELLKKA 4zla D 1.9 BS05 BES D 1 K258 D263 D281 D340 E342 T367 L368 T369 G370 A461 K242 D247 D265 D324 E326 T351 L352 T353 G354 A445 K270 R344 K254 R328 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 ic50=49.9nM O25294 26616008 505 MLKIKLEKTTFENAKAECSLVFIINKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKLEKSAKEALKYAEIMTESLNIVKDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLSVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGAGVRACTAFVEELLKKA 4zla E 1.9 BS05 BES E 1 K258 D263 M278 D281 D340 E342 T367 L368 T369 G370 K246 D251 M266 D269 D328 E330 T355 L356 T357 G358 K270 R344 K258 R332 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 ic50=49.9nM -logKd/Ki=7.30, IC50=49.9nM O25294 26616008 505 MLKIKLEKTTFENAKAECSLVFIINKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCGAALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPSLEKSAKEALKYAEIMTESLNIVKDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLSVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGAGVRACTAFVEELLKKA 4zla F 1.9 BS05 BES F 1 K258 D263 D281 D340 E342 T367 L368 T369 G370 A461 K246 D251 D269 D328 E330 T355 L356 T357 G358 A449 K270 R344 K258 R332 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 ic50=49.9nM O25294 26616008 505 MLKIKLEKTTFENAKAECSLVFIINKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCGANALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKSLEKSAKEALKYAEIMTESLNIVKDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLSVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGAGVRACTAFVEELLKKA 5ib9 A 1.4 BS05 BES A 1 D240 E272 E273 G275 D301 R345 I362 V366 Y370 H371 D236 E268 E269 G271 D297 R341 I358 V362 Y366 H367 H228 D240 E272 E273 D301 H371 H224 D236 E268 E269 D297 H367 ? 0004177,0006508,0008235,0046872 A2V759 1007 ADHQITKRTDAENMYNTIQFLSQAPRVAGSPEELKAVRYIEQQFKSYGYHVEVQPFQFEGYTAPSEVTLKIGTEKKEGEAFTYSPNSDVTAELVYVGLGTTADVAGKDLNGKIALIQRGNISFADKVRNAAKQGAKAVIIYNNTDGKLNGTLGGSDASFVAAVGITKQEGDALAANLRAGEKITATVKVAGAEVKTLTSHNVIATKKPDANKKNTNDIIIIGSHHDSVEKAPGANDDASGVAVTLELARVMSKLKTDTELRFITFGAEENGLIGSKKYAASLSEDEIKRTIGMFQLDMVGSKDAGDLIMYTIDGKKNRVTDLGAAASSRLSGVLPYGQEGRSDHESFHALGIPAALFIHAPVEPWYHTPNDTLDKISKEKLDNVADIVGSAVYQAARPGELVIEPIDYPRRN 5ntd A 2.3 BS03 BES A 1 K289 D294 K301 M309 D312 D371 E373 T401 L402 G404 Y498 K287 D292 K299 M307 D310 D369 E371 T399 L400 G402 Y496 K301 R375 K299 R373 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 605 TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd B 2.3 BS03 BES B 1 K289 D294 K301 M309 D312 D371 E373 T401 L402 G404 K287 D292 K299 M307 D310 D369 E371 T399 L400 G402 K301 R375 K299 R373 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 604 TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd C 2.3 BS03 BES C 1 K289 D294 K301 M309 D312 D371 E373 T401 L402 T403 G404 K286 D291 K298 M306 D309 D368 E370 T398 L399 T400 G401 K301 R375 K298 R372 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 604 LPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd D 2.3 BS03 BES D 1 K289 D294 K301 D312 N369 D371 E373 T401 L402 T403 G404 R467 A497 K287 D292 K299 D310 N367 D369 E371 T399 L400 T401 G402 R465 A495 K301 R375 K299 R373 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 604 TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd E 2.3 BS03 BES E 1 K289 D294 M309 D312 D371 E373 T401 L402 T403 G404 K287 D292 M307 D310 D369 E371 T399 L400 T401 G402 K301 R375 K299 R373 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 604 TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd F 2.3 BS03 BES F 1 K289 D294 K301 M309 D312 D371 E373 T401 L402 G404 K287 D292 K299 M307 D310 D369 E371 T399 L400 G402 K301 R375 K299 R373 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 604 TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd G 2.3 BS03 BES G 1 K289 D294 K301 M309 D312 D371 E373 T401 L402 G404 R467 K288 D293 K300 M308 D311 D370 E372 T400 L401 G403 R466 K301 R375 K300 R374 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 604 PTLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd H 2.3 BS03 BES H 1 K289 D294 K301 M309 D312 D371 E373 T401 L402 G404 K287 D292 K299 M307 D310 D369 E371 T399 L400 G402 K301 R375 K299 R373 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 604 TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd I 2.3 BS03 BES I 1 K289 D294 K301 M309 D312 N369 D371 E373 T401 L402 T403 K287 D292 K299 M307 D310 N367 D369 E371 T399 L400 T401 K301 R375 K299 R373 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 604 TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd J 2.3 BS03 BES J 1 K289 D294 K301 M309 D312 D371 E373 T401 L402 T403 G404 A497 K287 D292 K299 M307 D310 D369 E371 T399 L400 T401 G402 A495 K301 R375 K299 R373 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 604 TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd K 2.3 BS03 BES K 1 K289 D294 K301 M309 D312 D371 E373 T401 L402 G404 K287 D292 K299 M307 D310 D369 E371 T399 L400 G402 K301 R375 K299 R373 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 604 TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 5ntd L 2.3 BS03 BES L 1 K289 D294 M309 D312 D371 E373 T401 L402 G404 A497 K287 D292 M307 D310 D369 E371 T399 L400 G402 A495 K301 R375 K299 R373 ? 0004177,0005515,0005737,0006508,0008233,0019538,0030145,0046872,0070006 Q385B0 28815215 605 TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGTHKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRVVVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLPIAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAVATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERGYGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKPADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYRNDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATLTGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFNSNGATGFGPALLTEYFRKL 8j9d A 1.9 BS02 BES A 1 G72 N73 G277 E279 H308 E309 H312 E342 R399 Y414 G51 N52 G256 E258 H287 E288 H291 E321 R378 Y393 ? B0RY21 38646733 702 ATAAPQDVPFEGTLKIDVDATDLQHRIFKVKTTMPATPGPMTLLYPQWIPGNHSPTGPIDKLAGLVIKVDGKVVPWTRDQFDVYAFKVDVPQGASELVAEFKFLSPQASSQGRVMMTPEMLNLQWNTTALYPAGYFARNIKAQASVTLPAGWSYATAMETERRVGDTVTFKPIDFDDLVDSPMFAGKYYKRVELSAGKQPVYLNVFADEAKSLDAKPEQIKAHAALVQQMDKLYGARHFDHYEFLLALTKKLGGIGLEHHRSSENSGAPNYFTEWDKSWTGRDLLAHEFNHSWNGKYRRGADLATPNFNVPMGDSLLWLYEGQTQFWGEVMSARSGLWTQEQARDMLAGVAAQYERGRPGMAWRTVQDTTNDPTMSMRRPKAYRNYQMSEDYYSGGQMMWLEVDSKLRALTNNKRSIDDFGKAFFGMKNGDWDVNPYTFDDIVSTLNGVAAFDWASFLRSRMDGHGSLIGGIEANGWKLVYNDEPNLATKTDESDDKDASLTYSLGMSLKASGDISDVLWDGPAFNAGLITGNTIVAVNGRAFSSDVIKDAITAAKGTTVPIELLVKRLDRYDTVRIDYHGGLLYPHLERIAGKPDRLSELYKAR 8j9d B 1.9 BS02 BES B 1 G72 N73 G277 E279 H308 E309 H312 E342 R399 Y414 G51 N52 G256 E258 H287 E288 H291 E321 R378 Y393 ? B0RY21 38646733 702 ATAAPQDVPFEGTLKIDVDATDLQHRIFKVKTTMPATPGPMTLLYPQWIPGNHSPTGPIDKLAGLVIKVDGKVVPWTRDQFDVYAFKVDVPQGASELVAEFKFLSPQASSQGRVMMTPEMLNLQWNTTALYPAGYFARNIKAQASVTLPAGWSYATAMETERRVGDTVTFKPIDFDDLVDSPMFAGKYYKRVELSAGKQPVYLNVFADEAKSLDAKPEQIKAHAALVQQMDKLYGARHFDHYEFLLALTKKLGGIGLEHHRSSENSGAPNYFTEWDKSWTGRDLLAHEFNHSWNGKYRRGADLATPNFNVPMGDSLLWLYEGQTQFWGEVMSARSGLWTQEQARDMLAGVAAQYERGRPGMAWRTVQDTTNDPTMSMRRPKAYRNYQMSEDYYSGGQMMWLEVDSKLRALTNNKRSIDDFGKAFFGMKNGDWDVNPYTFDDIVSTLNGVAAFDWASFLRSRMDGHGSLIGGIEANGWKLVYNDEPNLATKTDESDDKDASLTYSLGMSLKASGDISDVLWDGPAFNAGLITGNTIVAVNGRAFSSDVIKDAITAAKGTTVPIELLVKRLDRYDTVRIDYHGGLLYPHLERIAGKPDRLSELYKAR 8j9d C 1.9 BS02 BES C 1 G72 N73 G277 E279 H308 E309 H312 E342 R399 Y414 G51 N52 G256 E258 H287 E288 H291 E321 R378 Y393 ? B0RY21 38646733 702 ATAAPQDVPFEGTLKIDVDATDLQHRIFKVKTTMPATPGPMTLLYPQWIPGNHSPTGPIDKLAGLVIKVDGKVVPWTRDQFDVYAFKVDVPQGASELVAEFKFLSPQASSQGRVMMTPEMLNLQWNTTALYPAGYFARNIKAQASVTLPAGWSYATAMETERRVGDTVTFKPIDFDDLVDSPMFAGKYYKRVELSAGKQPVYLNVFADEAKSLDAKPEQIKAHAALVQQMDKLYGARHFDHYEFLLALTKKLGGIGLEHHRSSENSGAPNYFTEWDKSWTGRDLLAHEFNHSWNGKYRRGADLATPNFNVPMGDSLLWLYEGQTQFWGEVMSARSGLWTQEQARDMLAGVAAQYERGRPGMAWRTVQDTTNDPTMSMRRPKAYRNYQMSEDYYSGGQMMWLEVDSKLRALTNNKRSIDDFGKAFFGMKNGDWDVNPYTFDDIVSTLNGVAAFDWASFLRSRMDGHGSLIGGIEANGWKLVYNDEPNLATKTDESDDKDASLTYSLGMSLKASGDISDVLWDGPAFNAGLITGNTIVAVNGRAFSSDVIKDAITAAKGTTVPIELLVKRLDRYDTVRIDYHGGLLYPHLERIAGKPDRLSELYKAR 8j9d D 1.9 BS02 BES D 1 G72 N73 G277 E279 H308 E309 H312 E342 R399 Y414 G51 N52 G256 E258 H287 E288 H291 E321 R378 Y393 ? B0RY21 38646733 702 ATAAPQDVPFEGTLKIDVDATDLQHRIFKVKTTMPATPGPMTLLYPQWIPGNHSPTGPIDKLAGLVIKVDGKVVPWTRDQFDVYAFKVDVPQGASELVAEFKFLSPQASSQGRVMMTPEMLNLQWNTTALYPAGYFARNIKAQASVTLPAGWSYATAMETERRVGDTVTFKPIDFDDLVDSPMFAGKYYKRVELSAGKQPVYLNVFADEAKSLDAKPEQIKAHAALVQQMDKLYGARHFDHYEFLLALTKKLGGIGLEHHRSSENSGAPNYFTEWDKSWTGRDLLAHEFNHSWNGKYRRGADLATPNFNVPMGDSLLWLYEGQTQFWGEVMSARSGLWTQEQARDMLAGVAAQYERGRPGMAWRTVQDTTNDPTMSMRRPKAYRNYQMSEDYYSGGQMMWLEVDSKLRALTNNKRSIDDFGKAFFGMKNGDWDVNPYTFDDIVSTLNGVAAFDWASFLRSRMDGHGSLIGGIEANGWKLVYNDEPNLATKTDESDDKDASLTYSLGMSLKASGDISDVLWDGPAFNAGLITGNTIVAVNGRAFSSDVIKDAITAAKGTTVPIELLVKRLDRYDTVRIDYHGGLLYPHLERIAGKPDRLSELYKAR 8pzm A 1.7 BS01 BES A 1 K287 D292 M307 D310 D369 E371 T396 L397 T398 W490 K270 D275 M290 D293 D352 E354 T379 L380 T381 W473 3.4.11.1,3.4.11.10 0004177,0005737,0006508,0008235,0019538,0030145,0046872,0070006 Q02RY8 37924287 601 FQGGMEFLVKSVRPETLKTATLVLAVGEGRKLGASAKAVDDATGGAISAVLKRGDLAGKVGQTLLLQSLPNLKAERVLLVGAGKERELGDRQYRKLASAVLSTLKGLAGADAALALGDLAVKGRGAHAKARLLVETLADGLYVFDRYKSQKAEPLKLKKLTLLADKADSAAVEQGSKEAQAIANGMALTRDLGNLPPNVCHPTFLGEQAKGLAKEFKSLKVEVLDEKKLRELGMGSFLAVAQGSDQPPRLIILQYNGAKKDQAPHVLVGKGITFDTGGISLKPGLGMDEMKFDMCGAASVFGTFRAVLELQLPINLVGLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDALTYAERFKPQSVIDIATLTGACIVALGSNTSGLMGNNEALVRQLLKAGEFADDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAGCFLSRFAKKYHWAHLDIAGTAWISGGKDKGATGRPVPLLTQYLLERAK