1uwh A 2.95 BS01 BAX A 1 A480 E500 L504 L513 T528 Q529 W530 C531 L566 F582 D593 F594 A34 E54 L58 L67 T82 Q83 W84 C85 L120 F136 D147 F148 D575 K577 N579 N580 D593 S615 D129 K131 N133 N134 D147 S157 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=7.66, IC50=22nM IC50=22nM, Kd=260nM, Ki=22nM P15056 15035987 1723 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTAPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK 1uwh B 2.95 BS01 BAX B 1 A480 E500 L504 L513 T528 Q529 W530 C531 H573 F582 G592 D593 F594 A34 E54 L58 L67 T82 Q83 W84 C85 H127 F136 G146 D147 F148 D575 K577 N579 N580 D593 S615 D129 K131 N133 N134 D147 S157 2.7.11.1 0004672,0005524,0006468 IC50=22nM, Kd=260nM, Ki=22nM P15056 15035987 1723 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTAPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK 1uwj A 3.5 BS01 BAX A 1 A480 K482 E500 I512 L513 Q529 W530 C531 D593 F594 A34 K36 E54 I66 L67 Q83 W84 C85 D147 F148 D575 K577 N579 N580 D593 S615 D129 K131 N133 N134 D147 S157 2.7.11.1 0004672,0005524,0006468 IC50=22nM, Kd=260nM, Ki=22nM P15056 15035987 1723 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATEKSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK 1uwj B 3.5 BS01 BAX B 1 A480 E500 L513 T528 Q529 W530 C531 G592 D593 F594 A34 E54 L67 T82 Q83 W84 C85 G146 D147 F148 D575 K577 N579 N580 D593 S615 D129 K131 N133 N134 D147 S156 2.7.11.1 0004672,0005524,0006468 IC50=22nM, Kd=260nM, Ki=22nM P15056 15035987 1723 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATEKGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK 3gcs A 2.1 BS01 BAX A 1 A51 E71 L74 I84 L108 M109 I141 I166 L167 D168 F169 A44 E64 L67 I77 L101 M102 I134 I159 L160 D161 F162 D150 K152 N155 D168 T185 D143 K145 N148 D161 T164 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0002862,0004672,0004674,0004707,0004708,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006935,0006974,0007165,0007166,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030168,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0033554,0034774,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0043536,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051149,0051403,0051525,0060045,0060348,0070935,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090398,0090400,0098586,0098978,0099179,0106310,1900015,1901741,1904813,2000379 Kd=56nM -logKd/Ki=7.25, Kd=56nM Kd=370nM, IC50=400nM Q16539 19572644 401 RPTFYRQELNKTIWEVPERYQNLSPVGYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKSQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGTRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSLESRDLLIDEWKSLTYDEVISFVPPP 3heg A 2.2 BS01 BAX A 1 V30 V38 A51 E71 L74 L75 I84 T106 M109 H148 I166 L167 D168 F169 V26 V30 A43 E63 L66 L67 I76 T98 M101 H140 I158 L159 D160 F161 D150 K152 N155 D168 T185 D142 K144 N147 D160 T166 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0002862,0004672,0004674,0004707,0004708,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006935,0006974,0007165,0007166,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030168,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0033554,0034774,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0043536,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051149,0051403,0051525,0060045,0060348,0070935,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090398,0090400,0098586,0098978,0099179,0106310,1900015,1901741,1904813,2000379 Kd=0.18uM -logKd/Ki=6.74, Kd=0.18uM Kd=370nM, IC50=400nM Q16539 20337484 1 RPTFYRQELNKTIWEVPERYQNLSPVYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP 3rgf A 2.2 BS01 BAX A 1 A50 K52 E66 L70 V78 I79 F97 Y99 A100 A172 D173 M174 F176 A47 K49 E63 L67 V75 I76 F94 Y96 A97 A162 D163 M164 F166 D151 K153 N156 D173 T196 D141 K143 N146 D163 T170 2.7.11.22,2.7.11.23 0004672,0005524,0006468 ic50=0.13uM Kd=310nM, IC50=1620nM P49336 21806996 465 DKMDYDFKVKLSSERERVEDLFEYEGCKVGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPY 3wze A 1.9 BS01 BAX A 1 V848 A866 E885 V916 F918 C919 G922 H1026 L1035 I1044 C1045 D1046 F1047 V34 A52 E71 V102 F104 C105 G108 H158 L167 I176 C177 D178 F179 D1028 A1030 R1032 N1033 D1046 K1055 D160 A162 R164 N165 D178 K187 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169 Kd=33nM IC50=90nM, Kd=59nM, Ki=22nM, EC50=500nM P35968 25589937 1201 EHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQAN 4asd A 2.03 BS01 BAX A 1 L840 V848 A866 K868 E885 L889 V916 E917 F918 C919 G922 L1019 L1035 I1044 C1045 D1046 F1047 L34 V42 A60 K62 E79 L83 V110 E111 F112 C113 G116 L156 L172 I181 C182 D183 F184 D1028 A1030 R1032 N1033 D1046 D1064 D165 A167 R169 N170 D183 D201 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169 Ki=0.52nM -logKd/Ki=9.28, Ki=0.52nM IC50=90nM, Kd=59nM, Ki=22nM, EC50=500nM P35968 22988103 1500 DPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANA 5hi2 A 2.512 BS01 BAX A 1 A481 E501 L505 L514 T529 Q530 W531 C532 F583 G593 D594 F595 A33 E48 L52 L61 T76 Q77 W78 C79 F130 G140 D141 F142 D576 K578 N580 N581 D594 S616 D123 K125 N127 N128 D141 S145 2.7.11.1 0004672,0005524,0006468 IC50=22nM, Kd=260nM, Ki=22nM P15056 26996308 801 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLSILWMAPEVIRMNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL