1dth A 2.0 BS03 BAT A 1 L108 G109 L110 T139 H142 E143 H152 C164 I165 R167 P168 G169 L170 T171 Y176 L108 G109 L110 T139 H142 E143 H152 C164 I165 R167 P168 G169 L170 T171 Y176 3.4.24.42 0004222,0006508,0008237 ic50=6nM -logKd/Ki=8.22, IC50=6nM P15167 8610113 972 QNLPQRYIELVVVADHRVFMKYNSDLNTIRTRVHEIVNFINGFYRSLNIHVSLTDLEIWSNEDQINIQSASSDTLNAFAEWRETDLLNRKSHDNAQLLTAIELDEETLGLAPLGTMCDPKLSIGIVQDHSPINLLMGVTMAHELGHNLGMEHDGKDCLRGASLCIMRPGLTKGRSYEFSDDSMHYYERFLKQYKPQCILNKP 1dth B 2.0 BS03 BAT B 1 L108 G109 V138 T139 H142 E143 H152 C164 I165 R167 P168 G169 L170 Y176 L108 G109 V138 T139 H142 E143 H152 C164 I165 R167 P168 G169 L170 Y176 3.4.24.42 0004222,0006508,0008237 ic50=6nM P15167 8610113 973 QNLPQRYIELVVVADHRVFMKYNSDLNTIRTRVHEIVNFINGFYRSLNIHVSLTDLEIWSNEDQINIQSASSDTLNAFAEWRETDLLNRKSHDNAQLLTAIELDEETLGLAPLGTMCDPKLSIGIVQDHSPINLLMGVTMAHELGHNLGMEHDGKDCLRGASLCIMRPGLTKGRSYEFSDDSMHYYERFLKQYKPQCILNKP 1jk3 A 1.09 BS06 BAT A 1 G179 I180 L181 A182 H218 H222 H228 P238 Y240 G74 I75 L76 A77 H113 H117 H123 P133 Y135 H218 A219 H222 H228 H113 A114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 11575928 900 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 1mmb A 2.1 BS05 BAT A 1 G158 I159 L160 A161 Y189 H197 E198 H201 H207 P217 N218 Y219 G74 I75 L76 A77 Y105 H113 E114 H117 H123 P133 N134 Y135 H197 E198 H201 H207 H113 E114 H117 H123 3.4.24.34 0004222,0006508,0008237,0008270,0031012 P22894 7577999 1 NPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYG 1rm8 A 1.8 BS05 BAT A 1 G204 F205 L206 A207 V243 H246 E247 H250 H256 P266 F267 Y268 G81 F82 L83 A84 V120 H123 E124 H127 H133 P143 F144 Y145 H246 E247 H250 H256 H123 E124 H127 H133 3.4.24.- 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=9.00, Ki=1nM P51512 14741217 800 GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGP 2j83 A 2.0 BS01 BAT A 1 S181 Q185 D186 I187 L188 G189 H228 E229 H232 H238 Y292 S119 Q123 D124 I125 L126 G127 H166 E167 H170 H176 Y230 3.4.24.- 0008237 ic50=61uM -logKd/Ki=4.21, IC50=61uM Q8TL28 17097044 996 EIVKIPVVVHVVWNEEEENISDAQIQSQIDILNKDFRKLNSDVSQVPSVWSNLIADLGIEFFLATKDPNGNQTTGITRTQTSVTFFTTSDEVKFASSGGEDAWPADRYLNIWVCHVLKSEIGQDILGYAQFPGGPAETDGVVIVDAAFGTTGTALPPFDKGRTATHEIGHWLNLYHIWGDELRFEDPCSRSDEVDDTPNQADPNFGAPSYPHVSCSNGPNGDMFMNYMDYVDDKCMVMFTQGQATRVNACLDGPRSSFL 2j83 B 2.0 BS01 BAT B 1 Q185 D186 I187 L188 G189 H228 E229 H232 H238 Y292 Q123 D124 I125 L126 G127 H166 E167 H170 H176 Y230 3.4.24.- 0008237 ic50=61uM -logKd/Ki=4.21, IC50=61uM Q8TL28 17097044 996 EIVKIPVVVHVVWNEEEENISDAQIQSQIDILNKDFRKLNSDVSQVPSVWSNLIADLGIEFFLATKDPNGNQTTGITRTQTSVTFFTTSDEVKFASSGGEDAWPADRYLNIWVCHVLKSEIGQDILGYAQFPGGPAETDGVVIVDAAFGTTGTALPPFDKGRTATHEIGHWLNLYHIWGDELRFEDPCSRSDEVDDTPNQADPNFGAPSYPHVSCSNGPNGDMFMNYMDYVDDKCMVMFTQGQATRVNACLDGPRSSFL 2rjq A 2.6 BS04 BAT A 1 D377 T378 L379 G380 M381 H410 E411 H414 H420 S441 I442 D114 T115 L116 G117 M118 H147 E148 H151 H157 S178 I179 3.4.24.- 0004222,0006508,0008237 Q9UNA0 18042673 559 SRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVD 4dd8 A 2.1 BS01 BAT A 1 T299 T300 V301 G302 F303 H334 E335 H338 H344 G366 S367 T99 T100 V101 G102 F103 H134 E135 H138 H144 G166 S167 3.4.24.- 0004222,0006508,0008237 P78325 22684055 1000 RETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPD 4dd8 A 2.1 BS04 BAT D 1 Q255 R257 Q59 R61 3.4.24.- 0004222,0006508,0008237 P78325 22684055 1000 RETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPD 4dd8 B 2.1 BS01 BAT B 1 T299 T300 V301 G302 H334 E335 H338 H344 G366 T103 T104 V105 G106 H138 E139 H142 H148 G170 3.4.24.- 0004222,0006508,0008237 P78325 22684055 1000 RETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPD 4dd8 C 2.1 BS01 BAT C 1 T299 T300 V301 G302 H334 E335 H338 H344 G366 S367 T100 T101 V102 G103 H135 E136 H139 H145 G167 S168 3.4.24.- 0004222,0006508,0008237 P78325 22684055 1000 RETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAP 4dd8 D 2.1 BS01 BAT D 1 T299 T300 V301 G302 H334 E335 H338 H344 G366 S367 T104 T105 V106 G107 H139 E140 H143 H149 G171 S172 3.4.24.- 0004222,0006508,0008237 P78325 22684055 1000 SRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLS 7w6x A 3.2 BS02 BAT A 1 I19 H22 E23 H26 F44 L66 G68 N394 D402 I19 H22 E23 H26 F44 L66 G68 N394 D402 3.4.24.- 0004175,0004222,0005886,0006508,0008237,0016020,0036460,0043856,0045893,0046872 P0AEH1 36001659 502 MLSFLWDLASFIVALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDKLGTEYVIALIPLGGYVKMLDERAEPVVPELRHHAFNNKSVGQRAAIIAAGPVANFIFAIFAYWLVFIIGVPGVRPVVGEIAANSIAAEAQIAPGTELKAVDGIETPDWDAVRLQLVDKIGDESTTITVAPFGSDQRRDVKLDLRHWAFEPDKEDPVSSLGIRPRGPQIEPVLENVQPNSAASKAGLQAGDRIVKVDGQPLTQWVTFVMLVRDNPGKSLALEIERQGSPLSLTLIPESKPGNGKAIGFVGIEPKVIPLPDEYKVVRQYGPFNAIVEATDKTWQLMKLTVSMLGKLITGDVKLNNLSGPISIAKGAGMTAELGVVYYLPFLALISVNLGIINLFPLPVLDGGHLLFLAIEKIKGGPVSERVQDFCYRIGSILLVLLMGLALFNDF 7w6y A 3.1 BS02 BAT A 1 V19 H22 E23 H26 F44 G68 N387 D395 V19 H22 E23 H26 F44 G68 N349 D357 3.4.24.- 0004222,0006508,0008237,0016020,0046872 C7R5Z1 36001659 502 MTDFLYSIFGLLILLGVLVTFHEWGHYWVAKKLGVKALRFSVGFGKPIWGRTNKHGTEFVIAPIPLGGYVRFVDEREGEVAEADLPFAFNRQQVWKRILIVLAGPMANFLLAIVVYAAVYMMGIAVGKPFVTNVLPNTVAAQANFPENSEILSVDGVQVKSLEDAIFAFVDHIKVVVKPLNQEPTTVVLTIFDSLGLGFGRVNGEPSLGLVAKDSPAEKGGLKVGDTVVSVNGESISLWSEFVSFIENNPGKPLELIVARDGYQQPLVVTPEANERDRTIGYLGISPAFQGYNVINYGFFESFGKGAEQTWVMVERIGSFLGKLITAQAGMVAFLLYLAMISVNLGFVNLLPIPMLDGGHLMYYLVELVRGKPVSEKIMELGMRVGIILVLTIMAIALFFDINRINQLYFQ 7w6z A 3.15 BS02 BAT A 1 V19 H22 E23 H26 F44 L66 G68 N387 L394 D395 V19 H22 E23 H26 F44 L66 G68 N366 L373 D374 3.4.24.- 0004222,0006508,0008237,0016020,0046872 C7R5Z1 36001659 502 MTDFLYSIFGLLILLGVLVTFHEWGHYWVAKKLGVKALRFSVGFGKPIWGRTNKHGTEFVIAPIPLGGYVRFVDEREGEVAEADLPFAFNRQQVWKRILIVLAGPMANFLLAIVVYAAVYMMGIAVGKPFVTNVLPNTVAAQANFPENSEILSVDGVQVKSLEDAIFAFVDHIDDDKTIKVVVKPLNQEPTTVVLDVSQWQEPDEGTIFDSLGLGFGRVNGEPSLGLVAKDSPAEKGGLKVGDTVVSVNGESISLWSEFVSFIENNPGKPLELIVARDGYQQPLVVTPEANERDRTIGYLGISPAFQGYNVINYGFFESFGKGAEQTWVMVERIGSFLGKLITAQAGMVAFLLYLAMISVNLGFVNLLPIPMLDGGHLMYYLVELVGIILVLTIMAIALFFDINRINQLESSFQ 8esv A 3.3 BS03 BAT A 1 G326 V327 L328 L330 T380 H383 E384 H393 A419 R420 A421 G109 V110 L111 L113 T163 H166 E167 H176 A202 R203 A204 3.4.24.81 0004222,0006508,0008237 O14672 37516108 804 EKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENI