6eip A 2.56 BS01 B7B A 1 I165 G166 V173 A186 V222 F238 M240 L241 N244 L294 V306 I32 G33 V40 A53 V89 F105 M107 L108 N111 L161 V173 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 -logKd/Ki=5.70, Ki=2015nM Ki=2015nM, IC50=4200nM Q13627 30095246 501 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 6eip B 2.56 BS01 B7B B 1 I165 G166 V173 A186 V222 F238 L241 N244 L294 V306 D307 I33 G34 V41 A54 V90 F106 L109 N112 L162 V174 D175 D287 K289 N292 D307 S324 D155 K157 N160 D175 S192 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Ki=2015nM, IC50=4200nM Q13627 30095246 501 RKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 6eip C 2.56 BS01 B7B C 1 I165 A186 F238 M240 L241 Y243 N244 L294 V306 I31 A52 F104 M106 L107 Y109 N110 L160 V172 D287 K289 N292 D307 S324 D153 K155 N158 D173 S190 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Ki=2015nM, IC50=4200nM Q13627 30095246 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 6eip D 2.56 BS01 B7B D 1 I165 A186 F238 L241 S242 Y243 N244 L294 V306 D307 I32 A53 F105 L108 S109 Y110 N111 L161 V173 D174 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Ki=2015nM, IC50=4200nM Q13627 30095246 501 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKYKPPGTRKLHNILGVETGGPGGGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF