6eij A 2.42 BS01 B5Z A 1 F170 A186 K188 F238 M240 L241 L294 V306 D307 F37 A53 K55 F105 M107 L108 L161 V173 D174 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Ki=1680nM -logKd/Ki=5.77, Ki=1680nM Ki=1680nM, IC50=3500nM Q13627 30095246 501 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 6eij B 2.42 BS01 B5Z B 1 F170 K188 F238 M240 L241 Y243 L294 D307 F38 K56 F106 M108 L109 Y111 L162 D175 D287 K289 N292 D307 S324 D155 K157 N160 D175 S192 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Ki=1680nM Ki=1680nM, IC50=3500nM Q13627 30095246 501 RKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 6eij C 2.42 BS01 B5Z C 1 F170 A186 K188 E203 F238 M240 L241 S242 L294 V306 D307 G309 S310 F36 A52 K54 E69 F104 M106 L107 S108 L160 V172 D173 G175 S176 D287 K289 N292 D307 S324 D153 K155 N158 D173 S190 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Ki=1680nM Ki=1680nM, IC50=3500nM Q13627 30095246 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPTWNLKKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 6eij D 2.42 BS01 B5Z D 1 I165 F170 A186 K188 F238 L241 S242 Y243 L294 D307 S310 I32 F37 A53 K55 F105 L108 S109 Y110 L161 D174 S177 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Ki=1680nM Ki=1680nM, IC50=3500nM Q13627 30095246 501 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF