3h2a A 2.4 BS01 B57 A 1 D101 N120 I122 M145 D184 F189 G216 K220 R254 D88 N107 I109 M132 D171 F176 G203 K207 R241 V28 D54 K220 R254 V27 D51 K207 R241 2.5.1.15 0004156,0005829,0009396,0016740,0042558,0044237,0046654,0046656,0046872 ic50=108.9uM -logKd/Ki=3.96, IC50=108.9uM IC50=108900nM Q81VW8 19899766 901 KWDYDLRCGEYTLNLNEKTLIMGILNVTPDSFSGSYNEVDAAVRHAKEMRDEGAHIIDIGGSVEEEIKRVVPMIQAVSKEVKLPISIDTYKAEVAKQAIEAGAHIINDIWGAKAEPKIAEVAAHYDVPIILMHNRDNMNYRNLMADMIADLYDSIKIAKDAGVRDENIILDPGIGFAKTPEQNLEAMRNLEQLNVLGYPVLLGTSRKSFIGHVLDLPVEERLEGTGATVCLGIEKGCEFVRVHDVKEMSRMAKMMDAMIGK 3h2a B 2.4 BS01 B57 B 1 D101 N120 I122 M145 D184 F189 G216 K220 R254 D104 N123 I125 M148 D187 F192 G219 K223 R257 V28 D54 K220 R254 V42 D63 K223 R257 2.5.1.15 0004156,0005829,0009396,0016740,0042558,0044237,0046654,0046656,0046872 ic50=108.9uM IC50=108900nM Q81VW8 19899766 902 SHHHHHHSSGLVPRMKWDYDLRCGEYTLNLNEKTLIMGILNVTPGGSYNEVDAAVRHAKEMRDEGAHIIDIGGESTVSVEEEIKRVVPMIQAVSKEVKLPISIDTYKAEVAKQAIEAGAHIINDIWGAKAEPKIAEVAAHYDVPIILMHNRDNMNYRNLMADMIADLYDSIKIAKDAGVRDENIILDPGIGFAKTPEQNLEAMRNLEQLNVLGYPVLLGTSRKSFIGHVLDLPVEERLEGTGATVCLGIEKGCEFVRVHDVKEMSRMAKMMDAMIGK 3mcn B 2.2 BS01 B57 B 1 N277 D346 K383 R418 N258 D312 K348 R381 0003848,0004156,0009396,0042558,0044237 21152407 423 HMVQYIIGIGTNSGFTIENIHLAITALESQQNIRIIRKASLYSSKAIRFLNTAVKISSSLKPDELLVLLKDIELKIGRPRVIDLDILAAEDLILETDKLTIPHKELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEIVKLKQTLANTIRMGIVNLSNQSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAPISIEEEFNKLNEFLEYFKSQLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVIIHNIDNVCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKSDTARYLLENIIEIKRRLELKALVGHSRKPSVLGLDSNLATLDRATRELSRKLEKLDIDIIRVHKI 3mcn B 2.2 BS02 B57 B 2 F59 N61 D101 F129 F49 N51 D83 F111 0003848,0004156,0009396,0042558,0044237 21152407 424 HMVQYIIGIGTNSGFTIENIHLAITALESQQNIRIIRKASLYSSKAIRFLNTAVKISSSLKPDELLVLLKDIELKIGRPRVIDLDILAAEDLILETDKLTIPHKELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEIVKLKQTLANTIRMGIVNLSNQSFSDGNFDDNQRKLNLDELIQSGAEIIDIGAESTKPDAPISIEEEFNKLNEFLEYFKSQLANLIYKPLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQLIAKYNKKYVIIHNIDNVCDYIEQKKQILLKHGIAQQNIYFDIGFGFGKSDTARYLLENIIEIKRRLELKALVGHSRKPSVLGLDSNLATLDRATRELSRKLEKLDIDIIRVHKI