3gc7 A 1.8 BS01 B45 A 1 Y35 A51 V52 K53 L104 T106 L108 M109 G110 A111 L167 D168 Y32 A48 V49 K50 L101 T103 L105 M106 G107 A108 L164 D165 D150 K152 N155 D168 T185 D147 K149 N152 D165 T182 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0002862,0004672,0004674,0004707,0004708,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006935,0006974,0007165,0007166,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030168,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0033554,0034774,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0043536,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051149,0051403,0051525,0060045,0060348,0070935,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090398,0090400,0098586,0098978,0099179,0106310,1900015,1901741,1904813,2000379 ic50=0.4nM -logKd/Ki=9.22, IC50=0.6nM IC50=5.6nM Q16539 19622861 361 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP 3gc8 A 2.4 BS01 B45 A 1 V30 Y35 V38 A51 V52 K53 L104 T106 L108 M109 G110 A111 S154 L167 V28 Y33 V36 A49 V50 K51 L102 T104 L106 M107 G108 A109 S152 L165 D150 K152 N155 D168 T185 D148 K150 N153 D166 T183 2.7.11.24 0000165,0001649,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005829,0006468,0010628,0016310,0031098,0032735,0033554,0035556,0038066,0045648,0051149,0051403,0060038,0060043,0060044,0060348,0071347,0071493,0090398,0098586,0106310 Q15759 19622861 365 GPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFK 3gc8 B 2.4 BS01 B45 B 1 V30 Y35 V38 A51 K53 L104 T106 L108 M109 G110 A111 S154 L167 V27 Y32 V35 A48 K50 L101 T103 L105 M106 G107 A108 S151 L164 D150 K152 N155 D168 T185 D147 K149 N152 D165 T182 2.7.11.24 0000165,0001649,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005829,0006468,0010628,0016310,0031098,0032735,0033554,0035556,0038066,0045648,0051149,0051403,0060038,0060043,0060044,0060348,0071347,0071493,0090398,0098586,0106310 Q15759 19622861 365 PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFK 3gc9 A 2.05 BS01 B45 A 1 V30 Y35 V38 A51 K53 T106 L108 M109 G110 A111 S154 L167 V28 Y33 V36 A49 K51 T104 L106 M107 G108 A109 S152 L165 D150 K152 S154 N155 D168 T185 D148 K150 S152 N153 D166 T172 2.7.11.24 0000165,0001649,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005829,0006468,0010628,0016310,0031098,0032735,0033554,0035556,0038066,0045648,0051149,0051403,0060038,0060043,0060044,0060348,0071347,0071493,0090398,0098586,0106310 Q15759 19622861 365 GPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLAATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSF 3gc9 B 2.05 BS02 B45 B 1 V30 Y35 V38 A51 V52 K53 T106 L108 M109 G110 A111 S154 L167 V29 Y34 V37 A50 V51 K52 T105 L107 M108 G109 A110 S153 L166 D150 K152 S154 N155 D168 T185 D149 K151 S153 N154 D167 T175 2.7.11.24 0000165,0001649,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005829,0006468,0010628,0016310,0031098,0032735,0033554,0035556,0038066,0045648,0051149,0051403,0060038,0060043,0060044,0060348,0071347,0071493,0090398,0098586,0106310 Q15759 19622861 365 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFK