3gen A 1.6 BS01 B43 A 1 L408 V416 A428 K430 M449 T474 Y476 M477 L528 S538 D539 F540 L17 V22 A34 K36 M55 T80 Y82 M83 L134 S144 D145 F146 D521 A523 R525 N526 D539 F559 D127 A129 R131 N132 D145 F165 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=9.14, IC50=0.72nM IC50=310nM Q06187 20052711 1 YGSWEIDPKDLTFLKELGFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEE 3vry A 2.481 BS01 B43 A 1 L273 V281 A293 K295 V323 T338 M341 L393 A403 D404 F405 L183 V191 A203 K205 V233 T248 M251 L303 A313 D314 F315 D386 R388 A390 N391 D404 F424 D296 R298 A300 N301 D314 F322 2.7.10.2 0004672,0004713,0005524,0006468 ic50=7.7nM -logKd/Ki=8.11, IC50=7.7nM P08631 23596204 601 RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYEEIP 3vry B 2.481 BS02 B43 B 1 L273 V281 A293 K295 V323 T338 M341 L393 D404 F405 L189 V197 A209 K211 V239 T254 M257 L309 D320 F321 D386 R388 A390 N391 D404 F424 D302 R304 A306 N307 D320 F328 2.7.10.2 0004672,0004713,0005524,0006468 ic50=7.7nM P08631 23596204 602 RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYEEIP 4ih8 A 2.877 BS01 B43 A 1 V65 A78 K80 M112 L126 E129 Y131 L181 D195 F196 V21 A34 K36 M68 L82 E85 Y87 L137 D149 F150 D174 K176 E178 N179 D195 T214 D130 K132 E134 N135 D149 T168 2.7.11.17 0004672,0004674,0004683,0005509,0005516,0005524,0005634,0005737,0006468,0009931,0016020,0016310,0018105,0035556,0046777,0046872 Q9BJF5 601 AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRASAVEHEVDQVLDAEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNGEVDFDEFQQMLLKLCGN