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BioLiP
Download all results in tab-seperated text for 16 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 2e93:A (2.12) BS01 B29 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... Q12051 17535895 PDBbind: -logKd/Ki=6.96, Ki=0.11uM
    BindingDB: Ki=110nM, IC50=280nM
    2 2e93:A (2.12) BS02 B29 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... Q12051 17535895 PDBbind: -logKd/Ki=6.96, Ki=0.11uM
    BindingDB: Ki=110nM, IC50=280nM
    3 2e93:B (2.12) BS01 B29 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... Q12051 17535895 PDBbind: -logKd/Ki=6.96, Ki=0.11uM
    BindingDB: Ki=110nM, IC50=280nM
    4 2e93:B (2.12) BS02 B29 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... Q12051 17535895 PDBbind: -logKd/Ki=6.96, Ki=0.11uM
    BindingDB: Ki=110nM, IC50=280nM
    5 2e98:A (1.9) BS01 B29 2.5.1.31 GO:0000287 ... P60472 17535895 PDBbind: -logKd/Ki=6.23, IC50=0.59uM
    6 2e98:A (1.9) BS02 B29 2.5.1.31 GO:0000287 ... P60472 17535895 PDBbind: -logKd/Ki=6.23, IC50=0.59uM
    7 2e98:A (1.9) BS03 B29 2.5.1.31 GO:0000287 ... P60472 17535895 PDBbind: -logKd/Ki=6.23, IC50=0.59uM
    8 2e98:A (1.9) BS04 B29 2.5.1.31 GO:0000287 ... P60472 17535895 PDBbind: -logKd/Ki=6.23, IC50=0.59uM
    9 2e98:B (1.9) BS01 B29 2.5.1.31 GO:0000287 ... P60472 17535895
    10 2e98:B (1.9) BS02 B29 2.5.1.31 GO:0000287 ... P60472 17535895
    11 2e98:B (1.9) BS03 B29 2.5.1.31 GO:0000287 ... P60472 17535895
    12 3wqm:A (2.1) BS01 B29 2.5.1.153 GO:0016102 ... P9WJ61 24475925 MOAD: Kd=560nM
    PDBbind: -logKd/Ki=6.25, Kd=560nM
    13 3wqm:A (2.1) BS02 B29 2.5.1.153 GO:0016102 ... P9WJ61 24475925 MOAD: Kd=560nM
    PDBbind: -logKd/Ki=6.25, Kd=560nM
    14 4w4s:A (2.0) BS01 B29 ? N/A Q45222 25269599 MOAD: ic50=9.5uM
    PDBbind: -logKd/Ki=5.02, IC50=9.5uM
    15 5zlf:A (2.845) BS01 B29 2.5.1.90 GO:0004659 ... P0AD57 30730737 PDBbind: -logKd/Ki=3.48, IC50~330uM
    16 5zlf:B (2.845) BS01 B29 2.5.1.90 GO:0004659 ... P0AD57 30730737 PDBbind: -logKd/Ki=3.48, IC50~330uM
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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