1azm A 2.0 BS02 AZM A 1 F91 H94 L198 T199 H200 F89 H92 L196 T197 H198 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T197 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 -logKd/Ki=6.10, Ki=0.8uM Ki=250nM, Kd=1400nM, IC50=5.8nM P00915 7932756 262 PDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 1dmy A 2.45 BS02 AZM A 1 H94 H96 H119 Y131 L198 T199 T200 H70 H72 H95 Y107 L174 T175 T176 Y64 H94 H96 E106 H119 T199 Y40 H70 H72 E82 H95 T175 4.2.1.1 0004089,0008270 Ki=60nM P23589 7479916 400 GTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEDSGISGGPLGNHYRLKQFHFHWGATDEWGSEHAVDGHTYPAELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCLMPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSFR 1dmy B 2.45 BS02 AZM B 1 H94 Y131 L198 T199 T200 H70 Y107 L174 T175 T176 Y64 H94 H96 E106 H119 T199 Y40 H70 H72 E82 H95 T175 4.2.1.1 0004089,0008270 Ki=60nM P23589 7479916 900 GTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEDSGISGGPLGNHYRLKQFHFHWGATDEWGSEHAVDGHTYPAELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCLMPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSFR 1jd0 A 1.5 BS02 AZM A 1 Q92 H94 H119 V121 L198 T199 T200 Q87 H89 H115 V117 L195 T196 T197 H64 H94 H96 E106 H119 T199 H64 H89 H91 E102 H115 T196 4.2.1.1 0004089,0008270 -logKd/Ki=8.24, Ki=5.7nM Ki=5.7nM, Kd=130nM, IC50=60nM O43570 11493685 1400 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS 1jd0 B 1.5 BS02 AZM B 1 Q92 H94 H119 V121 L198 T199 T200 Q86 H88 H114 V116 L194 T195 T196 H64 H94 H96 E106 H119 T199 H63 H88 H90 E101 H114 T195 4.2.1.1 0004089,0008270 Ki=5.7nM, Kd=130nM, IC50=60nM O43570 11493685 2401 WTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS 1rj6 A 2.9 BS02 AZM A 1 H94 L198 T199 T200 H90 L197 T198 T199 H64 H94 H96 E106 H119 T199 H65 H90 H92 E103 H116 T198 4.2.1.1 0004089,0008270 Q9WVT6 14660577 400 HHWTYEGPHGQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQLHLHWGQRGSLEGSEHHINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFASF 1rj6 B 2.9 BS02 AZM B 1 H94 H119 L198 T199 T200 H88 H114 L195 T196 T197 H64 H94 H96 E106 H119 T199 H63 H88 H90 E101 H114 T196 4.2.1.1 0004089,0008270 Q9WVT6 14660577 401 WTYEGPHGQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQLHLHWGQRGSLEGSEHHINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFASF 1yda A 2.1 BS02 AZM A 1 Q92 H94 H119 V121 F131 E198 T199 T200 Q88 H90 H115 V117 F126 E193 T194 T195 H64 H94 H96 E106 H119 T199 H60 H90 H92 E102 H115 T194 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=280nM -logKd/Ki=6.55, Kd=280nM Ki=12nM, Kd=17nM, IC50=10nM P00918 7696263 264 WGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSETTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASF 1ydb A 1.9 BS02 AZM A 1 Q92 H94 F198 T199 T200 Q88 H90 F193 T194 T195 H64 H94 H96 E106 H119 T199 H60 H90 H92 E102 H115 T194 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=5.8nM -logKd/Ki=8.24, Kd=5.8nM Ki=12nM, Kd=17nM, IC50=10nM P00918 7696263 264 WGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSFTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASF 1ydd A 2.1 BS02 AZM A 1 H94 H119 V121 F131 R198 T199 T200 H91 H116 V118 F127 R194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=86nM -logKd/Ki=7.07, Kd=86nM Ki=12nM, Kd=17nM, IC50=10nM P00918 7696263 264 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSRTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASF 1zsb A 2.0 BS02 AZM A 1 Q92 H94 H119 V121 F131 L198 T199 T200 Q89 H91 H116 V118 F127 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=250mM -logKd/Ki=0.60, Kd=250mM Ki=12nM, Kd=17nM, IC50=10nM P00918 8639494 264 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAQLHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 2h4n A 1.9 BS03 AZM A 1 Q92 N94 H96 H119 V121 F131 T199 T200 Q89 N91 H93 H116 V118 F127 T195 T196 H64 N94 H96 E106 H119 T199 H61 N91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Kd=0.002nM -logKd/Ki=8.70, Kd=2nM Ki=12nM, Kd=17nM, IC50=10nM P00918 9398308 264 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFNFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 2uy4 A 1.75 BS01 AZM A 1 F60 A110 D155 Q212 Y214 W285 L307 S310 F34 A84 D129 Q186 Y188 W259 L280 S283 3.2.1.14 0004553,0005975 Ki=21uM -logKd/Ki=4.68, Ki=21uM Ki=21000nM P29029 17524989 1311 TNIAVYWGQNSAGTQESLATYCESSDADIFLLSFLNQFPTLGLNFANACSDTFSDGLLHCTQIAEDIETCQSLGKKVLLSLGGASGSYLFSDDSQAETFAQTLWDTFGEGTGASERPFDSAVVDGFDFDIENNNEVGYSALATKLRTLFAEGTKQYYLSAAPQCPYPDASVGDLLENADIDFAFIQFYNNYCSVSGQFNWDTWLTYAQTVSPNKNIKLFLGLPGSASAAGSGYISDTSLLESTIADIASSSSFGGIALWDASQAFSNELGEPYVEILKNLLTS 2xtk A 2.0 BS01 AZM A 1 Y34 D172 E174 Q230 Y232 N233 W312 Y7 D145 E147 Q203 Y205 N206 W285 3.2.1.14 0004553,0005975 ic50=164uM -logKd/Ki=3.79, IC50=164uM B0Y2Y2 21044846 1339 FSNLAIYWGQGPNQLRLSHFCQETSLDIINIGFINYFPDMSPGHWPGSNFGNQCDGSVYVTNDGVVTKLLSGCHQIMEDIPICQAAGKKVLLSIGGAYPPDQSILSEDSAVAFATFLWGAFGPVAEGWEGPRPFGDVVVDGFDFDIEHNGGFGYATMVNTFRQYFNQVPERKFYLSAAPQCIIPDAQLSDAIFNAAFDFIWIQYYNTAACSAKSFIDTSLGTFNFDAWVTVLKASASKDAKLYVGLPASETAANQGYYLTPDEVESLVSTYMDRYPDTFGGIMLWEATASENNQIDGAPYADHMKDILLH 2xtk B 2.0 BS01 AZM B 1 F60 A124 Y125 D172 E174 Q230 Y232 W312 F32 A96 Y97 D144 E146 Q202 Y204 W284 3.2.1.14 0004553,0005975 ic50=164uM B0Y2Y2 21044846 1339 SNLAIYWGQGPNQLRLSHFCQETSLDIINIGFINYFPDMSPGHWPGSNFGNQCDGSVYVTNDGVVTKLLSGCHQIMEDIPICQAAGKKVLLSIGGAYPPDQSILSEDSAVAFATFLWGAFGPVAEGWEGPRPFGDVVVDGFDFDIEHNGGFGYATMVNTFRQYFNQVPERKFYLSAAPQCIIPDAQLSDAIFNAAFDFIWIQYYNTAACSAKSFIDTSLGTFNFDAWVTVLKASASKDAKLYVGLPASETAANQGYYLTPDEVESLVSTYMDRYPDTFGGIMLWEATASENNQIDGAPYADHMKDILLH 3czv A 2.0 BS02 AZM A 1 H94 F131 L198 T199 V200 H91 F128 L195 T196 V197 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T196 4.2.1.1 0004089,0005515,0005737,0005829,0006730,0008270,0016829,0043209,0043231,0046872 Ki=16nM -logKd/Ki=7.80, Ki=16nM Ki=17nM, Kd=50nM Q8N1Q1 18618712 263 SWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 3czv B 2.0 BS02 AZM B 1 Q92 H94 H119 V121 L198 T199 V200 Q90 H92 H117 V119 L196 T197 V198 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T197 4.2.1.1 0004089,0005515,0005737,0005829,0006730,0008270,0016829,0043209,0043231,0046872 Ki=16nM Ki=17nM, Kd=50nM Q8N1Q1 18618712 263 LSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASF 3dc3 A 1.7 BS02 AZM A 1 H94 H119 V121 F131 L198 T199 T200 H91 H116 V118 F127 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=4.9nM -logKd/Ki=8.31, Ki=4.9nM Ki=12nM, Kd=17nM, IC50=10nM P00918 19170619 263 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3hs4 A 1.1 BS03 AZM A 1 Q92 H94 H119 V121 F131 L198 T199 T200 Q89 H91 H116 V118 F127 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=10nM -logKd/Ki=8.00, Ki=10nM Ki=12nM, Kd=17nM, IC50=10nM P00918 19851004 701 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3hs4 A 1.1 BS04 AZM A 2 Y114 K213 E214 P215 Y111 K209 E210 P211 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=10nM -logKd/Ki=8.00, Ki=10nM Ki=12nM, Kd=17nM, IC50=10nM P00918 19851004 702 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3hs4 A 1.1 BS05 AZM A 3 H4 H15 D19 H1 H12 D16 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=10nM -logKd/Ki=8.00, Ki=10nM Ki=12nM, Kd=17nM, IC50=10nM P00918 19851004 703 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3iai A 2.2 BS02 AZM A 1 H94 V121 L198 T199 T200 W209 H92 V119 L197 T198 T199 W208 H64 H94 H96 E106 H119 T199 H66 H92 H94 E104 H117 T198 4.2.1.1 0004089,0008270 Ki=25nM, IC50=1520nM, Kd=20nM Q16790 19805286 263 GPDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 3iai B 2.2 BS02 AZM B 1 H94 V121 L198 T199 T200 W209 H87 V114 L192 T193 T194 W203 H64 H94 H96 E106 H119 T199 H61 H87 H89 E99 H112 T193 4.2.1.1 0004089,0008270 Ki=25nM, IC50=1520nM, Kd=20nM Q16790 19805286 263 HWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 3iai C 2.2 BS02 AZM C 1 H94 H119 V121 L198 T199 T200 W209 H87 H112 V114 L192 T193 T194 W203 H64 H94 H96 E106 H119 T199 H61 H87 H89 E99 H112 T193 4.2.1.1 0004089,0008270 Ki=25nM, IC50=1520nM, Kd=20nM Q16790 19805286 263 HWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 3iai D 2.2 BS02 AZM D 1 H94 H119 V121 L198 T199 T200 W209 H88 H113 V115 L193 T194 T195 W204 H64 H94 H96 E106 H119 T199 H62 H88 H90 E100 H113 T194 4.2.1.1 0004089,0008270 Ki=25nM, IC50=1520nM, Kd=20nM Q16790 19805286 263 SHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP 3ml5 A 2.05 BS02 AZM A 1 H94 V121 F131 L198 T199 T200 H94 V121 F131 L198 T199 T200 H64 H94 H96 E106 H119 T199 H64 H94 H96 E106 H119 T199 4.2.1.1 0004089,0005737,0005829,0006730,0008270,0016829,0032230,0032849,0046872,0051453,0070050,2001225 -logKd/Ki=8.52, Ki=3.0nM Ki=2.5nM, Kd=17nM, IC50=3440nM P43166 20688517 264 GHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKSLLPASRHYWTYPGSLTTPPLSESVTWIVLREPISISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA 3ucj A 1.85 BS02 AZM A 1 C47 D49 H103 G107 A108 A111 W115 T123 C42 D44 H98 G102 A103 A106 W110 T118 C47 D49 R51 H103 C106 C42 D44 R46 H98 C101 4.2.1.1 0004089,0008270,0015976,0016829,0046872 Ki=1uM -logKd/Ki=6.00, Ki=1uM Q96554 22162771 229 TADLSPLLEANRKWADECAAKDSTYFSKVAGSQAPEYLYIGCADSRVSPAQLFNMAPGEVFVQRNVGNLVSNKDLNCMSCLEYTVDHLKIKHILVCGHYNCGACKAGLVWHPKTAGVTNLWISDVREVRDKNAAKLHGLSADDAWDKMVELNVEAQVFNVCASPIVQAAWARGQPLSVHGIVYTPGTGLVKELIKPITGMEDAGALLRADLKQHCFFSESLA 3ucj A 1.85 BS03 AZM B 1 F66 Y88 F61 Y83 C47 D49 R51 H103 C106 C42 D44 R46 H98 C101 4.2.1.1 0004089,0008270,0015976,0016829,0046872 Ki=1uM -logKd/Ki=6.00, Ki=1uM Q96554 22162771 229 TADLSPLLEANRKWADECAAKDSTYFSKVAGSQAPEYLYIGCADSRVSPAQLFNMAPGEVFVQRNVGNLVSNKDLNCMSCLEYTVDHLKIKHILVCGHYNCGACKAGLVWHPKTAGVTNLWISDVREVRDKNAAKLHGLSADDAWDKMVELNVEAQVFNVCASPIVQAAWARGQPLSVHGIVYTPGTGLVKELIKPITGMEDAGALLRADLKQHCFFSESLA 3ucj B 1.85 BS01 AZM A 1 F66 Y88 F61 Y83 C47 D49 R51 H103 C106 C42 D44 R46 H98 C101 4.2.1.1 0004089,0008270,0015976,0016829,0046872 Ki=1uM -logKd/Ki=6.00, Ki=1uM Q96554 22162771 229 TADLSPLLEANRKWADECAAKDSTYFSKVAGSQAPEYLYIGCADSRVSPAQLFNMAPGEVFVQRNVGNLVSNKDLNCMSCLEYTVDHLKIKHILVCGHYNCGACKAGLVWHPKTAGVTNLWISDVREVRDKNAAKLHGLSADDAWDKMVELNVEAQVFNVCASPIVQAAWARGQPLSVHGIVYTPGTGLVKELIKPITGMEDAGALLRADLKQHCFFSESLA 3ucj B 1.85 BS03 AZM B 1 C47 D49 V71 H103 G107 A108 A111 W115 T123 C42 D44 V66 H98 G102 A103 A106 W110 T118 C47 D49 R51 H103 C106 C42 D44 R46 H98 C101 4.2.1.1 0004089,0008270,0015976,0016829,0046872 Ki=1uM -logKd/Ki=6.00, Ki=1uM Q96554 22162771 229 TADLSPLLEANRKWADECAAKDSTYFSKVAGSQAPEYLYIGCADSRVSPAQLFNMAPGEVFVQRNVGNLVSNKDLNCMSCLEYTVDHLKIKHILVCGHYNCGACKAGLVWHPKTAGVTNLWISDVREVRDKNAAKLHGLSADDAWDKMVELNVEAQVFNVCASPIVQAAWARGQPLSVHGIVYTPGTGLVKELIKPITGMEDAGALLRADLKQHCFFSESLA 3v2j A 1.699 BS02 AZM A 1 Q92 H94 V121 F131 L198 T199 T200 Q89 H91 V118 F127 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=12nM, Kd=17nM, IC50=10nM P00918 302 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3v2m A 1.471 BS02 AZM A 1 Q92 H94 H96 H119 V121 F131 L198 T199 T200 Q89 H91 H93 H116 V118 F127 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=12nM, Kd=17nM, IC50=10nM P00918 303 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3w6h A 2.964 BS03 AZM A 1 Q92 H94 L198 T199 H200 Q88 H90 L194 T195 H196 H64 H94 H96 E106 H119 T199 H60 H90 H92 E102 H115 T195 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 Ki=250nM, Kd=1400nM, IC50=5.8nM P00915 303 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 3w6h B 2.964 BS04 AZM B 1 H94 L198 T199 H200 H90 L194 T195 H196 H64 H94 H96 E106 H119 T199 H60 H90 H92 E102 H115 T195 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 Ki=250nM, Kd=1400nM, IC50=5.8nM P00915 303 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 4g0c A 2.0 BS02 AZM A 1 Q92 H94 F131 L198 T199 T200 Q89 H91 F127 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 -logKd/Ki=7.92, Ki=12nM Ki=12nM, Kd=17nM, IC50=10nM P00918 22928733 302 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4g7a A 1.8 BS02 AZM A 1 H89 H108 V110 L173 T174 T175 H88 H107 V109 L172 T173 T174 H64 H89 H91 E95 H108 T174 H63 H88 H90 E94 H107 T173 0004089,0008270 Ki=4.5nM 23695259 302 EWSYEGEKGPEHWAQLKPEFFWCKLKNQSPINIDKKYKVKANLPKLNLYYKTAKESEVVNNGHTIQINIKEDNTLNYLGEKYQLKQFHFHTPSEHTIEKKSYPLEIHFVHKTEDGKILVVGVMAKLGKTNKELDKILNVAPAEEGEKILDKNLNLNNLIPKDKRYMTYSGSLTTPPCTEGVRWIVLKKPISISKQQLEKLKSVMVNPNNRPVQEINSRWIIEGF 4g7a B 1.8 BS02 AZM B 1 H89 H108 V110 L173 T174 T175 H89 H108 V110 L173 T174 T175 H64 H89 H91 E95 H108 T174 H64 H89 H91 E95 H108 T174 0004089,0008270 Ki=4.5nM 23695259 302 HEWSYEGEKGPEHWAQLKPEFFWCKLKNQSPINIDKKYKVKANLPKLNLYYKTAKESEVVNNGHTIQINIKEDNTLNYLGEKYQLKQFHFHTPSEHTIEKKSYPLEIHFVHKTEDGKILVVGVMAKLGKTNKELDKILNVAPAEEGEKILDKNLNLNNLIPKDKRYMTYSGSLTTPPCTEGVRWIVLKKPISISKQQLEKLKSVMVNPNNRPVQEINSRWIIEGF 4k0s A 1.802 BS02 AZM A 1 H94 H119 V121 L198 T199 T200 H91 H116 V118 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=12nM, Kd=17nM, IC50=10nM P00918 302 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDLGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4lu3 A 2.0 BS02 AZM A 1 H94 H119 L131 L198 T199 T200 H89 H115 L127 L196 T197 T198 H64 H94 H96 E106 H119 T199 H64 H89 H91 E102 H115 T197 4.2.1.1 0004089,0008270 Ki=41nM, Kd=11nM, IC50=224nM Q9ULX7 24374484 302 HWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYT 4uov A 1.85 BS02 AZM A 1 H112 H131 V133 L197 T198 T199 H90 H109 V111 L175 T176 T177 H87 H112 H114 E118 H131 T198 H65 H90 H92 E96 H109 T176 4.2.1.1 0004089,0008270 E8T502 25286845 299 GAHWGYSGSIGPEHWGDLSPEYLMCKIGKNQSPIDINSADAVKACLAPVSVYYVSDAKYVVNNGHTIKVVMGGRGYVVVDGKRFYLKQFHFHAPSEHTVNGKHYPFEAHFVHLDKNGNITVLGVFFKVGKENPELEKVWRVMPEEPGQKRHLTARIDPEKLLPENRDYYRYSGSLTTPPCSEGVRWIVFKEPVEMSREQLEKFRKVMGFDNNRPVQPLNARKVMK 4uov B 1.85 BS02 AZM B 1 H112 H131 L197 T198 T199 H90 H109 L175 T176 T177 H87 H112 H114 E118 H131 T198 H65 H90 H92 E96 H109 T176 4.2.1.1 0004089,0008270 E8T502 25286845 299 GAHWGYSGSIGPEHWGDLSPEYLMCKIGKNQSPIDINSADAVKACLAPVSVYYVSDAKYVVNNGHTIKVVMGGRGYVVVDGKRFYLKQFHFHAPSEHTVNGKHYPFEAHFVHLDKNGNITVLGVFFKVGKENPELEKVWRVMPEEPGQKRHLTARIDPEKLLPENRDYYRYSGSLTTPPCSEGVRWIVFKEPVEMSREQLEKFRKVMGFDNNRPVQPLNARKVMK 4uov C 1.85 BS02 AZM C 1 H112 H131 L197 T198 T199 H90 H109 L175 T176 T177 H87 H112 H114 E118 H131 T198 H65 H90 H92 E96 H109 T176 4.2.1.1 0004089,0008270 E8T502 25286845 299 GAHWGYSGSIGPEHWGDLSPEYLMCKIGKNQSPIDINSADAVKACLAPVSVYYVSDAKYVVNNGHTIKVVMGGRGYVVVDGKRFYLKQFHFHAPSEHTVNGKHYPFEAHFVHLDKNGNITVLGVFFKVGKENPELEKVWRVMPEEPGQKRHLTARIDPEKLLPENRDYYRYSGSLTTPPCSEGVRWIVFKEPVEMSREQLEKFRKVMGFDNNRPVQPLNARKVMK 4uov D 1.85 BS02 AZM D 1 H112 H131 L197 T198 T199 H90 H109 L175 T176 T177 H87 H112 H114 E118 H131 T198 H65 H90 H92 E96 H109 T176 4.2.1.1 0004089,0008270 E8T502 25286845 299 GAHWGYSGSIGPEHWGDLSPEYLMCKIGKNQSPIDINSADAVKACLAPVSVYYVSDAKYVVNNGHTIKVVMGGRGYVVVDGKRFYLKQFHFHAPSEHTVNGKHYPFEAHFVHLDKNGNITVLGVFFKVGKENPELEKVWRVMPEEPGQKRHLTARIDPEKLLPENRDYYRYSGSLTTPPCSEGVRWIVFKEPVEMSREQLEKFRKVMGFDNNRPVQPLNARKVMK 4uov E 1.85 BS02 AZM E 1 H112 H131 V133 L197 T198 T199 H90 H109 V111 L175 T176 T177 H87 H112 H114 E118 H131 T198 H65 H90 H92 E96 H109 T176 4.2.1.1 0004089,0008270 E8T502 25286845 299 GAHWGYSGSIGPEHWGDLSPEYLMCKIGKNQSPIDINSADAVKACLAPVSVYYVSDAKYVVNNGHTIKVVMGGRGYVVVDGKRFYLKQFHFHAPSEHTVNGKHYPFEAHFVHLDKNGNITVLGVFFKVGKENPELEKVWRVMPEEPGQKRHLTARIDPEKLLPENRDYYRYSGSLTTPPCSEGVRWIVFKEPVEMSREQLEKFRKVMGFDNNRPVQPLNARKVMK 4uov F 1.85 BS02 AZM F 1 H112 H131 L197 T198 T199 H90 H109 L175 T176 T177 H87 H112 H114 E118 H131 T198 H65 H90 H92 E96 H109 T176 4.2.1.1 0004089,0008270 E8T502 25286845 299 GAHWGYSGSIGPEHWGDLSPEYLMCKIGKNQSPIDINSADAVKACLAPVSVYYVSDAKYVVNNGHTIKVVMGGRGYVVVDGKRFYLKQFHFHAPSEHTVNGKHYPFEAHFVHLDKNGNITVLGVFFKVGKENPELEKVWRVMPEEPGQKRHLTARIDPEKLLPENRDYYRYSGSLTTPPCSEGVRWIVFKEPVEMSREQLEKFRKVMGFDNNRPVQPLNARKVMK 4x5s A 1.95 BS02 AZM A 1 H89 L173 T174 T175 H88 L172 T173 T174 H64 H89 H91 E95 H108 T174 H63 H88 H90 E94 H107 T173 4.2.1.1 0004089,0006730,0008270,0016829,0016836,0046872 C1DTU5 25817590 302 HWSYEGENGPENWAKLNPEYFWCNLKNQSPVDISDNYKVHAKLEKLHINYNKAVNPEIVNNGHTIQVNVLEDFKLNIKGKEYHLKQFHFHAPSEHTVNGKYYPLEMHLVHKDKDGNIAVIGVFFKEGKANPELDKVFKNALKEEGSKVFDGSININALLPPVKNYYTYSGSLTTPPCTEGVLWIVLKQPITASKQQIELFKSIMKHNNNRPTQPINSRYILES 4x5s B 1.95 BS02 AZM B 1 H89 V110 L173 T174 T175 H88 V109 L172 T173 T174 H64 H89 H91 E95 H108 T174 H63 H88 H90 E94 H107 T173 4.2.1.1 0004089,0006730,0008270,0016829,0016836,0046872 C1DTU5 25817590 302 HWSYEGENGPENWAKLNPEYFWCNLKNQSPVDISDNYKVHAKLEKLHINYNKAVNPEIVNNGHTIQVNVLEDFKLNIKGKEYHLKQFHFHAPSEHTVNGKYYPLEMHLVHKDKDGNIAVIGVFFKEGKANPELDKVFKNALKEEGSKVFDGSININALLPPVKNYYTYSGSLTTPPCTEGVLWIVLKQPITASKQQIELFKSIMKHNNNRPTQPINSRYILES 4xiw A 2.6 BS02 AZM A 1 H160 H162 H179 L253 T254 T255 H87 H89 H106 L180 T181 T182 H134 H160 H162 E166 H179 T254 H61 H87 H89 E93 H106 T181 4.2.1.1 0004089,0008270 Q39588 25617045 402 AWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL 4xiw B 2.6 BS02 AZM B 1 H160 H179 L253 T254 T255 H87 H106 L180 T181 T182 H134 H160 H162 E166 H179 T254 H61 H87 H89 E93 H106 T181 4.2.1.1 0004089,0008270 Q39588 25617045 402 AWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL 4xiw C 2.6 BS02 AZM C 1 H160 H179 L253 T254 T255 H89 H108 L182 T183 T184 H134 H160 H162 E166 H179 T254 H63 H89 H91 E95 H108 T183 4.2.1.1 0004089,0008270 Q39588 25617045 402 MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL 4xiw D 2.6 BS02 AZM D 1 H160 H162 H179 L253 T254 T255 H87 H89 H106 L180 T181 T182 H134 H160 H162 E166 H179 T254 H61 H87 H89 E93 H106 T181 4.2.1.1 0004089,0008270 Q39588 25617045 402 AWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL 4xiw E 2.6 BS02 AZM E 1 Q158 H160 H179 L253 T254 T255 Q86 H88 H107 L181 T182 T183 H134 H160 H162 E166 H179 T254 H62 H88 H90 E94 H107 T182 4.2.1.1 0004089,0008270 Q39588 25617045 402 AAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL 4xiw F 2.6 BS02 AZM F 1 H160 H162 H179 V181 L253 T254 T255 H88 H90 H107 V109 L181 T182 T183 H134 H160 H162 E166 H179 T254 H62 H88 H90 E94 H107 T182 4.2.1.1 0004089,0008270 Q39588 25617045 402 AAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL 4xiw G 2.6 BS02 AZM G 1 H160 H179 V181 L253 T254 T255 H88 H107 V109 L181 T182 T183 H134 H160 H162 E166 H179 T254 H62 H88 H90 E94 H107 T182 4.2.1.1 0004089,0008270 Q39588 25617045 402 AAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL 4xiw H 2.6 BS02 AZM H 1 Q158 H160 H179 L253 T254 T255 Q87 H89 H108 L182 T183 T184 H134 H160 H162 E166 H179 T254 H63 H89 H91 E95 H108 T183 4.2.1.1 0004089,0008270 Q39588 25617045 402 MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL 4ygf A 2.0 BS02 AZM A 1 H110 H112 H129 V131 L190 T191 W201 H89 H91 H108 V110 L169 T170 W180 H85 H110 H112 E116 H129 T191 H64 H89 H91 E95 H108 T170 ? 0004089,0008270,0046872 Ki=21nM -logKd/Ki=7.68, Ki=21nM A0A0M3KL20 26010545 303 KWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4ygf B 2.0 BS02 AZM B 1 N108 H110 H129 V131 L190 T191 W201 N84 H86 H105 V107 L166 T167 W177 H85 H110 H112 E116 H129 T191 H61 H86 H88 E92 H105 T167 ? 0004089,0008270,0046872 Ki=21nM A0A0M3KL20 26010545 303 TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTDLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4ygf C 2.0 BS02 AZM C 1 H110 V131 L190 T191 H90 V111 L170 T171 H85 H110 H112 E116 H129 T191 H65 H90 H92 E96 H109 T171 ? 0004089,0008270,0046872 Ki=21nM A0A0M3KL20 26010545 303 TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4ygf D 2.0 BS02 AZM D 1 H110 H112 H129 V131 L190 T191 H89 H91 H108 V110 L167 T168 H85 H110 H112 E116 H129 T191 H64 H89 H91 E95 H108 T168 ? 0004089,0008270,0046872 Ki=21nM A0A0M3KL20 26010545 303 KWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4ygf E 2.0 BS02 AZM E 1 K88 H110 H112 H129 L190 T191 W201 K67 H89 H91 H108 L169 T170 W180 H85 H110 H112 E116 H129 T191 H64 H89 H91 E95 H108 T170 ? 0004089,0008270,0046872 Ki=21nM A0A0M3KL20 26010545 303 KWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4ygf F 2.0 BS02 AZM F 1 N108 H110 V131 L190 T191 N86 H88 V109 L168 T169 H85 H110 H112 E116 H129 T191 H63 H88 H90 E94 H107 T169 ? 0004089,0008270,0046872 Ki=21nM A0A0M3KL20 26010545 303 WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4ygf G 2.0 BS02 AZM G 1 H110 H129 V131 L190 T191 H91 H110 V112 L171 T172 H85 H110 H112 E116 H129 T191 H66 H91 H93 E97 H110 T172 ? 0004089,0008270,0046872 Ki=21nM A0A0M3KL20 26010545 303 NTKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4ygf H 2.0 BS02 AZM H 1 H110 H129 V131 L190 T191 H88 H107 V109 L168 T169 H85 H110 H112 E116 H129 T191 H63 H88 H90 E94 H107 T169 ? 0004089,0008270,0046872 Ki=21nM A0A0M3KL20 26010545 303 WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 5jn8 A 1.85 BS01 AZM A 1 Q92 H94 H119 L198 T199 T200 Q95 H97 H122 L199 T200 T201 H64 H94 H96 E106 H119 T199 H70 H97 H99 E109 H122 T200 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 -logKd/Ki=7.30, Kd=50nM Ki=74nM, Kd=100nM, IC50=17.5nM P22748 28975383 701 AESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5jn8 B 1.85 BS01 AZM B 1 Q92 H94 L198 T199 T200 Q92 H94 L195 T196 T197 H64 H94 H96 E106 H119 T199 H67 H94 H96 E106 H119 T196 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=74nM, Kd=100nM, IC50=17.5nM P22748 28975383 701 HWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5jn8 C 1.85 BS01 AZM C 1 Q92 H94 H96 H119 L198 T199 T200 Q93 H95 H97 H120 L204 T205 T206 H64 H94 H96 E106 H119 T199 H68 H95 H97 E107 H120 T205 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=74nM, Kd=100nM, IC50=17.5nM P22748 28975383 701 SHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5jn8 D 1.85 BS01 AZM D 1 Q92 H94 H119 V121 L198 T199 T200 W209 Q92 H94 H119 V121 L203 T204 T205 W214 H64 H94 H96 E106 H119 T199 H67 H94 H96 E106 H119 T204 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=74nM, Kd=100nM, IC50=17.5nM P22748 28975383 701 HWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5nek B 3.057 BS02 AZM B 1 D76 D77 H126 H130 Y167 W198 H230 D9 D10 H59 H63 Y100 W131 H163 3.5.1.104 0005886,0005975,0016787,0016810,0046872 Q81EJ6 29257674 302 RKVAYLTFDDGPGKYTAELLNTLKQHDAKATFFLIGANVKEFPDLVKRENAEGHYVGMHSMTHNFAKLYKNGEYVNEMKEDQGLIANIIGKSPKLTRPPYGSMPGLNEGLRNKVVEGGFKVWDWTIDSLDWRYNKMPVDAAAAQIAQNVLTNATKPQEVILMHDIHPQSVAAVPAILKGLKEKGYEFEAYHEESHFPVNFWHDNRM 5nek D 3.057 BS02 AZM D 1 D77 H126 H130 Y167 H230 D10 H59 H63 Y100 H163 3.5.1.104 0005886,0005975,0016787,0016810,0046872 Q81EJ6 29257674 302 RKVAYLTFDDGPGKYTAELLNTLKQHDAKATFFLIGANVKEFPDLVKRENAEGHYVGMHSMTHNFAKLYKNGEYVNEMKEDQGLIANIIGKSPKLTRPPYGSMPGLNEGLRNKVVEGGFKVWDWTIDSLDWRYNKMPVDAAAAQIAQNVLTNATKPQEVILMHDIHPQSVAAVPAILKGLKEKGYEFEAYHEESHFPVNFWHDNRM 6im3 A 2.0 BS02 AZM A 1 H107 H126 L192 T193 T194 H86 H105 L171 T172 T173 H82 H107 H109 E113 H126 T193 H61 H86 H88 E92 H105 T172 4.2.1.1 0004089,0008270 C0QRB5 31250619 302 GWSYHGEHGPEHWGDLKDEYIMCKIGKNQSPVDINRIVDAKLKPIKIEYRAGATKVLNNGHTIKVSYEPGSYIVVDGIKFELKQFHFHAPSEHKLKGQHYPFEAHFVHADKHGNLAVIGVFFKEGRENPILEKIWKVMPENAGEEVKLAHKINAEDLLPKDRDYYRYSGSLTTPPCSEGVRWIVMEEEMEMSKEQIEKFRKIMGGDTNRPVQPLNARMIMEK 6im3 B 2.0 BS02 AZM B 1 H107 H126 V128 L192 T193 T194 H86 H105 V107 L171 T172 T173 H82 H107 H109 E113 H126 T193 H61 H86 H88 E92 H105 T172 4.2.1.1 0004089,0008270 C0QRB5 31250619 302 GWSYHGEHGPEHWGDLKDEYIMCKIGKNQSPVDINRIVDAKLKPIKIEYRAGATKVLNNGHTIKVSYEPGSYIVVDGIKFELKQFHFHAPSEHKLKGQHYPFEAHFVHADKHGNLAVIGVFFKEGRENPILEKIWKVMPENAGEEVKLAHKINAEDLLPKDRDYYRYSGSLTTPPCSEGVRWIVMEEEMEMSKEQIEKFRKIMGGDTNRPVQPLNARMIMEK 6im3 C 2.0 BS02 AZM C 1 H107 H126 V128 L192 T193 T194 H86 H105 V107 L171 T172 T173 H82 H107 H109 E113 H126 T193 H61 H86 H88 E92 H105 T172 4.2.1.1 0004089,0008270 C0QRB5 31250619 302 GWSYHGEHGPEHWGDLKDEYIMCKIGKNQSPVDINRIVDAKLKPIKIEYRAGATKVLNNGHTIKVSYEPGSYIVVDGIKFELKQFHFHAPSEHKLKGQHYPFEAHFVHADKHGNLAVIGVFFKEGRENPILEKIWKVMPENAGEEVKLAHKINAEDLLPKDRDYYRYSGSLTTPPCSEGVRWIVMEEEMEMSKEQIEKFRKIMGGDTNRPVQPLNARMIMEK 6im3 D 2.0 BS02 AZM D 1 H107 H126 V128 L192 T193 T194 H86 H105 V107 L171 T172 T173 H82 H107 H109 E113 H126 T193 H61 H86 H88 E92 H105 T172 4.2.1.1 0004089,0008270 C0QRB5 31250619 302 GWSYHGEHGPEHWGDLKDEYIMCKIGKNQSPVDINRIVDAKLKPIKIEYRAGATKVLNNGHTIKVSYEPGSYIVVDGIKFELKQFHFHAPSEHKLKGQHYPFEAHFVHADKHGNLAVIGVFFKEGRENPILEKIWKVMPENAGEEVKLAHKINAEDLLPKDRDYYRYSGSLTTPPCSEGVRWIVMEEEMEMSKEQIEKFRKIMGGDTNRPVQPLNARMIMEK 6im3 E 2.0 BS04 AZM E 1 H107 V128 L192 T193 T194 H86 V107 L171 T172 T173 H82 H107 H109 E113 H126 T193 H61 H86 H88 E92 H105 T172 4.2.1.1 0004089,0008270 C0QRB5 31250619 302 GWSYHGEHGPEHWGDLKDEYIMCKIGKNQSPVDINRIVDAKLKPIKIEYRAGATKVLNNGHTIKVSYEPGSYIVVDGIKFELKQFHFHAPSEHKLKGQHYPFEAHFVHADKHGNLAVIGVFFKEGRENPILEKIWKVMPENAGEEVKLAHKINAEDLLPKDRDYYRYSGSLTTPPCSEGVRWIVMEEEMEMSKEQIEKFRKIMGGDTNRPVQPLNARMIMEK 6im3 F 2.0 BS04 AZM F 1 H107 V128 L192 T193 T194 H86 V107 L171 T172 T173 H82 H107 H109 E113 H126 T193 H61 H86 H88 E92 H105 T172 4.2.1.1 0004089,0008270 C0QRB5 31250619 302 GWSYHGEHGPEHWGDLKDEYIMCKIGKNQSPVDINRIVDAKLKPIKIEYRAGATKVLNNGHTIKVSYEPGSYIVVDGIKFELKQFHFHAPSEHKLKGQHYPFEAHFVHADKHGNLAVIGVFFKEGRENPILEKIWKVMPENAGEEVKLAHKINAEDLLPKDRDYYRYSGSLTTPPCSEGVRWIVMEEEMEMSKEQIEKFRKIMGGDTNRPVQPLNARMIMEK 6mwj A 2.05 BS02 AZM A 1 D10 H12 S37 H44 I59 F63 D65 F70 L78 D11 H13 S38 H45 I60 F64 D66 F71 L79 4.6.1.12 0008299,0008685,0016114,0016829,0019288,0046872 Q3JRA0 201 SMDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHFSDTDPRFKGADSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALVVRE 6qeb A -1.00 BS02 AZM A 1 H119 N243 H119 N243 H64 H94 H96 E106 H119 T198 H64 H94 H96 E106 H119 T198 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=12nM, Kd=17nM, IC50=10nM P00918 30688395 302 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 6yma A 2.5 BS02 AZM A 1 Q92 H94 H96 V121 F131 L198 T199 T200 Q89 H91 H93 V118 F127 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=12nM, Kd=17nM, IC50=6.7nM P00918 32737395 302 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 7coj A 2.0 BS02 AZM A 1 C119 D121 H175 G179 G180 C44 D46 H100 G104 G105 4.2.1.1 0004089,0005737,0008270,0015976,0016829,0034599,0046872,0071244 Q4WQ18 32975213 302 SLSDKFSAALAKNKEWAAKCSQEHPELLPTLAVGQHPEILWIGCSDSRCPETTILGLLPGDVFTHRNIANVIHPADLSSGAVIEFAVRHLRVKHVVICGHTKCGGVAAALGNKGLGILDPWLIPLRQLREQHLAELQSLSRDEAVVRLAELNVKEGLKALTQKSVVLEAMQERGLQVHGLIYDVGSGFLRQLDAAEPEEALKARLTSFKTD 7coj A 2.0 BS03 AZM B 1 F138 F160 F63 F85 4.2.1.1 0004089,0005737,0008270,0015976,0016829,0034599,0046872,0071244 Q4WQ18 32975213 302 SLSDKFSAALAKNKEWAAKCSQEHPELLPTLAVGQHPEILWIGCSDSRCPETTILGLLPGDVFTHRNIANVIHPADLSSGAVIEFAVRHLRVKHVVICGHTKCGGVAAALGNKGLGILDPWLIPLRQLREQHLAELQSLSRDEAVVRLAELNVKEGLKALTQKSVVLEAMQERGLQVHGLIYDVGSGFLRQLDAAEPEEALKARLTSFKTD 7coj B 2.0 BS01 AZM A 1 F138 F160 F61 F83 4.2.1.1 0004089,0005737,0008270,0015976,0016829,0034599,0046872,0071244 Q4WQ18 32975213 302 SDKFSAALAKNKEWAAKCSQEHPELLPTLAVGQHPEILWIGCSDSRCPETTILGLLPGDVFTHRNIANVIHPADLSSGAVIEFAVRHLRVKHVVICGHTKCGGVAAALGNKGLGILDPWLIPLRQLREQHLAELQSLSRDEAVVRLAELNVKEGLKALTQKSVVLEAMQERGLQVHGLIYDVGSGFLRQLDAAEPEEALKARLTSFKTD 7coj B 2.0 BS03 AZM B 1 C119 D121 H175 G179 G180 L193 C42 D44 H98 G102 G103 L116 4.2.1.1 0004089,0005737,0008270,0015976,0016829,0034599,0046872,0071244 Q4WQ18 32975213 302 SDKFSAALAKNKEWAAKCSQEHPELLPTLAVGQHPEILWIGCSDSRCPETTILGLLPGDVFTHRNIANVIHPADLSSGAVIEFAVRHLRVKHVVICGHTKCGGVAAALGNKGLGILDPWLIPLRQLREQHLAELQSLSRDEAVVRLAELNVKEGLKALTQKSVVLEAMQERGLQVHGLIYDVGSGFLRQLDAAEPEEALKARLTSFKTD 7coj C 2.0 BS02 AZM C 1 C119 D121 H175 G179 G180 C44 D46 H100 G104 G105 4.2.1.1 0004089,0005737,0008270,0015976,0016829,0034599,0046872,0071244 Q4WQ18 32975213 302 SLSDKFSAALAKNKEWAAKCSQEHPELLPTLAVGQHPEILWIGCSDSRCPETTILGLLPGDVFTHRNIANVIHPADLSSGAVIEFAVRHLRVKHVVICGHTKCGGVAAALGNKGLGILDPWLIPLRQLREQHLAELQSLSRDEAVVRLAELNVKEGLKALTQKSVVLEAMQERGLQVHGLIYDVGSGFLRQLDAAEPEEALKARLTSFKTD 7coj C 2.0 BS03 AZM D 1 F138 F160 F63 F85 4.2.1.1 0004089,0005737,0008270,0015976,0016829,0034599,0046872,0071244 Q4WQ18 32975213 302 SLSDKFSAALAKNKEWAAKCSQEHPELLPTLAVGQHPEILWIGCSDSRCPETTILGLLPGDVFTHRNIANVIHPADLSSGAVIEFAVRHLRVKHVVICGHTKCGGVAAALGNKGLGILDPWLIPLRQLREQHLAELQSLSRDEAVVRLAELNVKEGLKALTQKSVVLEAMQERGLQVHGLIYDVGSGFLRQLDAAEPEEALKARLTSFKTD 7coj D 2.0 BS01 AZM C 1 F138 F160 F60 F82 4.2.1.1 0004089,0005737,0008270,0015976,0016829,0034599,0046872,0071244 Q4WQ18 32975213 302 DKFSAALAKNKEWAAKCSQEHPELLPTLAVGQHPEILWIGCSDSRCPETTILGLLPGDVFTHRNIANVIHPADLSSGAVIEFAVRHLRVKHVVICGHTKCGGVAAALGNKGLGILDPWLIPLRQLREQHLAELQSLSRDEAVVRLAELNVKEGLKALTQKSVVLEAMQERGLQVHGLIYDVGSGFLRQLDAAEPEEALKARLTSFKTDA 7coj D 2.0 BS03 AZM D 1 C119 D121 H175 G179 G180 C41 D43 H97 G101 G102 4.2.1.1 0004089,0005737,0008270,0015976,0016829,0034599,0046872,0071244 Q4WQ18 32975213 302 DKFSAALAKNKEWAAKCSQEHPELLPTLAVGQHPEILWIGCSDSRCPETTILGLLPGDVFTHRNIANVIHPADLSSGAVIEFAVRHLRVKHVVICGHTKCGGVAAALGNKGLGILDPWLIPLRQLREQHLAELQSLSRDEAVVRLAELNVKEGLKALTQKSVVLEAMQERGLQVHGLIYDVGSGFLRQLDAAEPEEALKARLTSFKTDA 8dpo A 2.6 BS01 AZM A 1 H92 H94 H111 L176 T177 H88 H90 H107 L172 T173 4.2.1.1 0004089,0008270,0016829,0042597,0046872 Q50940 301 THWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVNYKPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKGRTFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKLNQPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEKFTRAVGSENNRPVQPLNARVVIE 8dpo C 2.6 BS01 AZM C 1 H92 H94 H111 L176 T177 H88 H90 H107 L172 T173 4.2.1.1 0004089,0008270,0016829,0042597,0046872 Q50940 301 THWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVNYKPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKGRTFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKLNQPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEKFTRAVGSENNRPVQPLNARVVIE 8dpo E 2.6 BS01 AZM E 1 H92 H94 H111 L176 T177 H88 H90 H107 L172 T173 4.2.1.1 0004089,0008270,0016829,0042597,0046872 Q50940 301 THWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVNYKPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKGRTFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKLNQPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEKFTRAVGSENNRPVQPLNARVVIE 8dpo G 2.6 BS01 AZM G 1 Q90 H92 H94 H111 L176 T177 Q86 H88 H90 H107 L172 T173 4.2.1.1 0004089,0008270,0016829,0042597,0046872 Q50940 301 THWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVNYKPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKGRTFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKLNQPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEKFTRAVGSENNRPVQPLNARVVIE 8dyq A 2.15 BS01 AZM A 1 H92 H111 V113 L176 T177 T178 H88 H107 V109 L172 T173 T174 4.2.1.1 0004089,0008270,0016829,0042597,0046872 Q50940 36655133 301 THWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVNYKPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKGRTFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKLNQPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEKFTRAVGSENNRPVQPLNARVVIE 8dyq C 2.15 BS01 AZM C 1 Q90 H92 H111 V113 L176 T177 T178 Q86 H88 H107 V109 L172 T173 T174 4.2.1.1 0004089,0008270,0016829,0042597,0046872 Q50940 36655133 301 THWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVNYKPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKGRTFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKLNQPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEKFTRAVGSENNRPVQPLNARVVIE 8dyq E 2.15 BS01 AZM E 1 Q90 H92 H94 L176 T177 T178 Q86 H88 H90 L172 T173 T174 4.2.1.1 0004089,0008270,0016829,0042597,0046872 Q50940 36655133 301 THWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVNYKPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKGRTFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKLNQPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEKFTRAVGSENNRPVQPLNARVVIE 8dyq G 2.15 BS01 AZM G 1 H92 H111 V113 L176 T177 T178 H88 H107 V109 L172 T173 T174 4.2.1.1 0004089,0008270,0016829,0042597,0046872 Q50940 36655133 301 THWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVNYKPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKGRTFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKLNQPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEKFTRAVGSENNRPVQPLNARVVIE