4ase A 1.83 BS01 AV9 A 1 L840 V848 A866 K868 E885 L889 V916 C919 L1035 C1045 D1046 F1047 N1167 A1168 L34 V42 A60 K62 E79 L83 V110 C113 L172 C182 D183 F184 N304 A305 D1028 A1030 R1032 N1033 D1046 D1064 D165 A167 R169 N170 D183 D201 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169 Ki=0.01nM -logKd/Ki=11.00, Ki=0.01nM P35968 22988103 3169 DPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANA 8bem A 2.6 BS01 AV9 A 1 V48 A61 E79 I80 I108 C111 G114 A172 D173 F174 V30 A43 E61 I62 I90 C93 G96 A154 D155 F156 2.7.11.1 0004672,0005524,0006468 Q9H2G2 401 SMKQYEHVKRDLNPEDFWEIIGELGDGGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGSFIGTPYWMAPEVVMCETPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKA 8bem B 2.6 BS01 AV9 B 1 L40 A61 E79 I108 F110 C111 G114 A172 D173 F174 L24 A45 E63 I92 F94 C95 G98 A156 D157 F158 2.7.11.1 0004672,0005524,0006468 Q9H2G2 401 SMKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGSFIGTPYWMAPEVVMCETPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAE 8bem D 2.6 BS01 AV9 D 1 L40 G41 V48 A61 I108 F110 C111 G114 A172 D173 F174 L24 G25 V30 A43 I90 F92 C93 G96 A154 D155 F156 2.7.11.1 0004672,0005524,0006468 Q9H2G2 401 SMKQYEHVKRDLNPEDFWEIIGELGDGGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGSFIGTPYWMAPEVVMCETPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAE 8bem G 2.6 BS01 AV9 G 1 L40 V48 A61 I106 I108 C111 L162 D173 F174 L24 V29 A42 I87 I89 C92 L143 D154 F155 2.7.11.1 0004672,0005524,0006468 Q9H2G2 401 SMKQYEHVKRDLNPEDFWEIIGELGDGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGFIGTPYWMAPEVVMCETPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKA