2c4h A 2.15 BS01 AT3 A 1 W84 G117 G118 E199 F330 H440 W81 G114 G115 E196 F327 H437 G118 G119 G151 S200 A201 A239 F290 F292 E327 H440 G115 G116 G148 S197 A198 A236 F287 F289 E324 H437 3.1.1.7 0001507,0003990,0004104,0005615,0005886,0006581,0019695,0043083,0045202,0052689,0098552 P04058 16763558 1540 SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPGFSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHNVICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPNEPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVFWNQFLPKLLNAT 2c4h A 2.15 BS02 AT3 A 2 Y70 Y121 W279 F330 Y334 Y67 Y118 W276 F327 Y331 G118 G119 G151 S200 A201 A239 F290 F292 E327 H440 G115 G116 G148 S197 A198 A236 F287 F289 E324 H437 3.1.1.7 0001507,0003990,0004104,0005615,0005886,0006581,0019695,0043083,0045202,0052689,0098552 P04058 16763558 1541 SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPGFSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHNVICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPNEPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVFWNQFLPKLLNAT 2c58 A 2.3 BS02 AT3 A 1 Y70 Y121 W279 F331 Y67 Y118 W276 F328 G118 G119 G151 S200 A201 A239 F290 F292 E327 H440 G115 G116 G148 S197 A198 A236 F287 F289 E324 H437 3.1.1.7 0001507,0003990,0004104,0005615,0005886,0006581,0019695,0043083,0045202,0052689,0098552 P04058 16763558 1537 SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPGFSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHNVICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPNEPHSQESKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVFWNQFLPKLLNAT 2ha5 A 2.15 BS01 AT3 A 1 W86 Y124 F297 F338 W86 Y124 F290 F331 G121 G122 G154 A203 A204 G242 F297 F299 E334 H447 G121 G122 G154 A203 A204 G242 F290 F292 E327 H440 3.1.1.7 0001919,0002076,0003990,0004104,0005515,0005518,0005576,0005604,0005615,0005794,0005886,0006581,0007155,0009986,0016020,0016787,0017171,0031594,0031623,0042166,0042802,0042803,0043236,0045202,0048471,0052689,0060041,0095500,0098552,0120162 -logKd/Ki=4.34, Kd=46uM P21836 16837465 1901 EGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGEAAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSA 2ha5 A 2.15 BS03 AT3 A 2 E81 M85 D131 E452 Y465 E81 M85 D131 E445 Y458 G121 G122 G154 A203 A204 G242 F297 F299 E334 H447 G121 G122 G154 A203 A204 G242 F290 F292 E327 H440 3.1.1.7 0001919,0002076,0003990,0004104,0005515,0005518,0005576,0005604,0005615,0005794,0005886,0006581,0007155,0009986,0016020,0016787,0017171,0031594,0031623,0042166,0042802,0042803,0043236,0045202,0048471,0052689,0060041,0095500,0098552,0120162 -logKd/Ki=4.34, Kd=46uM P21836 16837465 1902 EGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGEAAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSA 2ha5 B 2.15 BS01 AT3 B 1 W86 Y337 F338 W83 Y327 F328 G121 G122 G154 A203 A204 G242 F297 F299 E334 H447 G118 G119 G151 A200 A201 G239 F287 F289 E324 H437 3.1.1.7 0001919,0002076,0003990,0004104,0005515,0005518,0005576,0005604,0005615,0005794,0005886,0006581,0007155,0009986,0016020,0016787,0017171,0031594,0031623,0042166,0042802,0042803,0043236,0045202,0048471,0052689,0060041,0095500,0098552,0120162 P21836 16837465 1951 EDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGEAAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSAT 2ha5 B 2.15 BS03 AT3 B 2 E81 M85 D131 Y465 E78 M82 D128 Y455 G121 G122 G154 A203 A204 G242 F297 F299 E334 H447 G118 G119 G151 A200 A201 G239 F287 F289 E324 H437 3.1.1.7 0001919,0002076,0003990,0004104,0005515,0005518,0005576,0005604,0005615,0005794,0005886,0006581,0007155,0009986,0016020,0016787,0017171,0031594,0031623,0042166,0042802,0042803,0043236,0045202,0048471,0052689,0060041,0095500,0098552,0120162 P21836 16837465 1952 EDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGEAAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSAT 6uqy A 1.57 BS01 AT3 A 1 D37 S38 Y39 Y106 Y107 N147 W287 D16 S17 Y18 Y85 Y86 N126 W266 3.1.-.- 0004104,0005576,0016788 Q9HUP2 32371400 401 TSPLLAPVRQIHAFGDSYSDNGESQRLTREMLAKGIAGAQALPGEVYWQGRWSNGPTAVEVLARQLGAQLADHAVGGAKSGADNYYGWMSAYRHTGLAGQVDAYLATLDGKPVDGQALHFIFVSANDFFEHEDFAGEQPLEQLAGSSVANIRAAVQRLGEAGARRFLVVSSTDLSVVPAVVAGNRVERAQRYLQAVNASLPIQLAALRKTRGLELSWFDHLTFSRHLRRNPARYGLVELDAPCQPTQPSVRPACANPDQYYFWDEWNPTRRVHQLAGEAMAARYAR 6uqy B 1.57 BS01 AT3 B 1 D37 S38 Y39 W73 G98 Y106 Y107 N147 W287 D17 S18 Y19 W53 G78 Y86 Y87 N127 W267 3.1.-.- 0004104,0005576,0016788 Q9HUP2 32371400 401 HTSPLLAPVRQIHAFGDSYSDNGESQRLTREMLAKGIAGAQALPGEVYWQGRWSNGPTAVEVLARQLGAQLADHAVGGAKSGADNYYGWMSAYRHTGLAGQVDAYLATLDGKPVDGQALHFIFVSANDFFEHEDFAGEQPLEQLAGSSVANIRAAVQRLGEAGARRFLVVSSTDLSVVPAVVAGNRVERAQRYLQAVNASLPIQLAALRKTRGLELSWFDHLTFSRHLRRNPARYGLVELDAPCQPTQPSVRPACANPDQYYFWDEWNPTRRVHQLAGEAMAARYAR 6ur1 A 1.42 BS02 AT3 A 1 W73 Y106 Y107 W287 W52 Y85 Y86 W266 ? 0004104,0005576,0016788 Q9HUP2 32371400 402 TSPLLAPVRQIHAFGDAYSDNGESQRLTREMLAKGIAGAQALPGEVYWQGRWSNGPTAVEVLARQLGAQLADHAVGGAKSGADNYYGWMSAYRHTGLAGQVDAYLATLDGKPVDGQALHFIFVSANDFFEHEDFAGEQPLEQLAGSSVANIRAAVQRLGEAGARRFLVVSSTDLSVVPAVVAGNRVERAQRYLQAVNASLPIQLAALRKTRGLELSWFDHLTFSRHLRRNPARYGLVELDAPCQPTQPSVRPACANPDQYYFWDEWHPTRRVHQLAGEAMAARYAR 6ur1 B 1.42 BS02 AT3 B 1 W73 Y106 Y107 F150 W287 W52 Y85 Y86 F129 W266 ? 0004104,0005576,0016788 Q9HUP2 32371400 402 TSPLLAPVRQIHAFGDAYSDNGESQRLTREMLAKGIAGAQALPGEVYWQGRWSNGPTAVEVLARQLGAQLADHAVGGAKSGADNYYGWMSAYRHTGLAGQVDAYLATLDGKPVDGQALHFIFVSANDFFEHEDFAGEQPLEQLAGSSVANIRAAVQRLGEAGARRFLVVSSTDLSVVPAVVAGNRVERAQRYLQAVNASLPIQLAALRKTRGLELSWFDHLTFSRHLRRNPARYGLVELDAPCQPTQPSVRPACANPDQYYFWDEWHPTRRVHQLAGEAMAARYAR 8d8y A 1.54 BS01 AT3 A 1 D37 S38 G98 Y106 Y107 F150 H288 D17 S18 G78 Y86 Y87 F130 H268 ? 0004104,0005576,0016788 Q9HUP2 401 HTSPLLAPVRQIHAFGDSYSDNGESQRLTREMLAKGIAGAQALPGEVYWQGRWSNGPTAVEVLARQLGAQLADHAVGGAKSGADNYYGWMSAYRHTGLAGQVDAYLATLDGKPVDGQALHFIFVSAADFFEHEDFAGEQPLEQLAGSSVANIRAAVQRLGEAGARRFLVVSSTDLSVVPAVVAGNRVERAQRYLQAVNASLPIQLAALRKTRGLELSWFDHLTFSRHLRRNPARYGLVELDAPCQPTQPSVRPACANPDQYYFWDEWHPTRRVHQLAGEAMAARYAR 8d8y B 1.54 BS01 AT3 B 1 D37 S38 G98 Y106 Y107 F150 W287 H288 D17 S18 G78 Y86 Y87 F130 W267 H268 ? 0004104,0005576,0016788 Q9HUP2 401 HTSPLLAPVRQIHAFGDSYSDNGESQRLTREMLAKGIAGAQALPGEVYWQGRWSNGPTAVEVLARQLGAQLADHAVGGAKSGADNYYGWMSAYRHTGLAGQVDAYLATLDGKPVDGQALHFIFVSAADFFEHEDFAGEQPLEQLAGSSVANIRAAVQRLGEAGARRFLVVSSTDLSVVPAVVAGNRVERAQRYLQAVNASLPIQLAALRKTRGLELSWFDHLTFSRHLRRNPARYGLVELDAPCQPTQPSVRPACANPDQYYFWDEWHPTRRVHQLAGEAMAARYAR