1apz B 2.3 BS01 ASP B 1 T183 R211 D214 T234 G235 G237 T1 R29 D32 T52 G53 G55 T183 T201 R211 T234 G235 T1 T19 R29 T52 G53 3.5.1.26 0016787 Ki=600000nM P20933 8846222 551 TIGMVVIHKTGHIAAGTSTNGIKFKIHGRVGDSPIPGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYMRRGEDPTIACQKVISRIQKHFPEFFGAVICANVTGSYGAACNKLSTFTQFSFMVYNSEKNQPTEEKVDCI 1apz D 2.3 BS01 ASP D 1 T183 R211 T234 G235 G237 T1 R29 T52 G53 G55 T183 T201 R211 T234 G235 T1 T19 R29 T52 G53 3.5.1.26 0016787 Ki=600000nM P20933 8846222 552 TIGMVVIHKTGHIAAGTSTNGIKFKIHGRVGDSPIPGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYMRRGEDPTIACQKVISRIQKHFPEFFGAVICANVTGSYGAACNKLSTFTQFSFMVYNSEKNQPTEEKVDCI 1fiy A 2.8 BS01 ASP A 1 R587 M769 K773 I825 R832 R880 N881 R584 M759 K763 I815 R822 R870 N871 H138 R396 E506 D543 R581 R713 H135 R393 E503 D540 R578 R703 4.1.1.31 0000287,0003824,0005829,0006094,0006099,0006107,0008964,0015977,0016829,0042802,0051289 P00864 9927652 884 QYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDVYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG 1gc4 A 3.3 BS01 ASP A 1 W125 N175 Y322 R361 W125 N175 Y322 R361 2.6.1.1,2.6.1.78 0003824,0004069,0005737,0006520,0008483,0009058,0030170,0033853 Q56232 11432784 414 MRGLSRRVQAMKPDAVVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 1gc4 A 3.3 BS03 ASP B 1 Y64 R261 Y64 R261 2.6.1.1,2.6.1.78 0003824,0004069,0005737,0006520,0008483,0009058,0030170,0033853 Q56232 11432784 914 MRGLSRRVQAMKPDAVVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 1gc4 B 3.3 BS01 ASP B 1 V516 W625 N675 Y822 R861 V16 W125 N175 Y322 R361 2.6.1.1,2.6.1.78 0003824,0004069,0005737,0006520,0008483,0009058,0030170,0033853 Q56232 11432784 914 MRGLSRRVQAMKPDAVVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 1gc4 C 3.3 BS01 ASP C 1 W1125 N1175 Y1322 R1361 W125 N175 Y322 R361 2.6.1.1,2.6.1.78 0003824,0004069,0005737,0006520,0008483,0009058,0030170,0033853 Q56232 11432784 1414 MRGLSRRVQAMKPDAVVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 1gc4 C 3.3 BS03 ASP D 1 Y1064 R1261 Y64 R261 2.6.1.1,2.6.1.78 0003824,0004069,0005737,0006520,0008483,0009058,0030170,0033853 Q56232 11432784 1914 MRGLSRRVQAMKPDAVVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 1gc4 D 3.3 BS01 ASP C 1 Y1564 R1761 Y64 R261 W1625 D1703 I1705 K1734 W125 D203 I205 K234 2.6.1.1,2.6.1.78 0003824,0004069,0005737,0006520,0008483,0009058,0030170,0033853 Q56232 11432784 1414 MRGLSRRVQAMKPDAVVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 1gc4 D 3.3 BS02 ASP D 1 N1675 Y1822 R1861 N175 Y322 R361 W1625 D1703 I1705 K1734 W125 D203 I205 K234 2.6.1.1,2.6.1.78 0003824,0004069,0005737,0006520,0008483,0009058,0030170,0033853 Q56232 11432784 1914 MRGLSRRVQAMKPDAVVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 1gck A 2.5 BS01 ASP A 1 W125 N175 R361 W125 N175 R361 2.6.1.1,2.6.1.78 0003824,0004069,0005737,0006520,0008483,0009058,0030170,0033853 Q56232 11432784 414 MRGLSRRVQAMKPSATVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 1gck B 2.5 BS01 ASP A 1 Y564 R761 Y64 R261 W625 D703 I705 K734 W125 D203 I205 K234 2.6.1.1,2.6.1.78 0003824,0004069,0005737,0006520,0008483,0009058,0030170,0033853 Q56232 11432784 414 MRGLSRRVQAMKPSATVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 1gck B 2.5 BS02 ASP B 1 T516 G539 W625 N675 Y822 R861 T16 G39 W125 N175 Y322 R361 W625 D703 I705 K734 W125 D203 I205 K234 2.6.1.1,2.6.1.78 0003824,0004069,0005737,0006520,0008483,0009058,0030170,0033853 Q56232 11432784 914 MRGLSRRVQAMKPSATVAVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPSGAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLSYATSEENLRKALERFARVL 1ho3 A 2.5 BS01 ASP A 1 T12 S58 Q59 G88 T89 D90 T12 S58 Q59 G88 T89 D90 T12 F25 T89 D90 K162 E283 T12 F25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 11223513 399 LPNITILATGGTIAGGGDSATKSNFTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 1ho3 B 2.5 BS01 ASP B 1 T12 S58 G88 T89 D90 T12 S58 G88 T89 D90 T12 F25 T89 D90 K162 E283 T12 F25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 11223513 400 LPNITILATGGTIAGGGDSATKSNFTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 1j1z A 2.1 BS03 ASP A 1 A115 T116 G119 N120 D121 A115 T116 G119 N120 D121 D12 R92 D121 S173 D12 R92 D121 S168 6.3.4.5 0000050,0000053,0004055,0005524,0005737,0006526,0016874 P59846 12684518 530 MKIVLAYSGGLDTSIILKWLKETYRAEVIAFTADIGQGEEVEEAREKALRTGASKAIALDLKEEFVRDFVFPMMRAGAVYEGYYLLGTSIARPLIAKHLVRIAEEEGAEAIAHGATGKGNDQVRFELTAYALKPDIKVIAPWREWSFQGRKEMIAYAEAHGIPVPPYSMDANLLHISYEGGVLEDPWAEPPKGMFRMTQDPEEAPDAPEYVEVEFFEGDPVAVNGERLSPAALLQRLNEIGGRHGVGRVDIVENRFVGMKSRGVYETPGGTILYHARRAVESLTLDREVLHQRDMLSPKYAELVYYGFWYAPEREALQAYFDHVARSVTGVARLKLYKGNVYVVGRKAPKSLYRQDLVSFGYDQKDAEGFIKIQALRLRVRALVER 1j1z B 2.1 BS01 ASP A 2 A115 T116 G119 N120 D121 A115 T116 G119 N120 D121 D12 R92 D121 S173 D12 R92 D121 S168 6.3.4.5 0000050,0000053,0004055,0005524,0005737,0006526,0016874 P59846 12684518 2530 MKIVLAYSGGLDTSIILKWLKETYRAEVIAFTADIGQGEEVEEAREKALRTGASKAIALDLKEEFVRDFVFPMMRAGAVYEGYYLLGTSIARPLIAKHLVRIAEEEGAEAIAHGATGKGNDQVRFELTAYALKPDIKVIAPWREWSFQGRKEMIAYAEAHGIPVPPYSMDANLLHISYEGGVLEDPWAEPPKGMFRMTQDPEEAPDAPEYVEVEFFEGDPVAVNGERLSPAALLQRLNEIGGRHGVGRVDIVENRFVGMKSRGVYETPGGTILYHARRAVESLTLDREVLHQRDMLSPKYAELVYYGFWYAPEREALQAYFDHVARSVTGVARLKLYKGNVYVVGRKAPKSLYRQDLVSFGYDQKDAEGFIKIQALRLRVRALVER 1j1z C 2.1 BS01 ASP A 3 A115 T116 G119 N120 D121 A115 T116 G119 N120 D121 D12 R92 D121 S173 D12 R92 D121 S168 6.3.4.5 0000050,0000053,0004055,0005524,0005737,0006526,0016874 P59846 12684518 3530 MKIVLAYSGGLDTSIILKWLKETYRAEVIAFTADIGQGEEVEEAREKALRTGASKAIALDLKEEFVRDFVFPMMRAGAVYEGYYLLGTSIARPLIAKHLVRIAEEEGAEAIAHGATGKGNDQVRFELTAYALKPDIKVIAPWREWSFQGRKEMIAYAEAHGIPVPPYSMDANLLHISYEGGVLEDPWAEPPKGMFRMTQDPEEAPDAPEYVEVEFFEGDPVAVNGERLSPAALLQRLNEIGGRHGVGRVDIVENRFVGMKSRGVYETPGGTILYHARRAVESLTLDREVLHQRDMLSPKYAELVYYGFWYAPEREALQAYFDHVARSVTGVARLKLYKGNVYVVGRKAPKSLYRQDLVSFGYDQKDAEGFIKIQALRLRVRALVER 1j1z D 2.1 BS01 ASP A 4 A115 T116 G119 N120 D121 A115 T116 G119 N120 D121 D12 R92 D121 S173 D12 R92 D121 S168 6.3.4.5 0000050,0000053,0004055,0005524,0005737,0006526,0016874 P59846 12684518 4530 MKIVLAYSGGLDTSIILKWLKETYRAEVIAFTADIGQGEEVEEAREKALRTGASKAIALDLKEEFVRDFVFPMMRAGAVYEGYYLLGTSIARPLIAKHLVRIAEEEGAEAIAHGATGKGNDQVRFELTAYALKPDIKVIAPWREWSFQGRKEMIAYAEAHGIPVPPYSMDANLLHISYEGGVLEDPWAEPPKGMFRMTQDPEEAPDAPEYVEVEFFEGDPVAVNGERLSPAALLQRLNEIGGRHGVGRVDIVENRFVGMKSRGVYETPGGTILYHARRAVESLTLDREVLHQRDMLSPKYAELVYYGFWYAPEREALQAYFDHVARSVTGVARLKLYKGNVYVVGRKAPKSLYRQDLVSFGYDQKDAEGFIKIQALRLRVRALVER 1jqn A 2.35 BS02 ASP A 1 R587 M769 K773 R832 N881 R584 M760 K764 R823 N872 H138 R396 E506 D543 R581 R713 H135 R393 E503 D540 R578 R704 4.1.1.31 0000287,0003824,0005829,0006094,0006099,0006107,0008964,0015977,0016829,0042802,0051289 P00864 12467579 884 QYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDVYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG 1k97 A 2.0 BS01 ASP A 1 S129 T130 G133 N134 D135 S129 T130 G133 N134 D135 D22 R106 D135 S191 D22 R106 D135 S191 6.3.4.5 0000050,0000053,0004055,0005515,0005524,0005737,0005829,0006526,0016874,0042802,0042803 P0A6E4 11738042 501 TTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELQIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGATHEAKDLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRWVASQITGEVTLELRRGNDYSILNTVSENLTYKPESVFSPDDRIGQLTMRNLDITDTREKLFGYAKTGLLSSSAASGVPQVEN 1kh3 A 2.15 BS03 ASP A 1 A115 T116 G119 N120 D121 A115 T116 G119 N120 D121 D12 R92 D121 S173 D12 R92 D121 S168 6.3.4.5 0000050,0000053,0004055,0005524,0005737,0006526,0016874 P59846 12684518 530 MKIVLAYSGGLDTSIILKWLKETYRAEVIAFTADIGQGEEVEEAREKALRTGASKAIALDLKEEFVRDFVFPMMRAGAVYEGYYLLGTSIARPLIAKHLVRIAEEEGAEAIAHGATGKGNDQVRFELTAYALKPDIKVIAPWREWSFQGRKEMIAYAEAHGIPVPPYSMDANLLHISYEGGVLEDPWAEPPKGMFRMTQDPEEAPDAPEYVEVEFFEGDPVAVNGERLSPAALLQRLNEIGGRHGVGRVDIVENRFVGMKSRGVYETPGGTILYHARRAVESLTLDREVLHQRDMLSPKYAELVYYGFWYAPEREALQAYFDHVARSVTGVARLKLYKGNVYVVGRKAPKSLYRGYDQKDAEGFIKIQALRLRVRALVER 1kh3 B 2.15 BS02 ASP A 2 A115 T116 G119 N120 D121 A115 T116 G119 N120 D121 D12 R92 D121 S173 D12 R92 D121 S168 6.3.4.5 0000050,0000053,0004055,0005524,0005737,0006526,0016874 P59846 12684518 4530 MKIVLAYSGGLDTSIILKWLKETYRAEVIAFTADIGQGEEVEEAREKALRTGASKAIALDLKEEFVRDFVFPMMRAGAVYEGYYLLGTSIARPLIAKHLVRIAEEEGAEAIAHGATGKGNDQVRFELTAYALKPDIKVIAPWREWSFQGRKEMIAYAEAHGIPVPPYSMDANLLHISYEGGVLEDPWAEPPKGMFRMTQDPEEAPDAPEYVEVEFFEGDPVAVNGERLSPAALLQRLNEIGGRHGVGRVDIVENRFVGMKSRGVYETPGGTILYHARRAVESLTLDREVLHQRDMLSPKYAELVYYGFWYAPEREALQAYFDHVARSVTGVARLKLYKGNVYVVGRKAPKSLYRQDLVSFGYDQKDAEGFIKIQALRLRVRALVER 1kh3 C 2.15 BS02 ASP A 3 A115 T116 G119 N120 D121 A115 T116 G119 N120 D121 D12 R92 D121 S173 D12 R92 D121 S168 6.3.4.5 0000050,0000053,0004055,0005524,0005737,0006526,0016874 P59846 12684518 2530 MKIVLAYSGGLDTSIILKWLKETYRAEVIAFTADIGQGEEVEEAREKALRTGASKAIALDLKEEFVRDFVFPMMRAGAVYEGYYLLGTSIARPLIAKHLVRIAEEEGAEAIAHGATGKGNDQVRFELTAYALKPDIKVIAPWREWSFQGRKEMIAYAEAHGIPVPPYSMDANLLHISYEGGVLEDPWAEPPKGMFRMTQDPEEAPDAPEYVEVEFFEGDPVAVNGERLSPAALLQRLNEIGGRHGVGRVDIVENRFVGMKSRGVYETPGGTILYHARRAVESLTLDREVLHQRDMLSPKYAELVYYGFWYAPEREALQAYFDHVARSVTGVARLKLYKGNVYVVGRKAPKSLYRQDLVSFGYDQKDAEGFIKIQALRLRVRALVER 1kh3 D 2.15 BS02 ASP A 4 A115 T116 G119 N120 D121 A115 T116 G119 N120 D121 D12 R92 D121 S173 D12 R92 D121 S168 6.3.4.5 0000050,0000053,0004055,0005524,0005737,0006526,0016874 P59846 12684518 3530 MKIVLAYSGGLDTSIILKWLKETYRAEVIAFTADIGQGEEVEEAREKALRTGASKAIALDLKEEFVRDFVFPMMRAGAVYEGYYLLGTSIARPLIAKHLVRIAEEEGAEAIAHGATGKGNDQVRFELTAYALKPDIKVIAPWREWSFQGRKEMIAYAEAHGIPVPPYSMDANLLHISYEGGVLEDPWAEPPKGMFRMTQDPEEAPDAPEYVEVEFFEGDPVAVNGERLSPAALLQRLNEIGGRHGVGRVDIVENRFVGMKSRGVYETPGGTILYHARRAVESLTLDREVLHQRDMLSPKYAELVYYGFWYAPEREALQAYFDHVARSVTGVARLKLYKGNVYVVGRKAPKSLYRQDLVSFGYDQKDAEGFIKIQALRLRVRALVER 1kkk A 1.6 BS06 ASP A 1 N112 H142 E143 E166 H231 N112 H142 E143 E166 H231 H142 E143 H146 Y157 E166 D226 H231 H142 E143 H146 Y157 E166 D226 H231 3.4.24.27 0004222,0006508 P00800 1317 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 1nns A 1.95 BS01 ASP A 1 T12 V27 G57 S58 Q59 G88 T89 D90 T12 V27 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 12595697 427 LPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 1nns B 1.95 BS01 ASP B 1 T12 V27 G57 S58 Q59 G88 T89 D90 T12 V27 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 12595697 428 LPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 1onx A 2.1 BS03 ASP A 1 G74 G75 E77 T106 Y137 K162 D285 S289 G74 G75 E77 T106 Y137 K162 D285 S289 H68 H70 K162 H201 H230 D285 H68 H70 K162 H201 H230 D285 3.4.19.- 0005737,0005829,0006508,0008237,0008270,0008798,0016787,0016810,0042802,0046872 P39377 12718528 450 MIDYTAAGFTLLQGAHLYAPEDRGICDVLVANGKIIAVASNIPSDIVPNCTVVDLSGQILCPGFIDQHVHLIGGGGEAGPTTRTPEVALSRLTEAGVTSVVGLLGTDSISRHPESLLAKTRALNEEGISAWMLTGAYHVPSRTITGSVEKDVAIIDRVIGVKCAISDHRSAAPDVYHLANMAAESRVGGLLGGKPGVTVFHMGDSKKALQPIYDLLENCDVPISKLLPTHVNRNVPLFEQALEFARKGGTIDITSSIDEPVAPAEGIARAVQAGIPLARVTLSSDGNGSQPFFDDEGNLTHIGVAGFETLLETVQVLVKDYDFSISDALRPLTSSVAGFLNLTGKGEILPGNDADLLVMTPELRIEQVYARGKLMVKDGKACVKGTFET 1onx B 2.1 BS03 ASP B 1 G74 G75 Y137 K162 H201 D285 S289 G74 G75 Y137 K162 H201 D285 S289 H68 H70 K162 H201 H230 D285 H68 H70 K162 H201 H230 D285 3.4.19.- 0005737,0005829,0006508,0008237,0008270,0008798,0016787,0016810,0042802,0046872 P39377 12718528 550 MIDYTAAGFTLLQGAHLYAPEDRGICDVLVANGKIIAVASNIPSDIVPNCTVVDLSGQILCPGFIDQHVHLIGGGGEAGPTTRTPEVALSRLTEAGVTSVVGLLGTDSISRHPESLLAKTRALNEEGISAWMLTGAYHVPSRTITGSVEKDVAIIDRVIGVKCAISDHRSAAPDVYHLANMAAESRVGGLLGGKPGVTVFHMGDSKKALQPIYDLLENCDVPISKLLPTHVNRNVPLFEQALEFARKGGTIDITSSIDEPVAPAEGIARAVQAGIPLARVTLSSDGNGSQPFFDDEGNLTHIGVAGFETLLETVQVLVKDYDFSISDALRPLTSSVAGFLNLTGKGEILPGNDADLLVMTPELRIEQVYARGKLMVKDGKACVKGTFET 1qb4 A 2.6 BS02 ASP A 1 R587 M769 K773 R832 N881 R584 M759 K763 R822 N871 H138 R396 E506 D543 R581 R713 H135 R393 E503 D540 R578 R703 4.1.1.31 0000287,0003824,0005829,0006094,0006099,0006107,0008964,0015977,0016829,0042802,0051289 P00864 10481043 884 QYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDVYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG 1vlt A 2.2 BS01 ASP A 1 R64 Y149 F150 T154 R26 Y111 F112 T116 ? 0006935,0007165 P02941 8831788 389 GFVISNELRQQQSELTSTWDLMLQTRINLSRSAARMMMDASNQQSSAKTDLLQNAKTTLAQAAAHYANFKNMTPLPAMAEASANVDEKYQRYQAALAELIQFLDNGNMDAYFAQPTQGMQNALGEALGNYARVSENLYRQTF 1vlt A 2.2 BS02 ASP B 1 R69 R73 R31 R35 ? 0006935,0007165 P02941 8831788 189 GFVISNELRQQQSELTSTWDLMLQTRINLSRSAARMMMDASNQQSSAKTDLLQNAKTTLAQAAAHYANFKNMTPLPAMAEASANVDEKYQRYQAALAELIQFLDNGNMDAYFAQPTQGMQNALGEALGNYARVSENLYRQTF 1vlt B 2.2 BS01 ASP A 1 R69 R73 R32 R36 ? 0006935,0007165 P02941 8831788 389 QGFVISNELRQQQSELTSTWDLMLQTRINLSRSAARMMMDASNQQSSAKTDLLQNAKTTLAQAAAHYANFKNMTPLPAMAEASANVDEKYQRYQAALAELIQFLDNGNMDAYFAQPTQGMQNALGEALGNYARVSENLYRQTF 1vlt B 2.2 BS02 ASP B 1 R64 Y149 F150 T154 R27 Y112 F113 T117 ? 0006935,0007165 P02941 8831788 189 QGFVISNELRQQQSELTSTWDLMLQTRINLSRSAARMMMDASNQQSSAKTDLLQNAKTTLAQAAAHYANFKNMTPLPAMAEASANVDEKYQRYQAALAELIQFLDNGNMDAYFAQPTQGMQNALGEALGNYARVSENLYRQTF 1wat A 3.0 BS01 ASP B 1 R69 R73 R31 R35 ? 0006935,0007165 P02941 8486661 1 GFVISNELRQQQSELTSTWDLMLQTRINLSRSAARMMMDASNQQSSAKTDLLQNAKTTLAQAAAHYANFKNMTPLPAMAEASANVDEKYQRYQAALAELIQFLDNGNMDAYFAQPTQGMQNALGEALGNYARVSENLYRQTF 1wat B 3.0 BS01 ASP B 1 Y149 F150 Q152 T154 Y112 F113 Q115 T117 ? 0006935,0007165 P02941 8486661 1 QGFVISNELRQQQSELTSTWDLMLQTRINLSRSAARMMMDASNQQSSAKTDLLQNAKTTLAQAAAHYANFKNMTPLPAMAEASANVDEKYQRYQAALAELIQFLDNGNMDAYFAQPTQGMQNALGEALGNYARVSENLYRQTF 1y79 1 2.0 BS05 ASP 1 1 R593 Y594 Y611 Y614 R593 Y594 Y611 Y614 H469 E470 H473 H469 E470 H473 3.4.15.5 0004180,0004222,0005737,0005829,0006508,0008233,0008237,0030288,0046872 P24171 15876371 704 TTMNPFLVQSTLPYLAPHFDQIANHHYRPAFDEGMQQKRAEIAAIALNPQMPDFNNTILALEQSGELLTRVTSVFFAMTAAHTNDELQRLDEQFSAELAELANDIYLNGELFARVDAVWQRRESLGLDSESIRLVEVIHQRFVLAGAKLAQADKAKLKVLNTEAATLTSQFNQRLLAANKSGGLVVNDIAQLAGMSEQEIALAAEAAREKGLDNKWLIPLLNTTQQPALAEMRDRATREKLFIAGWTRAEKNDANDTRAIIQRLVEIRAQQATLLGFPHYAAWKIADQMAKTPEAALNFMREIVPAARQRASDELASIQAVIDKQQGGFSAQPWDWAFYAEQVRREKFDLDEAQLKPYFELNTVLNEGVFWTANQLFGIKFVERFDIPVYHPDVRVWEIFDHNGVGLALFYGDFFARDSKSGGAWMGNFVEQSTLNKTHPVIYNVCNYQKPAAGEPALLLWDDVITLFHEFGHTLHGLFARQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYQSGAAMPDELQQKMRNASLFNKGYEMSELLSAALLDMRWHCLEENEAMQDVDDFELRALVAENMDLPAIPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGLRFREAILSRGNSEDLERLYRQWRGKAPKIMPMLQHRGLNI 1zq1 A 3.0 BS01 ASP A 1 F145 S146 E147 T178 D179 F144 S145 E146 T177 D178 T102 A113 T178 D179 K256 G379 T101 A112 T177 D178 K255 G378 6.3.5.- 0004067,0005515,0005524,0006412,0006450,0006520,0016874,0050567 Q9V0T9 16216574 1000 RVDEFLKERNINVGDFVRITKEEDGEEVTYEGYIMPPYELSAGDTLVLKLENGYNIGIALEKIRRIEVLERAKVKPEVHFEALIEGKPGLPEVTIIGTGGTIASRIDYETGAVYPAFTAEELAKALPEIFEVANVKPKLLFNIFSEDMKPKHWVKIAHEVAKALNSGDYGVVVAHGTDTMGYTAAALSFMLRNLGKPVVLVGAQRSSDRPSSDAAMNLICSVRMATSEVAEVMVVMHGETGDTYCLAHRGTKVRKMHTSRRDAFRSINDVPIAKIWPNGEIEFLRKDYRKRSDEEVEVDDKIEEKVALVKVYPGISSEIIDFLVDKGYKGIVIEGTGLGHTPNDIIPSIERAVEEGVAVCMTSQCIYGRVNLNVYSTGRKLLKAGVIPCEDMLPETAYVKLMWVLGHTQNLEEVRKMMLTNYAGEITPYTRFDTYLR 1zq1 B 3.0 BS01 ASP B 1 S146 E147 T178 D179 S145 E146 T177 D178 T102 A113 T178 D179 K256 G379 T101 A112 T177 D178 K255 G378 6.3.5.- 0004067,0005515,0005524,0006412,0006450,0006520,0016874,0050567 Q9V0T9 16216574 5000 RVDEFLKERNINVGDFVRITKEEDGEEVTYEGYIMPPYELSAGDTLVLKLENGYNIGIALEKIRRIEVLERAKVKPEVHFEALIEGKPGLPEVTIIGTGGTIASRIDYETGAVYPAFTAEELAKALPEIFEVANVKPKLLFNIFSEDMKPKHWVKIAHEVAKALNSGDYGVVVAHGTDTMGYTAAALSFMLRNLGKPVVLVGAQRSSDRPSSDAAMNLICSVRMATSEVAEVMVVMHGETGDTYCLAHRGTKVRKMHTSRRDAFRSINDVPIAKIWPNGEIEFLRKDYRKRSDEEVEVDDKIEEKVALVKVYPGISSEIIDFLVDKGYKGIVIEGTGLGHTPNDIIPSIERAVEEGVAVCMTSQCIYGRVNLNVYSTGRKLLKAGVIPCEDMLPETAYVKLMWVLGHTQNLEEVRKMMLTNYAGEITPYTRFDTYLR 2bb4 A 1.6 BS02 ASP P 1 H57 Q192 G193 S195 H45 Q185 G186 S188 3.4.21.36 0004252,0005515,0005576,0005615,0006508,0008236,0046872 P00772 16754679 1001 VVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTLIRQNWVMTAAHCVDRELTFRVVVGEHNLNQNNGTEQYVGVQKIVVHPYWNTDDVAAGYDIALLRLAQSVTLNSYVQLGVLPRAGTILANNSPCYITGWGLTRTNGQLAQTLQQAYLPTVDYAICSSSSYWGSTVKNSMVCAGGDGVRSGCQGDSGGPLHCLVNGQYAVHGVTSFVSRLGCNVTRKPTVFTRVSAYISWINNVIASN 2cnu A 1.05 BS01 ASP A 1 S40 A41 Y42 D43 K260 R264 S39 A40 Y41 D42 K256 R260 6.3.2.6 0004639,0005515,0005524,0005634,0005737,0006164,0006189,0016874 P27616 1308 SITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTGSKWSH 2cnu A 1.05 BS02 ASP A 2 G184 E185 D186 L187 G180 E181 D182 L183 6.3.2.6 0004639,0005515,0005524,0005634,0005737,0006164,0006189,0016874 P27616 1309 SITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTGSKWSH 2cnu A 1.05 BS03 ASP A 3 R73 H110 R72 H109 6.3.2.6 0004639,0005515,0005524,0005634,0005737,0006164,0006189,0016874 P27616 1310 SITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTGSKWSH 2cnv A 2.0 BS01 ASP A 1 R73 H110 R72 H109 6.3.2.6 0004639,0005515,0005524,0005634,0005737,0006164,0006189,0016874 P27616 1309 SITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTGSKWSH 2cnv A 2.0 BS02 ASP A 2 G184 E185 D186 L187 G177 E178 D179 L180 6.3.2.6 0004639,0005515,0005524,0005634,0005737,0006164,0006189,0016874 P27616 1310 SITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTGSKWSH 2f5x A 1.72 BS01 ASP A 1 F13 P18 T19 H69 A133 A137 A138 S139 G161 T162 F12 P17 T18 H68 A132 A136 A137 S138 G160 T161 ? Q7VTS1 16403514 901 YPERPVNMVVPFAAGGPTDNVARSLAESMRPTLGETVVVENKGGAGGTIGTTQVARAQPDGYSILLMHAGFSTAPSLYKNPGYEPYTSFEPIGLVVDVPMTIIARGDFPPNNIKELAEYVKKNADKISLANAGIGAASHLCGTMLVEALGVNLLTIPYKGTAPAMNDLLGKQVDLMCDQTTNTTQQITSGKVKAYAVTSLKRVPTLPDLPTMDESGYKGFEVGIWHGMWAPKGTPKPVVDKLVKSLQAGLADPKFQERMKQLGAEVLTNEANPEALQAKVKQQVPQWAELFKKAGVEKQ 2f5x B 1.72 BS01 ASP B 1 F13 P18 T19 H69 A133 A137 A138 S139 G161 T162 F13 P18 T19 H69 A133 A137 A138 S139 G161 T162 ? Q7VTS1 16403514 902 EYPERPVNMVVPFAAGGPTDNVARSLAESMRPTLGETVVVENKGGAGGTIGTTQVARAQPDGYSILLMHAGFSTAPSLYKNPGYEPYTSFEPIGLVVDVPMTIIARGDFPPNNIKELAEYVKKNADKISLANAGIGAASHLCGTMLVEALGVNLLTIPYKGTAPAMNDLLGKQVDLMCDQTTNTTQQITSGKVKAYAVTSLKRVPTLPDLPTMDESGYKGFEVGIWHGMWAPKGTPKPVVDKLVKSLQAGLADPKFQERMKQLGAEVLTNEANPEALQAKVKQQVPQWAELFKKAGVEKQ 2f5x C 1.72 BS01 ASP C 1 F13 P18 T19 H69 A133 A137 A138 S139 G161 T162 F12 P17 T18 H68 A132 A136 A137 S138 G160 T161 ? Q7VTS1 16403514 903 YPERPVNMVVPFAAGGPTDNVARSLAESMRPTLGETVVVENKGGAGGTIGTTQVARAQPDGYSILLMHAGFSTAPSLYKNPGYEPYTSFEPIGLVVDVPMTIIARGDFPPNNIKELAEYVKKNADKISLANAGIGAASHLCGTMLVEALGVNLLTIPYKGTAPAMNDLLGKQVDLMCDQTTNTTQQITSGKVKAYAVTSLKRVPTLPDLPTMDESGYKGFEVGIWHGMWAPKGTPKPVVDKLVKSLQAGLADPKFQERMKQLGAEVLTNEANPEALQAKVKQQVPQWAELFKKAGVEKQ 2gvn A 1.9 BS01 ASP A 1 T15 G61 S62 E63 G94 T95 D96 T13 G59 S60 E61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 I1SBD9 18323619 3350 NLPNIVILATGGTIAGSAAANTQTTGYKAGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2gvn B 1.9 BS01 ASP B 1 T15 G61 S62 E63 G94 T95 D96 T13 G59 S60 E61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 I1SBD9 18323619 3351 NLPNIVILATGGTIAGSAAANTQTTGYKAGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2gvn C 1.9 BS01 ASP C 1 T15 G61 S62 E63 G94 T95 D96 T13 G59 S60 E61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 I1SBD9 18323619 3354 NLPNIVILATGGTIAGSAAANTQTTGYKAGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2gvn D 1.9 BS01 ASP D 1 T15 G61 S62 E63 G94 T95 D96 T13 G59 S60 E61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 I1SBD9 18323619 3355 NLPNIVILATGGTIAGSAAANTQTTGYKAGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2gvn E 1.9 BS01 ASP E 1 T15 G61 S62 E63 G94 T95 D96 T13 G59 S60 E61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 I1SBD9 18323619 3352 NLPNIVILATGGTIAGSAAANTQTTGYKAGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2gvn F 1.9 BS01 ASP F 1 T15 G61 S62 E63 G94 T95 D96 T13 G59 S60 E61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 I1SBD9 18323619 3353 NLPNIVILATGGTIAGSAAANTQTTGYKAGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2gvn G 1.9 BS01 ASP G 1 T15 G61 S62 E63 G94 T95 D96 T13 G59 S60 E61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 I1SBD9 18323619 3356 NLPNIVILATGGTIAGSAAANTQTTGYKAGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2gvn H 1.9 BS01 ASP H 1 T15 G61 S62 E63 G94 T95 D96 T13 G59 S60 E61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 I1SBD9 18323619 3357 NLPNIVILATGGTIAGSAAANTQTTGYKAGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2him A 1.82 BS01 ASP A 1 T14 D59 S60 G90 T91 D92 T12 D52 S53 G83 T84 D85 T14 T91 D92 K163 G286 T12 T84 D85 K156 G274 3.5.1.1 0004067,0005737,0005829,0006520,0016787,0033345,0042802,0051289 P0A962 17451745 7001 KKSIYVAYTGGTIGMQRIPVSGHLQRQLALMPEFHRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDDYDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPLAELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRTAKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGEGELIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRSYGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNMGNALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMSQNLRGELTP 2him B 1.82 BS01 ASP B 1 T14 D59 S60 G90 T91 D92 T20 D57 S58 G88 T89 D90 T14 T91 D92 K163 T20 T89 D90 K161 3.5.1.1 0004067,0005737,0005829,0006520,0016787,0033345,0042802,0051289 P0A962 17451745 7002 VPRGSHMQKKSIYVAYTGGTIGMQRSGHLQRQLALMPEFHRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDDYDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPLAELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRTAKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGEGELIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRSYGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNMNALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMSQNLRGELTPD 2him C 1.82 BS01 ASP C 1 T14 D59 S60 G90 T91 D92 T12 D51 S52 G82 T83 D84 T14 T91 D92 K163 G286 T12 T83 D84 K155 G273 3.5.1.1 0004067,0005737,0005829,0006520,0016787,0033345,0042802,0051289 P0A962 17451745 7003 KKSIYVAYTGGTIGMQIPVSGHLQRQLALMPEFHRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDDYDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPLAELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRTAKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGEGELIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRSYGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNMGNALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMSQNLRGELTPD 2him D 1.82 BS01 ASP D 1 T14 D59 S60 G90 T91 D92 T20 D60 S61 G91 T92 D93 T14 T91 D92 K163 T20 T92 D93 K164 3.5.1.1 0004067,0005737,0005829,0006520,0016787,0033345,0042802,0051289 P0A962 17451745 7004 VPRGSHMQKKSIYVAYTGGTIGMQRIPVSGHLQRQLALMPEFHRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDDYDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPLAELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRTAKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGEGELIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRSYGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNMALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMSQNLRGELTPD 2hmf A 2.7 BS02 ASP A 1 S40 T46 F193 R207 G208 S210 S39 T45 F192 R206 G207 S209 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 17012784 502 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK 2hmf B 2.7 BS02 ASP B 1 S40 T46 E130 F193 R207 G208 S210 S39 T45 E129 F192 R206 G207 S209 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 17012784 501 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK 2hmf C 2.7 BS02 ASP C 1 S40 T46 F193 R207 G208 S210 S39 T45 F192 R206 G207 S209 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 17012784 503 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK 2hmf D 2.7 BS02 ASP D 1 T46 F193 R207 G208 G209 S210 T45 F192 R206 G207 G208 S209 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 17012784 504 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK 2hse A 2.6 BS02 ASP A 1 R105 R167 R229 Q231 L267 P268 R105 R167 R229 Q231 L267 P268 R54 T55 K84 R105 H134 Q137 T228 P266 G292 R54 T55 K84 R105 H134 Q137 T228 P266 G292 2.1.3.2 0004070,0004088,0005515,0005737,0005829,0006207,0006221,0006520,0006541,0009347,0016597,0016740,0016743,0042802,0044205,0070207 P0A786 812 ANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLAPSEYANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRDLVL 2hse A 2.6 BS03 ASP A 2 R54 T55 S58 H134 Q137 A289 R296 R54 T55 S58 H134 Q137 A289 R296 R54 T55 K84 R105 H134 Q137 T228 P266 G292 R54 T55 K84 R105 H134 Q137 T228 P266 G292 2.1.3.2 0004070,0004088,0005515,0005737,0005829,0006207,0006221,0006520,0006541,0009347,0016597,0016740,0016743,0042802,0044205,0070207 P0A786 813 ANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLAPSEYANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRDLVL 2hse C 2.6 BS02 ASP C 1 R167 R229 Q231 L267 P268 R167 R229 Q231 L267 P268 R54 T55 K84 R105 H134 Q137 T228 P266 G292 R54 T55 K84 R105 H134 Q137 T228 P266 G292 2.1.3.2 0004070,0004088,0005515,0005737,0005829,0006207,0006221,0006520,0006541,0009347,0016597,0016740,0016743,0042802,0044205,0070207 P0A786 912 ANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLAPSEYANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRDLVL 2j0w A 2.5 BS01 ASP A 1 S39 T45 E119 F184 R198 G199 S201 S37 T43 E117 F182 R196 G197 S199 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009089,0009090,0016301,0016310,0042803 P08660 16905770 502 EIVVSKFGGTSVADFDAMNRSADIVLSDANVRLVVLSASAGITNLLVALAEGLEPGERFEKLDAIRNIQFAILERLRYPNVIREEIERLLENITVLAEAAALATSPALTDELVSHGELMSTLLFVEILRERDVQAQWFDVRKVMRTNDRFGRAEPDIAALAELAALQLLPRLNEGLVITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGIYTTDPRVVSAAKRIDEIAFAEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPRAGGTLVCNKTENPPLFRALALRRNQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTLDTTGSTSTGDTLLTQSLLMELSALCRVEVEEGLALVALIGNDLSKACGVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGEDAEQVVQKLHSNLFE 2j0x A 2.8 BS01 ASP A 1 F184 G199 G200 S201 D202 F182 G197 G198 S199 D200 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009089,0009090,0016301,0016310,0042803 P08660 16905770 502 EIVVSKFGGTSVADFDAMNRSADIVLSDANVRLVVLSASAGITNLLVALAEGLEPGERFEKLDAIRNIQFAILERLRYPNVIREEIERLLENITVLAEAAALATSPALTDELVSHGELMSTLLFVEILRERDVQAQWFDVRKVMRTNDRFGRAEPDIAALAELAALQLLPRLNEGLVITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGIYTTDPRVVSAAKRIDEIAFAEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPRAGGTLVCNKTENPPLFRALALRRNQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTLDTTGSTSTGDTLLTQSLLMELSALCRVEVEEGLALVALIGNDLSKACGVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGEDAEQVVQKLHSNLFE 2jk0 A 2.5 BS01 ASP A 1 T15 G61 S62 E63 G94 T95 D96 T13 G59 S60 E61 G92 T93 D94 T15 T95 D96 K168 T13 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 Q6Q4F4 18647344 1328 NLPNIVILATGGTIAGSAAANTQTTGYKAGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2jk0 B 2.5 BS01 ASP B 1 T15 G61 S62 E63 G94 T95 D96 T13 G48 S49 E50 G81 T82 D83 T15 T95 D96 K168 T13 T82 D83 K155 3.5.1.1 0004067,0006520,0006528,0016787 Q6Q4F4 18647344 1328 NLPNIVILATGGTIAGSAAALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2jk0 C 2.5 BS01 ASP C 1 T15 G61 S62 E63 G94 T95 D96 T13 G49 S50 E51 G82 T83 D84 T15 T95 D96 K168 T13 T83 D84 K156 3.5.1.1 0004067,0006520,0006528,0016787 Q6Q4F4 18647344 1328 NLPNIVILATGGTIAGSAAAALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2jk0 D 2.5 BS01 ASP D 1 T15 G61 S62 E63 G94 T95 D96 T13 G54 S55 E56 G87 T88 D89 T15 T95 D96 K168 T13 T88 D89 K161 3.5.1.1 0004067,0006520,0006528,0016787 Q6Q4F4 18647344 1328 NLPNIVILATGGTIAGSAAANTQAGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2jk0 E 2.5 BS01 ASP E 1 G14 T15 G61 S62 E63 G94 T95 D96 G12 T13 G46 S47 E48 G79 T80 D81 T15 T95 D96 K168 T13 T80 D81 K153 3.5.1.1 0004067,0006520,0006528,0016787 Q6Q4F4 18647344 1328 NLPNIVILATGGTIAGSAAGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2jk0 F 2.5 BS01 ASP F 1 T15 G61 S62 E63 G94 T95 D96 T13 G51 S52 E53 G84 T85 D86 T15 T95 D96 K168 T13 T85 D86 K158 3.5.1.1 0004067,0006520,0006528,0016787 Q6Q4F4 18647344 1328 NLPNIVILATGGTIAGSAAANTALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2jk0 G 2.5 BS01 ASP G 1 T15 G61 S62 E63 G94 T95 D96 T13 G43 S44 E45 G76 T77 D78 T15 T95 D96 K168 T13 T77 D78 K150 3.5.1.1 0004067,0006520,0006528,0016787 Q6Q4F4 18647344 1328 NLPNIVILATGGTIALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2jk0 H 2.5 BS01 ASP H 1 T15 S62 E63 G94 T95 D96 T13 S48 E49 G80 T81 D82 T15 T95 D96 K168 T13 T81 D82 K154 3.5.1.1 0004067,0006520,0006528,0016787 Q6Q4F4 18647344 1328 NLPNIVILATGGTIAGSGALGVETLIQAVPELKTLANIKGEQVASIGSENMTSDVLLTLSKRVNELLARSDVDGVVITHGTDTLDESPYFLNLTVKSDKPVVFVAAMRPATAISADGPMNLYGAVKVAADKNSRGRGVLVVLNDRIGSARFISKTNASTLDTFKAPEEGYLGVIIGDKIYYQTRLDKVHTTRSVFDVTNVDKLPAVDIIYGYQDDPEYMYDASIKHGVKGIVYAGMGAGSVSKRGDAGIRKAESKGIVVVRSSRTGSGIVPPDAGQPGLVADSLSPAKSRILLMLALTKTTNPAVIQDYFHAY 2lig A 2.0 BS01 ASP A 1 R64 Y149 F150 T154 R40 Y125 F126 T130 ? 0006935,0007165 P02941 1660187 189 MGGLLFSSLQHCQQGFVISNELRQQQSELTSTWDLMLQTRINLSRSAARMMMDASNQQSSAKTDLLQNAKTTLAQAAAHYANFKNMTPLPAMAEASANVDEKYQRYQAALAELIQFLDNGNMDAYFAQPTQGMQNALGEALGNYARVSENLYRQTFD 2lig B 2.0 BS01 ASP A 1 R69 R73 R45 R49 ? 0006935,0007165 P02941 1660187 189 MGGLLFSSLQHCQQGFVISNELRQQQSELTSTWDLMLQTRINLSRSAARMMMDASNQQSSAKTDLLQNAKTTLAQAAAHYANFKNMTPLPAMAEASANVDEKYQRYQAALAELIQFLDNGNMDAYFAQPTQGMQNALGEALGNYARVSENLYRQTFD 2nwl A 2.96 BS01 ASP C 1 R276 S278 T314 T352 A353 G354 V355 G359 D394 R397 T398 N401 R262 S264 T300 T338 A339 G340 V341 G345 D380 R383 T384 N387 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 -logKd/Ki=8.70, Kd=2nM Kd=1.000000nM O59010 17230192 501 YPVLIKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 2nwl B 2.96 BS01 ASP C 2 R276 S278 T314 G354 V355 G359 D394 R397 T398 N401 R258 S260 T296 G336 V337 G341 D376 R379 T380 N383 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 Kd=1.000000nM O59010 17230192 601 YPVLIKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 2nwl C 2.96 BS01 ASP C 3 R276 S278 T314 T352 A353 G354 V355 G359 D394 R397 T398 N401 R263 S265 T301 T339 A340 G341 V342 G346 D381 R384 T385 N388 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 Kd=1.000000nM O59010 17230192 701 YPVLIKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 2nwx A 3.29 BS03 ASP A 1 R276 S278 T314 G354 V355 P356 G359 D394 R397 T398 R260 S262 T298 G338 V339 P340 G343 D378 R381 T382 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 Kd=1.000000nM O59010 17230192 425 VLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 2nwx B 3.29 BS01 ASP A 2 R276 S278 G354 V355 P356 G357 G359 D394 R397 T398 N401 R256 S258 G334 V335 P336 G337 G339 D374 R377 T378 N381 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 Kd=1.000000nM O59010 17230192 426 VLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 2nwx C 3.29 BS01 ASP A 3 R276 S278 T314 G354 V355 G359 D394 R397 T398 N401 R261 S263 T299 G339 V340 G344 D379 R382 T383 N386 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 Kd=1.000000nM O59010 17230192 427 VLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 2nz2 A 2.4 BS01 ASP A 1 A118 T119 G122 N123 D124 A115 T116 G119 N120 D121 D16 R95 D124 S180 D13 R92 D121 S176 6.3.4.5 0000050,0000052,0000053,0001822,0001889,0003723,0004055,0005515,0005524,0005654,0005737,0005739,0005741,0005829,0006526,0006531,0006953,0007494,0007584,0007623,0009410,0009636,0010043,0010046,0014075,0015643,0016597,0016874,0032355,0032496,0042802,0043025,0043200,0043204,0043434,0045429,0048545,0051384,0060416,0060539,0070062,0070542,0070852,0071222,0071230,0071242,0071320,0071346,0071356,0071377,0071400,0071418,0071499,0071549,1903038 P00966 18323623 501 KGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKRNDLMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYILGRESPLSLYNEELVSNVQGDYEPTDATGFININSLRLKEYHRLQS 2p2n A 1.9 BS01 ASP A 1 T14 D59 S60 G90 T91 D92 T12 D35 S36 G66 T67 D68 T14 T91 D92 K163 T12 T67 D68 K139 3.5.1.1 0004067,0005737,0005829,0006520,0016787,0033345,0042802,0051289 P0A962 17451745 7001 KKSIYVAYTGGTIGMEFHRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDDYDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPLAELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRTTKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGEGELIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRSYGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMSQNLRGELTP 2p2n B 1.9 BS01 ASP B 1 D59 S60 G90 T91 D92 D50 S51 G81 T82 D83 T91 D92 K163 T82 D83 K154 3.5.1.1 0004067,0005737,0005829,0006520,0016787,0033345,0042802,0051289 P0A962 17451745 7003 PRGSHMQKKSIYVAYTGGSGHLQRQLALMPEFHRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDDYDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPLAELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRTTKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGEGELIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRSYGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNMALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMSQNLRGELTPD 2p2n C 1.9 BS01 ASP C 1 D59 S60 G90 T91 D92 D37 S38 G68 T69 D70 T91 D92 K163 T69 D70 K141 3.5.1.1 0004067,0005737,0005829,0006520,0016787,0033345,0042802,0051289 P0A962 17451745 7005 KKSIYVAYTGGQLALMPEFHRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDDYDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPLAELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRTTKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGEGELIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRSYGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNMALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMSQNLRGELTP 2p2n D 1.9 BS01 ASP D 1 D59 S60 G90 T91 D92 D49 S50 G80 T81 D82 T91 D92 K163 T81 D82 K153 3.5.1.1 0004067,0005737,0005829,0006520,0016787,0033345,0042802,0051289 P0A962 17451745 7007 VPRGSHMQKKSIYVAYTGGHLQRQLALMPEFHRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDDYDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPLAELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRTTKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGEGELIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRSYGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMSQNLRGELTPD 2pcu A 1.6 BS03 ASP B 1 H69 R127 N144 R145 H196 Y248 T268 E270 H66 R124 N141 R142 H193 Y245 T265 E267 H69 E72 R127 H196 E270 H66 E69 R124 H193 E267 3.4.17.- 0004181,0006508,0008270 Q9UI42 17506531 6 NNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRKTRSRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGSSIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNL 2v25 A 1.49 BS01 ASP A 1 K19 R67 T82 T84 R89 A131 T132 Y156 D174 I177 K17 R65 T80 T82 R87 A129 T130 Y154 D172 I175 ? -logKd/Ki=5.72, Kd=1.9uM Q0P9X8 17631313 1234 GKLESIKSKGQLIVGVKNDVPHYALLDQATGEIKGFEVDVAKLLAKSILGDDKKIKLVAVNAKTRGPLLDNGSVDAVIATFTITPERKRIYNFSEPYYQDAIGLLVLKEKKYKSLADMKGANIGVAQAATTKKAIGEAAKKIGIDVKFSEFPDYPSIKAALDAKRVDAFSVDKSILLGYVDDKSEILPDSFEPQSYGIVTKKDDPAFAKYVDDFVKEHKNEIDALAKKWGL 2v25 B 1.49 BS01 ASP B 1 K19 R67 T82 T84 R89 A131 T132 Y156 D174 I177 K17 R65 T80 T82 R87 A129 T130 Y154 D172 I175 ? Q0P9X8 17631313 1234 GKLESIKSKGQLIVGVKNDVPHYALLDQATGEIKGFEVDVAKLLAKSILGDDKKIKLVAVNAKTRGPLLDNGSVDAVIATFTITPERKRIYNFSEPYYQDAIGLLVLKEKKYKSLADMKGANIGVAQAATTKKAIGEAAKKIGIDVKFSEFPDYPSIKAALDAKRVDAFSVDKSILLGYVDDKSEILPDSFEPQSYGIVTKKDDPAFAKYVDDFVKEHKNEIDALAKKWGL 2wlt A 1.4 BS01 ASP A 1 T16 S31 G61 S62 Q63 G94 T95 D96 T12 S25 G55 S56 Q57 G88 T89 D90 T16 Y29 T95 D96 K168 E289 T12 Y23 T89 D90 K162 E283 3.5.1.1 0004067,0005737,0006520,0006528,0016787 Q9ZLB9 19966411 1333 LPTIALLATGGTIAGSGASLGSYKSGELGVKELLKAIPSLNKIARIQGEQVSNIGSQDMNEEIWFKLAQRAQELLDDSRIQGVVITHGTDTLEESAYFLNLVLHSTKPVVLVGAMRNASSLSADGALNLYEAVSVAVNEKSANKGVLVVMDDTIFSVREVVKTHTTHVSTFKALNSGAIGSVYYGKTRYYMQPLRKHTTESEFSLSQLKTPLPKVDIIYTHAGMTPDLFQASLNSHAKGVVIAGVGNGNVSAGFLKAMQEASQMGVVIVRSSRVGSGGVTSGEIDDKAYGFITSDNLNPQKARVLLQLALTKTNDKAKIQEMFEEY 2wt4 A 1.8 BS01 ASP A 1 T16 G61 S62 Q63 G94 T95 D96 T12 G44 S45 Q46 G77 T78 D79 T16 T95 D96 K168 E289 T12 T78 D79 K151 E272 3.5.1.1 0004067,0005737,0006520,0006528,0016787 Q9ZLB9 19966411 3613 LPTIALLATGGTIAGSGGVKELLKAIPSLNKIARIQGEQVSNIGSQDMNEEIWFKLAQRAQELLDDSRIQGVVITHGTDTLEESAYFLNLVLHSTKPVVLVGAMRNASSLSADGALNLYEAVSVAVNEKSANKGVLVVMDDTIFSVREVVKTHTTHVSTFKALNSGAIGSVYYGKTRYYMQPLRKHTTESEFSLSQLKTPLPKVDIIYTHAGMTPDLFQASLNSHAKGVVIAGVGNGNVSAGFLKAMQEASQMGVVIVRSSRVGSGGVTSGEIDDKAYGFITSDNLNPQKARVLLQLALTKTNDKAKIQEMFEEY 2zal B 1.9 BS01 ASP B 1 T179 M200 R207 D210 T230 G231 G233 T1 M22 R29 D32 T52 G53 G55 T179 T197 R207 T230 G231 T1 T19 R29 T52 G53 3.4.19.5 0016787 P37595 15946951 501 TVGAVALDLDGNLAAATSTGGMTNKLPGRVGDSPLVGAGCYANNASVAVSCTGTGEVFIRALAAYDIAALMDYGGLSLAEACERVVMEKLPALGGSGGLIAIDHEGNVALPFNTEGMYRAWGYAGDTPTTGIYRE 2zal D 1.9 BS01 ASP D 1 T179 M200 R207 D210 T230 G231 G233 T1 M22 R29 D32 T52 G53 G55 T179 T197 R207 T230 G231 T1 T19 R29 T52 G53 3.4.19.5 0016787 P37595 15946951 500 TVGAVALDLDGNLAAATSTGGMTNKLPGRVGDSPLVGAGCYANNASVAVSCTGTGEVFIRALAAYDIAALMDYGGLSLAEACERVVMEKLPALGGSGGLIAIDHEGNVALPFNTEGMYRAWGYAGDTPTTGIYRE 3c1m A 2.3 BS01 ASP A 1 T46 E130 F193 R207 G208 S210 T45 E129 F192 R206 G207 S209 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 471 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDSFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK 3c1m B 2.3 BS01 ASP B 1 T46 E130 F193 R207 G208 S210 T45 E129 F192 R206 G207 S209 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 472 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDSFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK 3c1m C 2.3 BS01 ASP C 1 T46 E130 F193 R207 G208 S210 T45 E129 F192 R206 G207 S209 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 472 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDGKKSFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK 3c1m D 2.3 BS01 ASP D 1 T46 E130 F193 R207 G208 S210 T45 E129 F192 R206 G207 S209 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 472 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDKSFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK 3c20 A 2.7 BS01 ASP A 1 S40 T46 E130 F193 R207 G208 S210 S39 T45 E129 F192 R206 G207 S209 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 474 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDSFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK 3c20 B 2.7 BS01 ASP B 1 S40 T46 R207 G208 G209 S210 S39 T45 R206 G207 G208 S209 2.7.2.4 0003824,0004072,0005524,0005829,0008652,0009088,0009089,0009090,0016301,0016310 Q57991 18334478 474 TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVEISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRIEELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIALEGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGYITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPKLSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITNDMEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVILISQGSSETNISLVVSEEDVDKALKALKREFGDKSFLNNNLIRDVSVDKDVCVISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKDLLNCVRKLHEKFIEK 3eca A 2.4 BS01 ASP A 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 8434007 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDDVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKTVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 3eca B 2.4 BS01 ASP B 1 G11 T12 A27 G57 S58 Q59 G88 T89 D90 G11 T12 A27 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 8434007 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDDVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKTVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 3eca C 2.4 BS01 ASP C 1 G11 T12 A27 G57 S58 Q59 G88 T89 D90 A114 G11 T12 A27 G57 S58 Q59 G88 T89 D90 A114 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 8434007 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDDVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKTVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 3eca D 2.4 BS01 ASP D 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 8434007 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDDVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKTVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 3h0r H 3.0 BS05 ASP H 1 H14 K81 E153 Y270 H12 K79 E151 Y268 6.3.5.- 0003824,0005524,0006412,0016874,0016884,0050566,0050567,0070681 O66766 19520089 482 EKYEAVIGLEIHVQMDTKTKMFCGCKVEFGAEPNTNVCPVCLGMPGALPIVNKRAVEYAIRASLALNCEVHEESVFARKHYFYPDLPKGYQISQYEKPLATNGWVELNLPNGEKKKVRIRRLHIEEDAGKNIHEGDKTLVDLNRAGTPLMEIVTEPDIRTPEEARLFLEKLRNIMRYAGVSKADMEKGQLRCDINVSIRPKGSKEFGTRVEIKNVNSFRFVQKALEYEIERQINVVEEGGEVVQETRTFDPQTGKTYPMRTKEEAEDYRYFPDPDLVPLKVKKEWIEEIKKNMPELPDQRFERLIKEYGLSEYEAGILVNHKEVGDFFEEAVRHFKEPKGIVNWLINDLLGLLRDKGISIEESPVKPEHLAELVKLIKEKVISTKIGKEVIKEMVETGKTPSQIVEEKGL 3h0r N 3.0 BS05 ASP N 1 K81 E153 K79 E151 6.3.5.- 0003824,0005524,0006412,0016874,0016884,0050566,0050567,0070681 O66766 19520089 482 EKYEAVIGLEIHVQMDTKTKMFCGCKVEFGAEPNTNVCPVCLGMPGALPIVNKRAVEYAIRASLALNCEVHEESVFARKHYFYPDLPKGYQISQYEKPLATNGWVELNLPNGEKKKVRIRRLHIEEDAGKNIHEGDKTLVDLNRAGTPLMEIVTEPDIRTPEEARLFLEKLRNIMRYAGVSKADMEKGQLRCDINVSIRPKGSKEFGTRVEIKNVNSFRFVQKALEYEIERQINVVEEGGEVVQETRTFDPQTGKTYPMRTKEEAEDYRYFPDPDLVPLKVKKEWIEEIKKNMPELPDQRFERLIKEYGLSEYEAGILVNHKEVGDFFEEAVRHFKEPKGIVNWLINDLLGLLRDKGISIEESPVKPEHLAELVKLIKEKVISTKIGKEVIKEMVETGKTPSQIVEEKGL 3kbc A 3.51 BS01 ASP A 1 R276 S277 S278 M311 T314 T352 G354 V355 A358 G359 D394 R397 T398 N401 R271 S272 S273 M306 T309 T347 G349 V350 A353 G354 D389 R392 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 19924125 500 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3kbc B 3.51 BS01 ASP B 1 R276 S277 S278 M311 T314 T352 G354 V355 A358 G359 D394 R397 T398 N401 R271 S272 S273 M306 T309 T347 G349 V350 A353 G354 D389 R392 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 19924125 500 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3kbc C 3.51 BS01 ASP C 1 R276 S277 S278 M311 T314 T352 G354 V355 A358 G359 D394 R397 T398 N401 R271 S272 S273 M306 T309 T347 G349 V350 A353 G354 D389 R392 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 19924125 500 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3nel A 1.954 BS01 ASP A 1 E170 Q192 K195 Y339 S364 R368 F406 G407 E170 Q192 K195 Y339 S364 R368 F406 G407 R214 E216 R222 H223 E361 S364 R412 R214 E216 R222 H223 E361 S364 R412 6.1.1.12 0000166,0000287,0003676,0003723,0004812,0004815,0005524,0005737,0005829,0006412,0006418,0006422,0017101,0046872 Q52428 9724658 500 MYRTHYSSEITEELNGQKVKVAGWVWEVKDLGGIKFLWIRDRDGIVQITAPKKKVDPELFKLIPKLRSEDVVAVEGVVNFTPKAKLGFEILPEKIVVLNRAETPLPLDPTGKVKAELDTRLDNRFMDLRRPEVMAIFKIRSSVFKAVRDFFHENGFIEIHTPKIIATATEGGTELFPMKYFEEDAFLAQSPQLYKQIMMASGLDRVYEIAPIFRAEEHNTTRHLNEAWSIDSEMAFIEDEEEVMSFLERLVAHAINYVREHNAKELDILNFELEEPKLPFPRVSYDKALEILGDLGKEIPWGEDIDTEGERLLGKYMMENENAPLYFLYQYPSEAKPFYIMKYDNKPEICRAFDLEYRGVEISSGGQREHRHDILVEQIKEKGLNPESFEFYLKAFRYGMPPHGGFGLGAERLIKQMLDLPNIREVILFPRDRRRLTP 3oek A 1.9 BS01 ASP A 1 H88 T116 R121 G172 S173 T174 Y214 H73 T101 R106 G157 S158 T159 Y199 ? 0015276,0016020 Q62645 21522138 1001 QHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNREKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARGTTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICH 3p8v A 1.8 BS01 ASP A 1 R99 Q116 D118 S218 G219 R222 A261 G262 R99 Q116 D118 S218 G219 R222 A261 G262 R99 E101 R109 H110 R99 E101 R109 H110 ? 0000166,0004812,0004816,0005524,0006412,0006418,0006421,0046872 Q9V228 21820443 295 MNAVEIISRDIYKAIDIQTKILDYMTKFFTDRGFKWLLPIMLSPITDPLWPDPAGEGIRPAEVDVYGVRMRLTHSMILHKQLAIAMGLEKIFVLSPNIRLESRRKDDGRHSYEFTQLDFEIEGAKMKDVMRLIEELIYGLFRKAEEWTGREFPRARHFKVYDYKDILEEFGSDEKASMEMEEPFWIVNIPREFYDREENGVWKNYDLILPYGYGEVSSGGEREWEYEKIVAKIRAAGLKEDSFRPYLEIARAGKLKPSAGAGIGVERLVRFIVGAKHIAEVQPFPRVPGIPAVI 3p8v B 1.8 BS01 ASP B 1 Q116 D118 S218 G219 R222 A261 G262 Q116 D118 S218 G219 R222 A261 G262 R99 E101 R109 H110 R99 E101 R109 H110 ? 0000166,0004812,0004816,0005524,0006412,0006418,0006421,0046872 Q9V228 21820443 295 MNAVEIISRDIYKAIDIQTKILDYMTKFFTDRGFKWLLPIMLSPITDPLWPDPAGEGIRPAEVDVYGVRMRLTHSMILHKQLAIAMGLEKIFVLSPNIRLESRRKDDGRHSYEFTQLDFEIEGAKMKDVMRLIEELIYGLFRKAEEWTGREFPRARHFKVYDYKDILEEFGSDEKASMEMEEPFWIVNIPREFYDREENGVWKNYDLILPYGYGEVSSGGEREWEYEKIVAKIRAAGLKEDSFRPYLEIARAGKLKPSAGAGIGVERLVRFIVGAKHIAEVQPFPRVPGIPAVI 3r6v A 2.6 BS02 ASP B 1 T187 H188 T183 H184 T187 H188 S318 K324 E331 T183 H184 S314 K320 E327 4.3.1.1 0003824,0005829,0006099,0006531,0008797,0016829 Q9LCC6 21661762 469 VRIEKDFLGEKEIPKDAYYGVQTIRATENFPITGYRIHPELIKSLGIVKKSAALANMEVGLLDKEVGQYIVKAADEVIEGKWNDQFIVDPIQGGAGTSINMNANEVIANRALELMGEEKGNYSKISPNSHVNMSQSTNDAFPTATHIAVLSLLNQLIETTKYMQQEFMKKADEFAGVIKMGRTHLQDAVPILLGQEFEAYARVIARDIERIANTRNNLYDINMGATAVGTGLNADPEYISIVTEHLAKFSGHPLRSAQHLVDATQNTDCYTEVSSALKVCMINMSKIANDLRLMASGPRAGLSEIVLPARQPGSSIMPGKVNPVMPEVMNQVAFQVFGNDLTITSASEAGQFELNVMEPVLFFNLIQSISIMTNVFKSFTENCLKGIKANEERMKEYVEKSIGIITAINPHVGYETAAKLAREAYLTGESIRELCIKYGVLTEEQLNEILNPYEMIHP 3r6v B 2.6 BS01 ASP B 1 T101 T141 N142 T97 T137 N138 T101 S140 T141 N142 H188 S318 K324 E331 T97 S136 T137 N138 H184 S314 K320 E327 4.3.1.1 0003824,0005829,0006099,0006531,0008797,0016829 Q9LCC6 21661762 469 VRIEKDFLGEKEIPKDAYYGVQTIRATENFPITGYRIHPELIKSLGIVKKSAALANMEVGLLDKEVGQYIVKAADEVIEGKWNDQFIVDPIQGGAGTSINMNANEVIANRALELMGEEKGNYSKISPNSHVNMSQSTNDAFPTATHIAVLSLLNQLIETTKYMQQEFMKKADEFAGVIKMGRTHLQDAVPILLGQEFEAYARVIARDIERIANTRNNLYDINMGATAVGTGLNADPEYISIVTEHLAKFSGHPLRSAQHLVDATQNTDCYTEVSSALKVCMINMSKIANDLRLMASGPRAGLSEIVLPARQPGSSIMPGKVNPVMPEVMNQVAFQVFGNDLTITSASEAGQFELNVMEPVLFFNLIQSISIMTNVFKSFTENCLKGIKANEERMKEYVEKSIGIITAINPHVGYETAAKLAREAYLTGESIRELCIKYGVLTEEQLNEILNPYEMIHPGIAG 3r6v C 2.6 BS01 ASP B 1 G317 S318 S319 K324 G313 S314 S315 K320 H188 S318 S319 K324 E331 H184 S314 S315 K320 E327 4.3.1.1 0003824,0005829,0006099,0006531,0008797,0016829 Q9LCC6 21661762 469 VRIEKDFLGEKEIPKDAYYGVQTIRATENFPITGYRIHPELIKSLGIVKKSAALANMEVGLLDKEVGQYIVKAADEVIEGKWNDQFIVDPIQGGAGTSINMNANEVIANRALELMGEEKGNYSKISPNSHVNMSQSTNDAFPTATHIAVLSLLNQLIETTKYMQQEFMKKADEFAGVIKMGRTHLQDAVPILLGQEFEAYARVIARDIERIANTRNNLYDINMGATAVGTGLNADPEYISIVTEHLAKFSGHPLRSAQHLVDATQNTDCYTEVSSALKVCMINMSKIANDLRLMASGPRAGLSEIVLPARQPGSSIMPGKVNPVMPEVMNQVAFQVFGNDLTITSASEAGQFELNVMEPVLFFNLIQSISIMTNVFKSFTENCLKGIKANEERMKEYVEKSIGIITAINPHVGYETAAKLAREAYLTGESIRELCIKYGVLTEEQLNEILNPYEMIHPGIAG 3r6v E 2.6 BS02 ASP F 1 T187 H188 T183 H184 H188 S318 K324 E331 H184 S314 K320 E327 4.3.1.1 0003824,0005829,0006099,0006531,0008797,0016829 Q9LCC6 21661762 469 VRIEKDFLGEKEIPKDAYYGVQTIRATENFPITGYRIHPELIKSLGIVKKSAALANMEVGLLDKEVGQYIVKAADEVIEGKWNDQFIVDPIQGGAGTSINMNANEVIANRALELMGEEKGNYSKISPNSHVNMSQSTNDAFPTATHIAVLSLLNQLIETTKYMQQEFMKKADEFAGVIKMGRTHLQDAVPILLGQEFEAYARVIARDIERIANTRNNLYDINMGATAVGTGLNADPEYISIVTEHLAKFSGHPLRSAQHLVDATQNTDCYTEVSSALKVCMINMSKIANDLRLMASGPRAGLSEIVLPARQPGSSIMPGKVNPVMPEVMNQVAFQVFGNDLTITSASEAGQFELNVMEPVLFFNLIQSISIMTNVFKSFTENCLKGIKANEERMKEYVEKSIGIITAINPHVGYETAAKLAREAYLTGESIRELCIKYGVLTEEQLNEILNPYEMIHPG 3r6v F 2.6 BS01 ASP F 1 T101 S140 T141 N142 T97 S136 T137 N138 H188 S318 K324 E331 H184 S314 K320 E327 4.3.1.1 0003824,0005829,0006099,0006531,0008797,0016829 Q9LCC6 21661762 469 VRIEKDFLGEKEIPKDAYYGVQTIRATENFPITGYRIHPELIKSLGIVKKSAALANMEVGLLDKEVGQYIVKAADEVIEGKWNDQFIVDPIQGGAGTSINMNANEVIANRALELMGEEKGNYSKISPNSHVNMSQSTNDAFPTATHIAVLSLLNQLIETTKYMQQEFMKKADEFAGVIKMGRTHLQDAVPILLGQEFEAYARVIARDIERIANTRNNLYDINMGATAVGTGLNADPEYISIVTEHLAKFSGHPLRSAQHLVDATQNTDCYTEVSSALKVCMINMSKIANDLRLMASGPRAGLSEIVLPARQPGSSIMPGKVNPVMPEVMNQVAFQVFGNDLTITSASEAGQFELNVMEPVLFFNLIQSISIMTNVFKSFTENCLKGIKANEERMKEYVEKSIGIITAINPHVGYETAAKLAREAYLTGESIRELCIKYGVLTEEQLNEILNPYEMIHPGIA 3r6v G 2.6 BS01 ASP F 1 G317 S318 S319 G314 S315 S316 H188 S318 K324 E331 H185 S315 K321 E328 4.3.1.1 0003824,0005829,0006099,0006531,0008797,0016829 Q9LCC6 21661762 469 DVRIEKDFLGEKEIPKDAYYGVQTIRATENFPITGYRIHPELIKSLGIVKKSAALANMEVGLLDKEVGQYIVKAADEVIEGKWNDQFIVDPIQGGAGTSINMNANEVIANRALELMGEEKGNYSKISPNSHVNMSQSTNDAFPTATHIAVLSLLNQLIETTKYMQQEFMKKADEFAGVIKMGRTHLQDAVPILLGQEFEAYARVIARDIERIANTRNNLYDINMGATAVGTGLNADPEYISIVTEHLAKFSGHPLRSAQHLVDATQNTDCYTEVSSALKVCMINMSKIANDLRLMASGPRAGLSEIVLPARQPGSSIMPGKVNPVMPEVMNQVAFQVFGNDLTITSASEAGQFELNVMEPVLFFNLIQSISIMTNVFKSFTENCLKGIKANEERMKEYVEKSIGIITAINPHVGYETAAKLAREAYLTGESIRELCIKYGVLTEEQLNEILNPYEMIHPGIAG 3reu B 1.9 BS01 ASP B 1 S75 Q116 D118 S218 R222 A261 G262 S70 Q111 D113 S213 R217 A256 G257 R99 E101 R109 H110 R94 E96 R104 H105 ? 0000166,0004812,0004816,0005524,0006412,0006418,0006421,0046872 Q9V228 21820443 295 MNAVEIISRDIYKAIDIQTKILDYMTKFFTDRGFKWLLPIMLSPITDPLWPDIRPAEVDVYGVRMRLTHSMILHKQLAIAMGLEKIFVLSPNIRLESRRKDDGRHSYEFTQLDFEIEGAKMKDVMRLIEELIYGLFRKAEEWTGREFPRARHFKVYDYKDILEEFGSDEKASMEMEEPFWIVNIPREFYDREENGVWKNYDLILPYGYGEVSSGGEREWEYEKIVAKIRAAGLKEDSFRPYLEIARAGKLKPSAGAGIGVERLVRFIVGAKHIAEVQPFPRVPGIPAVI 3tvi A 3.0 BS01 ASP A 1 S38 F170 G186 S187 S36 F166 G182 S183 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 Q97MC0 25170437 451 IVVTKFGGSSLADSNQFKKVKGIIDSDANRKYIIPSAPGKRTNKDYKITDLLYLCNAHVKNGIPFDDVFKLISQRYTEIVSELNIDMDIAYYLEKVKKNIENGASSDYAASRGEYLNGVILAKYLNAEFIDAAEVIFFDKCFDEKKSYEKIKEKVLSCNKAVIPGFYGSSFNGDVKTFSRGGSDVTGSIISAGVNADLYENWTDVSGFLMADPRIVENPKTISKISYKELRELSYMLHEEAIFPVKDSGIPINIKNTNKPSDPGTLILSDTHKEINLGTITGIAGKKNFTVIAIEKALLNSEVGFCRKILSILEMYGVSFEHMPSGVDSVSLVIEDCKLDGKCDKIIEEIKKQCNPDSIEIHPNMALVATVGTGMAKTKGIANKIFTALSKENVNIRMIDQGSSEINVIVGVETVDFEKAVKSIYNAFN 3tvi D 3.0 BS02 ASP D 1 S38 E116 S187 S38 E116 S187 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 Q97MC0 25170437 454 LKIVVTKFGGSSLADSNQFKKVKGIIDSDANRKYIIPSAPGKRTNKDYKITDLLYLCNAHVKNGIPFDDVFKLISQRYTEIVSELNIDMDIAYYLEKVKKNIENGASSDYAASRGEYLNGVILAKYLNAEFIDAAEVIFFDKSGCFDEKKSYEKIKEKVLSCNKAVIPGFYGSSFNGDVKTFSRGGSDVTGSIISAGVNADLYENWTDVSGFLMADPRIVENPKTISKISYKELRELSYMGATVLHEEAIFPVKDSGIPINIKNTNKPSDPGTLILSDTHKEINLGTITGIAGKKNFTVIAIEKALLNSEVGFCRKILSILEMYGVSFEHMPSGVDSVSLVIEDCKLDGKCDKIIEEIKKQCNPDSIEIHPNMALVATVGTGMAKTKGIANKIFTALSKENVNIRMIDQGSSEINVIVGVETVDFEKAVKSIYNAFN 3tvi E 3.0 BS01 ASP E 1 T51 E116 F170 G186 S187 T51 E116 F170 G186 S187 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 Q97MC0 25170437 455 LKIVVTKFGGSSLADSNQFKKVKGIIDSDANRKYIIPSAPGKRTNKDYKITDLLYLCNAHVKNGIPFDDVFKLISQRYTEIVSELNIDMDIAYYLEKVKKNIENGASSDYAASRGEYLNGVILAKYLNAEFIDAAEVIFFDKSGCFDEKKSYEKIKEKVLSCNKAVIPGFYGSSFNGDVKTFSRGGSDVTGSIISAGVNADLYENWTDVSGFLMADPRIVENPKTISKISYKELRELSYMGATVLHEEAIFPVKDSGIPINIKNTNKPSDPGTLILSDTHKEINLGTITGIAGKKNFTVIAIEKALLNSEVGFCRKILSILEMYGVSFEHMPSGVDSVSLVIEDCKLDGKCDKIIEEIKKQCNPDSIEIHPNMALVATVGTGMAKTKGIANKIFTALSKENVNIRMIDQGSSEINVIVGVETVDFEKAVKSIYNAFNEG 3tvi G 3.0 BS01 ASP G 1 A39 T51 E116 G186 A40 T52 E117 G187 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 Q97MC0 25170437 457 SLKIVVTKFGGSSLADSNQFKKVKGIIDSDANRKYIIPSAPGKRTNKDYKITDLLYLCNAHVKNGIPFDDVFKLISQRYTEIVSELNIDMDIAYYLEKVKKNIENGASSDYAASRGEYLNGVILAKYLNAEFIDAAEVIFFDKSGCFDEKKSYEKIKEKVLSCNKAVIPGFYGSSFNGDVKTFSRGGSDVTGSIISAGVNADLYENWTDVSGFLMADPRIVENPKTISKISYKELRELSYVLHEEAIFPVKDSGIPINIKNTNKPSDPGTLILSDTHKEINLGTITGIAGKKNFTVIAIEKALLNSEVGFCRKILSILEMYGVSFEHMPSGVDSVSLVIEDCKLDGKCDKIIEEIKKQCNPDSIEIHPNMALVATVGTGMAKTKGIANKIFTALSKENVNIRMIDQGSSEINVIVGVETVDFEKAVKSIYNAFNEG 3tvi H 3.0 BS01 ASP H 1 S38 E116 S187 S36 E114 S185 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 Q97MC0 25170437 458 IVVTKFGGSSLADSNQFKKVKGIIDSDANRKYIIPSAPGKRTNKDYKITDLLYLCNAHVKNGIPFDDVFKLISQRYTEIVSELNIDMDIAYYLEKVKKNIENGASSDYAASRGEYLNGVILAKYLNAEFIDAAEVIFFDKSGCFDEKKSYEKIKEKVLSCNKAVIPGFYGSSFNGDVKTFSRGGSDVTGSIISAGVNADLYENWTDVSGFLMADPRIVENPKTISKISYKELRELSYMGATVLHEEAIFPVKDSGIPINIKNTNKPSDPGTLILSDTHKEINLGTITGIAGKKNFTVIAIEKALLNSEVGFCRKILSILEMYGVSFEHMPSGVDSVSLVIEDCKLDGKCDKIIEEIKKQCNPDSIEIHPNMALVATVGTGMAKTKGIANKIFTALSKENVNIRMIDQGSSEINVIVGVETVDFEKAVKSIYNAFN 3tvi I 3.0 BS01 ASP I 1 E116 F170 S187 E114 F166 S183 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 Q97MC0 25170437 459 IVVTKFGGSSLADSNQFKKVKGIIDSDANRKYIIPSAPGKRTNKDYKITDLLYLCNAHVKNGIPFDDVFKLISQRYTEIVSELNIDMDIAYYLEKVKKNIENGASSDYAASRGEYLNGVILAKYLNAEFIDAAEVIFFDKCFDEKKSYEKIKEKVLSCNKAVIPGFYGSSFNGDVKTFSRGGSDVTGSIISAGVNADLYENWTDVSGFLMADPRIVENPKTISKISYKELRELSYLHEEAIFPVKDSGIPINIKNTNKPSDPGTLILSDTHKEINLGTITGIAGKKNFTVIAIEKALLNSEVGFCRKILSILEMYGVSFEHMPSGVDSVSLVIEDCKLDGKCDKIIEEIKKQCNPDSIEIHPNMALVATVGTGMAKTKGIANKIFTALSKENVNIRMIDQGSSEINVIVGVETVDFEKAVKSIYNAFN 3tvi L 3.0 BS01 ASP L 1 S38 E116 F170 S187 S36 E114 F166 S183 2.7.2.4 0004072,0005524,0005829,0008652,0009085,0009088,0009089,0009090,0016301,0016310 Q97MC0 25170437 462 IVVTKFGGSSLADSNQFKKVKGIIDSDANRKYIIPSAPGKRTNKDYKITDLLYLCNAHVKNGIPFDDVFKLISQRYTEIVSELNIDMDIAYYLEKVKKNIENGASSDYAASRGEYLNGVILAKYLNAEFIDAAEVIFFDKCFDEKKSYEKIKEKVLSCNKAVIPGFYGSSFNGDVKTFSRGGSDVTGSIISAGVNADLYENWTDVSGFLMADPRIVENPKTISKISYKELRELSYLHEEAIFPVKDSGIPINIKNTNKPSDPGTLILSDTHKEINLGTITGIAGKKNFTVIAIEKALLNSEVGFCRKILSILEMYGVSFEHMPSGVDSVSLVIEDCKLDGKCDKIIEEIKKQCNPDSIEIHPNMALVATVGTGMAKTKGIANKIFTALSKENVNIRMIDQGSSEINVIVGVETVDFEKAVKSIYNAFN 3v8f A 3.8 BS01 ASP A 1 S278 M311 T314 T352 G354 V355 P356 A358 G359 D394 R397 T398 N401 S272 M305 T308 T346 G348 V349 P350 A352 G353 D388 R391 T392 N395 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 22343718 901 YIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYCMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYACILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3v8f B 3.8 BS01 ASP B 1 S278 M311 T314 T352 G354 V355 A358 G359 D394 R397 T398 N401 S273 M306 T309 T347 G349 V350 A353 G354 D389 R392 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 22343718 901 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYCMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYACILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3v8f C 3.8 BS01 ASP C 1 S278 M311 T314 T352 G354 V355 A358 G359 D394 R397 T398 N401 S272 M305 T308 T346 G348 V349 A352 G353 D388 R391 T392 N395 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 22343718 901 YIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYCMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYACILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3v8g A 4.66 BS01 ASP A 1 R276 S277 S278 M311 T314 G354 V355 G359 D394 R397 T398 R271 S272 S273 M306 T309 G349 V350 G354 D389 R392 T393 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 22343718 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKICNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVCAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3v8g B 4.66 BS01 ASP B 1 R276 S277 S278 M311 T314 G354 V355 G359 D394 R397 T398 R264 S265 S266 M299 T302 G342 V343 G347 D382 R385 T386 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 22343718 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKICNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVCAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3v8g C 4.66 BS01 ASP C 1 R276 S277 S278 M311 G354 V355 P356 G359 D394 R397 T398 R260 S261 S262 M295 G338 V339 P340 G343 D378 R381 T382 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 22343718 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKICNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVCAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3v8g D 4.66 BS01 ASP D 1 R276 S277 S278 T314 G354 V355 G359 D394 R397 T398 R271 S272 S273 T309 G349 V350 G354 D389 R392 T393 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 22343718 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKICNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVCAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3v8g E 4.66 BS01 ASP E 1 R276 S277 S278 M311 T314 G354 V355 G359 D394 R397 T398 R263 S264 S265 M298 T301 G341 V342 G346 D381 R384 T385 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 22343718 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKICNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVCAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3v8g F 4.66 BS01 ASP F 1 R276 S277 S278 M311 G354 V355 P356 G359 D394 R397 T398 R252 S253 S254 M287 G330 V331 P332 G335 D370 R373 T374 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 22343718 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKICNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVCAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 3wvn A 2.2 BS01 ASP A 1 D230 S299 G325 K330 R331 D208 S273 G299 K304 R305 T185 A205 T327 E328 T163 A183 T301 E302 6.2.1.- 0003824 Q76KY2 25246523 601 KDLRYGGLVHDLLADSGKATPNSDAMEDAFGTWTYQELLNHSQAFSAWLDGKGVARGERIVVQLPNIRQTVAVFYGACRRGVVFVPLNPGMKPFHLRSVIADADPRLVIAEDETAADRLRDVTDLPVYSIDSLWADVERLRDAGAGAEAVEVSPEDLAVLIYTSGSTAAPKAVACPHQQIVFAASSINAVLGYHAEDIVFCRMSVSWDFGLYKVLISTLTGAKLVLADIALVKSLRESGATMMPIVPSLASMLTTLIRRDPEGAPTLRMFTNSAAALPQVTIDALRSAFPGAQVVRMYGQTECKRISIMPPHLEHERPDSVGLPLPGTTIEILTLLPPGEPGEITVTGPHVMAGYWRAPEITARAYMRLHTGDYGHLDEDGFLYFGG 3wvn B 2.2 BS01 ASP B 1 D230 S299 G325 K330 R331 D207 S260 G286 K291 R292 T185 A205 T327 E328 T162 A182 T288 E289 6.2.1.- 0003824 Q76KY2 25246523 601 DLRYGGLVHDLLADSGKATPNSDAMEDAFGTWTYQELLNHSQAFSAWLDGKGVARGERIVVQLPNIRQTVAVFYGACRRGVVFVPLNPGMKPFHLRSVIADADPRLVIAEDETAADRLRDVTDLPVYSIDSLWADVERLRDAGAGAEAVEVSPEDLAVLIYTSGSTAAPKAVACPHQQIVFAASSINAVLGYHAEDIVFCRMSVSWDFGLYKVLISTLTGAKLVLAGLVKSLRESGATMMPIVPSLASMLTTTLRMFTNSAAALPQVTIDALRSAFPGAQVVRMYGQTECKRISIMPPHLEHERVGLPLPGTTIGEITVTGPHVMAGYWRAPEITARAYMRLHTGDYGHLDFLYF 3zgb A 2.71 BS01 ASP A 1 R641 Q673 K829 R888 N964 R623 Q655 K807 R866 N918 H172 R450 E560 D597 R635 R767 H167 R432 E542 D579 R617 R745 4.1.1.31 0003824,0005737,0005829,0006099,0008964,0009507,0015977,0015979,0016829,0048046,0048366 Q01647 23443546 1967 LEKLASIDAQLRLLVPGKVSEDDKLIEYDALLLDKFLDILQDLHGEDLKEAVQECYELSAEYEGKHDPKKLEELGSVLTSLDPGDSIVIAKAFSHMLNLANLAEEVQIAYRRRIKLKRGDFADEANATTESDIEETFKKLVLKLNKSPEEVFDALKNQTVDLVLTAHPTQSVRRSLLQKHGRIRNCLAQLYAKDITPDDKQELDEALHREIQAAFRTDEIRRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGINERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMASNMYFSQIEDLMFEMSMWRCNSELRVRAEELYRTQVPPTEPYRVILGDVRDKLYNTRERSRHLLAHGISDIPEEAVYTNVEQFLEPLELCYRSLCDCGDRVIADGSLLDFLRQVSTFGLSLVKLDIRQESDRHTDVLDAITQHLEIGSYREWSEEKRQEWLLAELSGKRPLFGSDLPKTEEVKDVLDTFNVLAELPSDCFGAYIISMATSPSDVLAVELLQRECHVKHPLRVVPLFEKLADLEAAPAAMARLFSIDWYRNRIDGKQEVMIGYSDSGKDAGRFSAAWQLYKAQEEIIKVAKEFGVKLVIFHGRGGTVGRGGGPTHLAILSQPPDTIHGSLRVTVQGEVIEQSFGEEHLCFRTLQRFCAATLEHGMNPPISPRPEWRELMDQMAVVATEEYRSIVFKEPRFVEYFRLATPELEYGRMNIGSRPSKGGIESLRAIPWIFAWTQTRFHLPVWLGFGAAFKHAIKKDSKNLQMLQEMYKTWPFFRVTIDLVEMVFAKGDPGIAALNDKLLVSEDLWPFGESLRANYEETKDYLLKIAGHRDLLEGDPYLKQRIRLRDSYITTLNVCQAYTLKRIRDPNYHVTLRPHISKGLEDTLILTMKGIAAGMQNTG 3zgb B 2.71 BS01 ASP B 1 R641 Q673 K829 L881 R888 N964 R620 Q652 K803 L855 R862 N913 H172 R450 E560 D597 R635 R767 H163 R429 E539 D576 R614 R741 4.1.1.31 0003824,0005737,0005829,0006099,0008964,0009507,0015977,0015979,0016829,0048046,0048366 Q01647 23443546 1967 ASIDAQLRLLVPGKVSEDDKLIEYDALLLDKFLDILQDLHGEDLKEAVQECYELSAEYEGKHDPKKLEELGSVLTSLDPGDSIVIAKAFSHMLNLANLAEEVQIAYRRRIKLKRGDFADEANATTESDIEETFKKLVLKLNKSPEEVFDALKNQTVDLVLTAHPTQSVRRSLLQKHGRIRNCLAQLYAKDITPDDKQELDEALHREIQAAFRTDEIRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGINERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMASNMYFSQIEDLMFEMSMWRCNSELRVRAEELYRTARQVPPTEPYRVILGDVRDKLYNTRERSRHLLAHGISDIPEEAVYTNVEQFLEPLELCYRSLCDCGDRVIADGSLLDFLRQVSTFGLSLVKLDIRQESDRHTDVLDAITQHLEIGSYREWSEEKRQEWLLAELSGKRPLFGSDLPKTEEVKDVLDTFNVLAELPSDCFGAYIISMATSPSDVLAVELLQRECHVKHPLRVVPLFEKLADLEAAPAAMARLFSIDWYRNRIDGKQEVMIGYSDSGKDAGRFSAAWQLYKAQEEIIKVAKEFGVKLVIFHGRGGTVGRGGGPTHLAILSQPPDTIHGSLRVTVQGEVIEQSFGEEHLCFRTLQRFCAATLEHGMNPPISPRPEWRELMDQMAVVATEEYRSIVFKEPRFVEYFRLATPELEYGRMNIGSRPSKGIESLRAIPWIFAWTQTRFHLPVWLGFGAAFKHAIKKDSKNLQMLQEMYKTWPFFRVTIDLVEMVFAKGDPGIAALNDKLLVSEDLWPFGESLRANYEETKDYLLKIAGHRDLLEGDPYLKQRIRLRDSYITTLNVCQAYTLKRIRDPNYHVTLRPHISGLEDTLILTMKGIAAGMQNTG 3zge A 2.49 BS01 ASP A 1 R641 Q673 K829 R888 N964 R627 Q659 K802 R861 N914 H172 R450 E560 D597 R635 R767 H165 R436 E546 D583 R621 R740 4.1.1.31 0003824,0005737,0005829,0006099,0008964,0009507,0009760,0015977,0015979,0016829,0048046,0048366 P30694 23443546 1967 KLASIDAQLRLLVPGKVSEDDKLVEYDALLLDKFLDILQDLHGEDLKEAVQQCYELSAEYEGKHDPKKLEELGSLLTSLDTGDSIVIAKAFSHMLNLANLAEELQIAYRRRIKLKSGDFADEANATTESDIEETFKRLVHKLNKSPEEVFDALKNQTVELVLTAHPTQSVRRSLLQKHGRIRNCLAQLYADITPDDKQELDEALHREIQAAFRTDEIRRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGINERFPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMTSNMYFSQIEDLMIEMSMWRCNSELRVRAEELYRTHYIEFWKRIPPNQPYRVILGDVRDKLYNTRERSRHLLVDGKSDIPDEAVYTNVEQLLEPLELCYRSLCDCGDHVIADGSLLDFLRQVSTFGLSLVKLDIRQESDRHTEVLDAITQHLGIGSYREWSEEKRQEWLLAELSGKRPLIGPDLPKTEEVKDCLDTFKVLAELPSDCFGAYIISMATSTSDVLAVELLQREYHIKHPLRVVPLFEKLADLEAAPAAMTRLFSMDWYRNRIDGKQEVMIGYSDSGKDAGRFSAAWQLYKTQEQIVKIAKEFGVKLVIFHGRGGTVGRGGGPTHLALLSQPPDTINGSLRVTVQGEVIEQSFGEEHLCFRTLQRFCAATLEHGMNPPISPRPEWRELMDQMAVVATEEYRSVVFKEPRFVEYFRLATPELEFGRGGIESLRAIPWIFSWTQTRFHLPVWLGFGAAFKHAIQKDSKNLQMLQEMYKTWPFFRVTIDLVEMVFAKGNPGIAALNDKLLVSEDLRPFGESLRANYEETKNYLLKIAGHKDLLEGDPYLKQGIRLRDPYITTLNVCQAYTLKRIRDPNYHVTLRPHISKEGLEDTLILTMKGIAAGMQNTG 3zge B 2.49 BS01 ASP B 1 R641 Q673 K829 L881 R888 N964 R621 Q653 K796 L848 R855 N909 H172 R450 E560 D597 R635 R767 H165 R430 E540 D577 R615 R734 4.1.1.31 0003824,0005737,0005829,0006099,0008964,0009507,0009760,0015977,0015979,0016829,0048046,0048366 P30694 23443546 1967 KLASIDAQLRLLVPGKVSEDDKLVEYDALLLDKFLDILQDLHGEDLKEAVQQCYELSAEYEGKHDPKKLEELGSLLTSLDTGDSIVIAKAFSHMLNLANLAEELQIAYRRRIKLKSGDFADEANATTESDIEETFKRLVHKLNKSPEEVFDALKNQTVELVLTAHPTQSVRRSLLQKHGRIRNCLAQLYAITPDDKQELDEALHREIQAAFRTDETPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGINERFPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMTSNMYFSQIEDLMIEMSMWRNSELRVRAEELYKHYIEFWKRIPPNQPYRVILGDVRDKLYNTRERSRHLLVDGKSDIPDEAVYTNVEQLLEPLELCYRSLCDCGDHVIADGSLLDFLRQVSTFGLSLVKLDIRQESDRHTEVLDAITQHLGIGSYREWSEEKRQEWLLAELSGKRPLIGPDLPKTEEVKDCLDTFKVLAELPSDCFGAYIISMATSTSDVLAVELLQREYHIKHPLRVVPLFEKLADLEAAPAAMTRLFSMDWYRNRIDGKQEVMIGYSDSGKDAGRFSAAWQLYKTQEQIVKIAKEFGVKLVIFHGRGGTVGRGGGPTHLALLSQPPDTINGSLRVTVQGEVIEQSFGEEHLCFRTLQRFCAATLEHGMNPPISPRPEWRELMDQMAVVATEEYRSVVFKEPRFVEYFRLATPELEFGRGGIESLRAIPWIFSWTQTRFHLPVWLGFGAAFKHAIQKDSKNLQMLQEMYKTWPFFRVTIDLVEMVFAKGNPGIAALNDKLLVSEDLRPFGESLRANYEETKNYLLKIAGHKDLLEGDPYLKQGIRLRDPYITTLNVCQAYTLKRIRDPNYHVTLRPHISKAPGLEDTLILTMKGIAAGMQNTG 4fe2 A 2.288 BS03 ASP A 1 K10 E89 K176 K8 E87 K174 6.3.2.6 0004639,0005524,0006164,0006189,0009236,0016874 Q07296 24598753 306 KQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKLNVAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYLKEETRRINELLKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEIVWEKLQELK 4io3 A 1.66 BS01 ASP A 1 Y67 I86 T87 R92 R136 T139 R162 D180 Y61 I80 T81 R86 R130 T133 R156 D174 ? 0015276,0016020 Kd=875nM -logKd/Ki=6.06, Kd=0.87uM E9P5T5 23434404 301 GSARLKGITLRIGVIESVPFTIVANVNTTKLTGYVLDLIEYLRDKMGFVADVQLAPPNTSYTGLVLALANGDYDIAIGDITVTSARREIVAFSNSISDNSMRILMRKGTLIDGMDDLKNGKIPYNRIGIRIGTAGEDYYLREISGGSRNFYPLKSRQEMYDSLLAGIIDVSFMDIGTAEYVTNNIYCNLTLVGEDFDKSTFGIVTPKEWLYAKDLDVNILSLRETGILDNLKKKWFQTKACP 4io3 B 1.66 BS01 ASP B 1 Y67 I86 T87 R92 R136 T139 R162 D180 Y61 I80 T81 R86 R130 T133 R156 D174 ? 0015276,0016020 Kd=875nM E9P5T5 23434404 301 GSARLKGITLRIGVIESVPFTIVANVITTKLTGYVLDLIEYLRDKMGFVADVQLAPPNTSYTGLVLALANGDYDIAIGDITVTSARREIVAFSNSISDNSMRILMRKGTLIDGMDDLKNGKIPYNRIGIRIGTAGEDYYLREISGGSRNFYPLKSRQEMYDSLLAGIIDVSFMDIGTAEYVTNNIYCNLTLVGEDFDKSTFGIVTPKEWLYAKDLDVNILSLRETGILDNLKKKWFQTKACP 4izm A 4.5 BS03 ASP A 1 R276 S277 S278 G354 A358 G359 D394 R397 T398 R264 S265 S266 G342 A346 G347 D382 R385 T386 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 -logKd/Ki=6.66, Kd=220nM O59010 23563139 503 LQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASCVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYCFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 4izm B 4.5 BS03 ASP B 1 R276 S278 G354 A358 G359 D394 R397 T398 R264 S266 G342 A346 G347 D382 R385 T386 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 23563139 503 LQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASCVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYCFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 4izm C 4.5 BS03 ASP C 1 R276 S278 M311 T314 G354 G359 D394 R397 T398 N401 R264 S266 M299 T302 G342 G347 D382 R385 T386 N389 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 23563139 503 LQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASCVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYCFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 4kxa A 2.4 BS03 ASP A 1 T356 A358 Y479 R887 T281 A283 Y404 R808 E360 H393 E394 H397 E416 T471 Y479 E285 H318 E319 H322 E341 T396 Y404 3.4.11.7 0001525,0002003,0003081,0004177,0005615,0005737,0005765,0005886,0005903,0006508,0007267,0008217,0008233,0008237,0008270,0008283,0009897,0016324,0016477,0031410,0032835,0042277,0043171,0045177,0046872,0070006,0070062 Q07075 23888046 1019 DICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGRVKSIAATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLL 4mcs A 1.83 BS05 ASP A 1 N519 R534 Y552 H553 N465 R480 Y495 H496 3.4.17.21 0004180,0004181,0005737,0005886,0006508,0006760,0008233,0008237,0009986,0016020,0016805,0035609,0046872,0070062,1904492,1904493 Q04609 24863754 819 KHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVYNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA 4nje A 2.5 BS01 ASP A 1 T11 D51 S52 G82 T83 D84 T11 D51 S52 G82 T83 D84 T11 Y21 T83 D84 K154 T11 Y21 T83 D84 K154 3.5.1.1 Q8TZE8 25478837 201 MKILLIGMGGTIASVKGENGYEASLSVKEVLDIAGIKDCEDCDFLDLKNVDSTLIQPEDWVDLAETLYKNVKKYDGIIVTHGTDTLAYTSSMISFMLRNPPIPIVFTGSMIPATEENSDAPLNLQTAIKFATSGIRGVYVAFNGKVMLGVRTSKVRTMSRDAFESINYPIIAELRGEDLVVN 4o2d A 2.6 BS01 ASP A 1 E171 S193 Q195 Q231 H449 H450 G486 R490 I532 A533 E170 S192 Q194 Q228 H446 H447 G483 R487 I529 A530 R217 E219 R225 Q226 E483 G486 R538 R216 E218 R222 Q223 E480 G483 R535 6.1.1.23 0000166,0003676,0004812,0004815,0005524,0005737,0006412,0006418,0006422,0016874,0050560 A0QWN3 25613812 801 VLRTHAAGSLRPADAGQTVTLAGWVARRRDHGGVIFIDLRDASGVSQVVFREGDVLAAAHRLRAEFCVAVTGVVEVRPEGNENPEIPTGQIEVNATELTVLGESAPLPFQLDEQAGEEARLKYRYLDLRREGPGNALRLRSKVNAAARSVLAEHDFVEIETPTLTRSTPEGARDFLVPARLQPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFDRQPEFTQLDMEMSFVEADDVIAISEQVLKAVWATIGYDLPLPLPRISYEEAMRRFGSDKPDLRFGIELVECTEYFKDTTFRVFQAPYVGAVVMPGGASQPRRTLDGWQEFAKQRGHKGLAYVLVGEDGTLGGPVAKNLSDAERDGLVAHVGANPGDCIFFAAGPAKGARALLGATRIEIAKRLDLIDPNAWAFTWVVDFPMFEAADEATAAGDVAVGSGAWTAMHHAFTAPKPDSVDTFDSDPGNALSDAYDIVCNGNEIGGGSIRIHRRDIQERVFAMMGIDHDEAQEKFGFLLDAFSYGAPPHGGIAFGWDRITALLAGVDSIREVIAFPKSGGGVDPLTDAPAPITPQQRKESGID 4o2d B 2.6 BS01 ASP B 1 E171 S193 Q195 Q231 H450 G486 R490 I532 A533 E170 S192 Q194 Q228 H382 G418 R422 I464 A465 R217 E219 R225 Q226 E483 G486 R538 R216 E218 R222 Q223 E415 G418 R470 6.1.1.23 0000166,0003676,0004812,0004815,0005524,0005737,0006412,0006418,0006422,0016874,0050560 A0QWN3 25613812 801 VLRTHAAGSLRPADAGQTVTLAGWVARRRDHGGVIFIDLRDASGVSQVVFREGDVLAAAHRLRAEFCVAVTGVVEVRPEGNENPEIPTGQIEVNATELTVLGESAPLPFQLDEQAGEEARLKYRYLDLRREGPGNALRLRSKVNAAARSVLAEHDFVEIETPTLTRSTPEGARDFLVPARLQPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFDRQPEFTQLDMEMSFVEADDVIAISEQVLKAVWATIGYDLPLPLPRISYEEAMRRFGSDKPDLRFGIELVECTEYFPYVGAVVMPWQEFAKQRGFFAAGPAKGARALLGATRIEIAKRLDLIDPNAWAFTWVVDFPMFEAADEATAAGDVAVGSGAWTAMHHAFTAPKPDSVDTFDSDPGNALSDAYDIVCNGNEIGGGSIRIHRRDIQERVFAMMGIDHDEAQEKFGFLLDAFSYGAPPHGGIAFGWDRITALLAGVDSIREVIAFPKSGGGVDPLTDAPAPITPQQRKESGID 4o3a A 1.8 BS01 ASP A 1 Y61 T91 R96 G141 S142 T143 E193 Y61 T91 R96 G141 S142 T143 E193 ? 0015276,0016020 Ki=2.57mM -logKd/Ki=2.59, Ki=2.57mM P19491 24673938 302 GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 4o3a B 1.8 BS01 ASP B 1 Y61 L90 T91 R96 L138 S142 E193 Y61 L90 T91 R96 L138 S142 E193 ? 0015276,0016020 Ki=2.57mM P19491 24673938 301 GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 4o3a C 1.8 BS01 ASP C 1 Y61 L90 T91 R96 G141 S142 T143 E193 Y61 L90 T91 R96 G141 S142 T143 E193 ? 0015276,0016020 Ki=2.57mM P19491 24673938 301 GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 4o3c A 1.5 BS01 ASP A 1 Y61 T91 R96 G141 S142 T143 E193 Y61 T91 R96 G141 S142 T143 E193 ? 0015276,0016020 Ki=2.57mM -logKd/Ki=2.59, Ki=2.57mM P19491 24673938 301 GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 4o48 A 2.29 BS01 ASP A 1 T168 I189 R196 D199 T219 G220 T157 I178 R185 D188 T208 G209 0004067,0016787 24669941 402 HMEPVLVVHGGGASCISCERRQRVRQGVIRAASLGHGVLRAGGSAVDAVEAAVAALEDDAEFNAGHGSVLTENGDVEMDASIMDGRDLGAGAVSAVRCIANPIKLARLVMDKTPHCFLTGQGAAKFAADMGISEIPGEQLVTERNRKRLEKERQEKTVGAVALDCKGNVAYATSTGGIVNKMTGRVGDSPCIGSGGYADNSIGAVSTTGHGESILKVNLARLALFHLEQGGKTVDEAADLALGYMKSRLKGLGGLILVSRTGEWVAKWTSTSMPWAAVKGGKVHAGIDLNDTTVTDLC 4o48 B 2.29 BS01 ASP B 1 T168 I189 R196 D199 T219 G220 G222 T157 I178 R185 D188 T208 G209 G211 0004067,0016787 24669941 402 HMEPVLVVHGGGASCISCERRQRVRQGVIRAASLGHGVLRAGGSAVDAVEAAVAALEDDAEFNAGHGSVLTENGDVEMDASIMDGRDLGAGAVSAVRCIANPIKLARLVMDKTPHCFLTGQGAAKFAADMGISEIPGEQLVTERNRKRLEKERQEKTVGAVALDCKGNVAYATSTGGIVNKMTGRVGDSPCIGSGGYADNSIGAVSTTGHGESILKVNLARLALFHLEQGGKTVDEAADLALGYMKSRLKGLGGLILVSRTGEWVAKWTSTSMPWAAVKGGKVHAGIDLNDTTVTDLC 4o7t A 2.1 BS03 ASP A 1 A33 F34 D35 K210 R214 A22 F23 D24 K199 R203 6.3.2.6 0004639,0005524,0006164,0006189,0009236,0016874 O57978 303 AKKMIPIDDDKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKLLEEHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVELYYKNDELHDPMINYYHAKVLGISLDEIKKIEEIALKVNEILKDYLAKKGIILVDFKLEFGKDKNGDIVLADEISPDTCRFWDAKTKRSLDKDVFRFDKGDLIEAYKEIYERITGEKP 4pu6 B 2.3 BS01 ASP B 1 T196 R224 D227 T246 G247 G249 T1 R29 D32 T51 G52 G54 T196 T214 R224 T246 G247 T1 T19 R29 T51 G52 3.5.1.1 0016787 V7CU13 25004963 501 TVGCVVVDREGRCAAATSTGGLMNKMTGRIGDSPLIGAGTYACDVCGVSCTGEGEAIIRGTLAREVAAVMEYKGLKLHQAVDFVIKHRLDEGKAGLIAVSNTGEVACGFNCNGMFRACATEDGFMEVAIWD 4pvr A 1.75 BS01 ASP A 1 T168 R196 D199 T219 G220 G222 T158 R186 D189 T209 G210 G212 N62 T168 T186 R196 T219 G220 N63 T158 T176 R186 T209 G210 3.4.19.5,3.5.1.1 0001917,0003948,0004067,0005634,0005737,0005829,0006508,0008233,0008798,0016787,0033345 Q7L266 22861376 402 HMNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHNLGTVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP 4pvr B 1.75 BS01 ASP B 1 T168 R196 D199 T219 G220 G222 T155 R183 D186 T206 G207 G209 N62 T168 T186 R196 T219 G220 N63 T155 T173 R183 T206 G207 3.4.19.5,3.5.1.1 0001917,0003948,0004067,0005634,0005737,0005829,0006508,0008233,0008798,0016787,0033345 Q7L266 22861376 402 HMNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHTVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP 4pvs A 1.84 BS01 ASP A 1 T168 R196 D199 T219 G220 G222 T155 R183 D186 T206 G207 G209 N62 T168 T186 R196 T219 G220 N63 T155 T173 R183 T206 G207 3.4.19.5,3.5.1.1 0001917,0003948,0004067,0005634,0005737,0005829,0006508,0008233,0008798,0016787,0033345 Q7L266 22861376 402 HMNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHTVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP 4pvs B 1.84 BS01 ASP B 1 T168 R196 D199 T219 G220 G222 T155 R183 D186 T206 G207 G209 N62 T168 T186 R196 T219 G220 N63 T155 T173 R183 T206 G207 3.4.19.5,3.5.1.1 0001917,0003948,0004067,0005634,0005737,0005829,0006508,0008233,0008798,0016787,0033345 Q7L266 22861376 402 HMNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHTVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP 4r8l A 2.41 BS01 ASP A 1 T19 D84 S85 G115 T116 D117 T12 D77 S78 G108 T109 D110 T19 V28 T116 D117 K188 T12 V21 T109 D110 K181 3.5.1.1 H0W0T5 25320094 700 ERHLLLIYTGGTLGMQSKGGVLVPGPGLVTLLRTLPMFHDKEFAQAQGLPDHALALPPASHGPRVLYTVLECQPLLDSSDMTIDDWIRIAKIIERHYEQYQGFVVIHGTDTMASGASMLSFMLENLHKPVILTGAQVPIRVLWNDARENLLGALLVAGQYIIPEVCLFMNSQLFRGNRVTKVDSQKFEAFCSPNLSPLATVGADVTIAWDLVRKVKWKDPLVVHSNMEHDVALLRLYPGIPASLVRAFLQPPLKGVVLETFGSGNGPSKPDLLQELRAAAQRGLIMVNCSQCLRGSVTPGYATSLAGANIVSGLDMTSEAALAKLSYVLGLPELSLERRQELLAKDLRGEMTLP 4r8l B 2.41 BS01 ASP B 1 T19 D84 S85 G115 T116 D117 T12 D77 S78 G108 T109 D110 T19 V28 T116 D117 K188 T12 V21 T109 D110 K181 3.5.1.1 H0W0T5 25320094 700 ERHLLLIYTGGTLGMQSKGGVLVPGPGLVTLLRTLPMFHDKEFAQAQGLPDHALALPPASHGPRVLYTVLECQPLLDSSDMTIDDWIRIAKIIERHYEQYQGFVVIHGTDTMASGASMLSFMLENLHKPVILTGAQVPIRVLWNDARENLLGALLVAGQYIIPEVCLFMNSQLFRGNRVTKVDSQKFEAFCSPNLSPLATVGADVTIAWDLVRKVKWKDPLVVHSNMEHDVALLRLYPGIPASLVRAFLQPPLKGVVLETFGSGNGPSKPDLLQELRAAAQRGLIMVNCSQCLRGSVTPGYATSLAGANIVSGLDMTSEAALAKLSYVLGLPELSLERRQELLAKDLRGEMTLPT 4r8l C 2.41 BS01 ASP C 1 T19 D84 S85 G115 T116 D117 T12 D77 S78 G108 T109 D110 T19 V28 T116 D117 K188 T12 V21 T109 D110 K181 3.5.1.1 H0W0T5 25320094 700 ERHLLLIYTGGTLGMQSKGGVLVPGPGLVTLLRTLPMFHDKEFAQAQGLPDHALALPPASHGPRVLYTVLECQPLLDSSDMTIDDWIRIAKIIERHYEQYQGFVVIHGTDTMASGASMLSFMLENLHKPVILTGAQVPIRVLWNDARENLLGALLVAGQYIIPEVCLFMNSQLFRGNRVTKVDSQKFEAFCSPNLSPLATVGADVTIAWDLVRKVKWKDPLVVHSNMEHDVALLRLYPGIPASLVRAFLQPPLKGVVLETFGSGNGPSKPDLLQELRAAAQRGLIMVNCSQCLRGSVTPGYATSLAGANIVSGLDMTSEAALAKLSYVLGLPELSLERRQELLAKDLRGEMTLP 4r8l D 2.41 BS01 ASP D 1 T19 D84 S85 G115 T116 D117 T12 D77 S78 G108 T109 D110 T19 V28 T116 D117 K188 T12 V21 T109 D110 K181 3.5.1.1 H0W0T5 25320094 700 ERHLLLIYTGGTLGMQSKGGVLVPGPGLVTLLRTLPMFHDKEFAQAQGLPDHALALPPASHGPRVLYTVLECQPLLDSSDMTIDDWIRIAKIIERHYEQYQGFVVIHGTDTMASGASMLSFMLENLHKPVILTGAQVPIRVLWNDARENLLGALLVAGQYIIPEVCLFMNSQLFRGNRVTKVDSQKFEAFCSPNLSPLATVGADVTIAWDLVRKVKWKDPLVVHSNMEHDVALLRLYPGIPASLVRAFLQPPLKGVVLETFGSGNGPSKPDLLQELRAAAQRGLIMVNCSQCLRGSVTPGYATSLAGANIVSGLDMTSEAALAKLSYVLGLPELSLERRQELLAKDLRGEMTLPT 4rxm B 1.75 BS02 ASP B 1 L205 K206 E207 L183 K184 E185 403 KDELVVFSLPNLSSPFEVQLQKVAVETSKKLEIKLQVLDGQSSSTKQASDLENAITRGAKGIIISPNDVNAISGAVEEIIKEKIPAATLDRKVESSKPVPHFGANNYTGGQEVAKAVKAKYPNGAKIILLTGQPGSTSNIERTKGIRDELAAGGDKYKIVVDQTGNWLRSEGLRIIESVLPTLKEKPEVIISANDDMALGAIEALRSQGLKAGDILVTGFDSTPEALARVKDGWLYLTADQRPSFAVSTALEQVVGNIRESKEVSGADYPPKIILKDNLQEAERFAEI 4uc9 A 2.4 BS01 ASP A 1 Y135 R150 Y102 R117 ? 0003723,0019013 P03418 26246564 1300 SIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYG 4uc9 C 2.4 BS01 ASP C 1 Y135 E144 R150 Y103 E112 R118 ? 0003723,0019013 P03418 26246564 1300 SIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGL 4uc9 D 2.4 BS01 ASP D 1 Y135 R150 Y100 R115 ? 0003723,0019013 P03418 26246564 1300 SIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDIMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYG 4ufa A 1.8 BS03 ASP A 1 Q259 K489 Y498 Q256 K486 Y495 H331 A332 H361 E362 H365 E389 H491 Y501 H328 A329 H358 E359 H362 E386 H488 Y498 3.4.15.1 0006508,0008237,0008241,0016020 P12821 26403559 1302 LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSQMSRIYSTAKVCLTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEG 4ufa B 1.8 BS03 ASP B 1 Q259 K489 Y498 Q256 K486 Y495 H331 A332 H361 E362 H365 E389 H491 Y501 H328 A329 H358 E359 H362 E386 H488 Y498 3.4.15.1 0006508,0008237,0008241,0016020 P12821 26403559 1302 LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSQMSRIYSTAKVCLTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEG 4wj4 A 3.294 BS02 ASP A 1 S196 Q198 H451 R490 L532 S195 Q197 H450 R489 L531 R220 E222 R228 Q229 E483 G486 R538 R219 E221 R227 Q228 E482 G485 R537 6.1.1.23 0000166,0003676,0004812,0004815,0005524,0005737,0006412,0006418,0006422,0016874,0050560 Q51422 25548166 600 MRSHYCGQLNESLDGQEVTLCGWVHRRRDHGGVIFLDVRDREGLAQVVFDPDRAETFAKADRVRSEFVVKITGKVRLRPEGARNPNMASGSIEVLGYELEVLNQAETPPFPLDEYSDVGEETRLRYRFIDLRRPEMAAKLKLRARITSSIRRYLDDNGFLDVETPILGRPTPEGARDYLVPSRTYPGHFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDIETSFLDESDIIGITEKMVRQLFKEVLDVEFDEFPHMPFEEAMRRYGSDKPDLRIPLELVDVADQLKEVEFKVFSGPANDPKGRVAALRVPGAASMPRSQIDDYTKFVGIYGAKGLAYIKVNERAKGVEGLQSPIVKFIPEANLNVILDRVGAVDGDIVFFGADKAKIVCDALGALRIKVGHDLKLLTREWAPMWVVDFPMFEENDDGSLSALHHPFTSPKCTPAELEANPGAALSRAYDMVLNGTELGGGSIRIHDKSMQQAVFRVLGIDEAEQEEKFGFLLDALKYGAPPHGGLAFGLDRLVMLMTGASSIREVIAFPKTQSAGDVMTQAPGSVDGKALRELHIRLRE 4x2s A 4.21 BS01 ASP A 1 S276 S277 S278 T314 G354 V355 P356 G357 A358 G359 R397 T398 S265 S266 S267 T303 G343 V344 P345 G346 A347 G348 R386 T387 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 -logKd/Ki=6.55, Kd=285nM O59010 25652997 501 VLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDRGRTMVNVTGDLTGTAIVAKTE 4x2s B 4.21 BS01 ASP B 1 S276 S277 S278 T314 G354 V355 P356 G357 A358 G359 D394 R397 T398 S271 S272 S273 T309 G349 V350 P351 G352 A353 G354 D389 R392 T393 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 25652997 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDRGRTMVNVTGDLTGTAIVAKTE 4x2s C 4.21 BS01 ASP C 1 S276 S277 S278 T314 G354 V355 P356 G357 A358 G359 D394 R397 T398 S271 S272 S273 T309 G349 V350 P351 G352 A353 G354 D389 R392 T393 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 25652997 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDRGRTMVNVTGDLTGTAIVAKTEGTLV 4xmw A 2.2 BS02 ASP A 1 A260 A262 H297 E298 E320 Y376 Y381 A257 A259 H294 E295 E317 Y373 Y378 E264 H297 E298 H301 E320 N373 Y381 E261 H294 E295 H298 E317 N370 Y378 3.4.11.2 0004177,0005515,0005886,0006508,0008237,0008270,0042802,0046872 P04825 902 QPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNAGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4z9h A 1.452 BS01 ASP B 1 R69 R73 R43 R47 ? 0006935,0007165 P07017 27292793 201 SLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSNQQSNAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQ 4z9h B 1.452 BS01 ASP B 1 R64 Y149 F150 T154 R32 Y117 F118 T122 ? 0006935,0007165 P07017 27292793 201 LHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSNQQSNAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFA 4z9i A 1.57 BS01 ASP B 1 R69 R73 R42 R46 ? 0006935,0007165 P07017 27292793 201 LFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSNQQSNAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQ 4z9i B 1.57 BS01 ASP B 1 R64 Y149 F150 T154 R33 Y118 F119 T123 ? 0006935,0007165 P07017 27292793 201 SLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSNQQSNAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQ 5ama A 1.8 BS01 ASP A 1 H331 A332 T358 E362 H491 H326 A327 T353 E357 H486 H331 A332 H361 E362 H365 E389 H491 Y501 H326 A327 H356 E357 H360 E384 H486 Y496 3.4.15.1 0006508,0008237,0008241,0016020 P12821 26748546 907 LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSQMSRIYSTAKVCLTCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYP 5ama B 1.8 BS01 ASP B 1 H331 T358 E362 H491 H328 T355 E359 H488 H331 A332 H361 E362 H365 E389 H491 Y501 H328 A329 H358 E359 H362 E386 H488 Y498 3.4.15.1 0006508,0008237,0008241,0016020 P12821 26748546 907 LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSQMSRIYSTAKVCLTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYP 5ama C 1.8 BS01 ASP C 1 H331 A332 T358 H361 E362 H491 H326 A327 T353 H356 E357 H486 H331 A332 H361 E362 H365 E389 H491 Y501 H326 A327 H356 E357 H360 E384 H486 Y496 3.4.15.1 0006508,0008237,0008241,0016020 P12821 26748546 907 LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSQMSRIYSTAKVCLTCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLV 5ama D 1.8 BS01 ASP D 1 H331 T358 H361 E362 H491 H326 T353 H356 E357 H486 H331 A332 H361 E362 H365 E389 H491 Y501 H326 A327 H356 E357 H360 E384 H486 Y496 3.4.15.1 0006508,0008237,0008241,0016020 P12821 26748546 907 LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSQMSRIYSTAKVCLTCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGID 5b5u A 2.61 BS03 ASP A 1 T11 D51 S52 G82 T83 D84 S109 M110 T11 D51 S52 G82 T83 D84 S109 M110 T11 Y21 T83 D84 K154 T11 Y21 T83 D84 K154 3.5.1.1 Q8TZE8 33303914 201 MKILLIGMGGTIASVKGENGYEASLSVKEVLDIAGIKDCEDCDFLDLKNVDSTLIQPEDWVDLAETLYKNVKKYDGIIVTHGTDTLAYTSSMISFMLRNPPIPIVFTGSMIPATEENSDAPLNLQTAIKFATSGIRGVYVAFNGKVMLGVRTSKVRTMSRDAFESINYPIIAELR 5cfy A 3.5 BS01 ASP A 1 R276 S277 S278 T314 Y317 G354 G357 G359 D394 T398 R271 S272 S273 T309 Y312 G349 G352 G354 D389 T393 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 24842876 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGATMVNVTGDLTGTAIVAKTE 5cfy B 3.5 BS01 ASP B 1 R276 S277 S278 M311 T314 Y317 T352 G354 V355 G359 D394 T398 R271 S272 S273 M306 T309 Y312 T347 G349 V350 G354 D389 T393 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 24842876 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGATMVNVTGDLTGTAIVAKTE 5cfy C 3.5 BS01 ASP C 1 R276 S277 M311 T314 Y317 G354 V355 G357 G359 D394 T398 N401 R271 S272 M306 T309 Y312 G349 V350 G352 G354 D389 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 24842876 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGATMVNVTGDLTGTAIVAKTE 5cfy D 3.5 BS01 ASP D 1 R276 S277 M311 T314 Y317 G354 V355 G357 G359 D394 T398 N401 R271 S272 M306 T309 Y312 G349 V350 G352 G354 D389 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 24842876 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGATMVNVTGDLTGTAIVAKTE 5cfy E 3.5 BS01 ASP E 1 R276 S277 S278 T314 Y317 G354 G357 G359 D394 T398 N401 R271 S272 S273 T309 Y312 G349 G352 G354 D389 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 24842876 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGATMVNVTGDLTGTAIVAKTE 5cfy F 3.5 BS01 ASP F 1 R276 S277 S278 M311 T314 Y317 G354 V355 G359 D394 T398 R271 S272 S273 M306 T309 Y312 G349 V350 G354 D389 T393 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 24842876 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGATMVNVTGDLTGTAIVAKTE 5e9s A 2.8 BS01 ASP A 1 R278 S279 S280 T317 G357 V358 A361 G362 D398 R401 T402 R274 S275 S276 T313 G353 V354 A357 G358 D394 R397 T398 ? 0015293,0016020,0046942,0055085 Q5JID0 27830699 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWISH 5e9s B 2.8 BS01 ASP B 1 R278 S279 S280 M314 T317 T355 A356 V358 A361 G362 R401 T402 N405 R274 S275 S276 M310 T313 T351 A352 V354 A357 G358 R397 T398 N401 ? 0015293,0016020,0046942,0055085 Q5JID0 27830699 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWISH 5e9s C 2.8 BS01 ASP C 1 R278 S279 S280 T317 T355 G357 V358 G362 D398 R401 T402 R274 S275 S276 T313 T351 G353 V354 G358 D394 R397 T398 ? 0015293,0016020,0046942,0055085 Q5JID0 27830699 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 5f52 A 1.63 BS01 ASP A 1 T15 A61 S62 E63 G94 T95 D96 T12 A58 S59 E60 G91 T92 D93 T15 Y29 T95 D96 K168 T12 Y26 T92 D93 K165 3.5.1.1 0004067,0006520,0006528,0016787 P06608 26855287 401 LPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5f52 B 1.63 BS01 ASP B 1 T15 A61 S62 E63 G94 T95 D96 T12 A58 S59 E60 G91 T92 D93 T15 Y29 T95 D96 K168 T12 Y26 T92 D93 K165 3.5.1.1 0004067,0006520,0006528,0016787 P06608 26855287 401 LPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5f52 C 1.63 BS01 ASP C 1 T15 A61 S62 E63 G94 T95 D96 T12 A58 S59 E60 G91 T92 D93 T15 Y29 T95 D96 K168 T12 Y26 T92 D93 K165 3.5.1.1 0004067,0006520,0006528,0016787 P06608 26855287 401 LPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5f52 D 1.63 BS01 ASP D 1 T15 A61 S62 E63 G94 T95 D96 T12 A58 S59 E60 G91 T92 D93 T15 Y29 T95 D96 K168 T12 Y26 T92 D93 K165 3.5.1.1 0004067,0006520,0006528,0016787 P06608 26855287 401 LPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5fdn A 2.2 BS01 ASP A 1 R644 Q676 K832 R891 N966 R625 Q657 K801 R860 N912 H173 R452 E563 D600 R638 R770 H159 R433 E544 D581 R619 R739 4.1.1.31 0003824,0005737,0005829,0006099,0008964,0015977,0015979,0016829 Q84VW9 1001 QLRQLVPAKVSEDDKLVEYDALLLDRFLDILQDLHGEDLRETVQELYELSAEYEGKREPSKLEELGSVLTSLDPGDSIVISKAFSHMLNLANLAEEVQIAHRRRIKKLKKGDFVDESSATTESDIEETFKRLVSDLGKSPEEIFDALKNQTVDLVLTAHPTQSVRRSLLQKHGRIRDCLAQLYAKDITPDDKQELDESLQREIQAAFRTDEIRRTPPTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGIDERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAANLYYNQIENLMFELSMWRCTDEFRVRADELHRNAKHYIEFWKTIPPTEPYRVILGDVRDKLYHTRERSRQLLSNGISDIPEEATFTNVEQFLEPLELCYRSLCSCGDSPIADGSLLDFLRQVSTFGLSLVRLDIRQESERHTDVLDAITKHLDIGSSYRDWSEEGRQEWLLAELSGKRPLFGPDLPKTEEISDVLDTFKVISELPSDCFGAYIISMATSPSDVLAVELLQRECHVKNPLRVVPLFEKLADLEAAPAAVARLFSIDWYKNRINGKQEVMIGYSDSGKDAGRLSAAWELYKAQEELVKVAKKYGVKLTMFHGRGGTVGRGGGPTHLAILSQPPDTVNGSLRVTVQGEVIEQSFGEAHLCFRTLQRFTAATLEHGMNPPISPKPEWRALLDEMAVVATEEYRSVVFQEPRFVEYFRLATPELEYGRMGGIESLRAIPWIFAWTQTRFHLPVWLGFGAAFRYAIKKDVRNLHMLQDMYKQWPFFRVTIDLIEMVFAKGDPGIAALYDKLLVSEDLWAFGEKLRANFDETKNLVLQTAGHKDLLEGDPYLKQRLRLRDSYITTLNVCQAYTLKRIRDANYNVTLRPHISKGLEDTLILTMKGIAAGLQNTG 5fdn B 2.2 BS01 ASP B 1 R644 Q676 K832 R891 N966 R611 Q643 K787 R846 N898 H173 R452 E563 D600 R638 R770 H161 R419 E530 D567 R605 R725 4.1.1.31 0003824,0005737,0005829,0006099,0008964,0015977,0015979,0016829 Q84VW9 1001 DAQLRQLVPAKVSEDDKLVEYDALLLDRFLDILQDLHGEDLRETVQELYELSAEYEGKREPSKLEELGSVLTSLDPGDSIVISKAFSHMLNLANLAEEVQIAHRRRIKKLKKGDFVDESSATTESDIEETFKRLVSDLGKSPEEIFDALKNQTVDLVLTAHPTQSVRRSLLQKHGRIRDCLAQLYAKDITPDDKQELDESLQREIQAAFRTPQDEMRAGMSYFHETIWKGVPKFLRRVDTALKNIGIDERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAANLYYNQIENLMFELSMWRCTDEFRVRADELIEFWKTIPPTEPYRVILGDVRDKLYHTRERSRQLLSNGISDIPEEATFTNVEQFLEPLELCYRSLCSCGDSPIADGSLLDFLRQVSTFGLSLVRLDIRQESERHTDVLDAITKHLDIGSSYRDWSEEGRQEWLLAELSGKRPLFGPDLPKTEEISDVLDTFKVISELPSDCFGAYIISMATSPSDVLAVELLQRECHVKNPLRVVPLFEKLADLEAAPAAVARLFSIDWYKNRINGKQEVMIGYSDSGKDAGRLSAAWELYKAQEELVKVAKKYGVKLTMFHGRGGTVGRGGGPTHLAILSQPPDTVNGSLRVTVQGEVIEQSFGEAHLCFRTLQRFTAATLEHGMNPPISPKPEWRALLDEMAVVATEEYRSVVFQEPRFVEYFRLATPELEYGRMNIIESLRAIPWIFAWTQTRFHLPVWLGFGAAFRYAIKKDVRNLHMLQDMYKQWPFFRVTIDLIEMVFAKGDPGIAALYDKLLVSEDLWAFGEKLRANFDETKNLVLQTAGHKDLLEGDPYLKQRLRLRDSYITTLNVCQAYTLKRIRDANYNVTLRPHISKGLEDTLILTMKGIAAGLQNTG 5hrc A 1.765 BS01 ASP A 1 M10 T83 N84 T85 T125 C197 T198 E199 M10 T83 N84 T85 T125 C197 T198 E199 S14 I48 T83 T85 T125 C166 C197 S14 I48 T83 T85 T125 C166 C197 0016855,0036361,0047661 27001440 301 MKTIGLLGGMSWESTIPYYRLINEGIKQRLGGLHSAQVLLHSVDFHEIEECQRRGEWDKTGDILAEAALGLQRAGAEGIVLCTNTMHKVADAIESRCTLPFLHIADATGRAITGAGMTRVALLGTRYTMEQDFYRGRLTEQFSINCLIPEADERAKINQIIFEELCLGQFTEASRAYYAQVIARLAEQGAQGVIFGCTEIGLLVPEERSVLPVFDTAAIHAEDAVAFMLSLE 5hrc B 1.765 BS01 ASP B 1 M10 T83 N84 T85 C197 T198 E199 M10 T83 N84 T85 C197 T198 E199 I48 T83 T85 T125 C166 C197 I48 T83 T85 T125 C166 C197 0016855,0036361,0047661 27001440 301 MKTIGLLGGMSWESTIPYYRLINEGIKQRLGGLHSAQVLLHSVDFHEIEECQRRGEWDKTGDILAEAALGLQRAGAEGIVLCTNTMHKVADAIESRCTLPFLHIADATGRAITGAGMTRVALLGTRYTMEQDFYRGRLTEQFSINCLIPEADERAKINQIIFEELCLGQFTEASRAYYAQVIARLAEQGAQGVIFGCTEIGLLVPEERSVLPVFDTAAIHAEDAVAFMLSL 5i3z A 2.05 BS01 ASP A 1 T15 A61 S62 Q63 G94 T95 D96 T13 A59 S60 Q61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 KLPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5i3z B 2.05 BS01 ASP B 1 T15 A61 S62 Q63 G94 T95 D96 A120 T13 A59 S60 Q61 G92 T93 D94 A118 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 KLPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5i3z C 2.05 BS01 ASP C 1 T15 A61 S62 Q63 G94 T95 D96 T13 A59 S60 Q61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 KLPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5i3z D 2.05 BS01 ASP D 1 T15 A61 S62 Q63 G94 T95 D96 A120 T13 A59 S60 Q61 G92 T93 D94 A118 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 KLPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5i48 A 1.5 BS01 ASP A 1 T15 A61 S62 Q63 G94 T95 D96 T12 A58 S59 Q60 G91 T92 D93 T15 Y29 T95 D96 K168 T12 Y26 T92 D93 K165 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 LPNIVILATGGTIAGSAATGTQTTGYKIGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5i48 B 1.5 BS01 ASP B 1 T15 A61 S62 G94 T95 D96 T12 A58 S59 G91 T92 D93 T15 Y29 T95 D96 K168 T12 Y26 T92 D93 K165 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 LPNIVILATGGTIAGSAATGTQTTGYKIGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5i48 C 1.5 BS01 ASP C 1 T15 A61 S62 Q63 G94 T95 D96 T12 A58 S59 Q60 G91 T92 D93 T15 Y29 T95 D96 K168 T12 Y26 T92 D93 K165 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 LPNIVILATGGTIAGSAATGTQTTGYKIGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5i48 D 1.5 BS01 ASP D 1 T15 A61 S62 Q63 G94 T95 D96 T12 A58 S59 Q60 G91 T92 D93 T15 Y29 T95 D96 K168 T12 Y26 T92 D93 K165 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 LPNIVILATGGTIAGSAATGTQTTGYKIGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5i4b A 1.6 BS01 ASP A 1 T15 A61 S62 Q63 G94 T95 D96 T13 A59 S60 Q61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 KLPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGNVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5i4b B 1.6 BS01 ASP B 1 T15 A61 S62 Q63 G94 T95 D96 T13 A59 S60 Q61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 KLPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGNVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5i4b C 1.6 BS01 ASP C 1 T15 A61 S62 Q63 G94 T95 D96 T13 A59 S60 Q61 G92 T93 D94 T15 Y29 T95 D96 K168 T13 Y27 T93 D94 K166 3.5.1.1 0004067,0006520,0006528,0016787 P06608 27354283 400 KLPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGNVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 5jwg A 2.2 BS02 ASP A 1 H85 W218 T648 G649 G650 A652 R670 H65 W198 T628 G629 G630 A632 R650 3.4.14.- 0004177,0005576,0006508,0008236,0008239,0009986,0043171,0070009 F8WQK8 28588213 802 MDGGMWLMQQINGQVARMKSLGMQLEAADIYNPNGSSLKDAVVMFDGGCTGVLVSNQGLLLTNHHCGYDQIQKHSSVQHNYLKDGFWSYSLAEELVNPGLEVEIVDEITDVTAAVKKELERIKKPSGLEFLSPRYLSSLAPEIVGKKAASRPGYRYEIKAFYGGNRYYMFTKKVFRDVRLVAAPPSSIGKFGSDTDNWAWPRHTGDFSIFRLYADKNGNPAEYSKDNVPYRPKRWVKVNAQGVKEGDFALIMGYPGTTYKFFTADEVTEWSEIDNNIRIEMRGILQDVMLREMLADPKINIMYAAKYASSQNGYKRAQGANWAIRRRSLREIKLAQQQEVLAWAKQKGIATTEEAVRAISKAIEGRQDLRMRQRYLLEGILMGIEMSNAPAADSDIADHWDDPARREAGLQSIRKQFEAFFNKDYSPEVEKDQLAIALLTRYAERIPAEKQPISIREGIAEYGSAKAYVEMIFDKSIYASRERFEEFMKNPDRDRLLRDPMSRFAASVAYEHQKLAKEVAAFDAPLAAAQRSYVASVLDMKGQPNLAPDANLTLRFTYGEIKGYQPRDVVTYGAKSTLEGVMEKEDPNNWEYVVDPKLKALYEAKNYGRYANSDGSMPVNFCATTHTTGGNAGSPVMNARGELIGLNFDRNWEGVGGDIEYLPNYQRSIILDIRYLLFIIDKFAGCQRLIDEIQPQFHHHHHH 5jwg B 2.2 BS02 ASP B 1 H85 T648 G649 A652 R670 H65 T625 G626 A629 R647 3.4.14.- 0004177,0005576,0006508,0008236,0008239,0009986,0043171,0070009 F8WQK8 28588213 802 MDGGMWLMQQINGQVARMKSLGMQLEAADIYNPNGSSLKDAVVMFDGGCTGVLVSNQGLLLTNHHCGYDQIQKHSSVQHNYLKDGFWSYSLAEELVNPGLEVEIVDEITDVTAAVKKELERIKKPSGLEFLSPRYLSSLAPEIVGKKAASRPGYRYEIKAFYGGNRYYMFTKKVFRDVRLVAAPPSSIGKFGSDTDNWAWPRHTGDFSIFRLYADKNGNPAEYSKDNVPYRPKRWVKVNAQGVKEGDFALIMGYPGTTYKFFTADEVTEWSEIDNNIRIEMRGILQDVMLREMLADPKINIMYAAKYASSQNGYKRAQGANWAIRRRSLREIKLAQQQEVLAWAKQKGIATTEEAVRAISKAIEGRQDLRMRQRYLLEGILMGIEMSNAPSDIADHWDDPARREAGLQSIRKQFEAFFNKDYSPEVEKDQLAIALLTRYAERIPAEKQPISIREGIAEYGSAKAYVEMIFDKSIYASRERFEEFMKNPDRDRLLRDPMSRFAASVAYEHQKLAKEVAAFDAPLAAAQRSYVASVLDMKGQPNLAPDANLTLRFTYGEIKGYQPRDVVTYGAKSTLEGVMEKEDPNNWEYVVDPKLKALYEAKNYGRYANSDGSMPVNFCATTHTTGGNAGSPVMNARGELIGLNFDRNWEGVGGDIEYLPNYQRSIILDIRYLLFIIDKFAGCQRLIDEIQPQFH 5jxf A 2.1 BS02 ASP A 1 W211 T640 G641 S644 R662 W196 T622 G623 S626 R644 3.4.14.- 0004177,0006508,0008236,0008239,0043171,0070009 A6GWM2 28588213 802 TLQQGGMWIPSLLSGMNETEMKNLGMKISADDIYSVNHSSLKDAVPHFNGGCTSEVISPKGLILTNHHCGFDAIQNHSSVDHDYLTNGFWAMKMEDELPNENLVVTFIVSINDVTAQILDGVASITSETEKQNKIQENITKVTASFAKEAWQENKVRTFFEGNQYILFVTEVFKDVRLVGAPPSLIGKFGSDTDNWVWPRHTGDFSMFRVYANKNNHPAAYSKDNVPYIPKHFLPVSLDGVQEDDFTMVMGYPGKTQEYLPSFAVAQIVNETNPAKIEIREAALKVQDGFMRKDNAIKIQYASKYAGVANYWKKWIGESQGLKKSNAIGLKQNFEKDFQQKVIAAGKQNEYGNLLADFQKYYTEITPYAVSRDYFNEVVVKNTELLSLGYKLYQLEQVFITKGEQAFNDRKENLIKSQADFFKDFNSTVDEKVFEQLVALYATKAPKEFLPISVEYKKFAPSIYSKSKLVDYANFKALLSGDAKAVLKKISLDKGYAFVKSLADNYSKNIAPRYDEINLKINALQRIYMKAQLELYPNSRIFPDANSTLRVTYGKVKGYSPKDAIYYNPTTYLDGAIEKYIPGDYEFDVPKKLIDLYNNKDYGQYGENGKLPVCFIGTNHTTGGNSGSPAVDAQGNLIGLNFDRVWEGTMSDIHYDPSICRNVMVDMRYVLFIVDKFAGAKHLINEMKLVHPKK 5jxf B 2.1 BS02 ASP B 1 W211 T640 G641 S644 R662 W194 T620 G621 S624 R642 3.4.14.- 0004177,0006508,0008236,0008239,0043171,0070009 A6GWM2 28588213 802 QQGGMWIPSLLSGMNETEMKNLGMKISADDIYSVNHSSLKDAVPHFNGGCTSEVISPKGLILTNHHCGFDAIQNHSSVDHDYLTNGFWAMKMEDELPNENLVVTFIVSINDVTAQILDGVASITSETEKQNKIQENITKVTASFAKEAWQENKVRTFFEGNQYILFVTEVFKDVRLVGAPPSLIGKFGSDTDNWVWPRHTGDFSMFRVYANKNNHPAAYSKDNVPYIPKHFLPVSLDGVQEDDFTMVMGYPGKTQEYLPSFAVAQIVNETNPAKIEIREAALKVQDGFMRKDNAIKIQYASKYAGVANYWKKWIGESQGLKKSNAIGLKQNFEKDFQQKVIAAGKQNEYGNLLADFQKYYTEITPYAVSRDYFNEVVVKNTELLSLGYKLYQLEQVFITKGEQAFNDRKENLIKSQADFFKDFNSTVDEKVFEQLVALYATKAPKEFLPLNVEYKKFAPSIYSKSKLVDYANFKALLSGDAKAVLKKISLDKGYAFVKSLADNYSKNIAPRYDEINLKINALQRIYMKAQLELYPNSRIFPDANSTLRVTYGKVKGYSPKDAIYYNPTTYLDGAIEKYIPGDYEFDVPKKLIDLYNNKDYGQYGENGKLPVCFIGTNHTTGGNSGSPAVDAQGNLIGLNFDRVWEGTMSDIHYDPSICRNVMVDMRYVLFIVDKFAGAKHLINEMKLVHPKK 5k3o A 1.696 BS01 ASP A 1 T14 G59 S60 Q61 G92 T93 D94 T12 G57 S58 Q59 G90 T91 D92 T14 Y27 T93 D94 K166 E287 T12 Y25 T91 D92 K164 E285 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 28139703 400 KPQVTILATGGTIAGSGESSVKSSYSAGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRPGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 5k3o B 1.696 BS01 ASP B 1 T14 G59 S60 Q61 G92 T93 D94 A118 T12 G57 S58 Q59 G90 T91 D92 A116 T14 Y27 T93 D94 K166 E287 T12 Y25 T91 D92 K164 E285 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 28139703 400 KPQVTILATGGTIAGSGESSVKSSYSAGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRPGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 5k3o C 1.696 BS01 ASP C 1 T14 G59 S60 Q61 G92 T93 D94 A118 T12 G57 S58 Q59 G90 T91 D92 A116 T14 Y27 T93 D94 K166 E287 T12 Y25 T91 D92 K164 E285 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 28139703 400 KPQVTILATGGTIAGSGESSVKSSYSAGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRPGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 5k3o D 1.696 BS01 ASP D 1 T14 G59 S60 Q61 G92 T93 D94 A118 T12 G57 S58 Q59 G90 T91 D92 A116 T14 Y27 T93 D94 K166 E287 T12 Y25 T91 D92 K164 E285 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 28139703 400 KPQVTILATGGTIAGSGESSVKSSYSAGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRPGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 5k4g A 1.6 BS01 ASP A 1 S60 Q61 G92 T93 D94 S58 Q59 G90 T91 D92 T14 Y27 T93 D94 K166 E287 T12 Y25 T91 D92 K164 E285 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 28139703 400 KPQVTILATGGTIAGSGESSVKSSYSAGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRSGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 5k4g B 1.6 BS01 ASP B 1 G59 S60 Q61 G92 T93 D94 G57 S58 Q59 G90 T91 D92 T14 Y27 T93 D94 K166 E287 T12 Y25 T91 D92 K164 E285 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 28139703 400 KPQVTILATGGTIAGSGESSVKSSYSAGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRSGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 5k4g C 1.6 BS01 ASP C 1 G59 S60 Q61 G92 T93 D94 A118 G57 S58 Q59 G90 T91 D92 A116 T14 Y27 T93 D94 K166 E287 T12 Y25 T91 D92 K164 E285 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 28139703 400 KPQVTILATGGTIAGSGESSVKSSYSAGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRSGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 5k4g D 1.6 BS01 ASP D 1 G59 S60 Q61 G92 T93 D94 G57 S58 Q59 G90 T91 D92 T14 Y27 T93 D94 K166 E287 T12 Y25 T91 D92 K164 E285 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 28139703 400 KPQVTILATGGTIAGSGESSVKSSYSAGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRSGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 5kxj A 1.87 BS01 ASP A 1 E375 S391 L392 C395 E321 S337 L338 C341 Q242 H244 L257 E260 R263 R290 H351 Y352 R386 Q188 H190 L203 E206 R209 R236 H297 Y298 R332 1.4.3.16 0000166,0005737,0008734,0009435,0016491,0019363,0034628 Q8ZMX9 610 MMTTPELSCDVLIIGSGAAGLSLALRLAEKHKVIVLSKGPVDSIASHVEDTLIAGAGICDRHAVEFVASNARTCVQWLIDQGVKEVETTLVSRAQNHPNIQVLERSNAVDLIISDKMGLPGPRRVVGAWIWNRNKEWVETCHAKSVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGSRFMPDVDERGELAPRDIVARAIDHEMKQLGADCMFLDISHKPDDFVRQHFPMIYAKLLDLGMDLTKEPIPVVPAAHYTCGGVVVDDYGRTDVDGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAMDIDRRMPSVHSVDALPAWDESRVENADERVVIQHNWHELRLLMWDYVGIVRTTKRLERALRRITMLQQEIDEYYANFRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPQQLAESGPSILSPLT 5llm A 3.25 BS01 ASP A 1 S344 S345 T382 G422 I423 A426 G427 D456 R459 T460 N463 S265 S266 T303 G334 I335 A338 G339 D368 R371 T372 N375 ? 0015293,0016020 P43003,Q15758 28424515 602 TKEDVKSFLRRNALLLLTVLAVILGVVLGFLLRPYPLSPREVKYFAFPGELLMRMLKMLILPLIVSSLITGLASLDAKASGRLGMRAVVYYMSTTIIAVVLGIILVLIIHPEVLDCFLDLARNIFPSNLVSAAFRSYSTTPVGQEVEGMNILGLVVFSMVFGFALGKMGEQGQLLVDFFNSLNEATMKLVAIIMWYAPLGILFLIAGKIVEGGQLGMYMVTVIVGLVIHGLIVLPLIYFLITRKNPFVFIAGILQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEAVAAIFIAQQIITISITATAASIGAAGIPQAGLVTMVIVLTAVGLPTDDITLIIAVDWLLDRFRTMVNVLGDALGAGIVEHLSRKELEKQDA 5llu A 3.32 BS01 ASP A 1 S343 S344 S345 T382 G422 I423 A426 G427 D456 R459 T460 N463 S254 S255 S256 T293 G328 I329 A332 G333 D362 R365 T366 N369 ? 0015293,0016020 P43003,Q15758 28424515 602 EDVKSFLRRNALLLLTVLAVILGVVLGFLLRPYPLSPREVKYFAFPGELLMRMLKMLILPLIVSSLITGLASLDAKASGRLGMRAVVYYMSTTIIAVVLGIILVLIIEVLDCFLDLARNIFPSNLVSAAFRSYSTTQEVEGMNILGLVVFSIVFGIALGKMGEQGQLLVDFFNSLNEATMKLVAIIMWYAPLGILFLIAGKIVELGMYMVTVIVGLVIHGLIVLPLIYFLITRKNPFVFIAGILQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEAVAAIFIAQVNNGQIITISITATAASIGAAGIPQAGLVTMVIVLTAVGLPTDDITLIIAVDWLLDRFRTMVNVLGDALGAGIVEHLSRKELEKQDAELG 5lm4 A 3.1 BS01 ASP A 1 S344 S345 M379 T382 G422 I423 G427 D456 R459 T460 S253 S254 M288 T291 G325 I326 G330 D359 R362 T363 ? 0015293,0016020 P43003,Q15758 28424515 602 EDVKSFLRRNALLLLTVLAVILGVVLGFLLRPYPLSPREVKYFAFPGELLMRMLKMLILPLIVSSLITGLASLDAKASGRLGMRAVVYYMSTTIIAVVLGIILVLIIEVLDCFLDLARNIFPSNLVSAAFRSYSTQEVEGMNILGLVVFSIVFGIALGKMGEQGQLLVDFFNSLNEATMKLVAIIMWYAPLGILFLIAGKIVEGMYMVTVIVGLVIHGLIVLPLIYFLITRKNPFVFIAGILQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEAVAAIFIAQDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTAVGLPTDDITLIIAVDWLLDRFRTMVNVLGDALGAGIVEHLSRKELEKQD 5mq5 A 1.6 BS01 ASP A 1 T12 G57 S58 Q59 G88 T89 D90 T14 G47 S48 Q49 G78 T79 D80 T12 T89 D90 K162 E283 T14 T79 D80 K152 E273 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 29101342 401 HHLPNITILATGGTIAGGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 5mq5 B 1.6 BS01 ASP B 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 29101342 401 LPNITILATGGTIAGGGDSATKSSYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 5mq5 C 1.6 BS01 ASP C 1 T12 V27 G57 S58 Q59 G88 T89 D90 T12 V27 G57 S58 Q59 G88 T89 D90 T12 T89 D90 K162 E283 T12 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 29101342 401 LPNITILATGGTIAGGGDSATKSSYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 5mq5 D 1.6 BS01 ASP D 1 G11 T12 G57 S58 Q59 G88 T89 D90 G11 T12 G45 S46 Q47 G76 T77 D78 T12 T89 D90 K162 E283 T12 T77 D78 K150 E271 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 29101342 401 LPNITILATGGTIAGGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 5oxm A 2.295 BS19 ASP A 1 Y30 E299 N328 Y25 E287 N316 ? 0005886,0006857,0015833,0016020,0022857,0042802,0055085,1904680 -logKd/Ki=1.30, Kd>50mM Q5M4H8 29429879 521 KTFFGQPLGLSTLFMTEMWERFSYYGMRAILLYYMWFLISTGDLHITRATAASIMAIYASMVYLSGTIGGFVADRIIGARPAVFWGGVLIMLGHIVLALPFGASALFGSIILIIIGTGFLKPNVSTLVGTLYDEHDRRRDAGFSIFVFGINLGAFIAPLIVGAAQEAAGYHVAFSLAAIGMFIGLLVYYFGGKKTLDPHYLRPTDPLAPEEVKPLLVKVSLAVAGFIAIIVVMNLVGWNSLPAYINLLTIVAIAIPVFYFAWMSTEHLRVVSYIPLFIAAVLFWAIEEQGSVVLATFAAERVDSSWFPVSWFQSLNPLFIMLYTPFFAWLWTAQPSSPTKFAVGLMFAGLSFLLMAIPGALYGTSGKVSPLWLVGSWALVILGEMLISPVMSMWFLSSSVGSALNAQLVTLYNAKSEVAYFSYFGLGSVVLGIVLVFLS 5w25 A 2.65 BS01 ASP A 1 E173 Q197 R219 H451 H452 G488 R492 E174 Q198 R220 H452 H453 G489 R493 R219 E221 R227 Q228 E485 G488 R540 R220 E222 R228 Q229 E486 G489 R541 6.1.1.23 0000166,0003676,0004812,0004815,0005524,0005737,0006412,0006418,0006422,0009274,0016874,0050560 P9WFW3 701 FVLRSHAAGLLREGDAGQQVTLAGWVARRRDHGGVIFIDLRDASGIAQVVFRDPQDTEVLAQAHRLRAEFCVSVAGVVEIRPEGNANPEIATGEIEVNATSLTVLGECAPLPFQLDEPAGEELRLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLARHDFVEIETPTITRSTPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDAEDIIAISEEVLTELWALIGYRIPTPIPRIGYAEAMRRFGTDKPDLRFGLELVECTDFFSDTTFRVFQAPYVGAVVMPGGASQPRRTLDGWQDWAKQRGHRGLAYVLVAEDGTLGGPVAKNLTEAERTGLADHVGAKPGDCIFFSAGPVKSSRALLGAARVEIANRLGLIDPDAWAFVWVVDPPLFEPADEATAAGEVAVGSGAWTAVHHAFTAPKPEWEDRIESDTGSVLADAYDIVCNGHEIGGGSVRIHRRDIQERVFAVMGLDKAEAEEKFGFLLEAFMFGAPPHGGIAFGWDRTTALLAGMDSIREVIAFPKTGGGVDPLTDAPAPITAQQRKES 5w25 B 2.65 BS01 ASP B 1 E173 Q197 R219 H451 H452 G488 G489 R492 I534 A535 E174 Q198 R220 H435 H436 G472 G473 R476 I518 A519 R219 E221 R227 Q228 E485 G488 R540 R220 E222 R228 Q229 E469 G472 R524 6.1.1.23 0000166,0003676,0004812,0004815,0005524,0005737,0006412,0006418,0006422,0009274,0016874,0050560 P9WFW3 701 FVLRSHAAGLLREGDAGQQVTLAGWVARRRDHGGVIFIDLRDASGIAQVVFRDPQDTEVLAQAHRLRAEFCVSVAGVVEIRPEGNANPEIATGEIEVNATSLTVLGECAPLPFQLDEPAGEELRLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLARHDFVEIETPTITRSTPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDMEMSFVDAEDIIAISEEVLTELWALIGYRIPTPIPRIGYAEAMRRFGTDKPDLRFGLELVECTDFFSDTTFRVFQAPYVGAVVMPGGASQPRLAYVLVAEDGTLGGPVAKNLTEAERTGLADHVGAKPGDCIFFSAGPVKSSRALLGAARVEIANRLGLIDPDAWAFVWVVDPPLFEPADEATAAGEVAVGSGAWTAVHHAFTAPKPEWEDRIESDTGSVLADAYDIVCNGHEIGGGSVRIHRRDIQERVFAVMGLDKAEAEEKFGFLLEAFMFGAPPHGGIAFGWDRTTALLAGMDSIREVIAFPKTGGGVDPLTDAPAPITAQQRKES 5wxy A 2.63 BS01 ASP A 1 M14 R53 S87 C88 T89 K167 S195 T196 E197 M10 R49 S83 C84 T85 K163 S191 T192 E193 R53 S87 T89 T129 K167 S195 R49 S83 T85 T125 K163 S191 ? 0016853,0016855,0036361 Q9RNB4 31101340 301 LPILGVLGGMGPVVTAEFLKSIYEYNPFIDKEQESPNVIVFSFPSAPDRTGSIDSGKEREFIDFIQVNLEHLNKLADCIVIGSCTAHYALPQIPENLKDKLISLIKIADQELQEYNEPTLLLASTGTYQKKLFQEGCTTADLIISLSESDQKLIHEMIYKVLKRGHDPLSILRDIEALLEKYNTRSYISGSTEFHLLTKSLKLKGIDSIKAIDPLSTIAQNFSQLII 5zie A 2.0 BS01 ASP A 1 E134 S273 A275 S276 E277 H310 E311 H314 E333 R375 Y383 E122 S261 A263 S264 E265 H298 E299 H302 E321 R363 Y371 3.4.11.2 0004177,0006508,0008237,0008270,0046872 Q5ZVE3 30172821 911 SKVKKLSDYKSLDYFVIHVDLQIDLSKKPVESKARLTVVPNLNVDSHSNDLVLDGENMTLVSLQMNDNLLKENEYELTKDSLIIKNIPQNTPFTIEMTSLLGENTDLFGLYETEGVALVKAESEGLRRVFYLPDRPDNLATYKTTIIANQEDYPVLLSNGVLIEKKELPLGLHSVTWLDDVPKPSYLFALVAGNLQRSVTYYQTKSGRELPIEFYVPPSATSKCDFAKEVLKEAMAWDERTFNLECALRQHMVAGVDKYASGASEPTGLNLFNTENLFASPETKTDLGILRVLEVVAHEFFHYWSGDRVTIRDWFNLPLKEGLTTFRAAMFREELFGTDLIRLLDGKNLDERAPRQSAYTAVRSLYTAAAYEKSADIFRMMMLFIGKEPFIEAVAKFFKDNDGGAVTLEDFIESISNSSGKDLRSFLSWFTESGIPELIVTDELNPDTKQYFLKIKTVNGRNRPIPILMGLLDSSGAEIVADKLLIVDQEEIEFQFENIQTRPIPSLLRSFSAPVHMKYEYSYQDLLLLMQFDTNLYNRCEAAKQLISALINDFCIGKKIELSPQFFAVYKALLSDNSLNEWMLAELITLPSLEELIENQDKPDFEKLNEGRQLIQNALANELKTDFYNLLFRIQISGDDDKQKLKGFDLKQAGLRRLKSVCFSYLLNVDFEKTKEKLILQFEDALGKNMTETALALSMLCEINCEEADVALEDYYHYWKNDPGAVNNWFSIQALAHSPDVIERVKKLMRHGDFDLSNPNKVYALLGSFIKNPFGFHSVTGEGYQLVADAIFDLDKINPTLAANLTEKFTYWDKYDVNRQAMMISTLKIIYSNATSSDVRTMAKKGLDKV 5zie B 2.0 BS01 ASP B 1 K132 E134 S273 A275 S276 E277 H310 E311 H314 E333 R375 Y383 K120 E122 S261 A263 S264 E265 H298 E299 H302 E321 R363 Y371 3.4.11.2 0004177,0006508,0008237,0008270,0046872 Q5ZVE3 30172821 911 SKVKKLSDYKSLDYFVIHVDLQIDLSKKPVESKARLTVVPNLNVDSHSNDLVLDGENMTLVSLQMNDNLLKENEYELTKDSLIIKNIPQNTPFTIEMTSLLGENTDLFGLYETEGVALVKAESEGLRRVFYLPDRPDNLATYKTTIIANQEDYPVLLSNGVLIEKKELPLGLHSVTWLDDVPKPSYLFALVAGNLQRSVTYYQTKSGRELPIEFYVPPSATSKCDFAKEVLKEAMAWDERTFNLECALRQHMVAGVDKYASGASEPTGLNLFNTENLFASPETKTDLGILRVLEVVAHEFFHYWSGDRVTIRDWFNLPLKEGLTTFRAAMFREELFGTDLIRLLDGKNLDERAPRQSAYTAVRSLYTAAAYEKSADIFRMMMLFIGKEPFIEAVAKFFKDNDGGAVTLEDFIESISNSSGKDLRSFLSWFTESGIPELIVTDELNPDTKQYFLKIKTVNGRNRPIPILMGLLDSSGAEIVADKLLIVDQEEIEFQFENIQTRPIPSLLRSFSAPVHMKYEYSYQDLLLLMQFDTNLYNRCEAAKQLISALINDFCIGKKIELSPQFFAVYKALLSDNSLNEWMLAELITLPSLEELIENQDKPDFEKLNEGRQLIQNALANELKTDFYNLLFRIQISGDDDKQKLKGFDLKQAGLRRLKSVCFSYLLNVDFEKTKEKLILQFEDALGKNMTETALALSMLCEINCEEADVALEDYYHYWKNDPGAVNNWFSIQALAHSPDVIERVKKLMRHGDFDLSNPNKVYALLGSFIKNPFGFHSVTGEGYQLVADAIFDLDKINPTLAANLTEKFTYWDKYDVNRQAMMISTLKIIYSNATSSDVRTMAKKGLDKV 6a4r A 1.828 BS01 ASP A 1 G87 G88 S120 A121 N124 T133 N134 D135 P156 H157 G93 G94 S126 A127 N130 T139 N140 D141 P162 H163 3.4.13.21 0005737,0006508,0008236,0016805 P36936 30194851 301 NLYFQGSELLLLSNSTLPGKAWLEHALPLIANQLNGRRSAVFIPFAGVTQTWDEYTDKTAEVLAPLGVNVTGIHRVADPLAAIEKAEIIIVGGGNTFQLLKESRERGLLAPMADRVKRGALYIGWSAGANLACPTIRTTNDMPIVDPNGFDALDLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTVIGLPEGNWIQVSNGQAVLGGPNTTWVFKAGEEAVALEAGHRF 6a4r B 1.828 BS01 ASP B 1 G87 G88 S120 A121 N124 T133 N134 D135 P156 H157 G88 G89 S121 A122 N125 T134 N135 D136 P157 H158 3.4.13.21 0005737,0006508,0008236,0016805 P36936 30194851 301 GSELLLLSNSTLPGKAWLEHALPLIANQLNGRRSAVFIPFAGVTQTWDEYTDKTAEVLAPLGVNVTGIHRVADPLAAIEKAEIIIVGGGNTFQLLKESRERGLLAPMADRVKRGALYIGWSAGANLACPTIRTTNDMPIVDPNGFDALDLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTVIGLPEGNWIQVSNGQAVLGGPNTTWVFKAGEEAVALEAGHRF 6b5z A 2.3 BS02 ASP A 1 R29 G93 Y97 R29 G93 Y97 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 306 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b5z A 2.3 BS03 ASP A 2 N151 K164 R165 N151 K164 R165 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 307 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b5z B 2.3 BS02 ASP B 1 N151 K164 R165 N151 K164 R165 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 303 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b5z B 2.3 BS03 ASP B 2 R11 Y118 E125 R11 Y118 E125 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 304 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b5z B 2.3 BS04 ASP B 3 R29 G93 Y97 R29 G93 Y97 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 305 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b61 A 2.7 BS02 ASP A 1 R29 G93 Y97 R29 G93 Y97 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 304 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b61 A 2.7 BS03 ASP A 2 D85 Y155 A172 R191 D85 Y155 A172 R191 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 305 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b61 A 2.7 BS04 ASP A 3 K164 R165 K164 R165 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 306 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b61 A 2.7 BS05 ASP A 4 R165 R167 R165 R167 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 307 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b61 B 2.7 BS01 ASP A 4 T87 F88 T87 F88 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 307 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b61 B 2.7 BS03 ASP B 1 N151 K164 R165 N151 K164 R165 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 303 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b61 B 2.7 BS04 ASP B 2 R165 R167 R165 R167 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 304 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b61 B 2.7 BS05 ASP B 3 Y118 E125 Y118 E125 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 305 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b61 B 2.7 BS06 ASP B 4 R29 G93 Y97 R29 G93 Y97 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 306 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b61 B 2.7 BS07 ASP B 5 D85 A172 R191 D85 A172 R191 E67 D82 L84 D85 T87 D200 E67 D82 L84 D85 T87 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 307 MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b64 A 2.6 BS01 ASP A 1 D85 G170 S171 A172 R191 D200 D85 G170 S171 A172 R191 D200 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 502 MDERDALRISREIAGEVRKAIASMPLREAVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b64 A 2.6 BS05 ASP A 2 K164 R165 K164 R165 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 508 MDERDALRISREIAGEVRKAIASMPLREAVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b64 A 2.6 BS06 ASP A 3 R165 R167 R165 R167 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 509 MDERDALRISREIAGEVRKAIASMPLREAVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b64 B 2.6 BS01 ASP A 2 K43 R92 K43 R92 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 508 MDERDALRISREIAGEVRKAIASMPLREAVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b64 B 2.6 BS02 ASP B 1 K164 R165 K164 R165 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 301 MDERDALRISREIAGEVRKAIASMPLREAVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b64 B 2.6 BS03 ASP B 2 R165 R167 R165 R167 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 302 MDERDALRISREIAGEVRKAIASMPLREAVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6b64 B 2.6 BS04 ASP B 3 D85 Y155 G170 D85 Y155 G170 3.1.3.11,3.1.3.25 0006020,0007165,0008934,0016787,0042132,0046854,0046872,0052832,0052833,0052834 O30298 304 MDERDALRISREIAGEVRKAIASMPLREAVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK 6bat A 3.4 BS01 ASP A 1 R276 S278 M311 T314 G354 G359 D394 R397 T398 R268 S270 M303 T306 G346 G351 D386 R389 T390 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 29295993 503 EYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVKILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6bat B 3.4 BS01 ASP B 1 R276 S278 M311 T314 G354 V355 G359 D394 R397 T398 R268 S270 M303 T306 G346 V347 G351 D386 R389 T390 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 29295993 503 EYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVKILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6bat C 3.4 BS01 ASP C 1 R276 S278 M311 T314 G354 A358 G359 D394 R397 T398 N401 R268 S270 M303 T306 G346 A350 G351 D386 R389 T390 N393 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 29295993 503 EYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVKILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6bv1 A 2.0 BS01 ASP A 1 A346 A348 M349 E350 E406 Y472 A284 A286 M287 E288 E344 Y410 E350 H383 E384 H387 E406 S464 Y472 E288 H321 E322 H325 E344 S402 Y410 3.4.11.2 0001525,0001618,0004177,0005615,0005737,0005886,0006508,0008237,0008270,0030154,0042277,0043171,0046718,0046872,0070006 P15145 28465619 1024 QSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRFLCQEPTDVIIIHSKKLNYTTQGHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGELADDLAGFYRSEYMEGNVKKVLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTALSNMPPKGSSTPLAEDPNWSVTEFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWARPNAIAEGHGMYALNVTGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRENALLFDPQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADHAEPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQISEMFDSISYSKGASVIRMLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEHLQKAVDAQTSIRLPDTVRAIMDRWTLQMGFPVITVDTKTGNISQKHFLLDSESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRDVSQAQNDLFKTASDDWVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLRKQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQGVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHSS 6ctf A 4.05 BS01 ASP A 1 S276 S277 S278 M311 G354 V355 A358 G359 D394 R397 T398 N401 S271 S272 S273 M306 G349 V350 A353 G354 D389 R392 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 30255846 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDRGRTMVNVTGDLTGTAIVAKTE 6ctf B 4.05 BS01 ASP B 1 S276 S277 S278 M311 T314 G354 A358 G359 D394 R397 T398 N401 S271 S272 S273 M306 T309 G349 A353 G354 D389 R392 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 30255846 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDRGRTMVNVTGDLTGTAIVAKTE 6ctf C 4.05 BS01 ASP C 1 S276 S277 S278 M311 T314 G354 V355 A358 G359 D394 R397 T398 N401 S271 S272 S273 M306 T309 G349 V350 A353 G354 D389 R392 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 30255846 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDRGRTMVNVTGDLTGTAIVAKTE 6h1u A 1.68 BS01 ASP A 1 R147 T162 S164 R169 T211 T212 W232 D250 I253 R106 T121 S123 R128 T170 T171 W191 D209 I212 ? 0005576,0030288 Kd=4.8uM -logKd/Ki=5.32, Kd=4.8uM P96257 30065086 401 LPTPVGMEIMPPQPPLPPDSSSQDCDPTASLRPFATKAEADAAVADIRARGRLIVGLDIGSNLFSFRDPITGEITGFDVDIAGEVARDIFGVPSHVEYRILSAAERVTALQKSQVDIVVKTMSITCERRKLVNFSTVYLDANQRILAPRDSPITKVSDLSGKRVCVARGTTSLRRIREIAPPPVIVSVVNWADCLVALQQREIDAVSTDDTILAGLVEEDPYLHIVGPDMADQPYGVGINLDNTGLVRFVNGTLERIRNDGTWNTLYRKWLTVLGPAPAPPTPRYVD 6jks A 2.1 BS02 ASP A 1 R113 R174 R242 Q244 L288 R111 R172 R240 Q242 L283 R113 H141 Q144 T241 P287 G313 R111 H139 Q142 T239 P282 G308 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 Q4D3W3 402 ELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERFTSDDAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jks B 2.1 BS02 ASP B 1 R113 R174 T175 L288 R114 R175 T176 L268 R113 H141 Q144 T241 P287 G313 R114 H142 Q145 T242 P267 G293 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 Q4D3W3 402 SMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jks C 2.1 BS02 ASP C 1 R113 R174 R242 Q244 L288 R115 R176 R244 Q246 L268 R113 H141 Q144 T241 P287 G313 R115 H143 Q146 T243 P267 G293 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 Q4D3W3 402 GSMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQDITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jks D 2.1 BS02 ASP D 1 R113 R174 R242 Q244 L288 R115 R176 R244 Q246 L290 R113 H141 Q144 T241 P287 G313 R115 H143 Q146 T243 P289 G315 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 Q4D3W3 402 GSMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERFMASTSDDAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jks E 2.1 BS02 ASP E 1 R113 R174 R242 Q244 L288 R111 R172 R240 Q242 L264 R113 H141 Q144 T241 P287 G313 R111 H139 Q142 T239 P263 G289 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 Q4D3W3 402 ELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQDITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jks F 2.1 BS02 ASP F 1 R113 R174 T175 L288 R115 R176 T177 L280 R113 H141 Q144 T241 P287 G313 R115 H143 Q146 T243 P279 G305 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 Q4D3W3 402 GSMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQDAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl4 B 2.4 BS01 ASP B 1 R174 Q244 L288 P289 R175 Q245 L281 P282 R113 H141 Q144 T241 P287 G313 R114 H142 Q145 T242 P280 G306 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 401 SMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKDDAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl4 C 2.4 BS01 ASP C 1 R113 H141 R174 R242 Q244 L288 R114 H142 R175 R243 Q245 L285 R113 H141 Q144 T241 P287 G313 R114 H142 Q145 T242 P284 G310 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 401 SMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERTSDDAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl4 D 2.4 BS01 ASP D 1 R113 R174 R242 Q244 L288 P289 R114 R175 R243 Q245 L281 P282 R113 H141 Q144 T241 P287 G313 R114 H142 Q145 T242 P280 G306 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 401 SMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl4 E 2.4 BS01 ASP E 1 R113 R174 R242 Q244 P289 R114 R175 R243 Q245 P273 R113 H141 Q144 T241 P287 G313 R114 H142 Q145 T242 P271 G297 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 401 SMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERFADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl4 F 2.4 BS01 ASP F 1 R113 R174 R242 L288 P289 R113 R174 R242 L284 P285 R113 H141 Q144 T241 P287 G313 R113 H141 Q144 T241 P283 G309 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 401 MLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERFSDDAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl5 A 2.05 BS01 ASP A 1 R113 R174 R242 L288 P289 R115 R176 R244 L279 P280 R113 H141 Q144 T241 P287 G313 R115 H143 Q146 T243 P278 G304 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 402 GSMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl5 B 2.05 BS01 ASP B 1 R113 R174 R242 Q244 L288 R114 R175 R243 Q245 L289 R113 H141 Q144 T241 P287 G313 R114 H142 Q145 T242 P288 G314 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 402 SMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERFMASTSDDAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl5 C 2.05 BS01 ASP C 1 R113 R174 T175 R242 Q244 L288 R112 R173 T174 R241 Q243 L268 R113 H141 Q144 T241 P287 G313 R112 H140 Q143 T240 P267 G293 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 402 LELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERDITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl5 D 2.05 BS01 ASP D 1 R113 R174 R242 Q244 L288 R115 R176 R244 Q246 L273 R113 H141 Q144 T241 P287 G313 R115 H143 Q146 T243 P272 G298 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 402 GSMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl5 E 2.05 BS01 ASP E 1 R113 R174 R242 Q244 L288 R117 R178 R246 Q248 L276 R113 H141 Q144 T241 P287 G313 R117 H145 Q148 T245 P275 G301 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 402 PRGSMLELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERFKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl5 F 2.05 BS01 ASP F 1 R113 H141 R174 T175 R242 Q244 L288 R111 H139 R172 T173 R240 Q242 L286 R113 H141 Q144 T241 P287 G313 R111 H139 Q142 T239 P285 G311 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 402 ELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEASSINKGETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERFMASTSDDAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6jl6 C 2.0 BS01 ASP C 1 R113 H141 R174 R242 L288 R105 H133 R166 R234 L280 R113 H141 Q144 T241 P287 G313 R105 H133 Q136 T233 P279 G305 2.1.3.2 0004070,0006207,0006221,0006520,0016597,0016740,0016743,0044205 O15636 501 LELPPVASLKGKSITSAEQFSRADIYALIHLASAMQRKIDAGEVLNLLQGRIMTPLFFEDSSRTFSSFCAAMIRLGGSVVNFKVEETLADTIRTLDSYSDVLVMRHPRQDAIEEALSVAQHPILNAGNGAGEHPTQALLDTLTIHSELGSVDGITIALIGDLKMGRTVHSLLKLLVRNFSIKCVFLVAPDALQMPQDVLEPLQHEIATKGVIIHRTHALTDEVMQKSDVLYTTRLQKERFMASTSDDAAALQSFAAKADITIDAARMRLAKEKMIVMHPLPRNDELSTTVDADPRAAYFRQMRYGMFMRMAILWSVLA 6pa2 A 1.9 BS01 ASP A 1 T12 G57 S58 Q59 G88 T89 D90 A114 T13 G44 S45 Q46 G75 T76 D77 A101 T12 T89 D90 M162 E283 T13 T76 D77 M149 E270 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HLPNITILATGGTIAGVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pa2 B 1.9 BS01 ASP B 1 T12 G57 S58 Q59 G88 T89 D90 A114 T13 G58 S59 Q60 G89 T90 D91 A115 T12 Y25 T89 D90 M162 E283 T13 Y26 T90 D91 M163 E284 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HLPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pa2 C 1.9 BS01 ASP C 1 T12 G57 S58 G88 T89 D90 A114 T14 G42 S43 G73 T74 D75 A99 T12 T89 D90 M162 E283 T14 T74 D75 M147 E268 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HHLPNITILATGGTIAGENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pa2 D 1.9 BS01 ASP D 1 T12 G57 S58 Q59 G88 T89 D90 A114 T14 G43 S44 Q45 G74 T75 D76 A100 T12 T89 D90 M162 E283 T14 T75 D76 M148 E269 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HHLPNITILATGGTIAGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pa4 A 1.85 BS01 ASP A 1 T12 G57 S58 Q59 G88 V89 D90 T12 G52 S53 Q54 G83 V84 D85 T12 Y25 V89 D90 T162 E283 T12 Y25 V84 D85 T157 E278 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 LPNITILATGGTIAGGGDSATKSNYGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGVDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTTTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pa4 B 1.85 BS01 ASP B 1 T12 S58 G88 V89 D90 T12 S40 G70 V71 D72 T12 V89 D90 T162 E283 T12 V71 D72 T144 E265 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 LPNITILATGGTIVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGVDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTTTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pa4 C 1.85 BS01 ASP C 1 T12 G57 S58 Q59 G88 V89 D90 A114 T13 G54 S55 Q56 G85 V86 D87 A111 T12 Y25 V89 D90 T162 E283 T13 Y26 V86 D87 T159 E280 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HLPNITILATGGTIAGGGDSATKSNYTGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGVDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTTTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pa4 D 1.85 BS01 ASP D 1 S58 G88 V89 D90 A114 S44 G74 V75 D76 A100 T12 V89 D90 T162 E283 T15 V75 D76 T148 E269 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HHHLPNITILATGGTIAVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGVDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTTTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6paa A 1.85 BS01 ASP A 1 V12 G57 S58 G88 T89 D90 V13 G44 S45 G75 T76 D77 V12 T89 D90 K162 E283 V13 T76 D77 K149 E270 3.5.1.1 0004067,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HLPNITILATGGVIAGGGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6paa B 1.85 BS01 ASP B 1 V12 G57 S58 G88 T89 D90 A114 V13 G35 S36 G66 T67 D68 A92 V12 T89 D90 K162 E283 V13 T67 D68 K140 E261 3.5.1.1 0004067,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HLPNITILATGGVINAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6paa C 1.85 BS01 ASP C 1 V12 G57 S58 Q59 G88 T89 D90 V13 G45 S46 Q47 G76 T77 D78 V12 T89 D90 K162 E283 V13 T77 D78 K150 E271 3.5.1.1 0004067,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HLPNITILATGGVIAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6paa D 1.85 BS01 ASP D 1 V12 G57 S58 G88 T89 D90 V13 G43 S44 G74 T75 D76 V12 T89 D90 K162 E283 V13 T75 D76 K148 E269 3.5.1.1 0004067,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HLPNITILATGGVIAVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pab A 1.73 BS01 ASP A 1 T12 V27 G57 S58 Q59 G88 T89 D90 T16 V31 G61 S62 Q63 G92 T93 D94 T12 Y25 T89 D90 K162 E283 T16 Y29 T93 D94 K166 E287 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HHHHLPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pab B 1.73 BS01 ASP B 1 T12 G57 S58 G88 T89 D90 T13 G44 S45 G75 T76 D77 T12 T89 D90 K162 E283 T13 T76 D77 K149 E270 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HLPNITILATGGTIAKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pab C 1.73 BS01 ASP C 1 T12 V27 G57 S58 Q59 G88 T89 D90 T16 V31 G61 S62 Q63 G92 T93 D94 T12 Y25 T89 D90 K162 E283 T16 Y29 T93 D94 K166 E287 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HHHHLPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pab C 1.73 BS02 ASP C 2 K213 Y236 K217 Y240 T12 Y25 T89 D90 K162 E283 T16 Y29 T93 D94 K166 E287 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 402 HHHHLPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pab D 1.73 BS01 ASP D 1 T12 G57 S58 Q59 G88 T89 D90 T13 G43 S44 Q45 G74 T75 D76 T12 T89 D90 K162 E283 T13 T75 D76 K148 E269 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HLPNITILATGGTIAVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pac A 1.6 BS01 ASP A 1 T12 V27 G57 S58 Q59 G88 T89 D90 T16 V31 G61 S62 Q63 G92 T93 D94 T12 Y25 T89 D90 K162 E283 T16 Y29 T93 D94 K166 E287 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HHHHLPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pac B 1.6 BS01 ASP B 1 T12 G57 S58 Q59 G88 T89 D90 T16 G49 S50 Q51 G80 T81 D82 T12 T89 D90 K162 E283 T16 T81 D82 K154 E275 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HHHHLPNITILATGGTIAGGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pac C 1.6 BS01 ASP C 1 T12 V27 G57 S58 Q59 G88 T89 D90 T14 V29 G59 S60 Q61 G90 T91 D92 T12 Y25 T89 D90 K162 E283 T14 Y27 T91 D92 K164 E285 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HHLPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pac D 1.6 BS01 ASP D 1 T12 G57 S58 Q59 G88 T89 D90 T13 G47 S48 Q49 G78 T79 D80 T12 T89 D90 K162 E283 T13 T79 D80 K152 E273 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 31423681 401 HLPNITILATGGTIAGVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6pae A 1.6 BS01 ASP A 1 T15 A61 S62 E63 G94 T95 D96 T13 A51 S52 E53 G84 T85 D86 T15 T95 D96 K168 T13 T85 D86 K158 3.5.1.1 0004067,0006520,0006528,0016787 P06608 31423681 401 KLPNIVILATGGTIAGSAATGTALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVINDRIGSARYITKTNASTLDTFRANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKALEKGVVVMRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 6pae B 1.6 BS01 ASP B 1 T15 A61 S62 E63 G94 T95 D96 T13 A42 S43 E44 G75 T76 D77 T15 T95 D96 K168 T13 T76 D77 K149 3.5.1.1 0004067,0006520,0006528,0016787 P06608 31423681 400 KLPNIVILATGGTIAGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVINDRIGSARYITKTNASTLDTFRANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKALEKGVVVMRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 6pae C 1.6 BS01 ASP C 1 T15 A61 S62 E63 G94 T95 D96 T13 A47 S48 E49 G80 T81 D82 T15 T95 D96 K168 T13 T81 D82 K154 3.5.1.1 0004067,0006520,0006528,0016787 P06608 31423681 401 KLPNIVILATGGTIAGSAALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVINDRIGSARYITKTNASTLDTFRANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKALEKGVVVMRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 6pae D 1.6 BS01 ASP D 1 T15 A61 S62 E63 G94 T95 D96 T13 A44 S45 E46 G77 T78 D79 T15 T95 D96 K168 T13 T78 D79 K151 3.5.1.1 0004067,0006520,0006528,0016787 P06608 31423681 400 KLPNIVILATGGTIAGSGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVINDRIGSARYITKTNASTLDTFRANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKALEKGVVVMRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 6pq8 A 2.2 BS01 ASP A 1 L289 K291 L274 K276 G70 K73 S130 E166 K234 S237 G46 K49 S110 E146 K214 S217 3.5.2.6 0008800,0017001,0030655,0046677 Q9X6W1 31780261 301 KGTDSLKSSIEKYLKDKKAKVGVAVLGIEDNFKLNVNEKHHYPMQGTYKFHLALAVLDKLDKENISIDKKLFVKKSELLPNTWSPLRDKYPDGNVDLSISEILKATVSRSDNNGCDILFRFVGGTNKVHNFISKLGVKNISIKATEEEMHKAWNVQYTNWTTPDATVQLLKKFYKNEILSKNSYDYLLNTMIETTTGPKRLKGLLPDGTVVAHKTGSSDTNDKGITAATNDIGIITLPNGKHFAIAVYVSDSSEKSDVNEKIIAEICKSVWDYLVK 6qf3 A 1.521 BS06 ASP A 1 H142 E143 H146 Y157 E166 H231 H142 E143 H146 Y157 E166 H231 H142 E143 H146 Y157 E166 D226 H231 H142 E143 H146 Y157 E166 D226 H231 3.4.24.27 0004222,0006508 P00800 31316815 427 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 6qf3 A 1.521 BS07 ASP A 2 H142 E143 R203 H231 H142 E143 R203 H231 H142 E143 H146 Y157 E166 D226 H231 H142 E143 H146 Y157 E166 D226 H231 3.4.24.27 0004222,0006508 P00800 31316815 428 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 6rue A 1.65 BS01 ASP A 1 G59 S60 Q61 G92 T93 D94 A118 G47 S48 Q49 G80 T81 D82 A106 T14 T93 D94 K166 E287 T12 T81 D82 K154 E275 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 400 KPQVTILATGGTIAGSAGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRPGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 6rue B 1.65 BS01 ASP B 1 T14 G59 S60 Q61 G92 T93 D94 T12 G43 S44 Q45 G76 T77 D78 T14 T93 D94 K166 E287 T12 T77 D78 K150 E271 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 400 KPQVTILATGGTIAGVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRPGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 6rue C 1.65 BS01 ASP C 1 T14 G59 S60 Q61 G92 T93 D94 T12 G44 S45 Q46 G77 T78 D79 T14 T93 D94 K166 E287 T12 T78 D79 K151 E272 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 400 KPQVTILATGGTIAGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRPGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 6rue D 1.65 BS01 ASP D 1 T14 G59 S60 Q61 G92 T93 D94 T12 G46 S47 Q48 G79 T80 D81 T14 T93 D94 K166 E287 T12 T80 D81 K153 E274 3.5.1.1 0004067,0005737,0006520,0006528,0016787 P50286 400 KPQVTILATGGTIAGSGAVTVDKLLAAVPAINDLATIKGEQISSIGSQEMTGKVWLKLAKRVNELLAQKETEAVIITHGTDTMEETAFFLNLTVKSQKPVVLVGAMRPGSSMSADGPMNLYNAVNVAINKASTNKGVVIVMNDEIHAAREATKLNTTAVNAFASPNTGKIGTVYYGKVEYFTQSVRPHTLASEFDISKIEELPRVDILYAHPDDTDVLVNAALQAGAKGIIHAGMGNGNPFPLTQNALEKAAKSGVVVARSSRVGSGSTTQEAEVDDKKLGFVATESLNPQKARVLLMLALTKTSDREAIQKIFSTY 6tnh A 2.21 BS03 ASP A 1 T262 T263 V264 T264 T265 V266 S14 K17 G42 H43 Q187 S16 K19 G44 H45 Q189 6.3.4.25 0000166,0000287,0004019,0005524,0005737,0006164,0016874,0044208,0046040,0046872 G3FFN6 33926955 407 SHMENVDLVIDLQFGSTGKGLIAGYLAEKNGYDTVINANMPNAGHTYINAEGRKWMHKVLPNGIVSPNLKRVMLGAGSVFSINRLMEEIEMSKDLLHDKVAILIHPMATVLDEEAHKKAEVGIATSIGSTGQGSMAAMVEKLQRDPTNNTIVARDVAQYDGRIAQYVCTVEEWDMALMASERILAEGAQGFSLSLNQEFYPYCTSRDCTPARFLADMGIPLPMLNKVIGTARCHPIRVGGTSGGHYPDQEELTWEQLGQVPELTTVTKKVRRVFSFSFIQMQKAMWTCQPDEVFLNFCNYLSPMGWQDIVHQIEVAAQSRYCDAEVKYLGFGPTFNDVELREDVM 6uog A 2.29 BS01 ASP A 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 33607531 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6uog B 2.29 BS01 ASP B 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 33607531 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6uog C 2.29 BS01 ASP C 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 33607531 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6uog D 2.29 BS01 ASP D 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 33607531 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6uog E 2.29 BS01 ASP E 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 33607531 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6uog F 2.29 BS01 ASP F 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 33607531 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6uog G 2.29 BS01 ASP G 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 33607531 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6uog H 2.29 BS01 ASP H 1 T12 S58 Q59 G88 T89 D90 T12 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 33607531 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6uoh A 2.1 BS01 ASP A 1 T12 G57 S58 Q59 G88 T89 D90 T12 G57 S58 Q59 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 33607531 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDDVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKTVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6uoh B 2.1 BS01 ASP B 1 T12 G57 S58 G88 T89 D90 T12 G57 S58 G88 T89 D90 T12 Y25 T89 D90 K162 E283 T12 Y25 T89 D90 K162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 33607531 401 LPNITILATGGTIAGGGDSATKSNYTAGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDDVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKTVFDTLATAAKNGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6uwf A 3.08 BS01 ASP A 1 S278 T314 G354 A358 G359 D394 R397 T398 N401 S278 T314 G354 A358 G359 D394 R397 T398 N401 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 32514183 501 MGLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6uwl A 3.62 BS01 ASP A 1 T314 G354 V355 P356 A358 G359 D394 R397 T398 T299 G339 V340 P341 A343 G344 D379 R382 T383 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 32514183 501 MGLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6v24 A 1.9 BS01 ASP A 1 T12 G57 S58 Q59 G88 T89 D90 A114 T13 G58 S59 Q60 G89 T90 D91 A115 T12 Y25 T89 D90 M162 E283 T13 Y26 T90 D91 M163 E284 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 HLPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v24 D 1.9 BS01 ASP D 1 T12 G57 S58 Q59 G88 T89 D90 A114 T13 G58 S59 Q60 G89 T90 D91 A115 T12 Y25 T89 D90 M162 E283 T13 Y26 T90 D91 M163 E284 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 HLPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v25 A 1.78 BS01 ASP A 1 T12 Y25 G57 S58 Q59 G88 T89 D90 A114 T12 Y25 G57 S58 Q59 G88 T89 D90 A114 T12 Y25 T89 D90 M162 E283 T12 Y25 T89 D90 M162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 LPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v25 B 1.78 BS01 ASP B 1 T12 G57 S58 Q59 G88 T89 D90 A114 T12 G36 S37 Q38 G67 T68 D69 A93 T12 T89 D90 M162 E283 T12 T68 D69 M141 E262 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 LPNITILATGGTIAVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v26 A 1.8 BS01 ASP A 1 T12 G57 S58 Q59 G88 T89 D90 A114 T12 G57 S58 Q59 G88 T89 D90 A114 T12 Y25 T89 D90 M162 E283 T12 Y25 T89 D90 M162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 LPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v26 B 1.8 BS01 ASP B 1 T12 G57 S58 G88 T89 D90 T12 G37 S38 G68 T69 D70 T12 T89 D90 M162 E283 T12 T69 D70 M142 E263 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 LPNITILATGGTIAGVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v26 C 1.8 BS01 ASP C 1 T12 G57 S58 Q59 G88 T89 D90 A114 T12 G57 S58 Q59 G88 T89 D90 A114 T12 Y25 T89 D90 M162 E283 T12 Y25 T89 D90 M162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 LPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v26 D 1.8 BS01 ASP D 1 T12 V27 G57 S58 Q59 G88 T89 D90 A114 T12 V27 G57 S58 Q59 G88 T89 D90 A114 T12 Y25 T89 D90 M162 E283 T12 Y25 T89 D90 M162 E283 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 LPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTMTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v29 A 2.0 BS01 ASP A 1 G57 S58 Q59 G88 V89 D90 G42 S43 Q44 G73 V74 D75 T12 V89 D90 T162 E283 T13 V74 D75 T147 E268 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 HLPNITILATGGTIAGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGVDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTTTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v29 B 2.0 BS01 ASP B 1 G57 S58 Q59 G88 V89 D90 G37 S38 Q39 G68 V69 D70 T12 V89 D90 T162 E283 T13 V69 D70 T142 E263 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 HLPNITILATGGTNLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGVDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTTTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v29 C 2.0 BS01 ASP C 1 S58 Q59 G88 V89 D90 S44 Q45 G74 V75 D76 T12 V89 D90 T162 E283 T13 V75 D76 T148 E269 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 HLPNITILATGGTIAGGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGVDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTTTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v29 D 2.0 BS01 ASP D 1 G57 S58 Q59 G88 V89 D90 G41 S42 Q43 G72 V73 D74 T12 V89 D90 T162 E283 T13 V73 D74 T146 E267 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 32364696 401 HLPNITILATGGTIAVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGVDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTTTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v5f A 2.1 BS01 ASP A 1 T12 G57 S58 Q59 G88 T89 D90 A114 T12 G54 S55 Q56 G85 T86 D87 A111 T12 Y25 T89 D90 K162 E283 T12 Y24 T86 D87 K159 E280 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 401 LPNITILATGGTIAGGGSATKSNYTVGKVGVENLVNAVPQLKIANVGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 6v5f D 2.1 BS01 ASP D 1 G11 T12 V27 G57 S58 Q59 G88 T89 D90 G11 T12 V20 G50 S51 Q52 G81 T82 D83 T12 Y25 T89 D90 K162 T12 Y18 T82 D83 K155 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 401 LPNITILATGGTIAGGNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQ 6v75 B 2.85 BS02 ASP B 1 R106 H464 Y466 G468 I469 R93 H445 Y447 G449 I450 R73 R120 K270 T328 R60 R107 K251 T309 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 32144209 610 QTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGALVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6v75 C 2.85 BS04 ASP C 1 N44 G46 H464 Y466 I469 N30 G32 H450 Y452 I455 R73 R120 K270 T328 R59 R106 K256 T314 2.7.10.2,2.7.11.1,2.7.1.40 0000287,0003723,0003729,0003824,0004713,0004743,0005515,0005524,0005576,0005634,0005737,0005739,0005791,0005829,0005929,0006096,0006417,0012501,0016301,0016310,0023026,0030955,0031982,0032869,0034774,0045296,0046872,0061621,0062023,0070062,1903561,1903672,1904813,2000767 P14618 32144209 610 TQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 6v8g A 3.38 BS01 ASP A 1 R276 S277 S278 M311 T314 G354 A358 G359 D394 R397 T398 N401 R253 S254 S255 M288 T291 G331 A335 G336 D371 R374 T375 N378 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33185289 503 VLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQLAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTVVLASIGTAGVPGAGAIMLAMALHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6v8g B 3.38 BS01 ASP B 1 R276 S277 S278 M311 T314 G354 A358 G359 D394 R397 T398 N401 R253 S254 S255 M288 T291 G331 A335 G336 D371 R374 T375 N378 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33185289 503 VLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQLAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTVVLASIGTAGVPGAGAIMLAMALHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6v8g C 3.38 BS01 ASP C 1 R276 S277 S278 M311 T314 G354 A358 G359 D394 R397 T398 N401 R253 S254 S255 M288 T291 G331 A335 G336 D371 R374 T375 N378 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33185289 503 VLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQLAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTVVLASIGTAGVPGAGAIMLAMALHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6wyj A 3.7 BS01 ASP A 1 S277 S278 G354 V355 D394 R397 T398 S258 S259 G335 V336 D375 R378 T379 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHPLVKILLDIVPTNPFGALANGQVCPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASICTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6wyk A 4.0 BS01 ASP A 1 V355 P356 G359 D394 R397 T398 V353 P354 G357 D392 R395 T396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 LYRKYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVKILLDIVPTNPFGALANGQVCPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASICTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6wyl A 3.9 BS01 ASP A 1 S277 S278 T314 G354 V355 G359 D394 R397 S258 S259 T295 G335 V336 G340 D375 R378 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHPLVKILLDIVPTNPFGALANGQVCPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASICTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6wyl B 3.9 BS01 ASP B 1 S277 S278 T314 G354 V355 G359 D394 R397 S258 S259 T295 G335 V336 G340 D375 R378 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHPLVKILLDIVPTNPFGALANGQVCPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASICTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6wyl C 3.9 BS01 ASP C 1 S277 S278 T314 G354 V355 G359 D394 R397 S258 S259 T295 G335 V336 G340 D375 R378 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHPLVKILLDIVPTNPFGALANGQVCPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASICTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE 6wyw A 2.13 BS01 ASP A 1 G19 T20 A66 S67 E68 G99 T100 D101 G11 T12 A46 S47 E48 G79 T80 D81 T20 T100 D101 K173 E294 T12 T80 D81 K153 E274 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 LANVVILATGGTIAGAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSKAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wyw B 2.13 BS01 ASP B 1 G19 T20 A66 S67 G99 T100 D101 G11 T12 A47 S48 G80 T81 D82 T20 T100 D101 K173 E294 T12 T81 D82 K154 E275 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 LANVVILATGGTIAGAAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSKAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wyw C 2.13 BS01 ASP C 1 G19 T20 A66 S67 E68 G99 T100 D101 G11 T12 A45 S46 E47 G78 T79 D80 T20 T100 D101 K173 E294 T12 T79 D80 K152 E273 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 LANVVILATGGTIAGAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSKAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wyw D 2.13 BS01 ASP D 1 G19 T20 S67 E68 G99 T100 D101 G11 T12 S48 E49 G80 T81 D82 T20 T100 D101 K173 E294 T12 T81 D82 K154 E275 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 LANVVILATGGTIAGAAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSKAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wyx A 1.48 BS01 ASP A 1 T20 A66 S67 E68 G99 T100 D101 T12 A46 S47 E48 G79 T80 D81 T20 T100 D101 K173 E294 T12 T80 D81 K153 E274 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 LANVVILATGGTIAGAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSKAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wyx B 1.48 BS01 ASP B 1 T20 A66 S67 E68 G99 T100 D101 T14 A50 S51 E52 G83 T84 D85 T20 T100 D101 K173 E294 T14 T84 D85 K157 E278 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 QKLANVVILATGGTIAGAGAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSKAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wyx C 1.48 BS01 ASP C 1 T20 A66 S67 E68 G99 T100 D101 T12 A46 S47 E48 G79 T80 D81 T20 T100 D101 K173 E294 T12 T80 D81 K153 E274 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 LANVVILATGGTIAGAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSKAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wyx D 1.48 BS01 ASP D 1 T20 A66 S67 E68 G99 T100 D101 T13 A47 S48 E49 G80 T81 D82 T20 T100 D101 K173 E294 T13 T81 D82 K154 E275 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 KLANVVILATGGTIAGAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSKAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wz4 A 1.58 BS01 ASP A 1 T20 Y34 A66 S67 E68 G99 T100 D101 T13 Y27 A59 S60 E61 G92 T93 D94 T20 Y34 T100 D101 M173 E294 T13 Y27 T93 D94 M166 E287 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 KLANVVILATGGTIAGAGASAANSATYQAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSMAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wz4 B 1.58 BS01 ASP B 1 T20 Y34 A66 S67 E68 G99 T100 D101 T13 Y27 A59 S60 E61 G92 T93 D94 T20 Y34 T100 D101 M173 E294 T13 Y27 T93 D94 M166 E287 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 KLANVVILATGGTIAGAGASAANSATYQAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSMAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wz4 C 1.58 BS01 ASP C 1 T20 A66 S67 E68 G99 T100 D101 T13 A59 S60 E61 G92 T93 D94 T20 Y34 T100 D101 M173 E294 T13 Y27 T93 D94 M166 E287 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 KLANVVILATGGTIAGAGASAANSATYQAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSMAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wz4 D 1.58 BS01 ASP D 1 T20 A66 S67 E68 G99 T100 D101 T13 A59 S60 E61 G92 T93 D94 T20 Y34 T100 D101 M173 E294 T13 Y27 T93 D94 M166 E287 3.5.1.38 0004067,0004359,0006520,0006528,0016787,0042597,0050417 Q88K39 400 KLANVVILATGGTIAGAGASAANSATYQAAKLGVDKLIAGVPELADIANVRGEQVMQIASESISNDDLLKLGKRVAELAESKDVDGIVITHGTDTLEETAFFLNLVEKTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASDKQSRGKGVLVTMNDEIQSGRDVSMAVNIKTEAFKSAWGPMGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYGYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRVVPALQELRKNGVQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPQKARILAMVAMTKTQDSKELQRIFWEY 6wzb A 3.45 BS01 ASP A 1 S277 S278 T314 T352 G354 V355 A358 G359 D394 R397 T398 N401 S272 S273 T309 T347 G349 V350 A353 G354 D389 R392 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVKILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYCMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILCIDAILDMGRTMVNVTGDLTGTAIVAKTE 6wzb B 3.45 BS01 ASP B 1 S277 S278 T314 T352 G354 V355 A358 G359 D394 R397 T398 N401 S272 S273 T309 T347 G349 V350 A353 G354 D389 R392 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVKILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYCMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILCIDAILDMGRTMVNVTGDLTGTAIVAKTE 6wzb C 3.45 BS01 ASP C 1 S277 S278 T314 T352 G354 V355 A358 G359 D394 R397 T398 N401 S272 S273 T309 T347 G349 V350 A353 G354 D389 R392 T393 N396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 KYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPKQAPPLVKILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYCMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILCIDAILDMGRTMVNVTGDLTGTAIVAKTE 6x01 A 3.65 BS01 ASP A 1 R276 S277 S278 M311 G354 V355 A358 G359 D394 R397 T398 R260 S261 S262 M295 G338 V339 A342 G343 D378 R381 T382 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 VLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFPPLVKILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYCMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDCILDMGRTMVNVTGDLTGTAIVAKTE 6x01 B 3.65 BS01 ASP B 1 R276 S277 S278 G354 V355 G357 A358 G359 D394 R397 T398 R260 S261 S262 G338 V339 G341 A342 G343 D378 R381 T382 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 VLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFPPLVKILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYCMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDCILDMGRTMVNVTGDLTGTAIVAKTE 6x01 C 3.65 BS01 ASP C 1 R276 S278 G354 V355 G357 A358 G359 D394 R397 T398 R260 S262 G338 V339 G341 A342 G343 D378 R381 T382 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33597752 501 VLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFPPLVKILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYCMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLESVGLPLTDPNVAAAYAMILGIDCILDMGRTMVNVTGDLTGTAIVAKTE 6x15 A 3.05 BS04 ASP A 1 S277 S278 T314 G354 A358 G359 D394 R397 T398 S277 S278 T314 G354 A358 G359 D394 R397 T398 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33155546 504 MGLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGTL 6x15 B 3.05 BS04 ASP B 1 S277 S278 T314 G354 A358 G359 D394 R397 T398 S277 S278 T314 G354 A358 G359 D394 R397 T398 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33155546 505 MGLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGTL 6x15 C 3.05 BS04 ASP C 1 S277 S278 T314 G354 A358 G359 D394 R397 T398 S277 S278 T314 G354 A358 G359 D394 R397 T398 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 33155546 505 MGLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLCMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLCMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTEGTL 6x2z A 3.03 BS01 ASP A 1 S331 S333 T370 G410 V411 D444 R447 T448 S275 S277 T314 G354 V355 D388 R391 T392 ? 0001662,0001975,0002027,0005253,0005313,0005314,0005515,0005737,0005768,0005783,0005886,0006749,0006750,0006801,0006811,0006836,0006865,0006882,0007212,0007215,0007268,0007420,0007611,0007613,0007625,0007626,0009410,0009897,0009986,0010460,0010467,0010842,0015108,0015179,0015183,0015293,0015501,0015813,0016020,0016324,0016595,0019221,0022008,0030424,0030425,0030534,0031901,0031902,0031982,0032279,0033229,0034599,0035633,0036293,0042417,0042802,0042883,0043005,0043025,0043083,0043197,0043198,0043204,0043278,0043524,0043679,0045121,0045184,0045202,0046872,0048514,0048678,0050808,0051402,0051938,0055037,0055038,0060013,0060041,0060047,0060291,0061744,0070062,0070633,0070777,0070778,0070779,0071242,0071288,0071314,0071407,0071577,0071944,0072347,0090313,0090461,0097049,0097386,0097440,0098685,0098712,0098793,0098877,0099170,0099544,0140009,0140010,0150002,0150104,1902476,1903712,1903926,1990635,1990708 P43005 33658209 600 KNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGSTVDAMLDLIRNMFPENLVQACFQQYKTKREEEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDV 6x3e A 3.42 BS01 ASP A 1 S331 S333 T370 V411 G415 D444 R447 N451 S275 S277 T314 V355 G359 D388 R391 N395 ? 0001662,0001975,0002027,0005253,0005313,0005314,0005515,0005737,0005768,0005783,0005886,0006749,0006750,0006801,0006811,0006836,0006865,0006882,0007212,0007215,0007268,0007420,0007611,0007613,0007625,0007626,0009410,0009897,0009986,0010460,0010467,0010842,0015108,0015179,0015183,0015293,0015501,0015813,0016020,0016324,0016595,0019221,0022008,0030424,0030425,0030534,0031901,0031902,0031982,0032279,0033229,0034599,0035633,0036293,0042417,0042802,0042883,0043005,0043025,0043083,0043197,0043198,0043204,0043278,0043524,0043679,0045121,0045184,0045202,0046872,0048514,0048678,0050808,0051402,0051938,0055037,0055038,0060013,0060041,0060047,0060291,0061744,0070062,0070633,0070777,0070778,0070779,0071242,0071288,0071314,0071407,0071577,0071944,0072347,0090313,0090461,0097049,0097386,0097440,0098685,0098712,0098793,0098877,0099170,0099544,0140009,0140010,0150002,0150104,1902476,1903712,1903926,1990635,1990708 P43005 33658209 600 KNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGSTVDAMLDLIRNMFPENLVQACFQQYKTKREEEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDV 6xwo C 3.39 BS01 ASP C 1 S280 T317 V358 A361 G362 R401 T402 N405 S276 T313 V354 A357 G358 R397 T398 N401 ? 0015293,0016020,0046942,0055085 Q5JID0 32081874 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 6xwp B 3.38 BS01 ASP B 1 S279 S280 M314 T317 G357 V358 G362 R401 T402 N405 S275 S276 M310 T313 G353 V354 G358 R397 T398 N401 ? 0015293,0016020,0046942,0055085 Q5JID0 32081874 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 6xwp C 3.38 BS01 ASP C 1 S280 T317 G357 V358 A361 G362 D398 R401 T402 S276 T313 G353 V354 A357 G358 D394 R397 T398 ? 0015293,0016020,0046942,0055085 Q5JID0 32081874 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 6xwq A 3.41 BS01 ASP A 1 S280 V358 P359 G360 A361 G362 D398 R401 T402 N405 S276 V354 P355 G356 A357 G358 D394 R397 T398 N401 ? 0015293,0016020,0046942,0055085 Q5JID0 32081874 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 6xwq B 3.41 BS01 ASP B 1 S280 V358 P359 G360 A361 G362 D398 R401 T402 S276 V354 P355 G356 A357 G358 D394 R397 T398 ? 0015293,0016020,0046942,0055085 Q5JID0 32081874 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 6xwq C 3.41 BS01 ASP C 1 S280 V358 P359 G360 A361 G362 D398 R401 T402 S276 V354 P355 G356 A357 G358 D394 R397 T398 ? 0015293,0016020,0046942,0055085 Q5JID0 32081874 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 7awm A 3.25 BS01 ASP A 1 S344 S345 T382 G422 I423 A426 G427 D456 R459 T460 S268 S269 T306 G346 I347 A350 G351 D380 R383 T384 ? 0015293,0016020 P43003,Q15758 34747040 604 AKKKVQNITKEDVKSFLRRNALLLLTVLAVILGVVLGFLLRPYPLSPREVKYFAFPGELLMRMLKMLILPLIVSSLITGLASLDAKASGRLGMRAVVYYMSTTIIAVVLGIILVLIIHPEVLDCFLDLARNIFPSNLVSAAFRSYSTQEVEGMNILGLVVFSMVFGFALGKMGEQGQLLVDFFNSLNEATMKLVAIIMWYAPLGILFLIAGKIVGGQLGMYMVTVIVGLVIHGLIVLPLIYFLITRKNPFVFIAGILQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTAVGLPTDDITLIIAVDWLLDRFRTMVNVLGDALGAGIVEHLSRKELEKQDAE 7awq A 3.65 BS01 ASP A 1 S343 S344 S345 T382 G422 I423 A426 G427 D456 R459 T460 N463 S264 S265 S266 T303 G338 I339 A342 G343 D372 R375 T376 N379 ? 0015293,0016020 P43003,Q15758 34747040 603 KKVQNITKEDVKSFLRRNALLLLTVLAVILGVVLGFLLRPYPLSPREVKYFAFPGELLMRMLKMLILPLIVSSLITGLASLDAKASGRLGMRAVVYYMSTTIIAVVLGIILVLIIHKEVLDCFLDLARNIFPSNLVSAAFRSYSTTQEVEGMNILGLVVFSMVFGFALGKMGEQGQLLVDFFNSLNEATMKLVAIIMWYAPLGILFLIAGKIVQLGMYMVTVIVGLVIHGLIVLPLIYFLITRKNPFVFIAGILQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYQAVAAIFIAQVNNGQIITISITATAASIGAAGIPQAGLVTMVIVLTAVGLPTDDITLIIAVDWLLDRFRTMVNVLGDALGAGIVEHLSRKELEKQDAE 7bu3 A 2.0 BS01 ASP A 1 S315 A337 S314 A336 1.1.1.2 0006631,0008106,0008270,0016491,0016616,0042803,0046872 P27250 32455802 401 SMIKSYAAKEAGGELEVYEYDPGELRPQDVEVQVDYCGICHSDLSMIDNEWGFSQYPLVAGHEVIGRVVALGSAAQDKGLQVGQRVGIGWTARSCGHCDACISGNQINCEQGAVPTIMNRGGFAEKLRADWQWVIPLPENIDIESAGPLLCGGITVFKPLLMHHITATSRVGVIGIGGLGHIAIKLLHAMGCEVTAFSSNPAKEQEVLAMGADKVVNSRDPQALKALAGQFDLIINTVNVSLDWQPYFEALTYGGNFHTVGAVLTPLSVPAFTLIAGDRSVSGSATGTPYELRKLMRFAARSKVAPTTELFPMSKINDAIQHVRDGKARYRVVLKA 7cbu A 2.25 BS02 ASP A 1 A13 S56 G88 T89 D90 A12 S52 G84 T85 D86 A13 L24 E36 T89 D90 N156 K162 T274 A279 G280 S282 A12 L20 E32 T85 D86 N152 K158 T270 A275 G276 S278 ? 0004067,0006528,0016787,0046872 A0A6I7U6Y2 33371681 406 KKKVALITTGGAIASRKGRLAAGAISGPELAEMCSLPEDVQIDVYPAFQLPSMHITFQHLLELKQTVERVFQDGSYDGVVVTHGTDTLEETAYFLDLTLQDERPVVVTGSQRAPEQQGTDAYTNIRHAVYTACSPDIKGAGTVVVFNERIFNARYVKKVHASNLQGFDVFGFGYLGIIDNDKVYVYQKPLKRDVHQLQRPLPEVDIVKCYLDGDGKFIRAAVREGAAGIVLEGVGRGQVPPNMVGDIEQALHQGVYIVITTSAEEGEVYTTYDYAGSSYDLAKKGVILGKDYDSKKARMKLAVLLASYEEGIKDKFCY 7cbu B 2.25 BS03 ASP B 1 A13 S56 G88 T89 D90 A12 S55 G87 T88 D89 A13 L24 E36 T89 D90 N156 K162 T274 A279 G280 S282 A12 L23 E35 T88 D89 N155 K161 T273 A278 G279 S281 ? 0004067,0006528,0016787,0046872 A0A6I7U6Y2 33371681 407 KKKVALITTGGAIASRKTESGRLAAGAISGPELAEMCSLPEDVQIDVYPAFQLPSMHITFQHLLELKQTVERVFQDGSYDGVVVTHGTDTLEETAYFLDLTLQDERPVVVTGSQRAPEQQGTDAYTNIRHAVYTACSPDIKGAGTVVVFNERIFNARYVKKVHASNLQGFDVFGFGYLGIIDNDKVYVYQKPLKRDVHQLQRPLPEVDIVKCYLDGDGKFIRAAVREGAAGIVLEGVGRGQVPPNMVGDIEQALHQGVYIVITTSAEEGEVYTTYDYAGSSYDLAKKGVILGKDYDSKKARMKLAVLLASYEEGIKDKFCY 7ffp A 1.8 BS01 ASP A 1 G91 G92 S125 A126 N129 T138 N139 D140 P161 H162 G91 G92 S125 A126 N129 T138 N139 D140 P161 H162 3.4.13.21 0005737,0006508,0008236,0016805 Q91642 34431561 301 MMTMRRHLLLVSNSTLHGGGYLEHCQEHILKFLGAQVKRVLFIPYALHDRDAYAKTARQKFEALGYGLDSVHESPDPVDAVKKAEAIFIGGGNTFRLLKALYDNDLIAAIRKRVLEDGVPYIGSSAGTNVATISINTTNDMPIVYPPSLKALELVPFNINPHYLDPDGNSKHMGETREQRITQYHEEHDTPPVLGLREGCFLLVEGDKATLLGITRARLFLRGKNPTEHEPGHDFSFLLG 7m11 A 1.83 BS01 ASP A 1 T12 G57 S58 Q59 G88 T89 D90 T12 G48 S49 Q50 G79 T80 D81 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 401 LPNITILATGGTIAGNYTGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 7m11 B 1.83 BS01 ASP B 1 G11 T12 S58 Q59 G88 T89 D90 G11 T12 S34 Q35 G64 T65 D66 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 401 LPNITILATGGTVEVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 7m11 C 1.83 BS01 ASP C 1 T12 Y25 V27 G57 S58 Q59 G88 T89 D90 T12 Y25 V27 G57 S58 Q59 G88 T89 D90 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 401 LPNITILATGGTIAGGGDSATKSNYTVGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 7m11 D 1.83 BS01 ASP D 1 T12 G57 S58 Q59 G88 T89 D90 T12 G26 S27 Q28 G57 T58 D59 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 401 LPNITILATGGTIAANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 7n2r F 2.28 BS02 ASP F 1 Q201 A242 Q200 A241 36477533 301 GVTQTPKHLITATGQRVTLRCSPRSGDLSVYWYQQSLDQGLQFLIQYYNGEERAKGNILERFSAQQFPDLHSELNLSSLELGDSALYFCASSVATYSTDTQYFGPGTRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRA 7ngh A 3.5 BS01 ASP A 1 R278 S279 S280 M314 G357 V358 G360 A361 G362 D398 R401 T402 R263 S264 S265 M299 G342 V343 G345 A346 G347 D383 R386 T387 ? 0015293,0016020,0046942,0055085 Q5JID0 34140623 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 7ngh B 3.5 BS01 ASP B 1 S279 S280 T317 V358 A361 G362 D398 R401 T402 S275 S276 T313 V354 A357 G358 D394 R397 T398 ? 0015293,0016020,0046942,0055085 Q5JID0 34140623 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 7ngh C 3.5 BS01 ASP C 1 S279 T317 A356 G357 V358 G360 A361 G362 D398 R401 T402 S264 T302 A341 G342 V343 G345 A346 G347 D383 R386 T387 ? 0015293,0016020,0046942,0055085 Q5JID0 34140623 501 LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVNLPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 7rcp A 2.2 BS01 ASP A 1 R276 S277 S278 T314 G354 V355 A358 G359 D394 R397 T398 R275 S276 S277 T313 G353 V354 A357 G358 D393 R396 T397 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 35452090 500 GLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSEGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGNLTGTAIVAKTE 7rcp B 2.2 BS01 ASP B 1 R276 S277 S278 T314 G354 V355 A358 G359 D394 R397 T398 R275 S276 S277 T313 G353 V354 A357 G358 D393 R396 T397 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 35452090 500 GLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSEGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGNLTGTAIVAKTE 7rcp C 2.2 BS01 ASP C 1 R276 S277 S278 T314 G354 V355 A358 G359 D394 R397 T398 R275 S276 S277 T313 G353 V354 A357 G358 D393 R396 T397 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 35452090 500 GLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTRSSEGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGNLTGTAIVAKTE 7u6m A 1.75 BS01 ASP A 1 T15 A61 S62 Q63 G94 T95 D96 T15 A61 S62 Q63 G94 T95 D96 3.5.1.1 0004067,0006520,0006528,0016787 P06608 35979719 400 DDKLPNIVILATGGTIAGSAATGTQTTGYKIGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGQVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 7u6m B 1.75 BS01 ASP B 1 T15 A61 S62 Q63 G94 T95 D96 T15 A61 S62 Q63 G94 T95 D96 3.5.1.1 0004067,0006520,0006528,0016787 P06608 35979719 400 DDKLPNIVILATGGTIAGSAATGTQTTGYKIGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGQVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 7u6m C 1.75 BS01 ASP C 1 T15 A61 S62 Q63 G94 T95 D96 T30 A76 S77 Q78 G109 T110 D111 3.5.1.1 0004067,0006520,0006528,0016787 P06608 35979719 400 IEDICLPRWGCLWEDDDKLPNIVILATGGTIAGSAATGTQTTGYKIGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGQVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 7u6m D 1.75 BS01 ASP D 1 T15 A61 S62 Q63 G94 T95 D96 T15 A61 S62 Q63 G94 T95 D96 3.5.1.1 0004067,0006520,0006528,0016787 P06608 35979719 400 DDKLPNIVILATGGTIAGSAATGTQTTGYKIGALGVDTLINAVPEVKKLANVKGEQFSNMASQNMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGQVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY 7ugd A 2.95 BS01 ASP A 1 S276 S277 S278 G359 D394 R397 T398 S274 S275 S276 G357 D392 R395 T396 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 501 LYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAHVMAHQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYACILGIDAILDRGRTMVNVTGDLTGTAIVAKTE 7ugv A 2.94 BS01 ASP A 1 S277 S278 G354 A358 G359 D394 R397 T398 S276 S277 G353 A357 G358 D393 R396 T397 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 37023263 501 GLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAHVMAHQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYACILGIDAILDRGRTMVNVTGDLTGTAIVAKTEGT 7ugx A 2.96 BS01 ASP A 1 S276 S278 G354 V355 A358 G359 R397 T398 N401 S275 S277 G353 V354 A357 G358 R396 T397 N400 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 37023263 501 GLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAHVMAHQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYACILGIDAILDRGRTMVNVTGDLTGTAIVAKTE 7uh3 A 2.99 BS01 ASP A 1 S278 T314 V355 P356 G359 R397 T398 S277 T313 V354 P355 G358 R396 T397 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 501 GLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAHVMAHQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYACILGIDAILDRGRTMVNVTGDLTGTAIVAKTE 7uh6 A 3.44 BS01 ASP A 1 S278 T314 G354 P356 A358 G359 D394 R397 T398 N401 S278 T314 G354 P356 A358 G359 D394 R397 T398 N401 ? 0005283,0005886,0006865,0015108,0015183,0015293,0015501,0016020,0035725,0042802,0046872,0046942,0070207,0070778,0140009,1902476 O59010 501 MGLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAHVMAHQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAMLTAFVTSSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYACILGIDAILDRGRTMVNVTGDLTGTAIVAKT 7uio Bc 3.3 BS03 ASP Bc 1 L106 K107 L106 K107 ? 0000122,0000979,0003712,0003713,0005515,0005634,0006357,0016592,0032968,0034605,0045944,0051123,0060261,0061629,0070847 P40356 36731470 110 MDSIIPAGVKLDDLQVILAKNENETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEGSKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLK 7wae D 2.64 BS07 ASP D 1 N394 R458 N394 R458 6.3.2.29,6.3.2.30 0004326,0005524,0009058,0009059,0009396,0016874,0016881,0046872,0046901,0071160,0071161 Q113V7 36042318 1006 MKILKLQTLRGPNYWSIHRHKLVVMRLDLEDLYEKYTSDIPGFYKGLTEVLPSLVEHLCSPGVKGGFLTRVEKGTLIGHVIEHVAIELQELAGMPVGFGRTRETSTTGVFQVVIEYENEQAGRYAARAAVRLCQSIVDTGTYPATELQQDLEDLKELKNQASLGPSTEAIVKEAEARGIPWTQLGARFMIQFGYGVNQKKIQATLSNQTGILGVELACDKEGTKRILKDAGVPVPRGTVARYFDELQDAIEYVGGYPIVIKPLDGNHGRGITIDVKNWQEAEEAYDLARKASKTKTVIVERYYTGKDHRVLVVNGKVVAVAERVPAHVVGNGKSTIAELIEETNRDPQRGDGHDNILTRITVDKSALDILGKQGYSIDSIPLKGKKCFLRATANLSTGGIAVDRTDEIHPENVWLLSRVAKIIGLDIAGIDVVTEDISQPLREVEGVIVEVNAAPGFRMHVAPSRGLARNVAGAVMDMLFPGSKNGRIPILSVTGTNGKTTTTRLLAHIIKQTGKVVGYTTTDGTYIGEYLAETGDNTGPQSAHLILSDPTVEVAVLETARGGILRSGLGFSSCEVGIVLNVTADHLGIGDIDTIEQLAKLKSVVAESVMPKGYAVLNAEDPLVAAMADRVKGQVAYFSMDPNNELLLRHTEAGGLAAIYENGYISILKGDWTLRIEKAVNVPITMAGKAPFMIANALAACLAVFTQGVKIEHIRKGLSTFVAS 8afa A 3.25 BS01 ASP A 1 S279 S280 T317 G357 V358 A361 G362 D398 R401 T402 S250 S251 T288 G328 V329 A332 G333 D369 R372 T373 ? 0015293,0016020,0046942,0055085 Q5JID0 37002226 501 WKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYARIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 8afa B 3.25 BS01 ASP B 1 S279 S280 T317 G357 V358 A361 G362 D398 R401 T402 S251 S252 T289 G329 V330 A333 G334 D370 R373 T374 ? 0015293,0016020,0046942,0055085 Q5JID0 37002226 501 WKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYARIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 8afa C 3.25 BS01 ASP C 1 S279 S280 T317 G357 V358 A361 G362 D398 R401 T402 S251 S252 T289 G329 V330 A333 G334 D370 R373 T374 ? 0015293,0016020,0046942,0055085 Q5JID0 37002226 501 WKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVRLLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLIVGRLFNVGANVPPSLVQTLLNIVPTNPFASLAKGEVLPVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVMQYARIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLKVFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSFTLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIGTAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMVNVTGDLAGTVIVAKTEKELDESKWIS 8cp2 A 2.1 BS03 ASP A 1 R412 R416 S582 R411 R415 S581 ? 0000166 A0A2V1NMV1 37302552 703 PLSVAVVGAGPRGTSVLERLCASAPELLAPGVRLTVHVVDPAPPGPGRVWRTAQSEDLLMNTVASQVTLFTDESVNCSGPILAGPSLHEWADGAIGPDDYPTRALYGRYLEWVFARTLRHAPPSVRVETHRARAVRLDDAADGRQHLALDNGRTLTGLSAVVLAQGHLPVRPSAAVLRDTEHADRHALRHIPPANPADVDLTVISPGEPVLLRGLGLNFFDHMALLTTGRGGTYVREDGVLRYVPSGREPRVYAGSRRGLPYQARGDNAKGPYGRHLPEVLTPEAVSAFRKRADSGEAPDFLRDIWPLVAKEVETVYYTALVRHPDFAPRYLSLPYGDPQEAELLAEFGVDADARWDWERVSRPYAQREFAHRGEWRQWLLGYLRADAAEALRGNVDGPLKAALDVLRDLRNELRLVVDHRGLRGDSRRDHLDRWYTPLNAFLSIGPPRRRIEELTALLEAGVVEVLGPRLEVTREDGAWLARSPDVPGSAVRVTTLIEARLPEPDLGQTADALLAHLRETGQCRAHVVDGYTTGGIDVSARPYHLVDREGVAHPRRFAFGVPTEGVHWVTAAGARPGVDSVTLSDADAVARAVLRVAGQ 8cp2 A 2.1 BS04 ASP A 2 S79 R593 R597 S78 R592 R596 ? 0000166 A0A2V1NMV1 37302552 704 PLSVAVVGAGPRGTSVLERLCASAPELLAPGVRLTVHVVDPAPPGPGRVWRTAQSEDLLMNTVASQVTLFTDESVNCSGPILAGPSLHEWADGAIGPDDYPTRALYGRYLEWVFARTLRHAPPSVRVETHRARAVRLDDAADGRQHLALDNGRTLTGLSAVVLAQGHLPVRPSAAVLRDTEHADRHALRHIPPANPADVDLTVISPGEPVLLRGLGLNFFDHMALLTTGRGGTYVREDGVLRYVPSGREPRVYAGSRRGLPYQARGDNAKGPYGRHLPEVLTPEAVSAFRKRADSGEAPDFLRDIWPLVAKEVETVYYTALVRHPDFAPRYLSLPYGDPQEAELLAEFGVDADARWDWERVSRPYAQREFAHRGEWRQWLLGYLRADAAEALRGNVDGPLKAALDVLRDLRNELRLVVDHRGLRGDSRRDHLDRWYTPLNAFLSIGPPRRRIEELTALLEAGVVEVLGPRLEVTREDGAWLARSPDVPGSAVRVTTLIEARLPEPDLGQTADALLAHLRETGQCRAHVVDGYTTGGIDVSARPYHLVDREGVAHPRRFAFGVPTEGVHWVTAAGARPGVDSVTLSDADAVARAVLRVAGQ 8cp2 B 2.1 BS03 ASP B 1 R412 N413 R416 R577 S582 V583 R412 N413 R416 R577 S582 V583 ? 0000166 A0A2V1NMV1 37302552 703 MPLSVAVVGAGPRGTSVLERLCASAPELLAPGVRLTVHVVDPAPPGPGRVWRTAQSEDLLMNTVASQVTLFTDESVNCSGPILAGPSLHEWADGAIGPDDYPTRALYGRYLEWVFARTLRHAPPSVRVETHRARAVRLDDAADGRQHLALDNGRTLTGLSAVVLAQGHLPVRPSAAVLRDTEHADRHALRHIPPANPADVDLTVISPGEPVLLRGLGLNFFDHMALLTTGRGGTYVREDGVLRYVPSGREPRVYAGSRRGLPYQARGDNAKGPYGRHLPEVLTPEAVSAFRKRADSGEAPDFLRDIWPLVAKEVETVYYTALVRHPDFAPRYLSLPYGDPQEAELLAEFGVDADARWDWERVSRPYAQREFAHRGEWRQWLLGYLRADAAEALRGNVDGPLKAALDVLRDLRNELRLVVDHRGLRGDSRRDHLDRWYTPLNAFLSIGPPRRRIEELTALLEAGVVEVLGPRLEVTREDGAWLARSPDVPGSAVRVTTLIEARLPEPDLGQTADALLAHLRETGQCRAHVVDGYTTGGIDVSARPYHLVDREGVAHPRRFAFGVPTEGVHWVTAAGARPGVDSVTLSDADAVARAVLRVAG 8ecd A 1.62 BS01 ASP A 1 T12 T27 G57 S58 Q59 G88 T89 D90 T16 T31 G61 S62 Q63 G92 T93 D94 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 36310372 401 HHHHLPNITILATGGTIAGGGDSATKSNYTTGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 8ecd B 1.62 BS01 ASP B 1 T12 T27 G57 S58 Q59 G88 T89 D90 T16 T20 G50 S51 Q52 G81 T82 D83 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 36310372 401 HHHHLPNITILATGGTIAGTGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 8ecd C 1.62 BS01 ASP C 1 T12 G57 S58 Q59 G88 T89 D90 T16 G61 S62 Q63 G92 T93 D94 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 36310372 401 HHHHLPNITILATGGTIAGGGDSATKSNYTTGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 8ecd D 1.62 BS01 ASP D 1 T12 T27 G57 S58 Q59 G88 T89 D90 T16 T31 G61 S62 Q63 G92 T93 D94 3.5.1.1 0004067,0006520,0006528,0006530,0016787,0030288,0032991,0042597,0042802,0051289 P00805 36310372 902 HHHHLPNITILATGGTIAGGGDSATKSNYTTGKVGVENLVNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAKKINTDCDKTDGFVITHGTDTMEETAYFLDLTVKCDKPVVMVGAMRPSTSMSADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATFKSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYANASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSSRVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQIFNQY 8hrh A 2.07 BS01 ASP A 1 N31 Y32 S100 G101 T102 N31 Y32 S100 G101 T102 37547453 502 QVQLQQSGAELARPGASVKLSCKASGYTFTNYGLSWVKQRTGQGLEWIGENHPGSGIIYHNEKFRGKATLTADKSSSTAYVQLSSLTSEDSAVYFCARSSGTRGFAYWGQGTLVTVSAAKTTAPSVYPLAPVCGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR 8ovo A 1.7 BS01 ASP A 1 R21 R72 S87 T89 R94 T136 T137 H161 D179 R20 R71 S86 T88 R93 T135 T136 H160 D178 ? 0006091,0006865,0008218,0015813,0016020,0016595,0030288,0042597,0055052,0070335,0070778,0098712,0140009 P37902,P42212 601 AAGSTLDKIAKNGVIVVGHRESSVPFSYYDNQQKVVGYSQDYSNAIVEAVKKKLNKPDLQVKLIPITAQNRIPLLQNGTFDFECGSTTNNVERQKQAAFSDTIFVVGTRLLTKKGGDIKDFANLKDKAVVVTSGTTSEVLLNKLNEEQKMNMRIISAKDHGDSFRTLESGRAVAFMMDDVLLAGERAKAKKPDNWEIVGKPQSQEAYGCMLRKDDPQFKKLMDDTIAQVQTSGEAEKWFDKWFKNPILVSHNVYITADKQKNGIKANFKIRHNVEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSVLSKDPNEKRDHMVLLEFVTAAGITLSMSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYVQERTISFKDDGTYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNFNNPLNMNFELSDEMKALFKEPNDKAL 8ovo B 1.7 BS01 ASP B 1 R21 R72 S87 T89 R94 T136 T137 H161 D179 R18 R69 S84 T86 R91 T133 T134 H158 D176 ? 0006091,0006865,0008218,0015813,0016020,0016595,0030288,0042597,0055052,0070335,0070778,0098712,0140009 P37902,P42212 601 GSTLDKIAKNGVIVVGHRESSVPFSYYDNQQKVVGYSQDYSNAIVEAVKKKLNKPDLQVKLIPITAQNRIPLLQNGTFDFECGSTTNNVERQKQAAFSDTIFVVGTRLLTKKGGDIKDFANLKDKAVVVTSGTTSEVLLNKLNEEQKMNMRIISAKDHGDSFRTLESGRAVAFMMDDVLLAGERAKAKKPDNWEIVGKPQSQEAYGCMLRKDDPQFKKLMDDTIAQVQTSGEAEKWFDKWFKNPILVSHNVYITADKQKNGIKANFKIRHNVEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSVLSKDPNEKRDHMVLLEFVTAAGITLSMSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYVQERTISFKDDGTYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNFNNPLNMNFELSDEMKALFKEPNDKAL 8ovp A 1.7 BS01 ASP A 1 R21 R72 S87 D89 R94 T136 T137 H161 D179 R18 R69 S84 D86 R91 T133 T134 H158 D176 ? 0006091,0006865,0008218,0015813,0016020,0016595,0030288,0042597,0055052,0070335,0070778,0098712,0140009 P37902,P42212 601 GSTLDKIAKNGVIVVGHRESSVPFSYYDNQQKVVGFSQDYSNAIVEAVKKKLNKPDLQVKLIPITAQNRIPLLQNGTFDFECGSTDNNVERQKQAAFSDTIFVVTTRLLTKKGGDIKDFANLKDKAVVVTSGTTSEVLLNKLNEEQKMNMRIISAKDHGDSFRTLESGRAVAFMMDDVLLAGERARAKKPDNWEIVGKPQSQEAWGCMLRKDDPQFKKLMDDTIAQVRTSGEAEKWFDKWFKNPILVSHNVYITADKQKNGIKANFKIRHNVEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSVLSKDPNEKRDHMVLLEFVTAAGITLGMDELSMSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYVQERTISFKDDGTYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNFNNPLNMNFELSDEMKALFK 8ovp B 1.7 BS01 ASP B 1 R21 R72 S87 T88 D89 R94 T136 T137 H161 D179 R21 R72 S87 T88 D89 R94 T136 T137 H161 D179 ? 0006091,0006865,0008218,0015813,0016020,0016595,0030288,0042597,0055052,0070335,0070778,0098712,0140009 P37902,P42212 601 GAAGSTLDKIAKNGVIVVGHRESSVPFSYYDNQQKVVGFSQDYSNAIVEAVKKKLNKPDLQVKLIPITAQNRIPLLQNGTFDFECGSTDNNVERQKQAAFSDTIFVVTTRLLTKKGGDIKDFANLKDKAVVVTSGTTSEVLLNKLNEEQKMNMRIISAKDHGDSFRTLESGRAVAFMMDDVLLAGERARAKKPDNWEIVGKPQSQEAWGCMLRKDDPQFKKLMDDTIAQVRTSGEAEKWFDKWFKNPILVSHNVYITADKQKNGIKANFKIRHNVEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSVLSKDPNEKRDHMVLLEFVTAAGITLMSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICTTGKLPVPWPTLVTTLVQCFSRYPDHMKQHDFFKSAMPEGYVQERTISFKDDGTYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNFNNPLNMNFELSDEMKALFK 8paw A 2.14 BS01 ASP A 1 N295 E296 M298 N269 E270 M272 Q13043 401 TKQPEEVFDVLEKLGESVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAM 8u3g A 3.42 BS01 ASP A 1 F50 Y54 F179 F15 Y19 F118 ? 0005351,0005764,0005765,0005829,0005886,0006811,0006820,0006865,0009617,0015136,0015293,0015538,0015739,0016020,0016323,0022857,0030672,0031410,0034219,0042874,0042880,0045202,0098700,0098978,1902600 Q9NRA2 502 CSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALN 8uou A 1.35 BS01 ASP A 1 T16 D57 S58 G86 T87 D88 T16 D57 S58 G86 T87 D88 3.5.1.1 0004067,0016020,0016787 Q2RMX1 38501449 201 MAVSPSPLRIFTAGGTIDKDYRLEENGLVVGDPFVAEVLKTARLAGAVSIVALSRKDSLDFTEADREAIGRAVGQAVEDHILLTHGTDTMVETARYLGGLPELAGKTVVLSGAMVPGRVGGSDAAFNIGFACAAALMLAPGVYIAMHGKVFDPAKTRKNRGLGRFEPID 8uou B 1.35 BS01 ASP B 1 T16 D57 S58 G86 T87 D88 T11 D52 S53 G81 T82 D83 3.5.1.1 0004067,0016020,0016787 Q2RMX1 38501449 201 SPLRIFTAGGTIDKDYRLEENGLVVGDPFVAEVLKTARLAGAVSIVALSRKDSLDFTEADREAIGRAVGQAVEDHILLTHGTDTMVETARYLGGLPELAGKTVVLSGAMVPGRVGGSDAAFNIGFACAAALMLAPGVYIAMHGKVFDPAKTRKNRGLGRFEPI 8up3 E 1.76 BS01 ASP E 1 T16 D57 S58 G86 T87 D88 T12 D53 S54 G82 T83 D84 3.5.1.1 0004067,0016020,0016787 Q2RMX1 38501449 201 PSPLRIFTAGGTIDKDFRLEENGLVVGDPFVAEVLKTARLAGAVSIVALSRKDSLDFTEADREAIGRAVGQAVEDHILLTHGTDTMVETARYLGGLPELAGKTVVLSGAMVPGRVGGSDAAFNIGFACAAALMLAPGVYIAMHGKVFDPAKTRKNRGLGRFEPI 8up3 F 1.76 BS01 ASP F 1 T16 D57 S58 G86 T87 D88 T11 D52 S53 G81 T82 D83 3.5.1.1 0004067,0016020,0016787 Q2RMX1 38501449 201 SPLRIFTAGGTIDKDFRLEENGLVVGDPFVAEVLKTARLAGAVSIVALSRKDSLDFTEADREAIGRAVGQAVEDHILLTHGTDTMVETARYLGGLPELAGKTVVLSGAMVPGRVGGSDAAFNIGFACAAALMLAPGVYIAMHGKVFDPAKTRKNRGLGRFEPI 8up6 B 1.7 BS01 ASP B 1 T16 D57 S58 G86 T87 D88 T11 D52 S53 G81 T82 D83 3.5.1.1 0004067,0016020,0016787 Q2RMX1 38501449 201 SPLRIFTAGGTIDADYRLEENGLVVGDPFVAEVLKTARLAGAVSIVALSRKDSLDFTEADREAIGRAVGQAVEDHILLTHGTDTMVETARYLGGLPELAGKTVVLSGAMVPGRVGGSDAAFNIGFACAAALMLAPGVYIAMHGKVFDPAKTRKNRGLGRFEPI 8up6 C 1.7 BS01 ASP C 1 T16 D57 S58 G86 T87 D88 T12 D53 S54 G82 T83 D84 3.5.1.1 0004067,0016020,0016787 Q2RMX1 38501449 200 PSPLRIFTAGGTIDADYRLEENGLVVGDPFVAEVLKTARLAGAVSIVALSRKDSLDFTEADREAIGRAVGQAVEDHILLTHGTDTMVETARYLGGLPELAGKTVVLSGAMVPGRVGGSDAAFNIGFACAAALMLAPGVYIAMHGKVFDPAKTRKNRGLGRFEPI 8up8 A 1.9 BS01 ASP A 1 T16 D57 S58 G86 T87 D88 T16 D57 S58 G86 T87 D88 3.5.1.1 0004067,0016020,0016787 Q2RMX1 38501449 200 MAVSPSPLRIFTAGGTIDKDFRLEENGLVVGDPFVAEVLKTARLAGAVSIVALSRKDSLDFTEADREAIGRAVGQAVEDHILLTHGTDTMVETARYLGGLPELAGKTVVLSGAMVPGRVGGSDAAFNIGFACAAALMLAPGVYIAMHGKVFDPAKTRKNRGLGRFEPI 8up8 B 1.9 BS01 ASP B 1 T16 D57 S58 G86 T87 D88 T11 D52 S53 G81 T82 D83 3.5.1.1 0004067,0016020,0016787 Q2RMX1 38501449 201 SPLRIFTAGGTIDKDFRLEENGLVVGDPFVAEVLKTARLAGAVSIVALSRKDSLDFTEADREAIGRAVGQAVEDHILLTHGTDTMVETARYLGGLPELAGKTVVLSGAMVPGRVGGSDAAFNIGFACAAALMLAPGVYIAMHGKVFDPAKTRKNRGLGRFEPI 8up8 C 1.9 BS01 ASP C 1 T16 D57 S58 G86 T87 D88 T11 D52 S53 G81 T82 D83 3.5.1.1 0004067,0016020,0016787 Q2RMX1 38501449 200 SPLRIFTAGGTIDKDFRLEENGLVVGDPFVAEVLKTARLAGAVSIVALSRKDSLDFTEADREAIGRAVGQAVEDHILLTHGTDTMVETARYLGGLPELAGKTVVLSGAMVPGRVGGSDAAFNIGFACAAALMLAPGVYIAMHGKVFDPAKTRKNRGLGRFEPI