1nfq A 2.4 BS02 AOI A 1 L92 E142 C150 Y153 V194 I198 F199 L91 E141 C149 Y152 V193 I197 F198 G18 S140 Y153 K157 G17 S139 Y152 K156 1.1.1.53 0005886,0006706,0008202,0016491,0016616,0047044 P9WGT1 12524453 401 SGRLTGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAMAAELADAARYVHLDVTQPAQWKAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHN 1nfq B 2.4 BS02 AOI B 1 L92 E142 C150 V194 I198 F199 L91 E141 C149 V193 I197 F198 G18 S140 Y153 K157 G17 S139 Y152 K156 1.1.1.53 0005886,0006706,0008202,0016491,0016616,0047044 P9WGT1 12524453 1401 SGRLTGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAMAAELADAARYVHLDVTQPAQWKAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHN 1nfq C 2.4 BS02 AOI C 1 L92 E142 C150 V194 I198 F199 L91 E141 C149 V193 I197 F198 G18 S140 Y153 K157 G17 S139 Y152 K156 1.1.1.53 0005886,0006706,0008202,0016491,0016616,0047044 P9WGT1 12524453 2401 SGRLTGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAMAAELADAARYVHLDVTQPAQWKAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHN 1nfq D 2.4 BS02 AOI D 1 L92 E142 C150 V194 I198 F199 L91 E141 C149 V193 I197 F198 G18 S140 Y153 K157 G17 S139 Y152 K156 1.1.1.53 0005886,0006706,0008202,0016491,0016616,0047044 P9WGT1 12524453 3401 SGRLTGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAMAAELADAARYVHLDVTQPAQWKAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHN 1x8j A 2.35 BS03 AOI A 1 I111 Y298 I105 Y292 R73 H164 S193 R67 H158 S187 ? 0005737,0008146,0016740,0046872,0051923 Ki=0.11uM -logKd/Ki=6.96, Ki=0.11uM Q26490 15608121 400 LPFPYEFRELNPEEDKLVKANLGAFPTTYVKLGPKGYMVYRPYLKDAANIYNMPLRPTDVFVASYQRSGTTMTQELVWLIENDLNFEAAKTYMSLRYIYLDGFMIYDPEKQEEYNDILPNPENLDMERYLGLLEYSSRPGSSLLAAVPPTEKRFVKTHLPLSLMPPNMLDTVKMVYLARDPRDVAVSSFHHARLLYLLNKQSNFKDFWEMFHRGLYTLTPYFEHVKEAWAKRHDPNMLFLFYEDYLKDLPGSIARIADFLGKKLSEEQIQRLSEHLNFEKFKNNGAVNMEDYREIGILADGEHFIRKGKAGCWRDYFDEEMTKQAEKWIKDNLKDTDLRYPNM 1x8j B 2.35 BS03 AOI B 1 I111 Y298 I105 Y292 R73 H164 S193 R67 H158 S187 ? 0005737,0008146,0016740,0046872,0051923 Ki=0.11uM Q26490 15608121 500 LPFPYEFRELNPEEDKLVKANLGAFPTTYVKLGPKGYMVYRPYLKDAANIYNMPLRPTDVFVASYQRSGTTMTQELVWLIENDLNFEAAKTYMSLRYIYLDGFMIYDPEKQEEYNDILPNPENLDMERYLGLLEYSSRPGSSLLAAVPPTEKRFVKTHLPLSLMPPNMLDTVKMVYLARDPRDVAVSSFHHARLLYLLNKQSNFKDFWEMFHRGLYTLTPYFEHVKEAWAKRHDPNMLFLFYEDYLKDLPGSIARIADFLGKKLSEEQIQRLSEHLNFEKFKNNGAVNMEDYREIGILADGEHFIRKGKAGCWRDYFDEEMTKQAEKWIKDNLKDTDLRYPNM 1yb1 B 1.95 BS01 AOI B 1 S122 F125 S98 F101 S167 Y180 K184 S143 Y154 K158 1.1.1.62 Q8NBQ5 601 RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERIL