1aee A 2.1 BS02 ANL A 1 H175 T180 M230 M231 D235 H172 T177 M227 M228 D232 R48 H52 H175 G191 D235 R45 H49 H172 G188 D232 1.11.1.5 0004601,0006979,0020037,0034599 P00431 11812152 296 LVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHISGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWISSGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDAGYVRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGPGGAANNVFTNEFYLNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQDKFFKDFSKAFEKLLEDGITFPKDAPSPFIFKTLEEQGL 1hj9 A 0.95 BS01 ANL A 1 S190 V213 S172 V191 H57 D102 Q192 G193 D194 S195 G196 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 P00760 11264577 246 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAYGLEGKGDSCQGDSGGPVVCSGKLQGIVSWGSGCQAKNKPGVYTKVCNYVSWIKQTIASN 1ppa A 2.0 BS01 ANL A 1 C29 H48 C28 H47 N28 G30 G32 H48 K49 Y52 Y73 D99 N27 G29 G31 H47 K48 Y51 Y64 D89 3.1.1.4 0004623,0005509,0005543,0005576,0006644,0016042,0035821,0042130,0047498,0050482,0090729 P04361 2120215 134 SVLELGKMILQETGKNAITSYGSYGCNCGWGHRGQPKDATDRCCFVHKCCYKKLTDCNHKTDRYSYSWKNKAIICEEKNPCLKEMCECDKAVAICLRENLDTYNKKYKAYFKLKCKKPDTC 2ov4 A 2.5 BS02 ANL A 1 F5 G7 H43 M129 D132 I133 F5 G7 H43 M129 D132 I133 K111 K192 K195 K111 K192 K195 6.1.1.2 0000166,0004812,0004830,0005524,0005737,0006412,0006418,0006436 P00953 17428498 950 MKTIFSGIQPSGVITIGNYIGALRQFVELQHEYNCYFCIVDQHAITVWQDPHELRQNIRRLAALYLAVGIDPTQATLFIQSEVPAHAQAAWMLQCIVYIGELERMTQFKEKSAGKEAVSAGLLTYPPLMAADILLYNTDIVPVGEDQKQHIELTRDLAERFNKRYGELFTIPEARIPKVGARIMSLVDPTKKMSKSDPNPKAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGISNLLNIYSTLSGQSIEELERQYEGKGYGVFKADLAQVVIETLRPIQERYHHWMESEELDRVLDEGAEKANRVASEMVRKMEQAMGLGRRR 3gun A 1.5 BS01 ANL A 1 A99 E102 V111 A99 E102 V111 E11 D20 E11 D20 3.2.1.17 0003796,0009253,0016798,0016998,0030430,0031640,0042742,0044659 P00720 19663503 501 MNIFEMLRIDEGLRLKIYKDCEGYYTIGIGHLLTKSPDLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAAINEVFQMGVTGVAGFTNVLRMLQQKRWDEAAVNLAKSRWYNQCPDRAKRVITTFRTGTWDAYK 3gun B 1.5 BS02 ANL A 2 C97 I100 C97 I100 E11 D20 E11 D20 3.2.1.17 0003796,0009253,0016798,0016998,0030430,0031640,0042742,0044659 P00720 19663503 168 MNIFEMLRIDEGLRLKIYKDCEGYYTIGIGHLLTKSPDLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAAINEVFQMGVTGVAGFTNVLRMLQQKRWDEAAVNLAKSRWYNQCPDRAKRVITTFRTGTWDAYK 3gun B 1.5 BS03 ANL B 1 A99 E102 L118 A99 E102 L118 E11 D20 E11 D20 3.2.1.17 0003796,0009253,0016798,0016998,0030430,0031640,0042742,0044659 P00720 19663503 501 MNIFEMLRIDEGLRLKIYKDCEGYYTIGIGHLLTKSPDLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRCAAINEVFQMGVTGVAGFTNVLRMLQQKRWDEAAVNLAKSRWYNQCPDRAKRVITTFRTGTWDAYK 3ms3 A 1.54 BS06 ANL A 1 N112 V139 E143 L202 N112 V139 E143 L202 H142 E143 H146 Y157 E166 D226 H231 H142 E143 H146 Y157 E166 D226 H231 3.4.24.27 0004222,0006508 P00800 22213702 601 ITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK 5cie A 2.6 BS02 ANL A 1 H175 K179 T180 G191 D235 H175 K179 T180 G191 D235 R48 H52 H175 G191 D235 R48 H52 H175 G191 D235 1.11.1.5 0004601,0006979,0020037,0034599 P00431 27499202 302 TTPLVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHISGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWISSGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDAGYVRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGPGGAANNVFTNEFYLNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQDKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL 5cie C 2.6 BS02 ANL C 1 H175 T180 G191 M230 H175 T180 G191 M230 R48 H52 H175 G191 D235 R48 H52 H175 G191 D235 1.11.1.5 0004601,0006979,0020037,0034599 P00431 27499202 302 TTPLVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHISGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWISSGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDAGYVRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGPGGAANNVFTNEFYLNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQDKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL 5mnc A 0.916 BS02 ANL A 1 S190 Q192 S172 Q174 H57 D102 Q192 G193 D194 S195 G196 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 -logKd/Ki=1.31, Kd=48.5mM P00760 28371253 307 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 7bs0 A 1.85 BS02 ANL A 1 S195 C196 S172 C173 H63 D107 Q197 G198 D199 S200 G201 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 P00760 34094189 302 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 7bs7 A 1.04 BS02 ANL A 1 S195 C196 Q197 W216 S172 C173 Q174 W193 H63 D107 Q197 G198 D199 S200 G201 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 P00760 34094189 302 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 7bs7 A 1.04 BS03 ANL A 2 Y99 N100 S101 Y76 N77 S78 H63 D107 Q197 G198 D199 S200 G201 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 P00760 34094189 303 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN