3zu5 A 2.0 BS02 AEW A 1 Y225 Y235 A273 M285 Y230 Y240 A278 M290 1.3.1.9 0004318,0006633,0016491,0050343,0051287 Ki=1.5uM IC50=>1.00e+5nM Q8Z9U1 22244758 1401 SHMLEMIIKPRVRGFICVTAHPTGCEANVKKQIDYVTTEGPIANGPKRVLVIGASTGYGLAARITAAFGCGADTLGVFFERPGEEGKPGTSGWYNSAAFHKFAAQKGLYAKSINGDAFSDEIKQLTIDAIKQDLGQVDQVIYSLASPRRTHPKTGEVFNSALKPIGNAVNLRGLDTDKEVIKESVLQPATQSEIDSTVAVMGGEDWQMWIDALLDAGVLAEGAQTTAFTYLGEKITHDIYWNGSIGAAKKDLDQKVLAIRESLAAHGGGDARVSVLKAVVSQASSAIPMMPLYLSLLFKVMKEKGTHEGCIEQVYSLYKDSLCGDSPHMDQEGRLRADYKELDPEVQNQVQQLWDQVTNDNIYQLTDFVGYKSEFLNLFGFGIDGVDYDADVNPDVKIPNLIQG 4cuz A 3.1 BS01 AEW A 1 A95 F96 Y157 M160 S197 A93 F94 Y155 M158 S195 Y147 Y157 M160 K164 K199 Y145 Y155 M158 K162 K197 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 24739388 1257 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4cuz B 3.1 BS01 AEW B 1 A95 F96 A97 Y147 Y157 M160 S197 A93 F94 A95 Y145 Y155 M158 S195 Y147 Y157 M160 K164 K199 Y145 Y155 M158 K162 K197 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 24739388 1257 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4cuz C 3.1 BS01 AEW C 1 A95 F96 A97 L102 Y147 Y157 M160 S197 F204 A93 F94 A95 L100 Y145 Y155 M158 S195 F202 Y147 Y157 M160 K164 K199 Y145 Y155 M158 K162 K197 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 24739388 1258 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4cuz D 3.1 BS01 AEW D 1 F96 L102 Y147 Y157 M160 S197 F94 L100 Y145 Y155 M158 S195 Y147 Y157 M160 K164 K199 Y145 Y155 M158 K162 K197 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 24739388 1257 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4cuz E 3.1 BS01 AEW E 1 A95 F96 Y147 Y157 M160 S197 A93 F94 Y145 Y155 M158 S195 Y147 Y157 M160 K164 Y145 Y155 M158 K162 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 24739388 1257 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4cuz F 3.1 BS01 AEW F 1 F96 Y147 N156 Y157 M160 S197 V201 F94 Y145 N154 Y155 M158 S195 V199 Y147 Y157 M160 K164 Y145 Y155 M158 K162 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 24739388 1257 NLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK 4cuz G 3.1 BS01 AEW G 1 A95 F96 Y157 M160 S197 A94 F95 Y156 M159 S196 Y147 Y157 M160 K164 Y146 Y156 M159 K163 1.3.1.39 0000166,0004318,0006633,0016491,0042802,0141148 A0A0H3JLH9 24739388 1257 VNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK