2itp A 2.74 BS01 AEE A 1 L718 A743 K745 T790 Q791 M793 G796 E804 L844 L22 A47 K49 T94 Q95 M97 G100 E108 L148 D837 A839 R841 N842 D855 G874 D141 A143 R145 N146 D159 G178 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=7.95, Kd=11.3nM Kd=5.3nM, IC50=2nM P00533 17349580 2019 EAPNQALLRILKETEFKKIKVLSSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDMDEEDMDDVVDADEYLI 2itt A 2.73 BS01 AEE A 1 L718 K745 M766 T790 Q791 M793 G796 E804 L844 L22 K49 M70 T94 Q95 M97 G100 E108 L148 D837 A839 R841 N842 D855 D141 A143 R145 N146 D159 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=8.77, Kd=1.7nM Kd=5.3nM, IC50=2nM P00533 17349580 2020 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLMDEEDMDDVVDADEYLIP 2j6m A 3.1 BS01 AEE A 1 A743 T790 M793 P794 G796 E804 L844 A47 T94 M97 P98 G100 E108 L148 D837 A839 R841 N842 D855 G874 D141 A143 R145 N146 D159 G178 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=7.96, Kd=10.9nM Kd=5.3nM, IC50=2nM P00533 17349580 2021 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDDEEDMDDVVDADEYLIPQ 2jiu A 3.05 BS01 AEE A 1 L718 A743 K745 L792 M793 P794 G796 D800 L844 L23 A48 K50 L97 M98 P99 G101 D105 L149 D837 A839 R841 N842 D855 G874 D142 A144 R146 N147 D160 G179 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=7.56, Kd=27.6nM Kd=5.3nM, IC50=2nM P00533 18227510 2017 GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPVVDADE