1p7m A -1.00 BS02 ADK A 1 W6 Y13 Y16 W21 E38 W46 W6 Y13 Y16 W21 E38 W46 Y16 E38 W46 Y16 E38 W46 3.2.2.20 0003824,0005515,0006281,0006284,0006307,0008725,0016787,0046872 -logKd/Ki=4.38, Kd=42uM IC50=1500000nM P05100 13129925 189 MERCGWVSQDPLYIAYHDNEWGVPETDSKKLFEMICLEGQQAGLSWITVLKKRENYRACFHQFDPVKVAAMQEEDVERLVQDAGIIRHRGKIQAIIGNARAYLQMEQNGEPFADFVWSFVNHQPQMTQATTLSEIPTSTPASDALSKALKKRGFKFVGTTICYSFMQACGLVNDHVVGCCCYPGNKP 2ofi A 1.85 BS04 ADK A 1 W6 Y13 Y16 W21 E38 W46 S164 W6 Y13 Y16 W21 E38 W46 S164 3.2.2.20 0003824,0006281,0006284,0008725,0016798,0046872 Q8Z2A5 17410210 301 MQRCDWVSQDPLYIAYHDNEWGVPETDSRKLFEMICLEGQQAGLSWITVLKKRENYRACFHQFDPIRIAAMQEEDVERLLQNTGIIRHRGKIQAIISNARAWLAMEQNGESFADFVWSFVDGQPQITQAASLDKIPTSTPASDALAKALKKRGFKFVGTTICYSFMQACGLVNDHITGCFCHPG 4ai5 A 2.22 BS02 ADK A 1 F6 Y13 W21 E38 W46 F8 Y15 W23 E40 W48 0003824,0006281,0006284,0008725 Kd=1.2mM -logKd/Ki=2.92, Kd=1.2mM 22684054 400 GAMNECAFGTKDPVYLNFHDHVWGQPLYDSKALFKLLALESQHAGLSWLTILKKKEAYEEAFYDFEPEKVAQMTAQDIDRLMTFPNIVHHRKKLEAIVNQAQGYLKIEQAYGSFSKFLWSYVNGKPKDLQYEHASDRITVDDTATQLSKDLKQYGFKFLGPVTVFSFLEAAGLYDAHLKDCPSKPKHN 4ai5 B 2.22 BS02 ADK B 1 F6 Y13 W21 E38 W46 F6 Y13 W21 E38 W46 0003824,0006281,0006284,0008725 Kd=1.2mM 22684054 400 MNECAFGTKDPVYLNFHDHVWGQPLYDSKALFKLLALESQHAGLSWLTILKKKEAYEEAFYDFEPEKVAQMTAQDIDRLMTFPNIVHHRKKLEAIVNQAQGYLKIEQAYGSFSKFLWSYVNGKPKDLQYEHASDRITVDDTATQLSKDLKQYGFKFLGPVTVFSFLEAAGLYDAHLKDCPSKPKHN 4ai5 C 2.22 BS02 ADK C 1 F6 Y13 F16 W21 E38 W46 F6 Y13 F16 W21 E38 W46 0003824,0006281,0006284,0008725 Kd=1.2mM 22684054 400 MNECAFGTKDPVYLNFHDHVWGQPLYDSKALFKLLALESQHAGLSWLTILKKKEAYEEAFYDFEPEKVAQMTAQDIDRLMTFPNIVHHRKKLEAIVNQAQGYLKIEQAYGSFSKFLWSYVNGKPKDLQYEHASDRITVDDTATQLSKDLKQYGFKFLGPVTVFSFLEAAGLYDAHLKDCPSKPKHN 4ai5 D 2.22 BS02 ADK D 1 F6 Y13 F16 W21 E38 H41 W46 F8 Y15 F18 W23 E40 H43 W48 0003824,0006281,0006284,0008725 Kd=1.2mM 22684054 400 GAMNECAFGTKDPVYLNFHDHVWGQPLYDSKALFKLLALESQHAGLSWLTILKKKEAYEEAFYDFEPEKVAQMTAQDIDRLMTFPNIVHHRKKLEAIVNQAQGYLKIEQAYGSFSKFLWSYVNGKPKDLQYEHASDRITVDDTATQLSKDLKQYGFKFLGPVTVFSFLEAAGLYDAHLKDCPSKPKHN 4ai5 E 2.22 BS02 ADK E 1 F6 Y13 W21 E38 H41 W46 F8 Y15 W23 E40 H43 W48 0003824,0006281,0006284,0008725 Kd=1.2mM 22684054 400 GAMNECAFGTKDPVYLNFHDHVWGQPLYDSKALFKLLALESQHAGLSWLTILKKKEAYEEAFYDFEPEKVAQMTAQDIDRLMTFPNIVHHRKKLEAIVNQAQGYLKIEQAYGSFSKFLWSYVNGKPKDLQYEHASDRITVDDTATQLSKDLKQYGFKFLGPVTVFSFLEAAGLYDAHLKDCPSKPKHN 4aia A 1.8 BS02 ADK A 1 Y13 W21 E38 W46 Y15 W23 E40 W48 0003824,0006281,0006284,0008725 Kd=220uM -logKd/Ki=3.66, Kd=220uM 22684054 400 GAMNECAFGTKDPVYLNYHDHVWGQPLYDSKALFKLLALESQHAGLSWLTILKKKEAYEEAFYDFEPEKVAQMTAQDIDRLMTFPNIVHHRKKLEAIVNQAQGYLKIEQAYGSFSKFLWSYVNGKPKDLQYEHASDRITVDDTATQLSKDLKQYGFKFLGPVTVFSFLEAAGLYDAHLKDCPSKPKHN 4aia B 1.8 BS02 ADK B 1 Y13 Y16 W21 E38 W46 Y13 Y16 W21 E38 W46 0003824,0006281,0006284,0008725 Kd=220uM 22684054 400 MNECAFGTKDPVYLNYHDHVWGQPLYDSKALFKLLALESQHAGLSWLTILKKKEAYEEAFYDFEPEKVAQMTAQDIDRLMTFPNIVHHRKKLEAIVNQAQGYLKIEQAYGSFSKFLWSYVNGKPKDLQYEHASDRITVDDTATQLSKDLKQYGFKFLGPVTVFSFLEAAGLYDAHLKDCPSKPKH 4aia C 1.8 BS02 ADK C 1 F6 Y13 Y16 W21 E38 W46 F6 Y13 Y16 W21 E38 W46 0003824,0006281,0006284,0008725 Kd=220uM 22684054 400 MNECAFGTKDPVYLNYHDHVWGQPLYDSKALFKLLALESQHAGLSWLTILKKKEAYEEAFYDFEPEKVAQMTAQDIDRLMTFPNIVHHRKKLEAIVNQAQGYLKIEQAYGSFSKFLWSYVNGKPKDLQYEHASDRITVDDTATQLSKDLKQYGFKFLGPVTVFSFLEAAGLYDAHLKDCPSKPKHN 4aia D 1.8 BS02 ADK D 1 F6 Y13 Y16 W21 E38 W46 S164 F8 Y15 Y18 W23 E40 W48 S166 0003824,0006281,0006284,0008725 Kd=220uM 22684054 400 GAMNECAFGTKDPVYLNYHDHVWGQPLYDSKALFKLLALESQHAGLSWLTILKKKEAYEEAFYDFEPEKVAQMTAQDIDRLMTFPNIVHHRKKLEAIVNQAQGYLKIEQAYGSFSKFLWSYVNGKPKDLQYEHASDRITVDDTATQLSKDLKQYGFKFLGPVTVFSFLEAAGLYDAHLKDCPSKPKHN 4aia E 1.8 BS02 ADK E 1 F6 Y13 W21 E38 W46 F8 Y15 W23 E40 W48 0003824,0006281,0006284,0008725 Kd=220uM 22684054 400 GAMNECAFGTKDPVYLNYHDHVWGQPLYDSKALFKLLALESQHAGLSWLTILKKKEAYEEAFYDFEPEKVAQMTAQDIDRLMTFPNIVHHRKKLEAIVNQAQGYLKIEQAYGSFSKFLWSYVNGKPKDLQYEHASDRITVDDTATQLSKDLKQYGFKFLGPVTVFSFLEAAGLYDAHLKDCPSKPKHN