1hp0 A 2.1 BS02 AD3 A 1 N12 D14 D40 W83 M164 N173 E184 N186 Y257 W260 D261 N12 D14 D40 W83 M164 N173 E184 N186 Y249 W252 D253 D10 D15 D40 W83 T137 W185 N186 W260 D261 D10 D15 D40 W83 T137 W185 N186 W252 D253 3.2.2.1 0006139,0016798,0016799,0046872 Ki=0.2uM -logKd/Ki=6.70, Ki=0.2uM Q9GPQ4 11292348 1315 SAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCTHGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 1hp0 B 2.1 BS02 AD3 B 1 N12 D14 D40 W83 M164 N173 E184 N186 Y257 W260 D261 N12 D14 D40 W83 M164 N173 E184 N186 Y252 W255 D256 D10 D15 D40 W83 T137 W185 N186 W260 D261 D10 D15 D40 W83 T137 W185 N186 W255 D256 3.2.2.1 0006139,0016798,0016799,0046872 Ki=0.2uM Q9GPQ4 11292348 1316 SAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCTHDGDGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 1kie A 2.0 BS02 AD3 A 1 D40 M164 N173 E184 N186 W260 D261 D40 M164 N173 E184 N186 W248 D249 A10 D15 D40 W83 T137 W185 N186 W260 D261 A10 D15 D40 W83 T137 W185 N186 W248 D249 3.2.2.1 0006139,0016798,0016799,0046872 Q9GPQ4 11854281 801 SAKNVVLDHAGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 1kie B 2.0 BS02 AD3 B 1 N12 D14 D40 W83 M164 N173 E184 W185 N186 W260 D261 N11 D13 D39 W82 M163 N172 E183 W184 N185 W247 D248 A10 D15 D40 W83 T137 W185 N186 W260 D261 A9 D14 D39 W82 T136 W184 N185 W247 D248 3.2.2.1 0006139,0016798,0016799,0046872 Q9GPQ4 11854281 802 AKNVVLDHAGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 1r4f B 2.3 BS02 AD3 B 1 N12 D14 D40 W83 M164 N173 E184 N186 D261 N12 D14 D40 W83 M164 N173 E184 N186 D248 D10 D15 D40 W83 T137 W185 N186 A260 D261 D10 D15 D40 W83 T137 W185 N186 A247 D248 3.2.2.1 0006139,0016798,0016799,0046872 Q9GPQ4 15050818 330 SAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMYAADALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC 2ziz A 2.2 BS01 AD3 A 1 L68 H69 T71 D156 E218 T219 K248 D252 H363 G415 H416 M421 F425 L58 H59 T61 D146 E208 T209 K238 D242 H353 G405 H406 M411 F415 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=20uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2ziz B 2.2 BS02 AD3 B 1 H69 T71 D156 E218 T219 K248 D252 H363 H416 M421 H59 T61 D146 E208 T209 K238 D242 H353 H406 M411 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=20uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2ziz C 2.2 BS02 AD3 C 1 L68 H69 T71 D156 E218 T219 K248 D252 H363 L410 G415 H416 M421 F425 L58 H59 T61 D146 E208 T209 K238 D242 H353 L400 G405 H406 M411 F415 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=20uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2ziz D 2.2 BS03 AD3 D 1 L68 H69 T71 Q73 D156 E218 T219 K248 D252 H363 L410 G415 H416 M421 F425 L58 H59 T61 Q63 D146 E208 T209 K238 D242 H353 L400 G405 H406 M411 F415 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=20uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY