5wf7 B 2.5 BS09 A9G B 1 Y303 R304 G808 Y809 R843 V853 Y878 Y103 R104 G511 Y512 R546 V552 Y577 ? 0006338,0042054 ic50=98.5uM -logKd/Ki=4.01, IC50=98.5uM G0RYC6,G0SDW4 29904056 8009 WTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDAPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASDMSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLPPVEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVNKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVEPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wfd B 2.654 BS09 A9G B 1 I302 Y303 Y304 H307 G808 Y809 R843 Y878 I99 Y100 Y101 H104 G530 Y531 R565 Y590 ? 0006338,0042054 -logKd/Ki=4.58, IC50=26.2uM G0RYC6,G0SDW4 29904056 8009 EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPIYYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQHPPCRNECYRIHGNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELPPVEPTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTRPLLVPKTTQPLFDPLSKVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFILRRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPERVVIEATQVLNDARGRLRE 5wg6 A 3.901 BS08 A9G A 1 I109 W624 Y658 Y661 F665 T678 R685 F686 N688 I73 W285 Y319 Y322 F326 T339 R346 F347 N349 2.1.1.356,2.1.1.43 0000082,0000122,0000781,0000785,0000976,0000978,0000979,0001222,0003677,0003682,0003714,0003723,0005515,0005634,0005654,0005677,0005694,0005721,0006325,0006338,0006346,0006355,0006357,0008168,0008284,0009913,0010468,0010629,0010718,0014013,0014834,0014898,0016279,0021695,0021766,0030097,0030183,0030216,0030335,0031048,0031490,0031491,0031507,0031509,0032259,0032355,0034244,0035098,0035984,0036211,0036333,0042054,0042127,0042393,0042752,0043021,0043406,0043547,0043565,0045120,0045202,0045605,0045617,0045814,0045892,0046976,0048387,0048511,0048863,0050767,0051154,0051932,0070301,0070314,0070878,0071168,0071902,0090183,0097421,0106222,0140718,0140938,0140951,1900006,1900016,1902808,1904772,1990841,2000134,2000737 -logKd/Ki=4.54, IC50=28.6uM Q15022,Q15910 29904056 9009 RFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHRDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQK