6ih0 A 1.21 BS01 A5F A 1 H58 E73 H74 T179 F180 A181 I189 G198 L200 T203 H226 K227 D230 H253 H57 E72 H73 T178 F179 A180 I188 G197 L199 T202 H225 K226 D229 H252 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 O67648 301 GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQK 6moo A 2.2 BS02 A5F A 1 E77 T190 F191 I197 G209 S210 H237 D241 H264 E83 T192 F193 I199 G211 S212 H239 D243 H266 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 ic50=19nM -logKd/Ki=9.17, IC50=0.68nM P47205 31283109 302 HHEGAGTIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP