5orj A 1.99 BS05 A4Q A 1 P159 V162 I164 M221 M225 P157 V160 I162 M219 M223 D156 K158 N161 D175 S194 D154 K156 N159 D173 S192 2.7.11.1 0004672,0004674,0005524,0006468 IC50=160000nM P68400 29732088 405 GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 5orj A 1.99 BS06 A4Q A 2 Q36 Y39 I69 D103 T108 A110 Q34 Y37 I67 D101 T106 A108 D156 K158 N161 D175 S194 D154 K156 N159 D173 S192 2.7.11.1 0004672,0004674,0005524,0006468 IC50=160000nM P68400 29732088 406 GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 5orj B 1.99 BS04 A4Q B 1 F121 P159 V162 M221 M225 F118 P156 V159 M218 M222 D156 K158 N161 D175 S194 D153 K155 N158 D172 S191 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=4.77, Kd=17uM IC50=160000nM P68400 29732088 404 PVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV