1drv A 2.2 BS01 A3D A 1 G12 G15 R16 M17 E38 F79 T80 R81 G84 G102 A127 F129 R240 G9 G12 R13 M14 E35 F76 T77 R78 G81 G99 A124 F126 R237 H159 K163 H156 K160 1.17.1.8 0005737,0005829,0008652,0008839,0009085,0009089,0016491,0016726,0019877,0042802,0050661,0051287 Kd=0.29uM -logKd/Ki=6.54, Kd=0.29uM P04036 8873595 301 ANIRVAIAGAGGRMGRQLIQAALALEGVQLGAALEREGSSLLGSDAGELAGAGKTGVTVQSSLDAVKDDFDVFIDFTRPEGTLNHLAFCRQHGKGMVIGTTGFDEAGKQAIRDAAADIAIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAHALDKDLKDCAVYSREGHTGERVPGTIGFATVRAGDIVGEHTAMFADIGERLEITHKASSRMTFANGAVRSALWLSGKESGLFDMRDVLDLNNL 1pzf A 2.2 BS02 A3D A 1 G29 M30 I31 D53 V54 T97 A98 G99 L100 T101 I119 V138 N140 L142 M163 L167 H195 P250 G16 M17 I18 D38 V39 T83 A84 G85 L86 T87 I109 V129 N131 L133 M154 L158 H186 P245 R109 D168 R171 H195 R99 D159 R162 H186 1.1.1.27 0000166,0003824,0004459,0006089,0006090,0016491,0016616,0019752 P90613 14744130 401 PALVQRRKKVAMIGSGMIGGTMGYLCALRELADVVLYDVVKGMPEGKALDLSHVTSVVDTNVSVRAEYSYEAALTGADCVIVTAGLTKVPGKPDSEWSRNDLLPFNSKIIREIGQNIKKYCPKTFIIVVTNPLDCMVKVMCEASGVPTNMICGMACMLDSGRFRRYVADALSVSPRDVQATVIGTHGDCMVPLVRYITVNGYPIQKFIKDGVVTEKQLEEIAEHTKVSGGEIVRFLGQGSAYYAPAASAVAMATSFLNDEKRVIPCSVYCNGEYGLKDMFIGLPAVIGGAGIERVIELELNEEEKKQFQKSVDDVMALNKAVAALQAP 1pzf B 2.2 BS02 A3D B 1 G29 M30 I31 D53 V54 T97 A98 G99 L100 T101 I119 V138 T139 N140 L142 M163 L167 H195 P250 G16 M17 I18 D38 V39 T83 A84 G85 L86 T87 I109 V129 T130 N131 L133 M154 L158 H186 P245 R109 D168 R171 H195 R99 D159 R162 H186 1.1.1.27 0000166,0003824,0004459,0006089,0006090,0016491,0016616,0019752 P90613 14744130 403 PALVQRRKKVAMIGSGMIGGTMGYLCALRELADVVLYDVVKGMPEGKALDLSHVTSVVDTNVSVRAEYSYEAALTGADCVIVTAGLTKVPGKPDSEWSRNDLLPFNSKIIREIGQNIKKYCPKTFIIVVTNPLDCMVKVMCEASGVPTNMICGMACMLDSGRFRRYVADALSVSPRDVQATVIGTHGDCMVPLVRYITVNGYPIQKFIKDGVVTEKQLEEIAEHTKVSGGEIVRFLGQGSAYYAPAASAVAMATSFLNDEKRVIPCSVYCNGEYGLKDMFIGLPAVIGGAGIERVIELELNEEEKKQFQKSVDDVMALNKAVAALQAP 1pzf C 2.2 BS02 A3D C 1 G29 M30 I31 D53 V54 T97 A98 G99 L100 T101 I119 V138 N140 M163 H195 P250 G16 M17 I18 D38 V39 T83 A84 G85 L86 T87 I109 V129 N131 M154 H186 P245 R109 D168 R171 H195 R99 D159 R162 H186 1.1.1.27 0000166,0003824,0004459,0006089,0006090,0016491,0016616,0019752 P90613 14744130 405 PALVQRRKKVAMIGSGMIGGTMGYLCALRELADVVLYDVVKGMPEGKALDLSHVTSVVDTNVSVRAEYSYEAALTGADCVIVTAGLTKVPGKPDSEWSRNDLLPFNSKIIREIGQNIKKYCPKTFIIVVTNPLDCMVKVMCEASGVPTNMICGMACMLDSGRFRRYVADALSVSPRDVQATVIGTHGDCMVPLVRYITVNGYPIQKFIKDGVVTEKQLEEIAEHTKVSGGEIVRFLGQGSAYYAPAASAVAMATSFLNDEKRVIPCSVYCNGEYGLKDMFIGLPAVIGGAGIERVIELELNEEEKKQFQKSVDDVMALNKAVAALQ 1pzf D 2.2 BS02 A3D D 1 G29 M30 I31 D53 V54 T97 A98 G99 L100 T101 I119 V138 T139 N140 M163 H195 G16 M17 I18 D38 V39 T83 A84 G85 L86 T87 I109 V129 T130 N131 M154 H186 R109 D168 R171 H195 R99 D159 R162 H186 1.1.1.27 0000166,0003824,0004459,0006089,0006090,0016491,0016616,0019752 P90613 14744130 407 PALVQRRKKVAMIGSGMIGGTMGYLCALRELADVVLYDVVKGMPEGKALDLSHVTSVVDTNVSVRAEYSYEAALTGADCVIVTAGLTKVPGKPDSEWSRNDLLPFNSKIIREIGQNIKKYCPKTFIIVVTNPLDCMVKVMCEASGVPTNMICGMACMLDSGRFRRYVADALSVSPRDVQATVIGTHGDCMVPLVRYITVNGYPIQKFIKDGVVTEKQLEEIAEHTKVSGGEIVRFLGQGSAYYAPAASAVAMATSFLNDEKRVIPCSVYCNGEYGLKDMFIGLPAVIGGAGIERVIELELNEEEKKQFQKSVDDVMALNKAVAALQ 1pzg A 1.6 BS02 A3D A 1 G29 M30 I31 D53 V54 T97 A98 G99 L100 T101 I119 V138 T139 N140 L142 M163 L167 H195 P250 G16 M17 I18 D38 V39 T83 A84 G85 L86 T87 I109 V129 T130 N131 L133 M154 L158 H186 P245 R109 D168 R171 H195 R99 D159 R162 H186 1.1.1.27 0000166,0003824,0004459,0006089,0006090,0016491,0016616,0019752 Ki=25mM P90613 14744130 601 PALVQRRKKVAMIGSGMIGGTMGYLCALRELADVVLYDVVKGMPEGKALDLSHVTSVVDTNVSVRAEYSYEAALTGADCVIVTAGLTKVPGKPDSEWSRNDLLPFNSKIIREIGQNIKKYCPKTFIIVVTNPLDCMVKVMCEASGVPTNMICGMACMLDSGRFRRYVADALSVSPRDVQATVIGTHGDCMVPLVRYITVNGYPIQKFIKDGVVTEKQLEEIAEHTKVSGGEIVRFLGQGSAYYAPAASAVAMATSFLNDEKRVIPCSVYCNGEYGLKDMFIGLPAVIGGAGIERVIELELNEEEKKQFQKSVDDVMALNKAVAALQAP 1pzg B 1.6 BS02 A3D B 1 G29 M30 I31 D53 V54 T97 A98 G99 L100 T101 I119 V138 T139 N140 L142 M163 H195 P250 G16 M17 I18 D38 V39 T83 A84 G85 L86 T87 I109 V129 T130 N131 L133 M154 H186 P245 R109 D168 R171 H195 R99 D159 R162 H186 1.1.1.27 0000166,0003824,0004459,0006089,0006090,0016491,0016616,0019752 Ki=25mM P90613 14744130 603 PALVQRRKKVAMIGSGMIGGTMGYLCALRELADVVLYDVVKGMPEGKALDLSHVTSVVDTNVSVRAEYSYEAALTGADCVIVTAGLTKVPGKPDSEWSRNDLLPFNSKIIREIGQNIKKYCPKTFIIVVTNPLDCMVKVMCEASGVPTNMICGMACMLDSGRFRRYVADALSVSPRDVQATVIGTHGDCMVPLVRYITVNGYPIQKFIKDGVVTEKQLEEIAEHTKVSGGEIVRFLGQGSAYYAPAASAVAMATSFLNDEKRVIPCSVYCNGEYGLKDMFIGLPAVIGGAGIERVIELELNEEEKKQFQKSVDDVMALNKAVAALQAP 1pzg C 1.6 BS02 A3D C 1 G29 M30 I31 D53 V54 T97 A98 G99 L100 T101 I119 V138 N140 L142 M163 H195 P250 G15 M16 I17 D37 V38 T82 A83 G84 L85 T86 I108 V128 N130 L132 M153 H185 P244 R109 D168 R171 H195 R98 D158 R161 H185 1.1.1.27 0000166,0003824,0004459,0006089,0006090,0016491,0016616,0019752 Ki=25mM P90613 14744130 605 ALVQRRKKVAMIGSGMIGGTMGYLCALRELADVVLYDVVKGMPEGKALDLSHVTSVVDTNVSVRAEYSYEAALTGADCVIVTAGLTKVPGKPDSEWSRNDLLPFNSKIIREIGQNIKKYCPKTFIIVVTNPLDCMVKVMCEASGVPTNMICGMACMLDSGRFRRYVADALSVSPRDVQATVIGTHGDCMVPLVRYITVNGYPIQKFIKDGVVTEKQLEEIAEHTKVSGGEIVRFLGQGSAYYAPAASAVAMATSFLNDEKRVIPCSVYCNGEYGLKDMFIGLPAVIGGAGIERVIELELNEEEKKQFQKSVDDVMALNKAVAALQ 1pzg D 1.6 BS02 A3D D 1 G29 M30 I31 D53 V54 T97 A98 G99 L100 T101 I119 V138 T139 N140 L142 M163 H195 P250 G16 M17 I18 D38 V39 T83 A84 G85 L86 T87 I109 V129 T130 N131 L133 M154 H186 P245 R109 D168 R171 H195 R99 D159 R162 H186 1.1.1.27 0000166,0003824,0004459,0006089,0006090,0016491,0016616,0019752 Ki=25mM P90613 14744130 607 PALVQRRKKVAMIGSGMIGGTMGYLCALRELADVVLYDVVKGMPEGKALDLSHVTSVVDTNVSVRAEYSYEAALTGADCVIVTAGLTKVPGKPDSEWSRNDLLPFNSKIIREIGQNIKKYCPKTFIIVVTNPLDCMVKVMCEASGVPTNMICGMACMLDSGRFRRYVADALSVSPRDVQATVIGTHGDCMVPLVRYITVNGYPIQKFIKDGVVTEKQLEEIAEHTKVSGGEIVRFLGQGSAYYAPAASAVAMATSFLNDEKRVIPCSVYCNGEYGLKDMFIGLPAVIGGAGIERVIELELNEEEKKQFQKSVDDVMALNKAVAALQ 4nd2 A 2.0 BS01 A3D A 1 G30 Q31 I32 D53 I54 T97 A98 S99 I119 I138 N140 L142 M163 H195 P250 G13 Q14 I15 D35 I36 T79 A80 S81 I100 I120 N122 L124 M145 H177 P236 R109 D168 R171 H195 R90 D150 R153 H177 1.1.1.27 0000166,0003824,0004459,0006089,0006090,0016491,0016616,0019752 Q5CYZ2 25542170 401 MIERRKIAVIGSGQIGGNIAYIVGKDNLADVVLFDIAEGIPQGKALDITHSMVMFGSTSKVIGTNDYADISGSDVVIITASIPGRPKDDRSELLFGNARILDSVAEGVKKYCPNAFVICITNPLDVMVSHFQKVSGLPHNKVCGMAGVLDSSRFRTFIAQHFGVNASDVSANVIGGHGDGMVPATSSVSVGGVPLSSFIKQGLITQEQIDEIVCHTRIAWKEVADNLKTGTAYFAPAAAAVKMAEAYLKDKKAVVPCSAFCSNHYGVKGIYMGVPTIIGKNGVEDILELDLTPLEQKLLGESINEVNTISKVLDNAP 4nd2 B 2.0 BS01 A3D B 1 G30 Q31 I32 D53 I54 T97 A98 S99 I119 I138 N140 L142 M163 H195 P250 G13 Q14 I15 D35 I36 T79 A80 S81 I100 I120 N122 L124 M145 H177 P236 R109 D168 R171 H195 R90 D150 R153 H177 1.1.1.27 0000166,0003824,0004459,0006089,0006090,0016491,0016616,0019752 Q5CYZ2 25542170 401 MIERRKIAVIGSGQIGGNIAYIVGKDNLADVVLFDIAEGIPQGKALDITHSMVMFGSTSKVIGTNDYADISGSDVVIITASIPGRPKDDRSELLFGNARILDSVAEGVKKYCPNAFVICITNPLDVMVSHFQKVSGLPHNKVCGMAGVLDSSRFRTFIAQHFGVNASDVSANVIGGHGDGMVPATSSVSVGGVPLSSFIKQGLITQEQIDEIVCHTRIAWKEVADNLKTGTAYFAPAAAAVKMAEAYLKDKKAVVPCSAFCSNHYGVKGIYMGVPTIIGKNGVEDILELDLTPLEQKLLGESINEVNTISKVLDNAP 8qgw B 1.6 BS03 A3D B 1 G68 A69 F71 K76 E185 Y205 G66 A67 F69 K74 E183 Y203 7.1.1.- 0008137,0010181,0046872,0048038,0051539,1902600 O66841 38503292 503 SYPAIPRIYAETTLNMLLKRAKKPRVHSIDEYLKDGGYQALEKALNMSPEEIIDWVDKSTLRGRGGAGFPTGKKWKFAVQNPGPRYFICNADESEPGTFKDRIIIERDPHLLIEGIIISSYAIGANEAYIYIRGEYPAGYYILRDAIEEAKKKGFLGKNILGSGFDLEIYVARGAGAYICGEETALIESLEGKRGHPRLKPPYPVQKGLWGKPTVVNNVETIANVPFIISMGWEEYRYIGPSDYAGPKLFPVSGKVKKPGVYELPMNTTLREVIFKYAGGTLGNKKVKAVFSGALDCFSSEELDIPMDYSPLGFGGTGTVIVLTEEDDIVEAALKIAEFYEHETCGQCTPCRVGCYEQANLLEKIYKGEATEQDWEGFDFVNRNIQPTSICGLGAVAGRLIRQTLEKFPEEWEKYRKK 8qgw D 1.6 BS03 A3D D 1 G68 A69 F71 K76 F79 Y180 E185 Y205 V398 G67 A68 F70 K75 F78 Y179 E184 Y204 V397 7.1.1.- 0008137,0010181,0046872,0048038,0051539,1902600 O66841 38503292 503 RSYPAIPRIYAETTLNMLLKRAKKPRVHSIDEYLKDGGYQALEKALNMSPEEIIDWVDKSTLRGRGGAGFPTGKKWKFAVQNPGPRYFICNADESEPGTFKDRIIIERDPHLLIEGIIISSYAIGANEAYIYIRGEYPAGYYILRDAIEEAKKKGFLGKNILGSGFDLEIYVARGAGAYICGEETALIESLEGKRGHPRLKPPYPVQKGLWGKPTVVNNVETIANVPFIISMGWEEYRYIGPSDYAGPKLFPVSGKVKKPGVYELPMNTTLREVIFKYAGGTLGNKKVKAVFSGALDCFSSEELDIPMDYSPLGFGGTGTVIVLTEEDDIVEAALKIAEFYEHETCGQCTPCRVGCYEQANLLEKIYKGEATEQDWEGFDFVNRNIQPTSICGLGAVAGRLIRQTLEKFPEEWEKYRK 8qh4 B 1.96 BS03 A3D B 1 G68 A69 F71 K76 E185 Y205 G67 A68 F70 K75 E184 Y204 7.1.1.- 0008137,0010181,0046872,0048038,0051539,1902600 O66841 38503292 503 RSYPAIPRIYAETTLNMLLKRAKKPRVHSIDEYLKDGGYQALEKALNMSPEEIIDWVDKSTLRGRGGAGFPTGKKWKFAVQNPGPRYFICNADESEPGTFKDRIIIERDPHLLIEGIIISSYAIGANEAYIYIRGEYPAGYYILRDAIEEAKKKGFLGKNILGSGFDLEIYVARGAGAYICGEETALIESLEGKRGHPRLKPPYPVQKGLWGKPTVVNNVETIANVPFIISMGWEEYRYIGPSDYAGPKLFPVSGKVKKPGVYELPMNTTLREVIFKYAGGTLGNKKVKAVFSGALDCFSSEELDIPMDYSPLGFGGTGTVIVLTEEDDIVEAALKIAEFYEHETCGQCTPCRVGCYEQANLLEKIYKGEATEQDWEGFDFVNRNIQPTSICGLGAVAGRLIRQTLEKFPEEWEKYR 8qh4 D 1.96 BS03 A3D D 1 G68 A69 F71 K76 F79 E185 K202 Y205 G67 A68 F70 K75 F78 E184 K201 Y204 7.1.1.- 0008137,0010181,0046872,0048038,0051539,1902600 O66841 38503292 503 RSYPAIPRIYAETTLNMLLKRAKKPRVHSIDEYLKDGGYQALEKALNMSPEEIIDWVDKSTLRGRGGAGFPTGKKWKFAVQNPGPRYFICNADESEPGTFKDRIIIERDPHLLIEGIIISSYAIGANEAYIYIRGEYPAGYYILRDAIEEAKKKGFLGKNILGSGFDLEIYVARGAGAYICGEETALIESLEGKRGHPRLKPPYPVQKGLWGKPTVVNNVETIANVPFIISMGWEEYRYIGPSDYAGPKLFPVSGKVKKPGVYELPMNTTLREVIFKYAGGTLGNKKVKAVFSGALDCFSSEELDIPMDYSPLGFGGTGTVIVLTEEDDIVEAALKIAEFYEHETCGQCTPCRVGCYEQANLLEKIYKGEATEQDWEGFDFVNRNIQPTSICGLGAVAGRLIRQTLEKFPEEWEKYRK