4b80 A 2.5 BS01 A36 A 1 W86 Y124 Y337 F338 Y341 W86 Y124 Y333 F334 Y337 G121 G122 G154 S203 A204 G242 F297 F299 E334 H447 G121 G122 G154 S203 A204 G242 F293 F295 E330 H443 3.1.1.7 0001919,0002076,0003990,0004104,0005515,0005518,0005576,0005604,0005615,0005794,0005886,0006581,0007155,0009986,0016020,0016787,0017171,0031594,0031623,0042166,0042802,0042803,0043236,0045202,0048471,0052689,0060041,0095500,0098552,0120162 ic50=40uM -logKd/Ki=4.40, IC50=40uM IC50=40000nM P21836 23984975 1543 EGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPGGNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSA 4b80 B 2.5 BS01 A36 B 1 W86 G121 Y124 W286 F297 Y337 F338 Y341 H447 W83 G118 Y121 W277 F288 Y328 F329 Y332 H438 G121 G122 G154 S203 A204 G242 F297 F299 E334 H447 G118 G119 G151 S200 A201 G239 F288 F290 E325 H438 3.1.1.7 0001919,0002076,0003990,0004104,0005515,0005518,0005576,0005604,0005615,0005794,0005886,0006581,0007155,0009986,0016020,0016787,0017171,0031594,0031623,0042166,0042802,0042803,0043236,0045202,0048471,0052689,0060041,0095500,0098552,0120162 ic50=40uM IC50=40000nM P21836 23984975 1543 EDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSA