1yon A 1.95 BS01 A2R A 1 G9 A10 L11 L71 K72 H97 N98 T118 S244 R253 E256 G9 A10 L11 L71 K72 H97 N98 T118 S244 R253 E256 K176 K176 1.1.1.169 0005737,0008677,0015940,0016491,0016616,0050661 Kd=61uM -logKd/Ki=4.21, Kd=61uM P0A9J4 17242510 501 MKITVLGCGALGQLWLTALCKQGHEVQGWLRVPQPYCSVNLVETDGSIFNESLTANDPDFLATSDLLLVTLKAWQVSDAVKSLASTLPVTTPILLIHNGMGTIEELQNIQQPLLMGTTTHAARRDGNVIIHVANGITHIGPARQQDGDYSYLADILQTVLPDVAWHNNIRAELWRKLAVNCVINPLTAIWNCPNGELRHHPQEIMQICEEVAAVIEREGHHTSAEDLRDYVMQVIDATAENISSMLQDIRALRHTEIDYINGFLLRRARAHGIAVPENTRLFEMVKRKESEY 2pk3 A 1.82 BS01 A2R A 1 G10 F11 V12 R32 D47 I48 L69 A70 A71 S73 I112 Y140 K144 H170 G10 F11 V12 R32 D47 I48 L69 A70 A71 S73 I112 Y140 K144 H170 S114 S115 E116 Y140 K144 S114 S115 E116 Y140 K144 1.1.1.281 0016491,0033705 Q6T1X6 19459932 401 MRALITGVAGFVGKYLANHLTEQNVEVFGTSRNNEAKLPNVEMISLDIMDSQRVKKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAVRDSNLDCRILTIGSSEEYGMILPEESPVSEENQLRPMSPYGVSKASVGMLARQYVKAYGMDIIHTRTFNHIGPGQSLGFVTQDFAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIVQAYWLLSQYGKTGDVYNVCSGIGTRIQDVLDLLLAMANVKIDTELNPLQLRPSEVPTLIGSNKRLKDSTGWKPRIPLEKSLFEILQSYRQA 2pk3 B 1.82 BS01 A2R B 1 G10 F11 V12 R32 D47 I48 L69 A71 S73 I112 Y140 K144 H170 G10 F11 V12 R32 D47 I48 L69 A71 S73 I112 Y140 K144 H170 S114 S115 E116 Y140 K144 S114 S115 E116 Y140 K144 1.1.1.281 0016491,0033705 Q6T1X6 19459932 402 MRALITGVAGFVGKYLANHLTEQNVEVFGTSRNNEAKLPNVEMISLDIMDSQRVKKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAVRDSNLDCRILTIGSSEEYGMILPEESPVSEENQLRPMSPYGVSKASVGMLARQYVKAYGMDIIHTRTFNHIGPGQSLGFVTQDFAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIVQAYWLLSQYGKTGDVYNVCSGIGTRIQDVLDLLLAMANVKIDTELNPLQLRPSEVPTLIGSNKRLKDSTGWKPRIPLEKSLFEILQSYRQA 5j23 A 2.3 BS01 A2R A 1 V72 L150 G151 R152 I153 T172 R173 P202 S206 T207 R230 V70 L148 G149 R150 I151 T170 R171 P200 S204 T205 R228 L96 R230 D254 E259 H277 L94 R228 D252 E257 H275 ? 0000166,0005829,0016491,0016616,0016618,0030267,0046872,0051287 Q92LZ4 29309127 403 RPRILVPGKINPRVLERLPEMFETVRIERADAALVTADMRDVSGIAVSGKLPVPLMDAFPSLEIVANFGVGYDGVDVSRAAARGIVVTNTPDVLTEEVADTAIGLLLNTLRLLPQAEQWLRQGRWVREGAFPLSPLSLRGRTVGLFGLGRIGLAIARRLEAFGVSIAYHTRTPREGLGFTYHPTLVGMAEAVDTLIVIVPGTASTLKAVNADVLSALGPKGVLINVGRGSTVDEAALVTALQNGTIAGAGLDVFENEPNVPEALLSFPNVSLLPHVASASVVTRNAMSDLVVDNLKAWFSTGEALTPVAETPFRRRAI 5j23 B 2.3 BS01 A2R B 1 V72 L150 G151 R152 I153 T172 R173 P202 S206 T207 R230 V70 L148 G149 R150 I151 T170 R171 P200 S204 T205 R228 L96 R230 D254 E259 H277 L94 R228 D252 E257 H275 ? 0000166,0005829,0016491,0016616,0016618,0030267,0046872,0051287 Q92LZ4 29309127 404 RPRILVPGKINPRVLERLPEMFETVRIERADAALVTADMRDVSGIAVSGKLPVPLMDAFPSLEIVANFGVGYDGVDVSRAAARGIVVTNTPDVLTEEVADTAIGLLLNTLRLLPQAEQWLRQGRWVREGAFPLSPLSLRGRTVGLFGLGRIGLAIARRLEAFGVSIAYHTRTPREGLGFTYHPTLVGMAEAVDTLIVIVPGTASTLKAVNADVLSALGPKGVLINVGRGSTVDEAALVTALQNGTIAGAGLDVFENEPNVPEALLSFPNVSLLPHVASASVVTRNAMSDLVVDNLKAWFSTGEALTPVAETPFRRRAI 5j23 C 2.3 BS01 A2R C 1 L150 G151 R152 I153 T172 R173 P202 S206 T207 R230 L148 G149 R150 I151 T170 R171 P200 S204 T205 R228 L96 R230 D254 E259 H277 L94 R228 D252 E257 H275 ? 0000166,0005829,0016491,0016616,0016618,0030267,0046872,0051287 Q92LZ4 29309127 404 RPRILVPGKINPRVLERLPEMFETVRIERADAALVTADMRDVSGIAVSGKLPVPLMDAFPSLEIVANFGVGYDGVDVSRAAARGIVVTNTPDVLTEEVADTAIGLLLNTLRLLPQAEQWLRQGRWVREGAFPLSPLSLRGRTVGLFGLGRIGLAIARRLEAFGVSIAYHTRTPREGLGFTYHPTLVGMAEAVDTLIVIVPGTASTLKAVNADVLSALGPKGVLINVGRGSTVDEAALVTALQNGTIAGAGLDVFENEPNVPEALLSFPNVSLLPHVASASVVTRNAMSDLVVDNLKAWFSTGEALTPVAETPFRRRAI 5j23 D 2.3 BS01 A2R D 1 V72 F148 L150 G151 R152 I153 T172 R173 V201 P202 S206 T207 G229 R230 V70 F146 L148 G149 R150 I151 T170 R171 V199 P200 S204 T205 G227 R228 L96 R230 D254 E259 H277 L94 R228 D252 E257 H275 ? 0000166,0005829,0016491,0016616,0016618,0030267,0046872,0051287 Q92LZ4 29309127 403 RPRILVPGKINPRVLERLPEMFETVRIERADAALVTADMRDVSGIAVSGKLPVPLMDAFPSLEIVANFGVGYDGVDVSRAAARGIVVTNTPDVLTEEVADTAIGLLLNTLRLLPQAEQWLRQGRWVREGAFPLSPLSLRGRTVGLFGLGRIGLAIARRLEAFGVSIAYHTRTPREGLGFTYHPTLVGMAEAVDTLIVIVPGTASTLKAVNADVLSALGPKGVLINVGRGSTVDEAALVTALQNGTIAGAGLDVFENEPNVPEALLSFPNVSLLPHVASASVVTRNAMSDLVVDNLKAWFSTGEALTPVAETPFRRRAI 7bf5 A 2.05 BS01 A2R A 1 D22 I23 A38 N40 G47 G48 V49 A50 L126 S128 A129 G130 I131 F132 A154 F156 D157 D22 I23 A38 N40 G47 G48 V49 A50 L126 S128 A129 G130 I131 F132 A154 F156 D157 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- P0DTD1 33850605 202 HMVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEM 7bf5 B 2.05 BS01 A2R B 1 D22 I23 A38 N40 G47 G48 V49 A50 L126 S128 A129 G130 I131 F132 A154 F156 D21 I22 A37 N39 G46 G47 V48 A49 L125 S127 A128 G129 I130 F131 A153 F155 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- P0DTD1 33850605 201 MVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEM 7bf5 C 2.05 BS02 A2R C 1 D22 I23 A38 N40 G47 G48 V49 L126 S128 A129 G130 I131 F132 A154 F156 D23 I24 A39 N41 G48 G49 V50 L127 S129 A130 G131 I132 F133 A155 F157 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- P0DTD1 33850605 202 GHMVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEM 7bf5 E 2.05 BS02 A2R E 1 I23 A38 N40 G47 G48 V49 A50 L126 S128 A129 G130 I131 F132 A154 F156 I24 A39 N41 G48 G49 V50 A51 L127 S129 A130 G131 I132 F133 A155 F157 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- P0DTD1 33850605 202 GHMVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMK 7ecr A 1.73 BS01 A2R A 1 K122 D154 I155 S229 G230 N231 V232 D252 S253 K279 A320 T321 G344 S345 N346 N379 K122 D154 I155 S229 G230 N231 V232 D252 S253 K279 A320 T321 G344 S345 N346 N379 1.4.1.4 0000166,0004353,0004354,0005829,0006520,0006537,0016491,0016639 T2D1F5 34748226 507 MSNLPVEPEFEQAYKELASTLENSTLFQKNPEYRKALAVVSVPERVIQFRVVWENDKGEVQVNRGFRVQFNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKSDSEIRRFCVAFMTELCRHIGADTDVPAGDIGVTGREIGYLFGQYRKLRNSWEGVLTGKGGSWGGSLIRPEATGYGVVYYVEHMIAHATNGAESFAGKRVAISGSGNVAQYAALKVIELGGRVVSLSDSQGSLIVKDTAKDSFTPAEIDAIAALKVDRKQIAELVTDAAFADKFTYLPGQRPWVHVGAVDVALPSATQNEVSGEEAQALIAAGCKFIAEGSNMGCTQAAIDAFEAHREANKGAAAIWYAPGKAANAGGVAVSGLEMAQNSARLSWTAEEVDARLKDIMKSCFQNGLDTAKEYATPADGILPSLVTGSNIAGFTKVAAAMKDQGDWW 7ecr B 1.73 BS01 A2R B 1 K122 D154 I155 S229 G230 N231 V232 D252 S253 K279 A320 T321 S345 N346 N379 K122 D154 I155 S229 G230 N231 V232 D252 S253 K279 A320 T321 S345 N346 N379 1.4.1.4 0000166,0004353,0004354,0005829,0006520,0006537,0016491,0016639 T2D1F5 34748226 506 MSNLPVEPEFEQAYKELASTLENSTLFQKNPEYRKALAVVSVPERVIQFRVVWENDKGEVQVNRGFRVQFNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKSDSEIRRFCVAFMTELCRHIGADTDVPAGDIGVTGREIGYLFGQYRKLRNSWEGVLTGKGGSWGGSLIRPEATGYGVVYYVEHMIAHATNGAESFAGKRVAISGSGNVAQYAALKVIELGGRVVSLSDSQGSLIVKDTAKDSFTPAEIDAIAALKVDRKQIAELVTDAAFADKFTYLPGQRPWVHVGAVDVALPSATQNEVSGEEAQALIAAGCKFIAEGSNMGCTQAAIDAFEAHREANKGAAAIWYAPGKAANAGGVAVSGLEMAQNSARLSWTAEEVDARLKDIMKSCFQNGLDTAKEYATPADGILPSLVTGSNIAGFTKVAAAMKDQGDWW 7ecr C 1.73 BS01 A2R C 1 K122 D154 I155 S229 G230 N231 V232 D252 S253 K279 A320 T321 G344 S345 N346 N379 K122 D154 I155 S229 G230 N231 V232 D252 S253 K279 A320 T321 G344 S345 N346 N379 1.4.1.4 0000166,0004353,0004354,0005829,0006520,0006537,0016491,0016639 T2D1F5 34748226 509 MSNLPVEPEFEQAYKELASTLENSTLFQKNPEYRKALAVVSVPERVIQFRVVWENDKGEVQVNRGFRVQFNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKSDSEIRRFCVAFMTELCRHIGADTDVPAGDIGVTGREIGYLFGQYRKLRNSWEGVLTGKGGSWGGSLIRPEATGYGVVYYVEHMIAHATNGAESFAGKRVAISGSGNVAQYAALKVIELGGRVVSLSDSQGSLIVKDTAKDSFTPAEIDAIAALKVDRKQIAELVTDAAFADKFTYLPGQRPWVHVGAVDVALPSATQNEVSGEEAQALIAAGCKFIAEGSNMGCTQAAIDAFEAHREANKGAAAIWYAPGKAANAGGVAVSGLEMAQNSARLSWTAEEVDARLKDIMKSCFQNGLDTAKEYATPADGILPSLVTGSNIAGFTKVAAAMKDQGDWW