5opb A 1.55 BS01 A1N A 1 L15 E17 A36 M84 E85 L86 A87 G90 L137 L11 E13 A32 M75 E76 L77 A78 G81 L128 D130 K132 H134 N135 D148 T170 D121 K123 H125 N126 D139 T161 2.7.11.1 0000077,0004672,0004674,0005524,0006468 Ki=0.0241uM -logKd/Ki=7.62, Ki=0.0241uM O14757 29023112 301 FVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMCPENIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKK 8txz A 3.05 BS01 A1N A 1 L1885 V1893 A1950 G1953 R1957 L2001 A2016 L397 V405 A461 G464 R468 L512 A527 2.7.11.1,3.6.5.- 0004672,0005524,0005525,0006468 Q5S007 38039358 2601 RMKLMIVGNTGKTTLLQQATVGIDVKDWLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLKPWLFNIKARASSSPVILVGTPAIRDYHFVEKIILSERKNVPIEFPVIDRKRLLQNELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVPKGIISRRDVEKFYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLTLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATASIWLGLSFLDLNTEGYCLACLYCLLVGCLSESNVMWGGCGTKIFSFIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRLIRVIYNFCNSVRVMMTAQLLKNVMLVLGYNQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMR 8tzc A 2.7 BS01 A1N A 1 L1885 V1893 A1904 E1948 A1950 G1953 L2001 L357 V365 A376 E420 A422 G425 L473 2.7.11.1,3.6.5.- 0004672,0005524,0005525,0006468 Q5S007 38039358 2601 NRMKLMIVGNTGSGKTLLQQLMATVGIDVKDWPVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDPWLFPVILVGTIRDYHFVRKTIINESLAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILKGIISRRDVEKFYFKLLEKFQIALPILLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSALRPNRMYWRQGIYLNWSPEAYCLVGSEVLPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYSIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVFDELEIGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVASIWLGCGQLSFLDLEGYTSEEVARILCLALIVSGTQSGTLLVINSVTCLYCLLVGTADGKLAIFPLKILNITPLMCLSESMWGGCGTKIFSFTIQKLIETRTSQLFSYAAFSDNIITVVVDTALYIAKQNSPVVEVWDKTEKLCGLIDCVHFLYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLKNVMLVLGYNRIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMR 8tzg A 2.7 BS01 A1N A 1 L1885 V1893 R1895 A1904 M1947 E1948 A1950 G1953 L2001 D2017 L415 V423 R425 A434 M477 E478 A480 G483 L531 D547 2.7.11.1,3.6.5.- 0004672,0005524,0005525,0006468 Q5S007 38039358 2601 NRMKLMIVGNTGSGKTTLLQQTVGIDVKDWPLVLNVWDFAREEFYSTHPHFMTQRALYLAVAMKPWLFNIKARASSSPVILVGTAIRDYHFVLAKLRKTIINESLNFKIRDVELEKIILSERKNVPIEFPVIDRKRLLQLVRNELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILKGIISRRDVEKFMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGALRPNRMYWRQGIYLNWSPEAYCLVGSEVESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLTLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGTAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRILLPKNVIVECMVASIWLGCQLSFLILCLALVHIVSGTCLYCLLVGTGKLAIPLMCLSESVMWGGCGTKIFSFSIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQNVMLVLGYNRIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMR 8tzh A 3.9 BS01 A1N A 1 L1885 M1947 E1948 L1949 A1950 G1953 S1954 L2001 L983 M1044 E1045 L1046 A1047 G1050 S1051 L1098 2.7.11.1,3.6.5.- 0000139,0000149,0000165,0000287,0001934,0003779,0003924,0004672,0004674,0004706,0004709,0005096,0005515,0005524,0005525,0005615,0005737,0005739,0005741,0005743,0005759,0005764,0005768,0005783,0005789,0005794,0005798,0005802,0005829,0005856,0005886,0005902,0006338,0006468,0006606,0006897,0006914,0006979,0007005,0007029,0007030,0007040,0007154,0007165,0007254,0007266,0007283,0007528,0008017,0008021,0008104,0008340,0009267,0009966,0010468,0010506,0010508,0010955,0010977,0014041,0015631,0016242,0016301,0016310,0016787,0017075,0018105,0018107,0019722,0021756,0021772,0022028,0030154,0030159,0030182,0030276,0030424,0030425,0030426,0030672,0031267,0031398,0031410,0031647,0031966,0032091,0032092,0032436,0032473,0032760,0032839,0034211,0034260,0034599,0034614,0035556,0035564,0035640,0035641,0035751,0036479,0039706,0040012,0042391,0042802,0042803,0042995,0043005,0043025,0043068,0043195,0043204,0043231,0043406,0044024,0044325,0044753,0044754,0045121,0045202,0045335,0045746,0045860,0046039,0046777,0048312,0048812,0051018,0051646,0051770,0051900,0051966,0060070,0060079,0060159,0060161,0060628,0060828,0061001,0070062,0070585,0070971,0070973,0071287,0071407,0090140,0090263,0090394,0097487,0098794,0098978,0099400,0099523,0106310,0140058,0141161,1900242,1900244,1902236,1902499,1902692,1902803,1902823,1902902,1903125,1903215,1903217,1903351,1903980,1904713,1904887,1905279,1905289,1990904,1990909,2000172,2000300,2000377 Q5S007 38039358 2601 LAKILVSSLYRFKDVAEIQTKGQTILAIKLLVHHSFDLVIFHQMSSNIDQQFLNLCCKCFAKVALKNVMLERACDQNNSIMVECLLLLGAANQASLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPNIASTLARMVIRYQYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTVGIDVKDWPILVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVKACMSKITKELLNKRGFPAIRDYHFVNASDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVQLQLDENELPHAVHFLNESGVLLHFSDLYFVEPKWLCKIMAQILTPKGIISRRDVEKKNYMSQYFKLLEKFQLVPSSLSDCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPLRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIETLLKKWALYSFNKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGGTPGFRAPEVARQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVASIWLGGQLSFLDLRILCLALIVSGTQSGTLLVINSVTCLYCLLVGTADGKLAIFPLKILNIGTPLMCLSESVMWGGCGTKIFSFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLKNVMLVLGYNREIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMR