5w5o A 2.89 BS01 9XA A 1 S25 V32 L79 T95 Y97 M98 G101 E105 L153 S21 V28 L66 T82 Y84 M85 G88 E92 L140 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.10, IC50=0.008uM IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o B 2.89 BS01 9XA B 1 L24 S25 V32 A45 L79 T95 M98 P99 G101 E105 R109 L153 L20 S21 V28 A41 L66 T82 M85 P86 G88 E92 R96 L140 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o C 2.89 BS01 9XA C 1 S25 V32 A45 M98 P99 G101 L153 A163 D164 S21 V28 A41 M85 P86 G88 L140 A150 D151 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o D 2.89 BS01 9XA D 1 S25 V32 L79 T95 Y97 M98 G101 L153 A163 S21 V28 L66 T82 Y84 M85 G88 L140 A150 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o E 2.89 BS01 9XA E 1 S25 V32 K47 L79 T95 Y97 M98 G101 E105 L153 S21 V28 K43 L66 T82 Y84 M85 G88 E92 L140 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o F 2.89 BS01 9XA F 1 L24 S25 V32 A45 L79 T95 Y97 M98 P99 E105 R109 L153 L20 S21 V28 A41 L66 T82 Y84 M85 P86 E92 R96 L140 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o G 2.89 BS01 9XA G 1 L24 V32 A45 L79 T95 M98 G101 E105 L153 A163 L20 V28 A41 L66 T82 M85 G88 E92 L140 A150 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o H 2.89 BS01 9XA H 1 V32 K47 L79 T95 M98 G101 E105 L153 V28 K43 L66 T82 M85 G88 E92 L140 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o I 2.89 BS01 9XA I 1 S25 V32 A45 L79 T95 Y97 M98 G101 L153 S21 V28 A41 L66 T82 Y84 M85 G88 L140 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o J 2.89 BS01 9XA J 1 L24 V32 K47 L79 T95 M98 P99 G101 E105 Q150 L153 L20 V28 K43 L66 T82 M85 P86 G88 E92 Q137 L140 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o K 2.89 BS01 9XA K 1 L24 S25 V32 L79 T95 M98 G101 E105 L153 L20 S21 V28 L66 T82 M85 G88 E92 L140 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o L 2.89 BS01 9XA L 1 L24 S25 V32 K47 L79 T95 Y97 M98 G101 E105 L153 L20 S21 V28 K43 L66 T82 Y84 M85 G88 E92 L140 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o M 2.89 BS01 9XA M 1 L24 V32 L79 T95 Y97 M98 G101 E105 L153 L20 V28 L67 T83 Y85 M86 G89 E93 L141 D146 K148 Q150 N151 D164 T189 D134 K136 Q138 N139 D152 T162 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o N 2.89 BS01 9XA N 1 L24 S25 V32 L79 T95 M98 G101 L153 A163 L20 S21 V28 L63 T79 M82 G85 L137 A147 D146 K148 Q150 N151 D164 T189 D130 K132 Q134 N135 D148 T158 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o O 2.89 BS01 9XA O 1 L24 S25 V32 A45 K47 L79 T95 Y97 M98 G101 E105 L153 L20 S21 V28 A41 K43 L67 T83 Y85 M86 G89 E93 L141 D146 K148 Q150 N151 D164 T189 D134 K136 Q138 N139 D152 T162 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5w5o P 2.89 BS01 9XA P 1 S25 A45 L79 T95 M98 G101 S102 L153 A163 S21 A41 L66 T82 M85 G88 S89 L140 A150 D146 K148 Q150 N151 D164 T189 D133 K135 Q137 N138 D151 T161 2.7.10.2,2.7.11.1 0004672,0005524,0006468 IC50=8.0nM O43353 29057049 401 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMGTIIYMPPENYEPIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK