5w4w A 1.99 BS01 9WG A 1 I23 A36 K38 M80 M82 L85 I148 I21 A34 K36 M78 M80 L83 I146 D128 K130 D126 K128 2.7.11.1,2.7.11.26 0004672,0005524,0006468 ic50=8nM -logKd/Ki=8.10, IC50=8nM IC50=13nM P48730 28609096 4001 LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML 5w4w B 1.99 BS01 9WG B 1 I23 A36 K38 M80 M82 L85 I148 I21 A34 K36 M78 M80 L83 I146 D128 K130 D126 K128 2.7.11.1,2.7.11.26 0004672,0005524,0006468 ic50=8nM IC50=13nM P48730 28609096 4001 LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML 5w4w C 1.99 BS01 9WG C 1 I23 A36 K38 M80 M82 L85 L135 I148 I20 A33 K35 M77 M79 L82 L132 I145 D128 K130 D125 K127 2.7.11.1,2.7.11.26 0004672,0005524,0006468 ic50=8nM IC50=13nM P48730 28609096 401 RVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRQHIPYREKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML 5w4w D 1.99 BS01 9WG D 1 I15 I23 A36 K38 M80 M82 L85 L135 I148 I13 I21 A34 K36 M74 M76 L79 L129 I142 D128 K130 D122 K124 2.7.11.1,2.7.11.26 0004672,0005524,0006468 ic50=8nM IC50=13nM P48730 28609096 401 LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML