6adg A 3.0 BS02 9UO A 1 W124 M259 D273 Q277 S280 W122 M257 D271 Q275 S278 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 IC50=0.040000nM O75874 30131249 504 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL 6adg B 3.0 BS01 9UO A 1 W124 M259 D273 Q277 W122 M257 D271 Q275 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 IC50=0.040000nM O75874 30131249 504 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK 6adg C 3.0 BS01 9UO C 1 V255 M259 D273 Q277 S280 V232 M236 D250 Q254 S257 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 IC50=0.040000nM O75874 30131249 501 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCANGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK 6adi A 1.969 BS02 9UO A 1 V294 V297 D312 V315 Q316 I319 V254 V257 D272 V275 Q276 I279 1.1.1.42 0000287,0004450,0005739,0005759,0005777,0005829,0005975,0006097,0006099,0006102,0006103,0006739,0016491,0016616,0046872,0051287,0070062 ic50=31.7nM IC50=8.0nM P48735 30131249 502 DKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQHHHHHH 6adi B 1.969 BS01 9UO A 1 V294 V297 D312 V315 Q316 I319 V252 V255 D270 V273 Q274 I277 1.1.1.42 0000287,0004450,0005739,0005759,0005777,0005829,0005975,0006097,0006099,0006102,0006103,0006739,0016491,0016616,0046872,0051287,0070062 IC50=8.0nM P48735 30131249 502 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 6vei A 2.1 BS04 9UO B 1 W124 V255 M259 D273 V276 Q277 W122 V253 M257 D271 V274 Q275 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 IC50=0.040000nM O75874 32071674 502 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKLS 6vei B 2.1 BS02 9UO B 1 V255 M259 W267 D273 V276 Q277 S280 V253 M257 W265 D271 V274 Q275 S278 1.1.1.42 0000287,0004450,0005515,0005576,0005737,0005739,0005777,0005782,0005829,0006097,0006099,0006102,0006103,0006739,0006749,0006979,0008585,0014070,0016491,0016616,0034774,0042802,0042803,0045296,0046872,0048545,0050661,0051287,0060696,0070062,0071071,1904724,1904813 IC50=0.040000nM O75874 32071674 502 KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKLSLEHH 6vfz A 1.99 BS01 9UO A 1 V294 V297 D312 V315 Q316 I319 V254 V257 D272 V275 Q276 I279 1.1.1.42 0000287,0004450,0005739,0005759,0005777,0005829,0005975,0006097,0006099,0006102,0006103,0006739,0016491,0016616,0046872,0051287,0070062 IC50=8.0nM P48735 32071674 501 DKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQHHHH 6vfz B 1.99 BS01 9UO A 1 W164 V297 L298 V315 Q316 I319 W122 V255 L256 V273 Q274 I277 1.1.1.42 0000287,0004450,0005739,0005759,0005777,0005829,0005975,0006097,0006099,0006102,0006103,0006739,0016491,0016616,0046872,0051287,0070062 IC50=8.0nM P48735 32071674 501 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRA