6aah A 1.83 BS01 9T6 A 1 L881 A906 M956 F958 L959 G962 R1007 N1008 L1010 D1021 L17 A42 M87 F89 L90 G93 R138 N139 L141 D152 D1003 A1005 R1007 N1008 D1021 D134 A136 R138 N139 D152 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=8.41, IC50=3.9nM IC50=3.9nM P23458 30145050 1201 VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 6aah B 1.83 BS01 9T6 B 1 L881 A906 M956 E957 F958 L959 G962 R1007 N1008 L1010 L17 A42 M88 E89 F90 L91 G94 R139 N140 L142 D1003 A1005 R1007 N1008 D1021 D135 A137 R139 N140 D153 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=8.41, IC50=3.9nM IC50=3.9nM P23458 30145050 1201 VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 6aaj A 2.37 BS01 9T6 A 1 G856 V863 Y931 L932 L983 G14 V21 Y84 L85 L136 D976 R980 N981 D994 D129 R133 N134 D147 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=8.30, IC50=5.0nM IC50=5.0nM O60674 30145050 1201 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSNLKLIMEYLPYGSLRDYLQAHAERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNM 6aaj B 2.37 BS01 9T6 B 1 A880 L932 L983 A38 L79 L130 D976 R980 N981 D994 D123 R127 N128 D141 2.7.10.2 0004672,0004713,0005524,0006468 IC50=5.0nM O60674 30145050 1201 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHLRDFEREIEILKSLQHDNIVKYKGVCNLKLIMEYLPYGSLRDYLQAHAERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMA 6aak A 2.67 BS01 9T6 A 1 L828 A853 M902 Y904 L905 L956 L14 A39 M84 Y86 L87 L138 D949 A951 R953 N954 D967 D131 A133 R135 N136 D149 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=9.15, IC50=0.71nM IC50=0.700000nM P52333 30145050 1201 TIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMRDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDML 6aak B 2.67 BS01 9T6 B 1 A853 M902 E903 Y904 L905 L956 A39 M88 E89 Y90 L91 L142 D949 A951 R953 N954 D967 D135 A137 R139 N140 D153 2.7.10.2 0004672,0004713,0005524,0006468 IC50=0.700000nM P52333 30145050 1201 TIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSEDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWS 6aak C 2.67 BS01 9T6 C 1 L828 A853 Y904 L905 R953 L956 L15 A40 Y86 L87 R135 L138 D949 A951 R953 N954 D967 D131 A133 R135 N136 D149 2.7.10.2 0004672,0004713,0005524,0006468 IC50=0.700000nM P52333 30145050 1201 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLW 6aak D 2.67 BS01 9T6 D 1 L828 A853 L905 L956 D967 L15 A40 L87 L138 D149 D949 A951 R953 N954 D967 D131 A133 R135 N136 D149 2.7.10.2 0004672,0004713,0005524,0006468 IC50=0.700000nM P52333 30145050 1201 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDML 6aam A 1.98 BS01 9T6 A 1 L903 A928 I960 E979 Y980 V981 G984 L1030 D1041 L16 A35 I65 E84 Y85 V86 G89 L135 D146 N1023 A1025 R1027 N1028 D1041 P1064 N128 A130 R132 N133 D146 P155 2.7.10.2 0004672,0005524,0006468 -logKd/Ki=8.32, IC50=4.8nM IC50=4.8nM P29597 30145050 1201 DPTVFHKRYLKKIRDLGGKVSLYCYDPTNTGEMVAVKALDAGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGLAQGQMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQG