1lv8 A 2.3 BS02 9PP A 1 G32 S33 H86 N115 A116 A117 G118 F200 E201 M219 S220 N243 G30 S31 H84 N113 A114 A115 G116 F198 E199 M217 S218 N241 S33 H64 Y88 A116 M219 S220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM -logKd/Ki=5.46, Kd=3.5uM P55859 15342253 3001 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 B 2.3 BS02 9PP B 1 G1032 S1033 H1086 N1115 A1116 A1117 G1118 F1200 E1201 M1219 S1220 N1243 G30 S31 H84 N113 A114 A115 G116 F198 E199 M217 S218 N241 S1033 H1064 Y1088 A1116 M1219 S1220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM -logKd/Ki=5.46, Kd=3.5uM P55859 15342253 3002 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 C 2.3 BS02 9PP C 1 G2032 S2033 H2086 N2115 A2116 A2117 G2118 F2200 E2201 M2219 S2220 N2243 G30 S31 H84 N113 A114 A115 G116 F198 E199 M217 S218 N241 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM P55859 15342253 3003 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDGKQAAQKLEQFVSLLMASIPV 1lv8 D 2.3 BS02 9PP D 1 G32 S33 H86 N115 A116 A117 G118 F200 E201 M219 S220 N243 G30 S31 H84 N113 A114 A115 G116 F198 E199 M217 S218 N241 S33 H64 Y88 A116 M219 S220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM P55859 15342253 3006 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 E 2.3 BS02 9PP E 1 S1033 N1115 A1116 F1200 E1201 S1220 N1243 S31 N113 A114 F198 E199 S218 N241 S1033 H1064 Y1088 A1116 M1219 S1220 S31 H62 Y86 A114 M217 S218 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM P55859 15342253 3004 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDQAAQKLEQFVSLLMASIPV 1lv8 F 2.3 BS02 9PP F 1 G2032 S2033 H2086 N2115 A2116 A2117 G2118 F2200 E2201 M2219 S2220 N2243 G30 S31 H84 N113 A114 A115 G116 F198 E199 M217 S218 N241 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S31 H62 H84 Y86 E87 A114 M217 S218 N241 V243 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=3.5uM P55859 15342253 3005 NGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDKQAAQKLEQFVSLLMASIPV 1lvu A 2.05 BS02 9PP A 1 G32 S33 H86 N115 A116 G118 F200 E201 V217 M219 S220 N243 G31 S32 H85 N114 A115 G117 F199 E200 V216 M218 S219 N242 S33 H64 Y88 A116 M219 S220 S32 H63 Y87 A115 M218 S219 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM -logKd/Ki=5.32, Kd=4.8uM P55859 15342253 6100 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEEAGKQAAQKLEQFVSLLMASIPV 1lvu B 2.05 BS02 9PP B 1 G1032 S1033 R1084 H1086 N1115 A1116 A1117 G1118 F1200 E1201 V1217 M1219 S1220 N1243 G31 S32 R83 H85 N114 A115 A116 G117 F199 E200 V216 M218 S219 N242 S1033 H1064 Y1088 A1116 M1219 S1220 H1257 S32 H63 Y87 A115 M218 S219 H250 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM -logKd/Ki=5.32, Kd=4.8uM P55859 15342253 6200 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEHEEVLEAGKQAAQKLEQFVSLLMASIPV 1lvu C 2.05 BS02 9PP C 1 S2033 H2086 N2115 A2116 A2117 G2118 F2200 E2201 M2219 S2220 N2243 S33 H86 N115 A116 A117 G118 F200 E201 M219 S220 N243 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM P55859 15342253 6300 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKQAAQKLEQFVSLLMASIPV 1lvu D 2.05 BS02 9PP D 1 G32 S33 H86 N115 A116 A117 G118 F200 E201 M219 S220 N243 G31 S32 H85 N114 A115 A116 G117 F199 E200 M218 S219 N242 S33 H64 Y88 A116 M219 S220 H257 S32 H63 Y87 A115 M218 S219 H252 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM P55859 15342253 6400 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQHEEVLEAGKQAAQKLEQFVSLLMASIPV 1lvu E 2.05 BS02 9PP E 1 G1032 S1033 R1084 H1086 N1115 A1116 A1117 G1118 F1200 E1201 M1219 S1220 N1243 G31 S32 R83 H85 N114 A115 A116 G117 F199 E200 M218 S219 N242 S1033 H1064 Y1088 A1116 M1219 S1220 S32 H63 Y87 A115 M218 S219 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM P55859 15342253 6500 QNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYKQAAQKLEQFVSLLMASIPV 1lvu F 2.05 BS02 9PP F 1 G2032 S2033 H2086 N2115 A2116 A2117 G2118 F2200 E2201 V2217 M2219 S2220 N2243 G32 S33 H86 N115 A116 A117 G118 F200 E201 V217 M219 S220 N243 S2033 H2064 H2086 Y2088 E2089 A2116 M2219 S2220 N2243 V2245 S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 2.4.2.1 0003824,0004731,0005737,0006139,0006166,0009116,0016757,0016763,0047975 Kd=4.8uM P55859 15342253 6600 MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYEQAAQKLEQFVSLLMASIPV