3t3q A 2.1 BS02 9PL A 1 F107 F111 F118 N297 F300 A301 T305 F76 F80 F87 N266 F269 A270 T274 T305 F432 C439 T274 F401 C408 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=49uM Kd=3600nM, Ki=3000nM P11509 22051186 501 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGSFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMGLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3q B 2.1 BS02 9PL B 1 F107 F111 F118 N297 F300 A301 T305 F76 F80 F87 N266 F269 A270 T274 T305 F432 C439 T274 F401 C408 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=49uM Kd=3600nM, Ki=3000nM P11509 22051186 501 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGSFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMGLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3q C 2.1 BS02 9PL C 1 F107 F111 F118 N297 F300 A301 T305 F480 F76 F80 F87 N266 F269 A270 T274 F449 T305 F432 C439 T274 F401 C408 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=49uM Kd=3600nM, Ki=3000nM P11509 22051186 501 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGSFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMGLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3q D 2.1 BS02 9PL D 1 F107 F111 F118 N297 F300 A301 T305 F76 F80 F87 N266 F269 A270 T274 T305 F432 C439 T274 F401 C408 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=49uM Kd=3600nM, Ki=3000nM P11509 22051186 501 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGSFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMGLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3r A 2.4 BS02 9PL A 1 F107 F111 V117 F118 F209 N297 G301 T305 F76 F80 V86 F87 F178 N266 G270 T274 T305 F432 C439 T274 F401 C408 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=101uM Kd=3600nM, Ki=3000nM P11509 22051186 501 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3r B 2.4 BS02 9PL B 1 F107 F111 F209 N297 G301 T305 F76 F80 F178 N266 G270 T274 T305 F432 C439 T274 F401 C408 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=101uM Kd=3600nM, Ki=3000nM P11509 22051186 501 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3r C 2.4 BS02 9PL C 1 F107 F111 N297 I300 G301 T305 F480 F76 F80 N266 I269 G270 T274 F449 T305 F432 C439 T274 F401 C408 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=101uM Kd=3600nM, Ki=3000nM P11509 22051186 501 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3r D 2.4 BS02 9PL D 1 F107 F111 V117 N297 I300 G301 T305 F480 F76 F80 V86 N266 I269 G270 T274 F449 T305 F432 C439 T274 F401 C408 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=101uM Kd=3600nM, Ki=3000nM P11509 22051186 501 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPRH 3t3s A 3.0 BS02 9PL A 1 F107 F111 F209 N297 F300 T305 F77 F81 F179 N267 F270 T275 T305 F432 C439 T275 F402 C409 1.14.14.1 0004497,0005506,0005737,0005783,0005789,0006805,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0020037,0043231,0046222,0046872,0070330 Ki=1400nM, Kd=3000nM Q16696 22051186 1 GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3s B 3.0 BS02 9PL B 1 F107 F111 F118 N297 F300 A301 T305 F77 F81 F88 N267 F270 A271 T275 T305 F432 C439 T275 F402 C409 1.14.14.1 0004497,0005506,0005737,0005783,0005789,0006805,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0020037,0043231,0046222,0046872,0070330 Ki=1400nM, Kd=3000nM Q16696 22051186 1 GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3s C 3.0 BS02 9PL C 1 F107 F209 N297 A301 T305 F77 F179 N267 A271 T275 T305 F432 C439 T275 F402 C409 1.14.14.1 0004497,0005506,0005737,0005783,0005789,0006805,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0020037,0043231,0046222,0046872,0070330 Ki=1400nM, Kd=3000nM Q16696 22051186 1 GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3s D 3.0 BS02 9PL D 1 F107 F111 F118 F209 N297 F300 A301 T305 F77 F81 F88 F179 N267 F270 A271 T275 T305 F432 C439 T275 F402 C409 1.14.14.1 0004497,0005506,0005737,0005783,0005789,0006805,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0020037,0043231,0046222,0046872,0070330 Ki=1400nM, Kd=3000nM Q16696 22051186 1 GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3s E 3.0 BS02 9PL E 1 F107 F209 N297 F300 A301 T305 F77 F179 N267 F270 A271 T275 T305 F432 C439 T275 F402 C409 1.14.14.1 0004497,0005506,0005737,0005783,0005789,0006805,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0020037,0043231,0046222,0046872,0070330 Ki=1400nM, Kd=3000nM Q16696 22051186 1 GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3s F 3.0 BS02 9PL F 1 F107 N297 F300 A301 T305 F77 N267 F270 A271 T275 T305 F432 C439 T275 F402 C409 1.14.14.1 0004497,0005506,0005737,0005783,0005789,0006805,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0020037,0043231,0046222,0046872,0070330 Ki=1400nM, Kd=3000nM Q16696 22051186 1 GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR 3t3z A 2.35 BS02 9PL A 1 F116 F207 A299 T303 L368 F86 F177 A269 T273 L338 T303 F430 C437 T273 F400 C407 1.14.13.n7,1.14.14.1 0001676,0002933,0004497,0005506,0005737,0005739,0005743,0005783,0005789,0006631,0006805,0008202,0008392,0009617,0016098,0016491,0016705,0016709,0016712,0018601,0018885,0018910,0018960,0019373,0019825,0019899,0020037,0030544,0042197,0042759,0043231,0046872,0051879,0070330,0120319 Ki=765uM P05181 22051186 501 KLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRSH 3t3z B 2.35 BS03 9PL B 1 F116 F207 A299 T303 L368 F86 F177 A269 T273 L338 T303 F430 C437 T273 F400 C407 1.14.13.n7,1.14.14.1 0001676,0002933,0004497,0005506,0005737,0005739,0005743,0005783,0005789,0006631,0006805,0008202,0008392,0009617,0016098,0016491,0016705,0016709,0016712,0018601,0018885,0018910,0018960,0019373,0019825,0019899,0020037,0030544,0042197,0042759,0043231,0046872,0051879,0070330,0120319 Ki=765uM P05181 22051186 501 KLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRSH 3t3z C 2.35 BS02 9PL C 1 F116 F207 A299 T303 L368 F478 F86 F177 A269 T273 L338 F448 T303 F430 C437 T273 F400 C407 1.14.13.n7,1.14.14.1 0001676,0002933,0004497,0005506,0005737,0005739,0005743,0005783,0005789,0006631,0006805,0008202,0008392,0009617,0016098,0016491,0016705,0016709,0016712,0018601,0018885,0018910,0018960,0019373,0019825,0019899,0020037,0030544,0042197,0042759,0043231,0046872,0051879,0070330,0120319 Ki=765uM P05181 22051186 501 KLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRSH 3t3z D 2.35 BS03 9PL D 1 F207 A299 T303 L368 F478 F177 A269 T273 L338 F448 T303 F430 C437 T273 F400 C407 1.14.13.n7,1.14.14.1 0001676,0002933,0004497,0005506,0005737,0005739,0005743,0005783,0005789,0006631,0006805,0008202,0008392,0009617,0016098,0016491,0016705,0016709,0016712,0018601,0018885,0018910,0018960,0019373,0019825,0019899,0020037,0030544,0042197,0042759,0043231,0046872,0051879,0070330,0120319 Ki=765uM P05181 22051186 501 KLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRSH