5o5m A 1.583 BS02 9LQ A 1 T51 G52 G55 V57 A70 K72 Y122 V123 L173 D184 F327 T43 G44 G47 V49 A62 K64 Y114 V115 L165 D176 F317 D166 K168 N171 D184 T201 D158 K160 N163 D176 T193 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 -logKd/Ki=5.23, Kd=5.86uM P25321 401 GSEQESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGDTSNFDDYEEEEIRVSINEKCGKEFTEF 5ol3 A 1.58 BS02 9LQ A 1 T51 G52 G55 V57 A70 K72 M120 Y122 V123 L173 D184 F327 T42 G43 G46 V48 A61 K63 M111 Y113 V114 L164 D175 F318 D166 K168 N171 D184 T201 D157 K159 N162 D175 T192 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 P25321 401 SEQESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 5ot3 A 2.04 BS02 9LQ A 1 G52 G55 V57 A70 K72 M120 Y122 V123 L173 T183 D184 F327 G41 G44 V46 A59 K61 M109 Y111 V112 L162 T172 D173 F316 D166 K168 N171 D184 T201 D155 K157 N160 D173 T190 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 -logKd/Ki=5.23, Kd=5.86uM P25321 401 QESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 6egw A 1.74 BS02 9LQ A 1 T51 G52 G55 V57 A70 K72 M120 Y122 V123 L173 T183 D184 F327 T39 G40 G43 V45 A58 K60 M108 Y110 V111 L161 T171 D172 F313 D166 K168 N171 D184 T201 D154 K156 N159 D172 T189 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 P25321 401 ESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGGDTSNFDDYEEEEIRVSINEKCGKEFTEF 6i2b A 1.97 BS02 9LQ A 1 T51 G52 V57 A70 K72 Y122 V123 L173 T183 D184 F327 T48 G49 V54 A67 K69 Y119 V120 L170 T180 D181 F322 D166 K168 N171 D184 T201 D163 K165 N168 D181 T198 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 P25321 401 AAAKKGSEQESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGDTSNFDDYEEEEIRVSINEKCGKEFTEF 6i2b A 1.97 BS03 9LQ A 2 F18 L152 Y306 Q307 F15 L149 Y303 Q304 D166 K168 N171 D184 T201 D163 K165 N168 D181 T198 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 P25321 402 AAAKKGSEQESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGDTSNFDDYEEEEIRVSINEKCGKEFTEF 6i2d A 1.91 BS02 9LQ A 1 T51 G52 V57 A70 Y122 V123 L173 D184 F327 T44 G45 V50 A63 Y115 V116 L166 D177 F320 D166 K168 N171 D184 T201 D159 K161 N164 D177 T194 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 P25321 401 KGSEQESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF