1fsg A 1.05 BS02 9DG A 1 Y118 D150 K178 W199 I200 Y205 D206 Y121 D153 K181 W202 I203 Y208 D209 E146 D147 D150 W199 R212 E149 D150 D153 W202 R215 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 ic50=9.5uM -logKd/Ki=5.02, IC50=9.5uM Q26997 11188695 304 GSHMASKPIEDYGKGKGRIEPMYIPDNTFYNADDFLVPPHCKPYIDKILLPGGLVKDRVEKLAYDIHRTYFGEELHIICILKGSRGFFNLLIDYLATIQKYSGRESSVPPFFEHYVRLKSYQNDNSTGQLTVLSDDLSIFRDKHVLIVEDIVDTGFTLTEFGERLKAVGPKSMRIATLVEKRTDRSNSLKGDFVGFSIEDVWIVGCCYDFNEMFRDFDHVAVLSDAARKKFEK 1fsg C 1.05 BS02 9DG C 1 Y118 D150 K178 W199 I200 Y205 D206 Y121 D153 K181 W202 I203 Y208 D209 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 ic50=9.5uM Q26997 11188695 304 GSHMASKPIEDYGKGKGRIEPMYIPDNTFYNADDFLVPPHCKPYIDKILLPGGLVKDRVEKLAYDIHRTYFGEELHIICILKGSRGFFNLLIDYLATIQKYSGRESSVPPFFEHYVRLKSYQNDNSTGQLTVLSDDLSIFRDKHVLIVEDIVDTGFTLTEFGERLKAVGPKSMRIATLVEKRTDRSNSLKGDFVGFSIEDVWIVGCCYDFNEMFRDFDHVAVLSDAARKKFEK 1il4 A 2.6 BS01 9DG A 1 Y80 V81 G121 Y123 I172 E177 R180 Y80 V81 G121 Y123 I172 E177 R180 V81 E177 R180 V81 E177 R180 3.2.2.22 0017148,0030598 -logKd/Ki=2.85, IC50=1.4mM IC50=1400000nM P02879 11754581 301 IFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQF 1q2r A 2.9 BS03 9DG A 1 D102 Y106 D156 C158 G229 M260 D92 Y96 D146 C148 G219 M250 D102 D280 C318 C320 C323 H349 D92 D270 C308 C310 C313 H339 2.4.2.29 0002099,0005737,0005829,0006400,0008033,0008479,0008616,0016757,0016763,0046872,0101030 P28720 12949492 387 RPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVRATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPINIRNARFSEDLKPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRARYFARNS 1q2r B 2.9 BS03 9DG B 1 Y106 C158 G230 M260 Y96 C148 G220 M250 D102 D280 C318 C320 C323 H349 D92 D270 C308 C310 C313 H339 2.4.2.29 0002099,0005737,0005829,0006400,0008033,0008479,0008616,0016757,0016763,0046872,0101030 P28720 12949492 387 RPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVRATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPINIRNARFSEDLKPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRARYF 1q2r C 2.9 BS03 9DG C 1 D102 Y106 D156 C158 I201 G229 M260 D92 Y96 D146 C148 I191 G219 M250 D102 D280 C318 C320 C323 H349 D92 D270 C308 C310 C313 H339 2.4.2.29 0002099,0005737,0005829,0006400,0008033,0008479,0008616,0016757,0016763,0046872,0101030 P28720 12949492 387 RPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVRATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPINIRNARFSEDLKPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRARYFARNS 1q2r D 2.9 BS03 9DG D 1 D102 Y106 D156 C158 G229 G230 M260 D92 Y96 D146 C148 G219 G220 M250 D102 D280 C318 C320 C323 H349 D92 D270 C308 C310 C313 H339 2.4.2.29 0002099,0005737,0005829,0006400,0008033,0008479,0008616,0016757,0016763,0046872,0101030 P28720 12949492 387 RPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVRATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPINIRNARFSEDLKPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRARYF 1q2s C 3.2 BS03 9DG C 1 D102 Y106 D156 C158 M260 G261 D92 Y96 D146 C148 M250 G251 D102 D280 C318 C320 C323 H349 D92 D270 C308 C310 C313 H339 2.4.2.29 0002099,0005737,0005829,0006400,0008033,0008479,0008616,0016757,0016763,0046872,0101030 P28720 12949492 387 RPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVRATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPINIRNARFSEDLKPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRARYFARNS 6d9r A 1.64 BS01 9DG A 1 D103 K131 F152 V153 L158 D159 D97 K125 F146 V147 L152 D153 E99 D100 D103 F152 R165 E93 D94 D97 F146 R159 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 B9ZW32 31552824 201 AMMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFMADLLKRTDTYLEMDFMAVSSTGEVKILKDLDTSVEGRDILIVEDIIDSGLTLSYLVDLFKYRKAKSVKIVTLLDKPTGRKVDLKADYVGFTVPHEFVVGYGLDYKEQYRNLPYVGVLKPSVYS 6d9r B 1.64 BS01 9DG B 1 D103 F152 V153 L158 D159 D97 F146 V147 L152 D153 E99 D100 D103 F152 R165 E93 D94 D97 F146 R159 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0046100,0046872,0052657 B9ZW32 31552824 201 AMMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFMADLLKRTDTYLEMDFMAVSSTGEVKILKDLDTSVEGRDILIVEDIIDSGLTLSYLVDLFKYRKAKSVKIVTLLDKPTGRKVDLKADYVGFTVPHEFVVGYGLDYKEQYRNLPYVGVLKPSVYS 7nq4 A 2.88 BS03 9DG A 1 D105 F109 D159 V161 Q202 G228 S231 M259 D92 F96 D146 V148 Q189 G215 S218 M246 2.4.2.64 0005515,0005634,0005737,0005739,0005741,0006400,0008033,0008479,0016757,0016763,0032473,0032991,0042803,0046872,0046982,0101030,0120507,1990234 Q9BXR0 34241577 502 PRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTEQLDALGCRICLGNTYHLGLRPGPELIQKANGLHGFMNWPHNLLTDSGGFQMVSLVSLSEVTEEGVRFRSPYDGNETLLSPEKSVQIQNALGSDIIMQLDDVVSSTVTGPRVEEAMYRSIRWLDRCIAAHQRPDKQNLFAIIQGGLDADLRATCLEEMTKRDVPGFAIGGLSGGESKSQFWRMVALSTSRLPKDKPRYLMGVGYATDLVVCVALGCDMFDCVFPTRTARFGSALVPTGNLQLRKKVFEKDFGPIDPECTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQLQLMSAVRTSIVEKRFPDFVRDFMGAMYGDPTLCPTWATDALASVGITLG 8omr A 3.3 BS03 9DG A 1 D105 D159 D92 D146 2.4.2.64 0005515,0005634,0005737,0005739,0005741,0006400,0008033,0008479,0016757,0016763,0032473,0032991,0042803,0046872,0046982,0101030,0120507,1990234 Q9BXR0 38181786 502 PRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTEQLDALGCRICLGNTYHLGLRPGPELIQKANGLHGFMNWPHNLLTDSGGFQMVSLVSLSEVTEEGVRFRSPYDGNETLLSPEKSVQIQNALGSDIIMQLDDVVSSTVTGPRVEEAMYRSIRWLDRCIAAHQRPDKQNLFAIIQGGLDADLRATCLEEMTKRDVPGFAIGGLSGGESKSQFWRMVALSTSRLPKDKPRYLMGVGYATDLVVCVALGCDMFDCVFPTRTARFGSALVPTGNLQLRKKVFEKDFGPIDPECTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQLQLMSAVRTSIVEKRFPDFVRDFMGAMYGDPTLCPTWATDALASVGITLG