1pq6 A 2.4 BS01 965 A 1 F271 L274 A275 S278 M312 L313 T316 R319 F329 L330 F340 L345 F349 I350 I353 F354 H435 W457 F43 L46 A47 S50 M84 L85 T88 R91 F101 L102 F112 L117 F121 I122 I125 F126 H207 W229 ? 0003677,0004879,0006629 -logKd/Ki=8.10, IC50=7.94nM EC50=40.0nM, IC50=23nM, Ki=2.2nM P55055 12819202 1500 LTAAQELMIQQLVAAQLQCNKRSPKVTPWPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 1pq6 B 2.4 BS01 965 B 1 S242 L274 S278 I309 M312 L313 T316 F329 L330 F340 F349 I353 F354 H435 W457 S23 L55 S59 I90 M93 L94 T97 F110 L111 F121 F130 I134 F135 H216 W238 ? 0003677,0004879,0006629 EC50=40.0nM, IC50=23nM, Ki=2.2nM P55055 12819202 2500 LTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 1pq6 D 2.4 BS01 965 D 1 F271 L274 S278 I309 M312 L313 T316 R319 F329 L330 F340 F349 I353 F354 H435 W457 F41 L44 S48 I79 M82 L83 T86 R89 F99 L100 F110 F119 I123 F124 H205 W224 ? 0003677,0004879,0006629 EC50=40.0nM, IC50=23nM, Ki=2.2nM P55055 12819202 3500 LTAAQELMIQQLVAAQLQCNKRSFSKVTPWPLARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLKLPPLLSEIWDVH 3ipq A 2.0 BS02 965 A 1 F257 L260 S264 I295 M298 L299 T302 R305 F315 L316 F326 F335 I336 I339 F340 W443 F32 L35 S39 I70 M73 L74 T77 R80 F90 L91 F101 F110 I111 I114 F115 W218 ? 0003677,0004879,0006629 Ki=27nM -logKd/Ki=7.57, Ki=27nM EC50=200nM, IC50=235nM Q13133 20382159 801 QLSPEQLGMIEKLVAAQQTPWPEARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDV 4nqa B 3.102 BS04 965 B 1 F271 L274 S278 I309 M312 T316 R319 F329 L330 F340 L345 F354 H435 W457 F182 L185 S189 I220 M223 T227 R230 F240 L241 F251 L256 F265 H346 W368 ? 0003677,0003700,0004879,0006355,0006629,0008270,0043565 EC50=40.0nM, IC50=23nM, Ki=2.2nM P55055 24561505 501 KKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWD 4nqa I 3.102 BS04 965 I 1 F271 L274 S278 I309 M312 L313 T316 R319 I327 F329 L330 F340 L345 F349 I350 I353 F354 H435 W457 F197 L200 S204 I235 M238 L239 T242 R245 I253 F255 L256 F266 L271 F275 I276 I279 F280 H361 W383 ? 0003677,0003700,0004879,0006355,0006629,0008270,0043565 EC50=40.0nM, IC50=23nM, Ki=2.2nM P55055 24561505 501 KGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDV