5yto B 1.9 BS02 946 B 1 E21 P28 K30 W32 E100 E22 P29 K31 W33 E101 H46 H48 H63 H71 H80 D83 H120 R143 H47 H49 H64 H72 H81 D84 H121 R144 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 Kd=33uM -logKd/Ki=4.48, Kd=33uM P00441 29679384 203 MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 5yto B 1.9 BS04 946 H 1 K3 E21 K4 E22 H46 H48 H63 H71 H80 D83 H120 R143 H47 H49 H64 H72 H81 D84 H121 R144 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 Kd=33uM -logKd/Ki=4.48, Kd=33uM P00441 29679384 202 MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 5yto D 1.9 BS02 946 D 1 K9 G10 Q15 K11 G12 Q17 H46 H48 H63 H71 H80 D83 H120 R143 H48 H50 H65 H73 H82 D85 H122 R145 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 Kd=33uM P00441 29679384 202 AMATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 5yto H 1.9 BS02 946 H 1 K30 W32 S98 I99 K31 W33 S99 I100 H46 H48 H63 H71 H80 D83 H120 R143 H47 H49 H64 H72 H81 D84 H121 R144 1.15.1.1 0000302,0000303,0001541,0001819,0001890,0001895,0002262,0004784,0005507,0005515,0005576,0005615,0005634,0005654,0005737,0005739,0005758,0005759,0005777,0005829,0005886,0006749,0006801,0006879,0006915,0006979,0007283,0007566,0007605,0007626,0008089,0008090,0008217,0008270,0008340,0009408,0009410,0010467,0016209,0016491,0019226,0019228,0019430,0030346,0031267,0031410,0032287,0032839,0032930,0032991,0033081,0035234,0040014,0042542,0042554,0042802,0042803,0043025,0043065,0043066,0043087,0043410,0043524,0045471,0046620,0046716,0046872,0048538,0048678,0050665,0050728,0050766,0051087,0051093,0051881,0060047,0060052,0060087,0060088,0070062,0072593,0099610,1902177,1904115,2000242 Kd=33uM P00441 29679384 202 MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ