1kbq A 1.8 BS02 936 A 1 P68 Y126 Y128 F178 F232 F236 P67 Y125 Y127 F177 F231 F235 G149 Y155 H161 G148 Y154 H160 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 703 GRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq A 1.8 BS04 936 C 1 W105 G150 M154 H161 W104 G149 M153 H160 G149 Y155 H161 G148 Y154 H160 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 701 GRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq B 1.8 BS02 936 B 1 P68 Y126 Y128 F178 F232 F236 P66 Y124 Y126 F176 F230 F234 G149 Y155 H161 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 704 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq B 1.8 BS04 936 D 1 W105 M154 H161 W103 M152 H159 G149 Y155 H161 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 702 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq C 1.8 BS02 936 A 1 W105 G149 G150 M154 W103 G147 G148 M152 G149 Y155 H161 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 703 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq C 1.8 BS04 936 C 1 P68 Y126 Y128 F178 F232 F236 P66 Y124 Y126 F176 F230 F234 G149 Y155 H161 G147 Y153 H159 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 701 RRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq D 1.8 BS02 936 B 1 W105 G149 G150 M154 W104 G148 G149 M153 G149 Y155 H161 G148 Y154 H160 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 704 GRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK 1kbq D 1.8 BS04 936 D 1 P68 Y126 Y128 M131 F178 F236 P67 Y125 Y127 M130 F177 F235 G149 Y155 H161 G148 Y154 H160 1.6.5.2 0000209,0002931,0003723,0003955,0004128,0004784,0005515,0005634,0005737,0005829,0006116,0006743,0006801,0006805,0006809,0006979,0007271,0007584,0008753,0009410,0009636,0009725,0009743,0014070,0014075,0016491,0019430,0030163,0030425,0032355,0032496,0033574,0034599,0042177,0042360,0042373,0042802,0043025,0043066,0043279,0043525,0045087,0045202,0045454,0045471,0050136,0051602,0070301,0070995,0071248,0110076,1904772,1904844,1904880,1905395 Ki=0.45uM Ki=450nM P15559 11735396 702 GRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK