5mz3 A 2.15 BS01 8EN A 1 V38 A51 K53 E71 L74 I84 L104 T106 L108 M109 H148 L167 D168 F169 V35 A48 K50 E68 L71 I81 L101 T103 L105 M106 H145 L164 D165 F166 D150 K152 N155 D168 T185 D147 K149 N152 D165 T182 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0002862,0004672,0004674,0004707,0004708,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006935,0006974,0007165,0007166,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030168,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0033554,0034774,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0043536,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051149,0051403,0051525,0060045,0060348,0070935,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090398,0090400,0098586,0098978,0099179,0106310,1900015,1901741,1904813,2000379 ic50=0.0002uM -logKd/Ki=6.66, IC50=0.22uM IC50=220nM Q16539 29107542 401 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 6b8u A 2.68 BS01 8EN A 1 V471 A481 K483 E501 L505 L514 I527 T529 W531 C532 F583 G593 D594 F595 V23 A33 K35 E53 L57 L66 I79 T81 W83 C84 F135 G145 D146 F147 D576 K578 N580 N581 D594 S616 D128 K130 N132 N133 D146 S152 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=9.70, IC50=0.0002uM IC50=0.200000nM, EC50=230nM P15056 29107542 801 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAGSILWMAPEVIRMNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS 6b8u B 2.68 BS01 8EN B 1 V471 A481 K483 E501 L505 L514 I527 T529 W531 C532 L567 G593 D594 F595 V25 A35 K37 E51 L55 L64 I77 T79 W81 C82 L117 G143 D144 F145 D576 K578 N580 N581 D594 S616 D126 K128 N130 N131 D144 S147 2.7.11.1 0004672,0005524,0006468 IC50=0.200000nM, EC50=230nM P15056 29107542 801 SDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGSILWMAPEVIRMNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS