5xsu A 2.4 BS01 8E3 A 1 E102 H201 G202 G227 Y228 Y235 F236 A237 K242 S243 Y246 E102 H198 G199 G224 Y225 Y232 F233 A234 K239 S240 Y243 S243 Y246 E327 S240 Y243 E324 2.4.2.-,2.4.2.30 0003950 Kd=180nM -logKd/Ki=6.74, Kd=180nM Kd=1.8nM, IC50=244nM P09874 29335205 407 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 5xsu B 2.4 BS01 8E3 B 1 H201 G202 Y228 Y235 F236 A237 K242 S243 Y246 H192 G193 Y219 Y226 F227 A228 K233 S234 Y237 S243 Y246 E327 S234 Y237 E318 2.4.2.-,2.4.2.30 0003950 Kd=180nM Kd=1.8nM, IC50=244nM P09874 29335205 407 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAQGSSDSQILDLSNRFYTLIPHDFKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 5xsu C 2.4 BS01 8E3 C 1 H201 G202 Y228 Y235 F236 A237 K242 S243 Y246 E327 H181 G182 Y208 Y215 F216 A217 K222 S223 Y226 E305 S243 Y246 E327 S223 Y226 E305 2.4.2.-,2.4.2.30 0003950 Kd=180nM Kd=1.8nM, IC50=244nM P09874 29335205 403 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVLSNRFYTLIPHDPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 5xsu D 2.4 BS01 8E3 D 1 H201 G202 Y228 Y235 F236 A237 K242 S243 Y246 H177 G178 Y204 Y211 F212 A213 K218 S219 Y222 S243 Y246 E327 S219 Y222 E303 2.4.2.-,2.4.2.30 0003950 Kd=180nM Kd=1.8nM, IC50=244nM P09874 29335205 403 LPKPVQDLIKMIFDVESMKKAMVEYEIKMLGKLSKRQIQAAYSILEVQQAVDSQILDLSNRYTLIPHDPPLLNNDSVQAKAEMLDNLLDIEVAYSLLRGSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNF