3lq8 A 2.02 BS01 88Z A 1 I1084 V1092 A1108 K1110 E1127 M1131 F1134 L1157 Y1159 M1160 G1163 H1202 M1211 A1221 D1222 F1223 I32 V40 A56 K58 E72 M76 F79 L98 Y100 M101 G104 H143 M152 A162 D163 F164 D1204 A1206 R1208 N1209 D1222 A1243 D145 A147 R149 N150 D163 A176 2.7.10.1 0004672,0004713,0005524,0006468 ic50=0.4nM -logKd/Ki=9.40, IC50=0.4nM IC50=0.400000nM P08581 19808973 1 IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRIGEVSQFLTEGIIMKDFSHPNVLSLLGICLSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDDKEYYSAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFI 5ia4 A 1.797 BS01 88Z A 1 I619 A644 K646 E663 M667 Y694 M695 E696 L730 L746 S756 D757 F758 I15 A36 K38 E55 M59 Y86 M87 E88 L122 L138 S148 D149 F150 D739 A741 R743 N744 D757 D766 P780 D131 A133 R135 N136 D149 D158 P172 2.7.10.1 0004672,0004713,0005524,0006468 Kd=52nM -logKd/Ki=7.28, Kd=52nM P29317 27768280 1001 TTEIHPSCVTRQKVIGAGEFGEVYKGMLKKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRA 6i2y A 2.56 BS01 88Z A 1 L42 A63 L85 I110 C113 H155 L164 A174 D175 F176 L19 A40 L62 I87 C90 H132 L141 A151 D152 F153 D157 K159 G161 N162 D175 T195 D134 K136 G138 N139 D152 T162 2.7.11.1 0004672,0004674,0005524,0006468 O94804 2000 EHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNIGTPYWMAPEVVMCEPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLAIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEE 6i2y B 2.56 BS01 88Z B 1 L42 A63 L85 I110 C113 G116 L164 A174 D175 F176 L19 A40 L60 I84 C87 G90 L138 A148 D149 F150 D157 K159 G161 N162 D175 T195 D131 K133 G135 N136 D149 T159 2.7.11.1 0004672,0004674,0005524,0006468 O94804 2000 EHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNIGTPYWMAPEVVMCETPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLAIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEE 6sd9 A 2.35 BS01 88Z A 1 I1084 V1092 A1108 K1110 E1127 M1131 F1134 Y1159 M1160 M1211 V1220 A1221 D1222 F1223 I23 V31 A47 K49 E61 M65 F68 Y88 M89 M140 V149 A150 D151 F152 D1204 R1208 N1209 D1222 D133 R137 N138 D151 2.7.10.1 0004672,0004713,0005524,0006468 IC50=0.400000nM P08581 31531204 1402 LVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNREVSQFLTEGIIMKDFSHPNVLSLLGICLPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLAREYYSTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFI 6sdc A 1.67 BS01 88Z A 1 I1084 V1092 A1108 K1110 E1127 M1131 F1134 L1157 Y1159 M1160 K1161 F1200 H1202 M1211 V1220 A1221 D1222 F1223 I33 V41 A55 K57 E74 M78 F81 L104 Y106 M107 K108 F145 H147 M156 V165 A166 D167 F168 D1204 R1208 N1209 D1222 D149 R153 N154 D167 2.7.10.1 0004672,0004713,0005524,0006468 IC50=0.400000nM P08581 31531204 1401 HIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARVMYDKEYYSVAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG